{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:22:48Z","timestamp":1784892168792,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100018623","name":"Quanzhou City Science and Technology Program","doi-asserted-by":"crossref","award":["2023N011S"],"award-info":[{"award-number":["2023N011S"]}],"id":[{"id":"10.13039\/501100018623","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"DOI":"10.1186\/s12906-025-04841-x","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T17:17:09Z","timestamp":1742577429000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Based on network pharmacology and molecular docking technology to explore the pharmacodynamic components and mechanism of Gynostemmae Pentaphylli Herba reversing Cervical intraepithelial neoplasia"],"prefix":"10.1186","volume":"25","author":[{"given":"Huifang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"4841_CR1","doi-asserted-by":"publisher","unstructured":"Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, Arbyn M, Basu P, Bray F, Vaccarella S. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health. 2023;11(2):e197-e206. https:\/\/doi.org\/10.1016\/S2214-109X(22)00501-0. Epub 2022 Dec 14. PMID: 36528031; PMCID: PMC9848409.","DOI":"10.1016\/S2214-109X(22)00501-0"},{"key":"4841_CR2","doi-asserted-by":"publisher","unstructured":"Wang J, Zheng CX, Ma CL, Zheng XX, Lv XY, Lv GD, Tang J, Wu GH. Raman spectroscopic study of cervical precancerous lesions and cervical cancer. Lasers Med Sci. 2021;36(9):1855\u20131864. https:\/\/doi.org\/10.1007\/s10103-020-03218-5. Epub 2021 Jan 6. PMID: 33404885; PMCID: PMC8594213.","DOI":"10.1007\/s10103-020-03218-5"},{"key":"4841_CR3","doi-asserted-by":"publisher","first-page":"153303382211065","DOI":"10.1177\/15330338221106530.PMID:35730194;PMCID:PMC9228650","volume":"21","author":"F Guo","year":"2022","unstructured":"Guo F, Kong WN, Li DW, Zhao G, Wu HL, Anwar M, Shang XQ, Sun QN, Ma CL, Ma XM. Low Tumor Infiltrating Mast Cell Density Reveals Prognostic Benefit in Cervical Carcinoma. Technol Cancer Res Treat. 2022;21:15330338221106530. https:\/\/doi.org\/10.1177\/15330338221106530.PMID:35730194;PMCID:PMC9228650.","journal-title":"Technol Cancer Res Treat"},{"issue":"1","key":"4841_CR4","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12916-023-02965-w","volume":"21","author":"SJ Bowden","year":"2023","unstructured":"Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M. Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies. BMC Med. 2023;21(1):274. https:\/\/doi.org\/10.1186\/s12916-023-02965-w. PMID:37501128;PMCID:PMC10375747.","journal-title":"BMC Med"},{"key":"4841_CR5","doi-asserted-by":"publisher","unstructured":"Monti M, D\u2019Aniello D, Scopelliti A, Tibaldi V, Santangelo G, Colagiovanni V, Giannini A, DI Donato V, Palaia I, Perniola G, Giancotti A, Muzii L, Benedetti Panici P. Relationship between cervical excisional treatment for cervical intraepithelial neoplasia and obstetrical outcome. Minerva Obstet Gynecol. 2021;73(2):233\u2013246. https:\/\/doi.org\/10.23736\/S2724-606X.20.04678-X. Epub 2020 Nov 3. PMID: 33140628.","DOI":"10.23736\/S2724-606X.20.04678-X"},{"key":"4841_CR6","doi-asserted-by":"publisher","unstructured":"Gao M, Liu JJ, Wang D. The anti-proliferation effect of gypenosides on cervical cancer HeLa cells and its molecular mechanism.Tumor,2013,33(10):868\u2013872. https:\/\/doi.org\/10.3781\/j.issn.1000-7431.2013.10.004.","DOI":"10.3781\/j.issn.1000-7431.2013.10.004"},{"key":"4841_CR7","doi-asserted-by":"publisher","unstructured":"Lai ZQ, Wu LN, Li YH, Tang YX.Preparation and antitumor study of aptamer modified gynostemma pentaphyllum targeted li-posomes. Journal of Guangxi Medical University\u00a0,2022,39(3):450\u2013455. https:\/\/doi.org\/10.16190\/j.cnki.45-1211\/r.2022.03.018.","DOI":"10.16190\/j.cnki.45-1211\/r.2022.03.018"},{"key":"4841_CR8","doi-asserted-by":"publisher","first-page":"155424","DOI":"10.1016\/j.phymed.2024.155424","volume":"128","author":"C Ma","year":"2024","unstructured":"Ma C, Zhao J, Zheng G, Wu S, Wu R, Yu D, Liao J, Zhang H, Liu L, Jiang L, Qian F, Zeng H, Wu G, Lu Z, Ye J, Zhang W. Qijiao Shengbai Capsule alleviated leukopenia by interfering leukotriene pathway: Integrated network study of multi-omics. Phytomedicine. 