{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:58:19Z","timestamp":1777442299097,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Provincial Key R&D Plan","award":["2018GSF118062"],"award-info":[{"award-number":["2018GSF118062"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Health Serv Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12913-019-4006-4","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T13:03:04Z","timestamp":1553259784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China"],"prefix":"10.1186","volume":"19","author":[{"given":"Xinlong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guigang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongsheng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianchang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"4006_CR1","doi-asserted-by":"publisher","unstructured":"Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N, et al. Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One. 2015. https:\/\/doi.org\/10.1371\/journal.pone.0143304 .","DOI":"10.1371\/journal.pone.0143304"},{"key":"4006_CR2","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1001\/jama.2014.13259","volume":"312","author":"ME Clement","year":"2014","unstructured":"Clement ME, Okeke NL, Hicks CB. Treatment of syphilis: a systematic review. JAMA. 2014;312:1905\u201317.","journal-title":"JAMA."},{"key":"4006_CR3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S2214-109X(16)30135-8","volume":"4","author":"NS Wijesooriya","year":"2016","unstructured":"Wijesooriya NS, Rochat RW, Kamb ML, Turlapati P, Temmerman M, Broutet N, et al. Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. Lancet Glob Health. 2016;4:525\u201333.","journal-title":"Lancet Glob Health"},{"key":"4006_CR4","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/infdis\/160.3.530","volume":"160","author":"EW Hook III","year":"1989","unstructured":"Hook EW III. Syphilis and HIV infection. J Infect Dis. 1989;160:530\u20134.","journal-title":"J Infect Dis"},{"key":"4006_CR5","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(16)32411-4","volume":"389","author":"HEW Rd","year":"2017","unstructured":"Rd HEW. Syphilis. Lancet. 2017;389:1550\u20137. https:\/\/doi.org\/10.1016\/S0140-6736(16)32411-4 .","journal-title":"Lancet."},{"key":"4006_CR6","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1517\/14656566.6.13.2271","volume":"6","author":"L Dayan","year":"2005","unstructured":"Dayan L, Ooi C. Syphilis treatment: old and new. Expert Opin Pharmacother. 2005;6:2271\u201380.","journal-title":"Expert Opin Pharmacother"},{"key":"4006_CR7","first-page":"107","volume":"25","author":"H Xiao","year":"2017","unstructured":"Xiao H, Liu D, Li Z, Zheng R, Li Z, Hou J, et al. Comparison of doxycycline and Benzathine penicillin G for the treatment of early syphilis. Acta Dermatovenerol Croat. 2017;25:107\u201311.","journal-title":"Acta Dermatovenerol Croat"},{"key":"4006_CR8","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.otohns.2006.10.007","volume":"136","author":"ME Pichichero","year":"2007","unstructured":"Pichichero ME, Casey JR. Safe use of selected cephalosporins in penicillin-allergic patients. Otolaryngol Head Neck Surg. 2007;136:340\u20137.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"4006_CR9","first-page":"34","volume":"64","author":"Centers for Disease Control and Prevention","year":"2015","unstructured":"Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. 2015 MMWR Recomm Rep. 2015;64:34\u201350.","journal-title":"2015 MMWR Recomm Rep"},{"key":"4006_CR10","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/j.1471-0528.2000.tb13339.x","volume":"107","author":"T Heikkinen","year":"2000","unstructured":"Heikkinen T, Laine K, Neuvonen PJ, Ekblad U. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin, and azithromycin. BJOG. 2000;107:770\u20135.","journal-title":"BJOG."