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Although hormone therapy is effective, concerns about risks and adverse effects contribute to limited utilization, highlighting the need for non-hormonal options. Curcuminoids have antioxidant and anti-inflammatory properties and may improve vasomotor symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This 12-week, randomized, double-blind, placebo-controlled pilot proof-of-concept trial evaluated the preliminary efficacy of curcuminoids (1000\u00a0mg\/day) versus placebo in healthy postmenopausal women (41\u201365 years;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). The prespecified primary endpoint was the between-group difference in change in weekly hot flash frequency from baseline to Week 12. Secondary outcomes included changes in Menopause Rating Scale II (MRS II) and Menopause-Specific Quality of Life (MENQOL) scores. Safety and tolerability were assessed throughout.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All participants completed the intervention with high adherence and no serious adverse events. At Week 12 (primary endpoint), the between-group difference in change in weekly hot flash frequency from baseline was \u2212\u20097.35 episodes\/week (95% CI\u2009\u2212\u200910.29 to \u2212\u20094.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), favoring curcuminoids; results were concordant using the Hodges\u2013Lehmann estimate (\u2212\u20096.00; 95% CI\u2009\u2212\u200910.00 to \u2212\u20094.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A significant between-group difference was also observed at Week 6. No statistically significant between-group differences were observed at Week 12 for total MENQOL or total MRS II, although the MENQOL vasomotor domain improved at Week 6 and showed supportive evidence in baseline-adjusted sensitivity analysis at Week 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot proof-of-concept randomized trial, curcuminoid supplementation significantly reduced weekly hot flash frequency compared with placebo and showed a preliminary signal toward improved vasomotor-related quality of life, particularly at Week 6, with good tolerability. These preliminary, hypothesis-generating findings require confirmation in larger, adequately powered randomized trials, ideally incorporating biomarker endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Thai Clinical Trials Registry (TCTR) TCTR20241210002 (retrospectively registered).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-026-05358-7","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:07:15Z","timestamp":1774336035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcuminoid supplementation for vasomotor symptoms in postmenopausal women: a pilot, randomized, double-blind, placebo-controlled proof-of-concept trial"],"prefix":"10.1186","volume":"26","author":[{"given":"Jinjutha","family":"Buntoonprayuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5887-7596","authenticated-orcid":false,"given":"Kitti","family":"Chattrakulchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-007X","authenticated-orcid":false,"given":"Orawin","family":"Vallibhakara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-2293","authenticated-orcid":false,"given":"Pimpun","family":"Prasanchit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-3297","authenticated-orcid":false,"given":"Sakda Arj-Ong","family":"Vallibhakara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"issue":"9614","key":"5358_CR1","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/s0140-6736(08)60346-3","volume":"371","author":"HD Nelson","year":"2008","unstructured":"Nelson HD, Menopause. 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