{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:06:07Z","timestamp":1787976367603,"version":"build-2784847793"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP13067824"],"award-info":[{"award-number":["AP13067824"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"DOI":"10.1186\/s12911-024-02640-x","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T14:46:48Z","timestamp":1724770008000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development and validation of a machine learning-based model to assess probability of systemic inflammatory response syndrome in patients with severe multiple traumas"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-4749","authenticated-orcid":false,"given":"Alexander","family":"Prokazyuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-6627","authenticated-orcid":false,"given":"Aidos","family":"Tlemissov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0610-0112","authenticated-orcid":false,"given":"Marat","family":"Zhanaspayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-4230","authenticated-orcid":false,"given":"Sabina","family":"Aubakirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-0345","authenticated-orcid":false,"given":"Arman","family":"Mussabekov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"2640_CR1","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00423-008-0334-2","volume":"393","author":"F Gebhard","year":"2008","unstructured":"Gebhard F, Huber-Lang M. Polytrauma - Pathophysiology and management principles. Langenbeck\u2019s Arch Surg. 2008;393:825\u201331. https:\/\/doi.org\/10.1007\/s00423-008-0334-2.","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"2640_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/329452","volume":"2013","author":"R Nicola","year":"2013","unstructured":"Nicola R. Early total care versus damage control: current concepts in the Orthopedic Care of Polytrauma patients. ISRN Orthop. 2013;2013:1\u20139. https:\/\/doi.org\/10.1155\/2013\/329452.","journal-title":"ISRN Orthop"},{"key":"2640_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0228082","volume":"15","author":"S Halvachizadeh","year":"2020","unstructured":"Halvachizadeh S, Baradaran L, Cinelli P, et al. How to detect a polytrauma patient at risk of complications: a validation and database analysis of four published scales. PLoS ONE. 2020;15:1\u201316. https:\/\/doi.org\/10.1371\/journal.pone.0228082.","journal-title":"PLoS ONE"},{"key":"2640_CR4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/978-1-4612-1222-5_29","volume-title":"Multiple organ failure","author":"H-C Pape","year":"2000","unstructured":"Pape H-C, Tscherne H. Early definitive fracture fixation with Polytrauma: advantages Versus Systemic\/Pulmonary consequences. Multiple organ failure. New York, NY: Springer New York; 2000. pp. 279\u201390."},{"key":"2640_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0148844","volume":"11","author":"R Pfeifer","year":"2016","unstructured":"Pfeifer R, Teuben M, Andruszkow H, et al. Mortality patterns in patients with multiple trauma: a systematic review of autopsy studies. PLoS ONE. 2016;11:1\u20139. https:\/\/doi.org\/10.1371\/journal.pone.0148844.","journal-title":"PLoS ONE"},{"key":"2640_CR6","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/TA.0000000000000199","volume":"76","author":"M Fr\u00f6hlich","year":"2014","unstructured":"Fr\u00f6hlich M, Lefering R, Probst C, et al. Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31,154 patients from the TraumaRegister DGU. J Trauma Acute Care Surg. 2014;76:921\u20137. https:\/\/doi.org\/10.1097\/TA.0000000000000199.","journal-title":"J Trauma Acute Care Surg"},{"key":"2640_CR7","doi-asserted-by":"crossref","unstructured":"Cimbanassi S, O\u2019Toole R, Maegele M et al. (2020) Orthopedic injuries in patients with multiple injuries: Results of the 11th trauma update international consensus conference Milan, December 11, 2017.","DOI":"10.1097\/TA.0000000000002407"},{"key":"2640_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/ijerph14091045","volume":"14","author":"CS Rau","year":"2017","unstructured":"Rau CS, Wu SC, Kuo PJ, et al. Polytrauma defined by the new berlin definition: a validation test based on propensity-score matching approach. Int J Environ Res Public Health. 