},{"key":"4006_CR11","doi-asserted-by":"crossref","unstructured":"A2058G Prevalence Workgroup. Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007to2009. Sex Transm Dis 2012;39:794\u20138.","DOI":"10.1097\/OLQ.0b013e31826f36de"},{"issue":"Suppl 2","key":"4006_CR12","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1086\/342108","volume":"35","author":"GD Wendel","year":"2002","unstructured":"Wendel GD, Sheffield JS, Hollier LM, Hill JB, Ramsey PS, Sanchez PJ. Treatment of syphilis in pregnancy and prevention of congenital syphilis. Clin Infect Dis. 2002;35(Suppl 2):200\u20139.","journal-title":"Clin Infect Dis"},{"key":"4006_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000239106","volume":"39","author":"R Lang","year":"1993","unstructured":"Lang R, Shalit I, Segal J, Arbel Y, Markov S, Hass H, et al. Maternal and fetal serum and tissue levels of ceftriaxone following preoperative prophylaxis in emergency cesarean section. Chemotherapy. 1993;39:77\u201381.","journal-title":"Chemotherapy."},{"key":"4006_CR14","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1001\/jama.2009.143","volume":"301","author":"JM Douglas Jr","year":"2009","unstructured":"Douglas JM Jr. Penicillin treatment of syphilis: clearing away the shadow on the land. JAMA. 2009;301:769\u201371.","journal-title":"JAMA."},{"key":"4006_CR15","unstructured":"World Health Organization. Technical consultation on preventing and managing global stock outs of medicines. http:\/\/apps.who.int\/medicinedocs\/documents\/s22365en\/s22365en.pdf (2015). Accessed 30 Dec 2015."},{"key":"4006_CR16","doi-asserted-by":"publisher","unstructured":"Taylor MM, Nurse-Findlay S, Zhang X, Hedman L, Kamb ML, Broutet N, et al. Estimating benzathine penicillin need for the treatment of pregnant women diagnosed with syphilis during antenatal care in high-morbidity countries. PLoS One. 2016. https:\/\/doi.org\/10.1371\/journal.pone.0159483 .","DOI":"10.1371\/journal.pone.0159483"},{"key":"4006_CR17","doi-asserted-by":"publisher","unstructured":"Nurse-Findlay S, Taylor MM, Savage M, Mello MB, Saliyou S, Lavayen M, et al. Shortages of benzathine penicillin for prevention of mother-to-child transmission of syphilis: an evaluation from multi-country surveys and stakeholder interviews. PLoS Med 2017; https:\/\/doi.org\/10.1371\/journal.pmed 1002473.","DOI":"10.1371\/journal.pmed"},{"key":"4006_CR18","unstructured":"69th World Health Assembly closes. News release. Geneva: World Health Organization; 2016. http:\/\/www.who.int\/mediacentre\/news\/releases\/2016\/wha69-28-may-2016\/en\/. Accessed 28 May 2016."},{"key":"4006_CR19","unstructured":"Chinese Center for Disease Control and Prevention. Epidemic of infectious diseases in China, 2017. http:\/\/www.sohu.com\/a\/224556770_776214 (2018). Accessed 26 Feb 2018."},{"key":"4006_CR20","first-page":"693","volume":"48","author":"N Jiang","year":"2014","unstructured":"Jiang N, Gong X, Yue X. Estimation of syphilis epidemic through application of workbook method among populations aged from 15 to 49 years old in China in 2011. Zhonghua Yu Fang Yi Xue Za Zhi. 2014;48:693\u20138.","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"4006_CR21","doi-asserted-by":"publisher","unstructured":"Dou L, Wang X, Wang F, Wang Q, Qiao Y, Su M, et al. Epidemic profile of maternal syphilis in China in 2013. Biomed Res Int. 2016. https:\/\/doi.org\/10.1155\/2016\/9194805 .","DOI":"10.1155\/2016\/9194805"},{"key":"4006_CR22","unstructured":"Health and Family Planning Commission of Shandong Province. 2017 shandong province health and family planning development statistics bulletin. http:\/\/www.sdwsjs.gov.cn\/jksd\/ tjsj_763\/zytjbg\/201805\/t20180515_1312944.html (2018). Accessed 15 May 2018."