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Medical students in clerkship who are transitioning from medical studies to clinical practice face a variety of workplace demands that can lead to negative learning experiences and poor quality of life. This study explored whether medical students\u2019 resilience plays a protective role against the stresses incurred during workplace training and on their professional quality of life during clerkships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 1-year prospective web-based questionnaire study comprising one cohort of medical students in their fifth year who were working as clerks as part of their 6-year medical education programme at one medical school in Taiwan between September 2017 and July 2018. Web-based, validated, structured, self-administered questionnaires were used to measure the students\u2019 resilience at the beginning of the clerkship and their perceived training stress (i.e. physical and psychological demands) and professional quality of life (i.e. burnout and compassion satisfaction) at each specialty rotation. Ninety-three medical students who responded to our specialty rotation surveys at least three times in the clerkship were included and hierarchical regressions were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study verified the negative effects of medical students\u2019 perceived training stress on burnout and compassion satisfaction. However, although the buffering (protective) effects of resilience were observed for physical demands (one key risk factor related to medical students\u2019 professional quality of life), this was not the case for psychological demands (another key risk factor). In addition, through the changes in R square (\u2206R<jats:sup>2<\/jats:sup>) values of the hierarchical regression building, our study found that medical students\u2019 perceived training stresses played a critical role on explaining their burnout but their resilience on their compassion satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Medical students\u2019 resilience demonstrated a buffering effect on the negative relationship between physical demands and professional quality of life during clerkships. Moreover, different mechanisms (predictive paths) leading to medical students\u2019 professional quality of life such as burnout and compassion satisfaction warrant additional studies.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12909-019-1912-4","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T18:02:42Z","timestamp":1577469762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Medical students\u2019 resilience: a protective role on stress and quality of life in clerkship"],"prefix":"10.1186","volume":"19","author":[{"given":"Yung Kai","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Der","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-9643","authenticated-orcid":false,"given":"Blossom Yen-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Der-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"1912_CR1","doi-asserted-by":"publisher","DOI":"10.1017\/9781108349246","volume-title":"Resilience: The science of mastering life's greatest challenges","author":"SM Southwick","year":"2018","unstructured":"Southwick SM, Charney DS. 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All participants provided written statements of consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Blossom Yen-Ju Lin, is a member of the editorial board (Associate Editor) of BMC Medical Education. All authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"473"}}