2024;128: 155424. https:\/\/doi.org\/10.1016\/j.phymed.2024.155424. (Epub 2024 Feb 7 PMID: 38537441).","journal-title":"Phytomedicine"},{"key":"4841_CR9","doi-asserted-by":"publisher","first-page":"154538","DOI":"10.1016\/j.phymed.2022.154538","volume":"108","author":"ZY Wang","year":"2023","unstructured":"Wang ZY, Li MZ, Li WJ, Ouyang JF, Gou XJ, Huang Y. Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology. Phytomedicine. 2023;108: 154538. https:\/\/doi.org\/10.1016\/j.phymed.2022.154538. (Epub 2022 Nov 9 PMID: 36370638).","journal-title":"Phytomedicine"},{"key":"4841_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.780387","volume":"11","author":"H Ji","year":"2022","unstructured":"Ji H, Li K, Xu W, Li R, Xie S, Zhu X. Prediction of the Mechanisms by Which Quercetin Enhances Cisplatin Action in Cervical Cancer: A Network Pharmacology Study and Experimental Validation. Front Oncol. 2022;11: 780387. https:\/\/doi.org\/10.3389\/fonc.2021.780387. PMID:35070983;PMCID:PMC8770278.","journal-title":"Front Oncol"},{"key":"4841_CR11","doi-asserted-by":"publisher","unstructured":"Yin Z, Hua X, Lu M. Integrated network pharmacology and metabolomics to dissect the mechanisms of naringin for treating cervical cancer. Comb Chem High Throughput Screen. 2023. https:\/\/doi.org\/10.2174\/1386207326666230504124030. Epub ahead of print. PMID: 37143280.","DOI":"10.2174\/1386207326666230504124030"},{"issue":"7","key":"4841_CR12","doi-asserted-by":"publisher","first-page":"4689","DOI":"10.3390\/curroncol29070372","volume":"29","author":"AD Campos-Parra","year":"2022","unstructured":"Campos-Parra AD, P\u00e9rez-Quintanilla M, Mart\u00ednez-Gutierrez AD, P\u00e9rez-Montiel D, Coronel-Mart\u00ednez J, Millan-Catalan O, De Le\u00f3n DC, P\u00e9rez-Plasencia C. Molecular Differences between Squamous Cell Carcinoma and Adenocarcinoma Cervical Cancer Subtypes: Potential Prognostic Biomarkers. Curr Oncol. 2022;29(7):4689\u2013702. https:\/\/doi.org\/10.3390\/curroncol29070372. PMID:35877232;PMCID:PMC93223650.","journal-title":"Curr Oncol"},{"key":"4841_CR13","doi-asserted-by":"publisher","unstructured":"Liu H, Liang H, Li D, Wang M, Li Y. Association of Cervical Dysbacteriosis, HPV Oncogene Expression, and Cervical Lesion Progression. Microbiol Spectr. 2022;10(5):e0015122. https:\/\/doi.org\/10.1128\/spectrum.00151-22. Epub 2022 Aug 29. PMID: 36036584; PMCID: PMC9602310.","DOI":"10.1128\/spectrum.00151-22"},{"key":"4841_CR14","doi-asserted-by":"publisher","first-page":"104780","DOI":"10.1016\/j.micpath.2021.104780","volume":"152","author":"S Kumari","year":"2021","unstructured":"Kumari S, Bhor VM. Association of cervicovaginal dysbiosis mediated HPV infection with cervical intraepithelial neoplasia. Microb Pathog. 2021;152: 104780. https:\/\/doi.org\/10.1016\/j.micpath.2021.104780. (Epub 2021 Feb 3 PMID: 33545325).","journal-title":"Microb Pathog"},{"key":"4841_CR15","doi-asserted-by":"publisher","first-page":"1022030","DOI":"10.3389\/fmed.2023.1022030","volume":"10","author":"S Huang","year":"2023","unstructured":"Huang S, Qi Y, Chen S, He B, Chen X, Xu J. Effect of heat-clearing and dampness-eliminating Chinese medicine for high-risk cervical cancer papillomavirus infection: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2023;10:1022030. https:\/\/doi.org\/10.3389\/fmed.2023.1022030. PMID:37692777;PMCID:PMC10484520.","journal-title":"Front Med (Lausanne)"},{"key":"4841_CR16","doi-asserted-by":"publisher","unstructured":"Jesus ACC, Meniconi MCG, Galo LK, Duarte MIS, Sotto MN, Pagliari C. Plasmacytoid Dendritic Cells, the Expression of the Stimulator of Interferon Genes Protein (STING) and a Possible Role of Th17 Immune Response in Cervical Lesions Mediated by Human Papillomavirus. Indian J Microbiol. 