{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T10:31:41Z","timestamp":1649068301649},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"regional health management of castile and le\u00f3n","award":["2181\/A\/2020"],"award-info":[{"award-number":["2181\/A\/2020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nurs"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The increase in the survival of oncology patients include multiple side effects as cancer-related asthenia and dyspnea, which represents a serious health problem. An implementation of the conventional clinical practice, developed through multimodal physical exercise and functional rehabilitation program intervention, may be useful in controlling dyspnoea. This study aims to evaluate the effects of a multimodal exercise and functional rehabilitation program on fatigue, pain, functional capacity, and quality of life in cancer patients with cancer-related asthenia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a protocol for an experimental, prospective, randomised study using a parallel, fixed assignment scheme, with an experimental group and a control group in patients from the oncology hospitalisation unit at the Salamanca University Hospital Complex in Spain, using consecutive sampling to select 50 participants with oncological asthenia who are hospitalised at the time of inclusion. After the baseline evaluation, the participants will be randomised into two groups. Both groups will receive standard clinical practice care and the normal health education program at discharge, but in addition, the participants assigned to the experimental group will also complete a multimodal exercise and functional rehabilitation program lasting one month. The primary outcomes will be basic activities of daily living (Barthel Index) and degree of asthenia (FACT-An scale). Additionally, physical performance will be evaluated with the Short Physical Performance Battery (SPPB), as will the attention and executive functions (Trail-Making Test), fear\/avoidance of movement (TAMPA scale), pain (VAS scale), and body composition (waist, hip, brachial, thigh, wrist, and ankle circumferences).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The results of this study may be translated to clinical practice, incorporating a specific autonomy recovery programme into comprehensive rehabilitation programmes of care for cancer patients with asthenia. The current study addresses to improve the conventional clinical practice by proposing a multimodal physical exercise and functional rehabilitation program intervention, which will be implemented by an interdisciplinary team, to try to improve the autonomy of cancer patients with cancer-related asthenia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov; ID: NCT04761289. (February 18, 2021).\u00a0<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/\">https:\/\/clinicaltrials.gov\/ct2\/show\/<\/jats:ext-link> NCT04761289.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12912-021-00734-9","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T12:05:00Z","timestamp":1634904300000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimodal physical exercise and functional rehabilitation program in oncological patients with asthenia. study protocol"],"prefix":"10.1186","volume":"20","author":[{"given":"Eduardo Jos\u00e9","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Gonz\u00e1lez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Silvia","family":"Puente-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ignacio","family":"Recio-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"S\u00e1nchez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"M\u00e9ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jes\u00fas","family":"Cruz-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Rihuete-Galve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"734_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"734_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"734_CR3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/SPC.0b013e32835391dc","volume":"6","author":"GJ Koelwyn","year":"2012","unstructured":"Koelwyn GJ, Jones LW, Hornsby W, Eves ND. Exercise therapy in the management of dyspnea in patients with cancer. Curr Opin Support Palliat Care. 2012;6:129\u201337.","journal-title":"Curr Opin Support Palliat Care"},{"issue":"Suppl 1","key":"734_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1634\/theoncologist.12-S1-4","volume":"12","author":"M Hofman","year":"2007","unstructured":"Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR. Cancer-related fatigue: the scale of the problem. Oncologist. 