2017;14:4\u201313. https:\/\/doi.org\/10.3390\/ijerph14091045.","journal-title":"Int J Environ Res Public Health"},{"key":"2640_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00590-013-1172-7","volume":"24","author":"W Carlino","year":"2014","unstructured":"Carlino W. Damage control resuscitation from major haemorrhage in polytrauma. Eur J Orthop Surg Traumatol. 2014;24:137\u201341. https:\/\/doi.org\/10.1007\/s00590-013-1172-7.","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"2640_CR10","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/JTN.0000000000000450","volume":"26","author":"L Schwing","year":"2019","unstructured":"Schwing L, Faulkner TD, Bucaro P, et al. Trauma Team activation: accuracy of Triage when Minutes Count: a synthesis of literature and performance improvement process. J Trauma Nurs. 2019;26:208\u201314. https:\/\/doi.org\/10.1097\/JTN.0000000000000450.","journal-title":"J Trauma Nurs"},{"key":"2640_CR11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/bjs.11361","volume":"107","author":"E Cole","year":"2020","unstructured":"Cole E, Gillespie S, Vulliamy P, et al. Multiple organ dysfunction after trauma. Br J Surg. 2020;107:402\u201312. https:\/\/doi.org\/10.1002\/bjs.11361.","journal-title":"Br J Surg"},{"key":"2640_CR12","doi-asserted-by":"publisher","first-page":"523","DOI":"10.5090\/kjtcs.2014.47.6.523","volume":"47","author":"JH Baek","year":"2014","unstructured":"Baek JH, Kim MS, Lee JC, Lee JH. Systemic inflammation response syndrome score predicts the mortality in multiple trauma patients. Korean J Thorac Cardiovasc Surg. 2014;47:523\u20138. https:\/\/doi.org\/10.5090\/kjtcs.2014.47.6.523.","journal-title":"Korean J Thorac Cardiovasc Surg"},{"key":"2640_CR13","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/00005373-200105000-00007","volume":"50","author":"GV Bochicchio","year":"2001","unstructured":"Bochicchio GV, Napolitano LM, Joshi M, et al. Systemic inflammatory response syndrome score at admission independently predicts infection in blunt trauma patients. J Trauma - Inj Infect Crit Care. 2001;50:817\u201320. https:\/\/doi.org\/10.1097\/00005373-200105000-00007.","journal-title":"J Trauma - Inj Infect Crit Care"},{"key":"2640_CR14","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1007\/S00268-005-7796-Y","volume":"29","author":"CA Kuhne","year":"2005","unstructured":"Kuhne CA, Ruchholtz S, Kaiser GM, et al. Mortality in severely injured elderly trauma patients\u2013when does age become a risk factor? World J Surg. 2005;29:1476\u201382. https:\/\/doi.org\/10.1007\/S00268-005-7796-Y.","journal-title":"World J Surg"},{"key":"2640_CR15","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/S00508-016-1140-4","volume":"128","author":"S Kocuvan","year":"2016","unstructured":"Kocuvan S, Brilej D, Stropnik D, et al. Evaluation of major trauma in elderly patients - a single trauma center analysis. Wien Klin Wochenschr. 2016;128:535\u201342. https:\/\/doi.org\/10.1007\/S00508-016-1140-4.","journal-title":"Wien Klin Wochenschr"},{"key":"2640_CR16","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s00068-019-01284-1","volume":"47","author":"K M\u00f6rs","year":"2021","unstructured":"M\u00f6rs K, Wagner N, Sturm R, et al. Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients. Eur J Trauma Emerg Surg. 2021;47:1065\u201372. https:\/\/doi.org\/10.1007\/s00068-019-01284-1.","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2640_CR17","doi-asserted-by":"publisher","unstructured":"Vourc\u2019h M, Roquilly A, Asehnoune K. Trauma-induced damage-associated molecular patterns-mediated remote organ injury and immunosuppression in the acutely ill patient. Front Immunol. 2018;9. https:\/\/doi.org\/10.3389\/fimmu.2018.01330.","DOI":"10.3389\/fimmu.2018.01330"},{"key":"2640_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-022-02126-3","author":"J Scherer","year":"2022","unstructured":"Scherer J, Coimbra R, Mariani D, et al. Standards of fracture care in polytrauma: results of a Europe-wide survey by the ESTES polytrauma section. Eur J Trauma Emerg Surg. 2022. https:\/\/doi.org\/10.1007\/s00068-022-02126-3.","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2640_CR19","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.surg.2020.07.038","volume":"169","author":"DP Stonko","year":"2021","unstructured":"Stonko DP, Guillamondegui OD, Fischer PE, Dennis BM. Artificial intelligence in trauma systems. Surg (United States). 