},{"key":"4006_CR23","unstructured":"China Ministry of Health. Notice of the Ministry of Health on issuing National Program for Prevention and Control of Syphilis in China (2010\u20132020); http:\/\/www.chinacdc.cn\/n272442\/n272530\/n272577\/n4020087\/38003.html (2010). Accessed 3 June 2010."},{"key":"4006_CR24","unstructured":"National People\u2019s Congress. The Infectious Disease Prevention Act (The 17th Presidential Decree of the People\u2019s Republic of China). https:\/\/wenku.baidu.com\/view\/6289c5492b160b4e767fcfde.html (2004). Accessed 24 Dec 2004."},{"key":"4006_CR25","doi-asserted-by":"publisher","unstructured":"Gonzalez-Estrada A, Radojicic C. Penicillin allergy: a practical guide for clinicians. Cleve Clin J Med. 2015; dio. https:\/\/doi.org\/10.3949\/ccjm.82a.14111 .","DOI":"10.3949\/ccjm.82a.14111"},{"key":"4006_CR26","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.anai.2017.03.013","volume":"118","author":"MN Pham","year":"2017","unstructured":"Pham MN, Ho HE, Desai M. Penicillin desensitization: treatment of syphilis in pregnancy in penicillin-allergic patients. Ann Allergy Asthma Immunol. 2017;118:537\u201341.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"4006_CR27","unstructured":"China's Ministry of Health. Notice on provision of the administration of National Essential Drugs List. http:\/\/wsj.yueyang.gov.cn\/wsj\/11129\/11139\/content_478952.html (2009). Accessed 18 Aug 2009."},{"key":"4006_CR28","unstructured":"China\u2019s Ministry of Health. National Essential Drugs List (2012 version). http:\/\/www.sdadr.gov.cn\/WS01\/CL0009\/1622.html (2013). Accessed 21 Aug 2013."},{"key":"4006_CR29","unstructured":"China Ministry of Health. Notice on further strengthening the management of clinical application of antibacterials; http:\/\/wsjsw.qingdao.gov.cn\/n28356065\/n32563120\/n32563122\/150914000000666440.html (2015). Accessed 24 Jul 2015."},{"key":"4006_CR30","unstructured":"State Council. The 13th Five-Year Plan for Deepening the Medical and Health System Reform; http:\/\/www.gov.cn\/zhengce\/content\/2017-01\/09\/content_5158053.htm(2016). Accessed 27 Dec 2016."},{"key":"4006_CR31","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/heapol\/czt023","volume":"29","author":"SL Barber","year":"2014","unstructured":"Barber SL, Borowitz M, Bekedam H, Ma J. The hospital of the future in China: China's reform of public hospitals and trends from industrialized countries. Health Policy Plan. 2014;29:367\u201378.","journal-title":"Health Policy Plan"},{"key":"4006_CR32","doi-asserted-by":"crossref","unstructured":"Liu YL, Hsiao WC, Eggleston K. Equity in health and health care: the Chinese experience. Soc Sci Med. 1999;(10):1349\u201356.","DOI":"10.1016\/S0277-9536(99)00207-5"},{"key":"4006_CR33","unstructured":"State Council. Notice on Universal Expansion of Comprehensive Reforms on Public Hospitals; http:\/\/www.gsws.gov.cn\/single\/11205\/75854.html (2017). Accessed 19 April 2017."}],"container-title":["BMC Health Services Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12913-019-4006-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12913-019-4006-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12913-019-4006-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T05:43:06Z","timestamp":1663134186000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmchealthservres.biomedcentral.com\/articles\/10.1186\/s12913-019-4006-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4006"],"URL":"https:\/\/doi.org\/10.1186\/s12913-019-4006-4","relation":{},"ISSN":["1472-6963"],"issn-type":[{"value":"1472-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]},"assertion":[{"value":"28 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The objects of this study were hospitals rather than human being or animals. We think that it is not applicable to provide a statement on ethics approval and consent to participate.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"188"}}