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These properties suggest a potential role in promoting tissue repair and wound healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Extracts and fractions of\n                      <jats:italic>C. latifolia<\/jats:italic>\n                      were phytochemically profiled and evaluated for antioxidant activity. The ethyl acetate (EtOAc) fraction was further assessed for wound healing potential using BJ-1 human skin fibroblast cells. In silico molecular docking and dynamics simulations were conducted to explore the interactions of representative compounds with wound-healing\u2013related protein targets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty compounds were identified in sub-fraction 1, in which Citric acid tri-methyl ester (23%) and Oleic acid (7.57%) were considered the major compounds. Fourteen compounds were identified in sub-fraction 2; Methyl 7-hydroxyheptanoate (36.04%), 9-Hexadecenoic acid (12.29%) and 1, 8 cineole (6.92%) were the major constituents. Ten compounds were identified from the third fraction, in which 9-octadecenoic acid (63.43%) was the most significant, followed by Linalool (13.20%) and \u03c1- allyl anisole (5.24%).\u00a0\n                      <jats:italic>Citrus latifolia<\/jats:italic>\n                      \u00a0fruits showed total phenols (44.42 mg GAE\/g) and total flavonoids (38.60 mg CE\/g). The performance, interaction, and stability of the key chemicals discovered by GC\u2013MS when bound to a protein's active site were predicted using a molecular dynamic simulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The significant results may be attributed to the major identified phenolic compounds mentioned above in EtOAc fractions, suggesting possible biological effects that should be investigated in the near future. Therefore, expanding this type of research is recommended to produce therapies for wound healing activity of natural origin with cheap, safe, and less harmful side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-026-05309-2","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:53:23Z","timestamp":1773795203000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The wound healing effects of Citrus latifolia extracts: phytochemical profiling and in silico investigations"],"prefix":"10.1186","volume":"26","author":[{"given":"Mona T. 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M. Ghanem and Heba D. Hassanein. The incorrect author names are: Mona T. M. Ghanema and Heba D. Hassaneina. The correct author names are: Mona T. M. Ghanem and Heba D. Hassanein. The author group has been updated above and the original article [1] has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12906-026-05408-0","URL":"https:\/\/doi.org\/10.1186\/s12906-026-05408-0","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}