2021;169:1295\u20139. https:\/\/doi.org\/10.1016\/j.surg.2020.07.038.","journal-title":"Surg (United States)"},{"key":"2640_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-35617-3","volume":"13","author":"A Choi","year":"2023","unstructured":"Choi A, Choi SY, Chung K, et al. Development of a machine learning-based clinical decision support system to predict clinical deterioration in patients visiting the emergency department. Sci Rep. 2023;13:1\u201310. https:\/\/doi.org\/10.1038\/s41598-023-35617-3.","journal-title":"Sci Rep"},{"key":"2640_CR21","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.ajem.2020.10.050","volume":"45","author":"H Ehrlich","year":"2021","unstructured":"Ehrlich H, McKenney M, Elkbuli A. The niche of artificial intelligence in trauma and emergency medicine. Am J Emerg Med. 2021;45:669\u201370. https:\/\/doi.org\/10.1016\/j.ajem.2020.10.050.","journal-title":"Am J Emerg Med"},{"key":"2640_CR22","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1097\/TA.0000000000000453","volume":"77","author":"HC Pape","year":"2014","unstructured":"Pape HC, Lefering R, Butcher N, et al. The definition of polytrauma revisited: an international consensus process and proposal of the New Berlin definition. J Trauma Acute Care Surg. 2014;77:780\u20136. https:\/\/doi.org\/10.1097\/TA.0000000000000453.","journal-title":"J Trauma Acute Care Surg"},{"key":"2640_CR23","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1097\/00005373-199712000-00009","volume":"43","author":"T Osler","year":"1997","unstructured":"Osler T, Baker SP, Long W. A modification of the Injury Severity score that both improves accuracy and simplifies Scoring. J Trauma Inj Infect Crit Care. 1997;43:922\u20136. https:\/\/doi.org\/10.1097\/00005373-199712000-00009.","journal-title":"J Trauma Inj Infect Crit Care"},{"key":"2640_CR24","unstructured":"Chakraborty RK, Burns B. (2023) Systemic Inflammatory Response Syndrome."},{"key":"2640_CR25","unstructured":"Gennarelli TA, Wodzin E. others (2008) Abbreviated injury scale 2005: update 2008. Russ Reeder 200:2008."},{"key":"2640_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.spinee.2023.09.001","volume":"24","author":"X Shi","year":"2024","unstructured":"Shi X, Cui Y, Wang S, et al. Development and validation of a web-based artificial intelligence prediction model to assess massive intraoperative blood loss for metastatic spinal disease using machine learning techniques. Spine J. 2024;24:146\u201360. https:\/\/doi.org\/10.1016\/j.spinee.2023.09.001.","journal-title":"Spine J"},{"key":"2640_CR27","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4037\/ajcc2009267","volume":"18","author":"EG NeSmith","year":"2009","unstructured":"NeSmith EG, Weinrich SP, Andrews JO, et al. Systemic inflammatory response syndrome score and race as predictors of length of stay in the intensive care unit. Am J Crit Care. 2009;18:339\u201346. https:\/\/doi.org\/10.4037\/ajcc2009267.","journal-title":"Am J Crit Care"},{"key":"2640_CR28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.injury.2012.04.019","volume":"44","author":"NE Butcher","year":"2013","unstructured":"Butcher NE, Balogh ZJ. The practicality of including the systemic inflammatory response syndrome in the definition of polytrauma: experience of a level one trauma centre. Injury. 2013;44:12\u20137. https:\/\/doi.org\/10.1016\/j.injury.2012.04.019.","journal-title":"Injury"},{"key":"2640_CR29","doi-asserted-by":"publisher","unstructured":"Schefzik R, Hahn B, Schneider-Lindner V. Dissecting contributions of individual systemic inflammatory response syndrome criteria from a prospective algorithm to the prediction and diagnosis of sepsis in a polytrauma cohort. Front Med. 2023;10. https:\/\/doi.org\/10.3389\/fmed.2023.1227031.","DOI":"10.3389\/fmed.2023.1227031"},{"key":"2640_CR30","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s00268-019-05267-6","volume":"44","author":"L Mica","year":"2020","unstructured":"Mica L, Niggli C, Bak P, et al. Development of a Visual Analytics Tool for Polytrauma patients: Proof of Concept for a New Assessment Tool using a multiple layer Sankey Diagram in a single-center database. World J Surg. 2020;44:764\u201372. https:\/\/doi.org\/10.1007\/s00268-019-05267-6.","journal-title":"World J Surg"},{"key":"2640_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2023.1281674","volume":"14","author":"M Fachet","year":"2023","unstructured":"Fachet M, Mushunuri RV, Bergmann CB, et al. Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma. Front Immunol. 2023;14:1\u201315. https:\/\/doi.org\/10.3389\/fimmu.2023.1281674.","journal-title":"Front Immunol"},{"key":"2640_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpubh.2023.1145013","volume":"11","author":"X Li","year":"2023","unstructured":"Li X, Lu Y, Chen C, et al. Development and validation of a patient-specific model to predict postoperative SIRS in older patients: a two-center study. Front Public Heal. 2023;11:1\u201310. https:\/\/doi.org\/10.3389\/fpubh.2023.1145013.","journal-title":"Front Public Heal"},{"key":"2640_CR33","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0969-9961(02)00030-X","volume":"12","author":"HJ Thompson","year":"2003","unstructured":"Thompson HJ, Tkacs NC, Saatman KE, et al. Hyperthermia following traumatic brain injury: a critical evaluation. Neurobiol Dis. 2003;12:163\u201373. https:\/\/doi.org\/10.1016\/S0969-9961(02)00030-X.","journal-title":"Neurobiol Dis"},{"key":"2640_CR34","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.3390\/ph16101382","volume":"16","author":"RW Keane","year":"2023","unstructured":"Keane RW, Hadad R, Scott XO, et al. Neural\u2013cardiac Inflammasome Axis after Traumatic Brain Injury. Pharmaceuticals. 2023;16:1382. https:\/\/doi.org\/10.3390\/ph16101382.","journal-title":"Pharmaceuticals"},{"key":"2640_CR35","doi-asserted-by":"publisher","unstructured":"Ma RN, He YX, Bai FP, et al. Machine Learning Model for Predicting Acute Respiratory failure in individuals with moderate-to-severe traumatic brain Injury. Front Med. 2021;8. https:\/\/doi.org\/10.3389\/fmed.2021.793230.","DOI":"10.3389\/fmed.2021.793230"},{"key":"2640_CR36","doi-asserted-by":"publisher","first-page":"113080","DOI":"10.1016\/j.expneurol.2019.113080","volume":"323","author":"N Kerr","year":"2020","unstructured":"Kerr N, de Rivero Vaccari JP, Dietrich WD, Keane RW. Neural-respiratory inflammasome axis in traumatic brain injury. Exp Neurol. 2020;323:113080. https:\/\/doi.org\/10.1016\/j.expneurol.2019.113080.","journal-title":"Exp Neurol"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-024-02640-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12911-024-02640-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-024-02640-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:02:31Z","timestamp":1724803351000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-024-02640-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2640"],"URL":"https:\/\/doi.org\/10.1186\/s12911-024-02640-x","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]},"assertion":[{"value":"9 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study received approval from the Local Ethical Committee of the Non-Commercial Joint Stock Company \u201cSemey Medical University\u201d in Semey city, Republic of Kazakhstan (permission No. 2, dated 10\/28\/2020). Additionally, it was retrospectively registered in the ClinicalTrials.gov database of the National Library of Medicine () under the identifier NCT06323096. The need for consent to participate was waived by an Institutional Review Boards of participating centers \u00abMunicipal state enterprise with the right of economic management Emergency hospital of the Abai region\u00bb (Semey, the Republic of Kazakhstan, act No. act No. 06\u2009\u2212\u200901\/366, dated 02\/14\/2023); \u00abMultidisciplinary Hospital named after Prof. H. Makazhanov\u00bb (Karaganda, the Republic of Kazakhstan, act No. 06\u2009\u2212\u200901\/367, dated 02\/14\/2023); \u00abThe National Scientific Center of Traumatology and Orthopaedics named after Academician Batpenov N.D.\u00bb (Astana, the Republic of Kazakhstan, act No. 06\u2009\u2212\u200901\/368, dated 02\/14\/2023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"235"}}