2007;12(Suppl 1):4\u201310.","journal-title":"Oncologist"},{"key":"734_CR5","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00520-007-0380-2","volume":"16","author":"DH Henry","year":"2008","unstructured":"Henry DH, Viswanathan HN, Elkin EP, Traina S, Wade S, Cella D. Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S. Support care cancer Off. J Multinatl Assoc Support Care Cancer. 2008;16:791\u2013801.","journal-title":"J Multinatl Assoc Support Care Cancer"},{"key":"734_CR6","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/jcsm.12199","volume":"8","author":"ECW Neefjes","year":"2017","unstructured":"Neefjes ECW, van den Hurk RM, Blauwhoff-Buskermolen S, van der Vorst MJDL, Becker-Commissaris A, de van der Schueren MAE, et al. Muscle mass as a target to reduce fatigue in patients with advanced cancer. J Cachexia Sarcopenia Muscle. 2017;8:623\u20139.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"734_CR7","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.6004\/jnccn.2016.0144","volume":"14","author":"AM Berger","year":"2016","unstructured":"Berger AM, Mooney K. Dissemination and Implementation of Guidelines for Cancer-Related Fatigue. J Natl Compr Canc Netw. 2016;14:1336\u20138.","journal-title":"J Natl Compr Canc Netw"},{"key":"734_CR8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/wvn.12352","volume":"16","author":"C Wu","year":"2019","unstructured":"Wu C, Zheng Y, Duan Y, Lai X, Cui S, Xu N, et al. Nonpharmacological Interventions for Cancer-Related Fatigue: A Systematic Review and Bayesian Network Meta-Analysis. Worldviews evidence-based Nurs. 2019;16:102\u201310.","journal-title":"Worldviews evidence-based Nurs"},{"key":"734_CR9","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1002\/cncr.20111","volume":"100","author":"AM Barsevick","year":"2004","unstructured":"Barsevick AM, Dudley W, Beck S, Sweeney C, Whitmer K, Nail L. A randomized clinical trial of energy conservation for patients with cancer-related fatigue. Cancer. 2004;100:1302\u201310.","journal-title":"Cancer"},{"key":"734_CR10","first-page":"2953","volume":"25","author":"M Keilani","year":"2017","unstructured":"Keilani M, Hasenoehrl T, Baumann L, Ristl R, Schwarz M, Marhold M, et al. Effects of resistance exercise in prostate cancer patients: a meta-analysis. Support care cancer Off J Multinatl Assoc Support Care Cancer. 2017;25:2953\u201368.","journal-title":"Support care cancer Off J Multinatl Assoc Support Care Cancer"},{"key":"734_CR11","first-page":"4687","volume":"27","author":"C-J Yen","year":"2019","unstructured":"Yen C-J, Hung C-H, Kao C-L, Tsai W-M, Chan S-H, Cheng H-C, et al. Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy. Support care cancer Off J Multinatl Assoc Support Care Cancer. 2019;27:4687\u201395.","journal-title":"Support care cancer Off J Multinatl Assoc Support Care Cancer"},{"key":"734_CR12","first-page":"521","volume":"21","author":"C Fern\u00e1ndez-Lao","year":"2013","unstructured":"Fern\u00e1ndez-Lao C, Cantarero-Villanueva I, Ariza-Garcia A, Courtney C, Fern\u00e1ndez-de-las-Pe\u00f1as C, Arroyo-Morales M. Water versus land-based multimodal exercise program effects on body composition in breast cancer survivors: a controlled clinical trial. Support care cancer Off J Multinatl Assoc Support Care Cancer. 2013;21:521\u201330.","journal-title":"Support care cancer Off J Multinatl Assoc Support Care Cancer"},{"key":"734_CR13","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3322\/caac.21579","volume":"69","author":"KH Schmitz","year":"2019","unstructured":"Schmitz KH, Campbell AM, Stuiver MM, Pinto BM, Schwartz AL, Morris GS, et al. Exercise is medicine in oncology: Engaging clinicians to help patients move through cancer. CA Cancer J Clin. 2019;69:468\u201384.","journal-title":"CA Cancer J Clin"},{"key":"734_CR14","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","volume":"51","author":"KL Campbell","year":"2019","unstructured":"Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, et al. Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable. Med Sci Sports Exerc. 2019;51:2375\u201390.","journal-title":"Med Sci Sports Exerc"},{"key":"734_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10549-014-3255-5","volume":"149","author":"SM Bluethmann","year":"2015","unstructured":"Bluethmann SM, Vernon SW, Gabriel KP, Murphy CC, Bartholomew LK. Taking the next step: a systematic review and meta-analysis of physical activity and behavior change interventions in recent post-treatment breast cancer survivors. Breast Cancer Res Treat. 2015;149:331\u201342.","journal-title":"Breast Cancer Res Treat"},{"key":"734_CR16","first-page":"467","volume":"38","author":"P Sheeran","year":"2019","unstructured":"Sheeran P, Abraham C, Jones K, Villegas ME, Avishai A, Symes YR, et al. Promoting physical activity among cancer survivors: Meta-analysis and meta-CART analysis of randomized controlled trials. Heal Psychol Off J Div Heal Psychol Am Psychol Assoc. 2019;38:467\u201382.","journal-title":"Heal Psychol Off J Div Heal Psychol Am Psychol Assoc"},{"key":"734_CR17","first-page":"CD010192","volume":"9","author":"RR Turner","year":"2018","unstructured":"Turner RR, Steed L, Quirk H, Greasley RU, Saxton JM, Taylor SJ, et al. Interventions for promoting habitual exercise in people living with and beyond cancer. Cochrane database Syst Rev. 2018;9:CD010192.","journal-title":"Cochrane database Syst Rev"},{"key":"734_CR18","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/pon.1971","volume":"21","author":"MJ Velthuis","year":"2012","unstructured":"Velthuis MJ, Van den Bussche E, May AM, Gijsen BCM, Nijs S, Vlaeyen JWS. Fear of movement in cancer survivors: validation of the modified Tampa scale of kinesiophobia-fatigue. Psychooncology. 2012;21:762\u201370.","journal-title":"Psychooncology"},{"key":"734_CR19","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Rodr\u00edguez EJ, Gonz\u00e1lez-S\u00e1nchez J, Puente-Gonz\u00e1lez AS, Recio-Rodr\u00edguez JI, S\u00e1nchez-G\u00f3mez C, M\u00e9ndez-S\u00e1nchez R, Cruz-Hern\u00e1ndez JJ, Rihuete-Galve MI. Specific autonomy recovery programme in a comprehensive rehabilitation on functionality and respiratory parameters in oncological patients with dyspnoea. Study protocol. BMC Nurs. 2021 Jul;5(1):120. 20(.","DOI":"10.1186\/s12912-021-00633-z"},{"issue":"1","key":"734_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.medcli.2020.05.058","volume":"157","author":"EJ Fern\u00e1ndez Rodr\u00edguez","year":"2021","unstructured":"Fern\u00e1ndez Rodr\u00edguez EJ, Rihuete Galve MI, Cruz Hern\u00e1ndez JJ. Impact of a comprehensive functional rehabilitation programme on the quality of life of the oncological patient with dyspnoea. Med Clin (Barc). 2021;157(1):10\u20136.","journal-title":"Med Clin (Barc)."},{"key":"734_CR21","doi-asserted-by":"crossref","unstructured":"Mahoney FI, Barthel DW. Functional Evaluation: The Barthel Index. Md State Med J. 1965 Feb;14:61\u20135.","DOI":"10.1037\/t02366-000"},{"issue":"3 Suppl 2","key":"734_CR22","first-page":"13","volume":"34","author":"D Cella","year":"1997","unstructured":"Cella D. The Functional Assessment of Cancer Therapy-Anemia (FACT-An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol. 1997;34(3 Suppl 2):13\u20139.","journal-title":"Semin Hematol"},{"key":"734_CR23","unstructured":"Reitan RM. Trail Making Test: Manual for administration and scoring. Reitan Neuropsychology Laboratory; 1992."},{"key":"734_CR24","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1023\/A:1008894502042","volume":"7","author":"X Badia","year":"1998","unstructured":"Badia X, Schiaffino A, Alonso J, Herdman M. Using the EuroQoI 5-D in the Catalan general population: feasibility and construct validity. Qual life Res an Int J Qual life Asp Treat care Rehabil. 