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It is traditionally used both in social ceremonies and for treating a wide range of ailments, including malaria, respiratory infections, gastrointestinal disturbances, hepatitis, metabolic and sexual disorders. Despite its importance and popularity, a great deal of information and basic knowledge is still missing about the species. Particularly lack of studies is related to therapeutic efficacy and safety of bitter kola uses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to document ethnomedicinal uses of bitter kola among native populations in Nigeria, to identify commonly used plant parts and the dosages, record perceived side effects and to compare these findings with scientific evidence, and to estimate its potential clinical applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected by a structured questionnaire distributed both online and in-person to members of the Nigerian public.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 152 respondents participated, primarily from the Ibibio, Annang, and Igbo ethnic groups. Most participants reported using fresh seeds of bitter kola, mainly for treating respiratory symptoms, stomach upset, and general well-being. Regular use was common, typically, monthly or as needed, depending on the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several traditional uses of bitter kola are supported by clinical studies: including its antioxidant and immunomodulatory effects and its benefits for gastric, hepatic, glycemic, respiratory, reproductive and pain-modulation related conditions. Evidence also suggests antimicrobial and hepatoprotective potential. However, further studies are required to establish standardised dosages and safety profiles for different plant parts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-026-05287-5","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:54:49Z","timestamp":1771224889000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Traditional use of Garcinia kola Heckel in Nigeria \u2013 the results of questionnaire survey compared with scientific evidence"],"prefix":"10.1186","volume":"26","author":[{"given":"Uyai-Abasi Otuekong","family":"Ukut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-9492","authenticated-orcid":false,"given":"Eszter","family":"Csik\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Papp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-0777","authenticated-orcid":false,"given":"Dragica","family":"Purger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"issue":"5","key":"5287_CR1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3923\/rjmsci.2011.280.285","volume":"5","author":"KP Osemene","year":"2011","unstructured":"Osemene KP, Elujoba AA, Ilori MO. 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Our study was approved by the Regional Research Ethics Committee, University of P\u00e9cs, Hungary (10317\/PTE2026). Our study was conducted in accordance with the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"109"}}