{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:08:55Z","timestamp":1761300535781,"version":"build-2065373602"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"DOI":"10.1186\/s12906-025-05092-6","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:04:19Z","timestamp":1761300259000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute toxicity evaluation of the ethanol extract from Minquartia Guianensis Aubl (Huacap\u00fa) leaves: hematological and histopathological analysis in an animal model"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-3398","authenticated-orcid":false,"given":"Julia","family":"Espinoza-Rivera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6255-4099","authenticated-orcid":false,"given":"Juana","family":"Ch\u00e1vez-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-4940","authenticated-orcid":false,"given":"Janet","family":"Serv\u00e1n-Mel\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4333-542X","authenticated-orcid":false,"given":"Michelle","family":"Lozada-Urbano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-2332","authenticated-orcid":false,"given":"Jaime","family":"Rosales-Rimache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"5092_CR1","unstructured":"Situaci\u00f3n de las plantas medicinales en Per\u00fa. nforme de reuni\u00f3n del grupo de expertos en plantas medicinales. Organizaci\u00f3n Panamericana de la Salud. Lima. 2019. Available at: https:\/\/iris.paho.org\/bitstream\/handle\/10665.2\/50479\/OPSPER19001_spa.pdf?sequence=1%26;isAllowed=y"},{"key":"5092_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.18004\/rspp.2018.junio.7-8","volume":"8","author":"N Soria","year":"2018","unstructured":"Soria N. Las Plantas medicinales y Su Aplicaci\u00f3n En La Salud p\u00fablica. Rev Salud Publica Parag. 2018;8:7\u20138.","journal-title":"Rev Salud Publica Parag"},{"issue":"4","key":"5092_CR3","first-page":"368","volume":"33","author":"G Prance","year":"1999","unstructured":"Prance G. The poisons and narcotics of the Amazonian Indians. J R Coll Physicians Lond. 1999;33(4):368\u201376.","journal-title":"J R Coll Physicians Lond"},{"issue":"11","key":"5092_CR4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.33588\/rn.5511.2012343","volume":"55","author":"FJ Carod-Artal","year":"2012","unstructured":"Carod-Artal FJ. [Curares and timb\u00f3s, poisons used in the amazon]. Revista De Neurologia. 2012;55(11):689\u201398.","journal-title":"Revista De Neurologia"},{"issue":"2","key":"5092_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.26722\/rpmi.2017.22.51","volume":"2","author":"FA Torres-Guevara","year":"2017","unstructured":"Torres-Guevara FA, Ganoza-Yupanqui ML. Etnobot\u00e1nica y Sistemas de extracci\u00f3n Para compuestos fenolicos, actividad antioxidante y Toxicidad de Plantas de Paramos y bosques nublados Del Norte Peruano. Revista Peruana De Med Integrativa. 2017;2(2):101\u20139.","journal-title":"Revista Peruana De Med Integrativa"},{"key":"5092_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.24841\/fa.v10i1-2.251","volume":"10","author":"G Nebel","year":"2016","unstructured":"Nebel G. Minquartia Guianensis aubl.: uso, ecolog\u00eda y Manejo En Forester\u00eda y agroforester\u00eda. Folia Amazon. 2016;10:201.","journal-title":"Folia Amazon"},{"key":"5092_CR7","unstructured":"Lozano Useche F. Ahumado, Minquartia guianensis Aubl. In. Colombia: Corpoinca Regional. 1992. https:\/\/repository.agrosavia.co\/bitstream\/handle\/20.500.12324\/35724\/45013.pdf;jsessionid=B26192B313D83EAB78BD5CA019E50166?sequence=1."},{"key":"5092_CR8","volume-title":"T\u00e9cnicas integrales de Viverismo En La Amazon\u00eda Colombiana","author":"B Giraldo Benavidez","year":"2020","unstructured":"Giraldo Benavidez B, Oidor Causaya M, Ochica Gait\u00e1n P, Ruiz Fuentes H. T\u00e9cnicas integrales de Viverismo En La Amazon\u00eda Colombiana. Bogot\u00e1, Colombia: Instituto Amaz\u00f3nico de Investigaciones Cient\u00edficas SINCHI; 2020."},{"issue":"2","key":"5092_CR9","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.jep.2010.10.039","volume":"133","author":"L Ruiz","year":"2011","unstructured":"Ruiz L, Ruiz L, Maco M, Cobos M, Gutierrez-Choquevilca A-L, Roumy V. Plants used by native Amazonian groups from the Nanay river (Peru) for the treatment of malaria. J Ethnopharmacol. 