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Viability was tested using WST-1 assays. AnnexinV\/PI staining and flow cytometry analysis were used to investigate apoptosis and necrosis. A549 and NuLi-1 cells were stimulated with toll-like receptor (TLR)7- and TLR8-agonists, mimicking viral infection. Cytokine secretion was analyzed using the bead-based LEGENDplex\u2122 assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Non-toxic concentrations of the ivy-, thyme- or\n                      <jats:italic>Pelargonium\u00a0<\/jats:italic>\n                      - containing medications, but not the medication containing cineole, significantly reduced the secretion of inflammatory cytokines and chemokines after the stimulation of TLR7 and TLR8 in A549 and NuLi-1 cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Medications derived from ivy, thyme and\n                      <jats:italic>Pelargonium<\/jats:italic>\n                      extracts exhibit anti-inflammatory properties in a model mimicking viral infection in human lung epithelial cells.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-026-05307-4","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:14:25Z","timestamp":1773386065000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulating effects of herbal cough medication - in vitro screening in a TLR7- and TLR8-mediated inflammatory model"],"prefix":"10.1186","volume":"26","author":[{"given":"Johanna","family":"Voigts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Niederreiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Kowarschik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"5307_CR1","unstructured":"Influenza. 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