2023;63(4):588\u2013595. https:\/\/doi.org\/10.1007\/s12088-023-01117-1. Epub 2023 Nov 9. PMID: 38031606; PMCID: PMC10682341.","DOI":"10.1007\/s12088-023-01117-1"},{"issue":"24","key":"4841_CR17","doi-asserted-by":"publisher","first-page":"5248","DOI":"10.1158\/0008-5472.CAN-15-0732","volume":"75","author":"B Walch-R\u00fcckheim","year":"2015","unstructured":"Walch-R\u00fcckheim B, Mavrova R, Henning M, Vicinus B, Kim YJ, Bohle RM, Juhasz-B\u00f6ss I, Solomayer EF, Smola S. Stromal Fibroblasts Induce CCL20 through IL6\/C\/EBP\u03b2 to Support the Recruitment of Th17 Cells during Cervical Cancer Progression. Cancer Res. 2015;75(24):5248\u201359. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-0732. (Epub 2015 Dec 2 PMID: 26631268).","journal-title":"Cancer Res"},{"key":"4841_CR18","doi-asserted-by":"publisher","unstructured":"Matamoros JA, da Silva MIF, de Moura PMMF, Leit\u00e3o MDCG, Coimbra EC. Reduced Expression of IL-1\u03b2 and IL-18 Proinflammatory Interleukins Increases the Risk of Developing Cervical Cancer. Asian Pac J Cancer Prev. 2019;20(9):2715\u20132721. https:\/\/doi.org\/10.31557\/APJCP.2019.20.9.2715. PMID: 31554368; PMCID: PMC6976845.","DOI":"10.31557\/APJCP.2019.20.9.2715"},{"key":"4841_CR19","doi-asserted-by":"publisher","unstructured":"Long DL, Song HL, Qu PP. Cytokines profiles in cervical mucosa in patients with cervical high-risk human papillomavirus infection. J Infect Dev Ctries. 2021;15(5):719\u2013725. https:\/\/doi.org\/10.3855\/jidc.12147. PMID: 34106897.","DOI":"10.3855\/jidc.12147"},{"key":"4841_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12967-014-0255-5","volume":"12","author":"ML Tornesello","year":"2014","unstructured":"Tornesello ML, Annunziata C, Buonaguro L, Losito S, Greggi S, Buonaguro FM. TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix. J Transl Med. 2014;12:255. https:\/\/doi.org\/10.1186\/s12967-014-0255-5. PMID:25220666;PMCID:PMC4174264.","journal-title":"J Transl Med"},{"issue":"5","key":"4841_CR21","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1158\/1055-9965.EPI-08-0830","volume":"18","author":"J Koshiol","year":"2009","unstructured":"Koshiol J, Hildesheim A, Gonzalez P, Bratti MC, Porras C, Schiffman M, Herrero R, Rodriguez AC, Wacholder S, Yeager M, Chanock SJ, Burk RD, Wang SS. Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3\/cancer revisited. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1631\u20137. https:\/\/doi.org\/10.1158\/1055-9965.EPI-08-0830. PMID:19423538;PMCID:PMC2764239.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"4841_CR22","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/s41379-022-01079-7","volume":"35","author":"C Parra-Herran","year":"2022","unstructured":"Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC. HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva. Mod Pathol. 2022;35(10):1317\u201326. https:\/\/doi.org\/10.1038\/s41379-022-01079-7. (Epub 2022 Apr 18 PMID: 35437330).","journal-title":"Mod Pathol"},{"key":"4841_CR23","doi-asserted-by":"publisher","first-page":"3997562","DOI":"10.1155\/2022\/3997562","volume":"2022","author":"C Zou","year":"2022","unstructured":"Zou C, Xu F, Shen J, Xu S. Identification of a Ferroptosis-Related Prognostic Gene PTGS2 Based on Risk Modeling and Immune Microenvironment of Early-Stage Cervical Cancer. J Oncol. 2022;2022:3997562. https:\/\/doi.org\/10.1155\/2022\/3997562. PMID:35432535;PMCID:PMC9012634.","journal-title":"J Oncol"},{"issue":"1","key":"4841_CR24","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s12672-023-00788-y","volume":"14","author":"M Chu","year":"2023","unstructured":"Chu M, Ji H, Li K, Liu H, Peng M, Wang Z, Zhu X. Investigating the potential mechanism of quercetin against cervical cancer. Discov Oncol. 2023;14(1):170. https:\/\/doi.org\/10.1007\/s12672-023-00788-y. PMID:37704909;PMCID:PMC10499770.","journal-title":"Discov Oncol"},{"key":"4841_CR25","doi-asserted-by":"publisher","unstructured":"Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS. Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase. Anat Cell Biol. 2018;51(4):274\u2013283. https:\/\/doi.org\/10.5115\/acb.2018.51.4.274. Epub 2018 Dec 29. PMID: 30637162; PMCID: PMC6318463.","DOI":"10.5115\/acb.2018.51.4.274"},{"issue":"1","key":"4841_CR26","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1620\/tjem.2023.J014","volume":"260","author":"SS Wang","year":"2023","unstructured":"Wang SS, Liu Y, Zhang XT, Yu DQ. Rhamnazin Enhanced Anti-Tumor Efficacy of Anti-PD-1 Therapy for Lung Cancer in Mice through Inhibition of PD-L1 Expression. Tohoku J Exp Med. 2023;260(1):63\u201373. https:\/\/doi.org\/10.1620\/tjem.2023.J014. (Epub 2023 Feb 23 PMID: 36823182).","journal-title":"Tohoku J Exp Med"},{"key":"4841_CR27","doi-asserted-by":"publisher","first-page":"9304552","DOI":"10.1155\/2022\/9304552","volume":"2022","author":"X Li","year":"2022","unstructured":"Li X, Liu H, Lv C, Du J, Lian F, Zhang S, Wang Z, Zeng Y. Gypenoside-Induced Apoptosis via the PI3K\/AKT\/mTOR Signaling Pathway in Bladder Cancer. Biomed Res Int. 2022;2022:9304552. https:\/\/doi.org\/10.1155\/2022\/9304552. PMID:35402614;PMCID:PMC8984741.","journal-title":"Biomed Res Int"},{"key":"4841_CR28","doi-asserted-by":"publisher","first-page":"1243353","DOI":"10.3389\/fphar.2024.1243353","volume":"15","author":"H Wu","year":"2024","unstructured":"Wu H, Lai W, Wang Q, Zhou Q, Zhang R, Zhao Y. Gypenoside induces apoptosis by inhibiting the PI3K\/AKT\/mTOR pathway and enhances T-cell antitumor immunity by inhibiting PD-L1 in gastric cancer. Front Pharmacol. 2024;15:1243353. https:\/\/doi.org\/10.3389\/fphar.2024.1243353. PMID:38482051;PMCID:PMC10933075.","journal-title":"Front Pharmacol"},{"key":"4841_CR29","doi-asserted-by":"publisher","first-page":"110674","DOI":"10.1016\/j.cbi.2023.110674","volume":"383","author":"MY Xiao","year":"2023","unstructured":"Xiao MY, Li FF, Xie P, Qi YS, Xie JB, Pei WJ, Luo HT, Guo M, Gu YL, Piao XL. Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1. Chem Biol Interact. 2023;383: 110674. https:\/\/doi.org\/10.1016\/j.cbi.2023.110674. (Epub 2023 Aug 19 PMID: 37604220).","journal-title":"Chem Biol Interact"},{"issue":"5","key":"4841_CR30","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/030089161109700507","volume":"97","author":"DR Misson","year":"2011","unstructured":"Misson DR, Abdalla DR, Borges AM, Shimba DS, Adad SJ, Michelin MA, Murta EF. Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-\u03b1 2b. Tumori. 2011;97(5):578\u201384.","journal-title":"Tumori"},{"key":"4841_CR31","doi-asserted-by":"publisher","unstructured":"Vahedpour Z, Abedzadeh-Kalahroudi M, Sehat M, Piroozmand A, Memar M. Comparison of Cervical Levels of Interleukins-6 and -8 in Patients with and without Cervical Intraepithelial Neoplasia. Asian Pac J Cancer Prev. 2021;22(4):1225\u20131230. https:\/\/doi.org\/10.31557\/APJCP.2021.22.4.1225. PMID: 33906316; PMCID: PMC8325114.","DOI":"10.31557\/APJCP.2021.22.4.1225"},{"issue":"3","key":"4841_CR32","doi-asserted-by":"publisher","first-page":"579","DOI":"10.2174\/1871520621666210903143922","volume":"22","author":"J Chen","year":"2022","unstructured":"Chen J, Wang L. Maslinic Acid Inhibits Cervical Intraepithelial Neoplasia by Suppressing Interleukin- 6 and Enhancing Apoptosis in a Mouse Model. Anticancer Agents Med Chem. 2022;22(3):579\u201385. https:\/\/doi.org\/10.2174\/1871520621666210903143922. (PMID: 34477530).","journal-title":"Anticancer Agents Med Chem"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-04841-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-025-04841-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-04841-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T17:17:23Z","timestamp":1742577443000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-025-04841-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4841"],"URL":"https:\/\/doi.org\/10.1186\/s12906-025-04841-x","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"3 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Quanzhou Medical College.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}