2011;133(2):917\u201321.","journal-title":"J Ethnopharmacol"},{"key":"5092_CR10","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1590\/S0100-40422012001100011","volume":"35","author":"L Cursino","year":"2012","unstructured":"Cursino L, Nunez C, Paula R, Nascimento M, Santos P. Triterpenes from Minquartia guianensis (Olacaceae) and in vitro antimalarial activity. Quim Nova. 2012;35:2165\u20138.","journal-title":"Quim Nova"},{"key":"5092_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jep.2018.10.007","volume":"229","author":"G Schmeda-Hirschmann","year":"2019","unstructured":"Schmeda-Hirschmann G, Burgos-Edwards A, Theoduloz C, Jim\u00e9nez-Aspee F, Vargas-Arana G. Male sexual enhancers from the Peruvian Amazon. J Ethnopharmacol. 2019;229:167\u201379.","journal-title":"J Ethnopharmacol"},{"key":"5092_CR12","doi-asserted-by":"publisher","first-page":"e1597","DOI":"10.32712\/2446-4775.2024.1597","volume":"18","author":"L Rodrigues","year":"2024","unstructured":"Rodrigues L, Rebou\u00e7as N, Santos A, Garcia D. Potencial terap\u00eautico Da esp\u00e9cie Minquartia Guianensis (Aubl.): Uma Breve revis\u00e3otherapeutic potential of the species Minquartia Guianensis (Aubl.): a brief review. Revista Fitos. 2024;18:e1597.","journal-title":"Revista Fitos"},{"issue":"2","key":"5092_CR13","first-page":"263","volume":"55","author":"IA Agyigra","year":"2017","unstructured":"Agyigra IA, Ejiofor JI, Magaji MG. Acute and subchronic toxicity evaluation of methanol stem-bark extract of Ximenia americana Linn (Olacaceae) in Wistar rats. Bull Fac Pharm Cairo Univ. 2017;55(2):263\u20137.","journal-title":"Bull Fac Pharm Cairo Univ"},{"key":"5092_CR14","doi-asserted-by":"publisher","unstructured":"Leite AM, Lima EO, Souza EL, Diniz MFFM, Leite SP, Xavier AL, et al. Preliminary study of the molluscicidal and larvicidal properties of some essential oils and phytochemicals from medicinal plants. Rev Bras Farmacogn. 2009;19(4):842\u20136. https:\/\/doi.org\/10.1590\/S0102-695X2009000600005.","DOI":"10.1590\/S0102-695X2009000600005"},{"key":"5092_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.yrtph.2004.12.006","volume":"42","author":"E Schlede","year":"2005","unstructured":"Schlede E, Genschow E, Spielmann H, Stropp G, Kayser D. Oral acute toxic class method: a successful alternative to the oral LD50 test. Regul Toxicol Pharmacology: RTP. 2005;42:15\u201323.","journal-title":"Regul Toxicol Pharmacology: RTP"},{"issue":"4","key":"5092_CR16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0278-6915(92)90009-A","volume":"30","author":"A Whitehead","year":"1992","unstructured":"Whitehead A, Curnow RN. Statistical evaluation of the fixed-dose procedure. Food Chem Toxicol. 1992;30(4):313\u201324.","journal-title":"Food Chem Toxicol"},{"key":"5092_CR17","unstructured":"National Research Council (US) Institute of Laboratory Animal Resources. Annual report, January 1977\u2013December 31, 1977. Washington (DC): National Academies Press; 1977."},{"issue":"4","key":"5092_CR18","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s11418-021-01545-7","volume":"75","author":"N Tanaka","year":"2021","unstructured":"Tanaka N, Kashiwada Y. Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies. J Nat Med. 2021;75(4):762\u201383.","journal-title":"J Nat Med"},{"issue":"4","key":"5092_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/plants6040042","volume":"6","author":"A Altemimi","year":"2017","unstructured":"Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA. Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts. Plants. 2017;6(4):42.","journal-title":"Plants"},{"issue":"3","key":"5092_CR20","first-page":"346","volume":"59","author":"D Pang","year":"2020","unstructured":"Pang D, Laferriere C. Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents. J Am Association Lab Anim Science: JAALAS. 