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This narrative review examines the synergistic impact of AI-powered virtual reality (VR) simulations, such as those used in surgical training and patient communication, on knowledge acquisition, clinical skill development, and collaborative competencies among healthcare students. It also explores long-term knowledge retention, ethical considerations within virtual scenarios, and the psychological impact of high-stakes simulations on learner resilience.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This review is distinguished by its exhaustive literature search, which spanned PubMed, CINAHL, Scopus, Google Scholar, and other pertinent databases, to identify studies published between 2005 and 2024. The distinct focus on AI and VR interventions in healthcare education, particularly those with outcomes related to interdisciplinary learning or patient safety, distinguishes this review. Data were thematically analyzed across domains, including adaptive learning, technical skill development, teamwork, patient safety, and ethics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The findings of this review carry significant practical implications. Five key themes emerged: adaptive learning (<jats:italic>n<\/jats:italic>\u2009=\u200917), immersive skill development (<jats:italic>n<\/jats:italic>\u2009=\u200910), teamwork enhancement (<jats:italic>n<\/jats:italic>\u2009=\u200910), patient safety (<jats:italic>n<\/jats:italic>\u2009=\u200918), and ethical considerations (<jats:italic>n<\/jats:italic>\u2009=\u200921). These themes underscore the potential of AI and VR in healthcare education. AI-driven adaptive systems enabled personalized VR training, enhancing engagement and knowledge retention. Real-time AI feedback during simulations improved decision-making in safe, controlled environments. Interdisciplinary team simulations enhanced communication and collaboration, which are crucial for effective clinical care. Ethical modules embedded in VR scenarios promoted moral reasoning. Several studies also reported increased learner confidence in performing clinical procedures following VR training, suggesting enhanced preparedness for practice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The integration of AI and VR holds the potential to revolutionize healthcare education, fostering personalized, immersive, and ethically informed learning. These technologies enhance technical proficiency and equip students with the complex demands of modern clinical practice. Strategic implementation can contribute to error reduction, improved patient outcomes, and a culture of safety. However, the journey is not over. Continued research is crucial for assessing the long-term outcomes and cost-effectiveness of these educational innovations, as well as for keeping pace with the rapidly evolving field of AI and VR in healthcare education.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12909-025-07589-7","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:25:15Z","timestamp":1752236715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The combined impact of AI and VR on interdisciplinary learning and patient safety in healthcare education: a narrative review"],"prefix":"10.1186","volume":"25","author":[{"given":"Emmanuel Aoudi","family":"Chance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"7589_CR1","unstructured":"Klingler N. 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