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Una responsabilidad y Un compromiso \u00c9tico Que Nos compete a Todos. 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Moreover, the recommendations proposed by Russell\u2019s three Rs (reduce, replace, and refine), focused on experimental animal research, were considered []. The protocol was approved by the Internal Committee for the Care and Use of Laboratory Animals of the Institute of Health Sciences of the Universidad Veracruzana, whose registration number is CICUAL-ICS 2018-0002B dated 18 February 2019. All methods are reported in accordance with the ARRIVE guidelines for the reporting of animal experiments. Regarding the biological plant material used in the present study, it was not collected in the wild, so it was not deposited in an herbarium or public collection, as Resveratrol was purchased in a food supplement formulation under the trade name Resveratrol (General Nutrition Centers GNC Laboratories, Pittsburgh, PA, USA; each capsule weighed 0.7\u00a0g and contained 500\u00a0mg of standardized Resveratrol extract. These laboratories authenticated the contents of the container as Resveratrol under batch number VA3020; therefore, it was not authenticated by a taxonomist, and a voucher was not needed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}