2020;59(3):346.","journal-title":"J Am Association Lab Anim Science: JAALAS"},{"key":"5092_CR21","doi-asserted-by":"publisher","unstructured":"Morton DB, Abbot D, Barclay R, Close B, Ewbank R, Gask D, et al. Removal of blood from laboratory mammals and birds: First report of the BVA\/FRAME\/RSPCA\/UFAW Joint Working Group on Refinement. Lab Anim. 1993;27(1):1\u201322. https:\/\/doi.org\/10.1258\/002367793781082412.","DOI":"10.1258\/002367793781082412"},{"key":"5092_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.22490\/24629448.1006","volume":"10","author":"R Quintana-Arias","year":"2012","unstructured":"Quintana-Arias R. Estudio de Plantas medicinales Usadas En La Comunidad ind\u00edgena Tikuna Del Alto amazonas, Macedonia. Nova. 2012;10:181.","journal-title":"Nova"},{"key":"5092_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1590\/S0044-59672009000100018","volume":"39","author":"L Cursino","year":"2009","unstructured":"Cursino L, Mesquita A, de Oliveira W, Fernandes C, Junior O, Amaral I, Nunez C. Triterpenes from the leaves of Minquartia Guianensis aubl. (Olacaceae). Acta Amazonica. 2009;39:181\u20135.","journal-title":"Acta Amazonica"},{"key":"5092_CR24","doi-asserted-by":"publisher","first-page":"883","DOI":"10.53660\/CLM-920-23B61","volume":"23","author":"A Alexandre","year":"2023","unstructured":"Alexandre A, Fachin-Espinar M, Nunez C. Triterpenes, steroids and phenolic isolated from Minquartia Guianensis aubl. (Coulaceae) and antibacterial activity: triterpenos, esteroides e Fen\u00f3lico Isolados de Minquartia Guianensis aubl. (Coulaceae) e Atividade antibacteriana. Concilium. 2023;23:883\u201395.","journal-title":"Concilium"},{"key":"5092_CR25","doi-asserted-by":"publisher","unstructured":"Ballesteros-Ram\u00edrez R, Lasso P, Urue\u00f1a C, Saturno J, Fiorentino S. Assessment of acute and chronic toxicity in Wistar rats (Rattus norvegicus) and New Zealand rabbits (Oryctolagus cuniculus) of an enriched polyphenol extract obtained from Caesalpinia spinosa. J Toxicol. 2024;2024:3769933. https:\/\/doi.org\/10.1155\/2024\/3769933.","DOI":"10.1155\/2024\/3769933"},{"issue":"11","key":"5092_CR26","first-page":"1","volume":"12","author":"L Go\u00f1i Avelina Caridad","year":"2011","unstructured":"Go\u00f1i Avelina Caridad L, Blanco D, Pe\u00f1a A, Ronda M, Gonz\u00e1lez BO, Arteaga ME, Bada AM, Gonz\u00e1lez Y, Mancebo A. Valores hematol\u00f3gicos y bioqu\u00edmicos de Las Ratas Sprague Dawley producidas En CENPALAB, cenp: SPRD. REDVET Revista Electr\u00f3nica De Vet. 2011;12(11):1\u201310.","journal-title":"REDVET Revista Electr\u00f3nica De Vet"},{"key":"5092_CR27","doi-asserted-by":"publisher","unstructured":"Moore CJ, Holstege CP, Papin JA. Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responses. 2023.https:\/\/doi.org\/10.1101\/2023.02.07.527430.","DOI":"10.1101\/2023.02.07.527430"},{"issue":"1","key":"5092_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0022-3565(24)29523-9","volume":"297","author":"LH Lash","year":"2001","unstructured":"Lash LH, Qian W, Putt DA, Hueni SE, elfarra AA, Krause RJ, et al. Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences. J Pharmacol Exp Ther. 2001;297(1):155\u201364.","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"5092_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.33326\/29585309.2023.1.1875","volume":"2","author":"L Velasco Lopez","year":"2023","unstructured":"Velasco Lopez L, Valdivia Quispe LA. Valores de Los par\u00e1metros hematol\u00f3gicos y bioqu\u00edmicos de Roedores domesticados y reproducidos En El Bioterio de La Universidad Nacional Jorge Basadre Grohmann. Revista Ciencias Biol\u00f3gicas Y Ambientales. 2023;2(1):17\u201325.","journal-title":"Revista Ciencias Biol\u00f3gicas Y Ambientales"},{"key":"5092_CR30","volume":"23","author":"EO Amoateng","year":"2024","unstructured":"Amoateng EO, Amoateng P, Ossei PPS, Asare Fenteng E, Amponsah IK, Ayibor WG, et al. An acute and sub-acute toxicological assessment of reissantia indica plant extract in male Sprague-Dawley rats: hematological, serum biochemical and histopathology. Sci Afr. 2024;23:e02089.","journal-title":"Sci Afr"},{"key":"5092_CR31","doi-asserted-by":"publisher","first-page":"33","DOI":"10.5958\/0973-970X.2014.01131.6","volume":"38","author":"D Giri","year":"2014","unstructured":"Giri D, Ghosh RC, Mondal M. Pathology of acute oral toxicity of sodium fluoride in Wistar rats. Indian J Vet Pathol. 