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The availability of a great amount of data makes it possible to tackle this issue with the adoption of data mining techniques, making the auditing process more efficient and effective. This research has the objective of developing a novel data mining model devoted to fraud detection among hospitals using Hospital Discharge Charts (HDC) in Administrative Databases. In particular, it is focused on the DRG upcoding practice, i.e., the tendency of registering codes for provided services and inpatients health status so to make the hospitalization fall within a more remunerative DRG class.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We propose a two-step algorithm: the first step entails kmeans clustering of providers to identify <jats:italic>locally consistent<\/jats:italic> and <jats:italic>locally similar<\/jats:italic> groups of hospitals, according to their characteristics and <jats:italic>behavior<\/jats:italic> treating a specific disease, in order to spot outliers within this groups of peers. An initial grid search for the best number of features to be selected (through Principal Feature Analysis) and the best number of local groups makes the algorithm extremely flexible. In the second step, we propose a human-decision support system that helps auditors cross-validating the identified outliers, analyzing them w.r.t. fraud-related variables, and the complexity of patients\u2019 casemix they treated. The proposed algorithm was tested on a database relative to HDC collected by Regione Lombardia (Italy) in a time period of three years (2013-2015), focusing on the treatment of Heart Failure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The model identified 6 clusters of hospitals and 10 outliers among the 183 units. Out of those providers, we report the in depth the application of Step Two on three Hospitals (two private and one public). Cross-validating with the patients\u2019 population and the hospitals\u2019 characteristics, the public hospital seemed justified in its outlierness, while the two private providers were deemed interesting for a further investigation by auditors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proposed model is promising in identifying anomalous DRG coding behavior and it is easily transferrable to all diseases and contexts of interest. Our proposal contributes to the limited literature regarding <jats:italic>behavioral models<\/jats:italic> for fraud detection, identifying the most \u2019cautious\u2019 fraudsters. The results of the first and the second Steps together represent a valuable set of information for auditors in their preliminary investigation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-020-01143-9","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T13:29:27Z","timestamp":1594733367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Data mining application to healthcare fraud detection: a two-step unsupervised clustering method for outlier detection with administrative databases"],"prefix":"10.1186","volume":"20","author":[{"given":"Michela Carlotta","family":"Massi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Lettieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"1143_CR1","unstructured":"OECD. 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