1998;7:311\u201322.","journal-title":"Qual life Res an Int J Qual life Asp Treat care Rehabil"},{"key":"734_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0196-0644(96)70223-8","volume":"27","author":"K Ho","year":"1996","unstructured":"Ho K, Spence J, Murphy MF. Review of pain-measurement tools. Ann Emerg Med. 1996;27:427\u201332.","journal-title":"Ann Emerg Med"},{"key":"734_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0304-3959(97)00005-5","volume":"72","author":"SL Collins","year":"1997","unstructured":"Collins SL, Moore RA, McQuay HJ. The visual analogue pain intensity scale: what is moderate pain in millimetres? Pain. 1997;72:95\u20137.","journal-title":"Pain"},{"key":"734_CR27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.22201\/facmed.14058871p.2017.4.61898","volume":"24","author":"F Martinez-Monje","year":"2017","unstructured":"Martinez-Monje F, Cort\u00e9s-G\u00e1lvez JM, Cartagena-P\u00e9rez Y, Alfonso-Cano C, S\u00e1nchez-L\u00f3pez MI, Leal-Hern\u00e1ndez M. Assessment with Short Physical Performance Battery Scale of Functional Ability in the Elderly over 70 years. Atenci\u00f3n Fam. 2017;24:145\u20139.","journal-title":"Atenci\u00f3n Fam"},{"key":"734_CR28","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s10067-013-2277-4","volume":"32","author":"J Nijs","year":"2013","unstructured":"Nijs J, Roussel N, Van Oosterwijck J, De Kooning M, Ickmans K, Struyf F, et al. Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice. Clin Rheumatol. 2013;32:1121\u20139.","journal-title":"Clin Rheumatol"},{"key":"734_CR29","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1249\/MSS.0b013e3181e0c112","volume":"42","author":"KH Schmitz","year":"2010","unstructured":"Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galv\u00e3o DA, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42:1409\u201326.","journal-title":"Med Sci Sports Exerc"},{"key":"734_CR30","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1249\/JSR.0b013e31829a68cf","volume":"12","author":"PD Thompson","year":"2013","unstructured":"Thompson PD, Arena R, Riebe D, Pescatello LS. ACSM\u2019s new preparticipation health screening recommendations from ACSM\u2019s guidelines for exercise testing and prescription, ninth edition. Curr Sports Med Rep. 2013;12:215\u20137.","journal-title":"Curr Sports Med Rep"},{"key":"734_CR31","unstructured":"Rihuete Galve MI, Fern\u00e1ndez Rodr\u00edguez EJ. Effectiveness of educational program on quality of life of fatigue reported by the oncologic disease. Fundaci\u00f3n Index; 2018. https:\/\/scielo.isciii.es\/scielo.php?script=sci_arttext&pid=S1132-12962018000100002&lng=es&nrm=iso&tlng=es."}],"container-title":["BMC Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12912-021-00734-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12912-021-00734-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12912-021-00734-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T12:06:49Z","timestamp":1634904409000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnurs.biomedcentral.com\/articles\/10.1186\/s12912-021-00734-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["734"],"URL":"https:\/\/doi.org\/10.1186\/s12912-021-00734-9","relation":{},"ISSN":["1472-6955"],"issn-type":[{"value":"1472-6955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"7 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Clinical Research Ethics Committee of the Area of Health of Salamanca (ID: PI 202007547), having obtained the prior written informed consent of the study subjects and in conformance with the Helsinki Declaration. The participants will be informed of the objectives of the project and the risks and benefits of the interventions that will be carried out during the work. Participants will be fully informed, and we will guarantee that their data will be treated with the utmost confidentiality throughout the study and also after its completion. Consequently, data and information will not be shared with third parties. Researchers involved in the study will strictly adhere to professional confidentiality and the confidentiality of the participants will be guaranteed at all times in accordance with the laws on the protection of personal data and biomedical research presented in the provisions of Organic Law 3\/2018 of December 5 on the Protection of Personal Data and the Guarantee of Digital Rights, Regulation (EU) 2016\/679 of the European Parliament and Council of 27 April 2016 on data protection (GDPR), and under the conditions established by Law 14\/2007 on biomedical research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"207"}}