2014;38:33.","journal-title":"Indian J Vet Pathol"},{"issue":"1\u20133","key":"5092_CR32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0300-483X(99)00198-5","volume":"144","author":"HR Andersen","year":"2000","unstructured":"Andersen HR, Nielsen JB, Grandjean P. Toxicologic evidence of developmental neurotoxicity of environmental chemicals. Toxicology. 2000;144(1\u20133):121\u20137.","journal-title":"Toxicology"},{"issue":"4 Suppl","key":"5092_CR33","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1542\/peds.113.S3.984","volume":"113","author":"RL Brent","year":"2004","unstructured":"Brent RL. Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents). Pediatrics. 2004;113(4 Suppl):984\u201395.","journal-title":"Pediatrics"},{"issue":"10","key":"5092_CR34","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.34067\/KID.0000000000000227","volume":"4","author":"J Liang","year":"2023","unstructured":"Liang J, Liu Y. Animal models of kidney disease: challenges and perspectives. Kidney360. 2023;4(10):1479\u201393.","journal-title":"Kidney360"},{"issue":"2","key":"5092_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1177\/0960327117695633","volume":"37","author":"MY Zhang","year":"2018","unstructured":"Zhang MY, Yu YY, Wang SF, Zhang Q, Wu HW, Wei JY, et al. Cardiotoxicity evaluation of nine alkaloids from rhizoma Coptis. Hum Exp Toxicol. 2018;37(2):185\u201395.","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"5092_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s13659-020-00237-1","volume":"10","author":"YL Zhao","year":"2020","unstructured":"Zhao YL, Su M, Shang JH, Wang X, Njateng GSS, Bao GL, et al. Acute and chronic toxicity of indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. in mice and rats. Nat Prod Bioprospect. 2020;10(2):77\u201388.","journal-title":"Nat Prod Bioprospect"},{"issue":"2","key":"5092_CR37","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1177\/0192623313482208","volume":"42","author":"E Buse","year":"2014","unstructured":"Buse E, H\u00e4eger JD, Svensson-Arvelund J, Markert UR, Faas MM, Ernerudh J, Dixon D, Cline JM, Pfarrer C. The placenta in toxicology. Part I: animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis). Toxicol Pathol. 2014;42(2):314\u201326.","journal-title":"Toxicol Pathol"},{"issue":"6","key":"5092_CR38","doi-asserted-by":"publisher","first-page":"855","DOI":"10.2131\/jts.38.855","volume":"38","author":"K Hayakawa","year":"2013","unstructured":"Hayakawa K, Mimura Y, Tachibana S, Furuya M, Kodama T, Aoki T, Hosokawa S, Fukui M, Shibata S, Yoshida M, et al. A study for collecting background data on [crl:wi(han)]istar [crl:wi(han)]annover [Crl:WI(Han)] [crl:wi(han)]ats in general toxicity studies - comparative data to Sprague Dawley [crl:wi(han)]ats. J Toxicol Sci. 2013;38(6):855\u201373.","journal-title":"J Toxicol Sci"},{"issue":"2","key":"5092_CR39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s43188-021-00106-0","volume":"38","author":"CR Silva-Correa","year":"2022","unstructured":"Silva-Correa CR, Villarreal-La Torre VE, Gonz\u00e1lez-Siccha AD, Cruzado-Razco JL, Gonz\u00e1lez-Blas MV, Sag\u00e1stegui-Guarniz WA, et al. Acute toxicity of aqueous extract of ambrosia arborescens Mill. on biochemical and histopathological parameters in rats. Toxicol Res. 2022;38(2):225\u201333.","journal-title":"Toxicol Res"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-05092-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-025-05092-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-05092-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:04:25Z","timestamp":1761300265000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-025-05092-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5092"],"URL":"https:\/\/doi.org\/10.1186\/s12906-025-05092-6","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"9 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Norbert Wiener Private University on August 11, 2021 (Exp. No.: 901\u20132021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to the publication of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"397"}}