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The aims of this study were to analyse long-term work-related predictors of life satisfaction among established doctors in Norway and to identify predictors in a subgroup of doctors who reported a decline in life satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two nationwide cohorts of doctors (<jats:italic>n<\/jats:italic>\u00a0=\u20091052), who graduated medical school 6\u2009years apart, were surveyed at graduation from medical school (T1, 1993\/94 and 1999), and 4 (T2), 10 (T3), and 15 (T4) years later. Work-related predictors of life satisfaction (three items) obtained at T2 to T4 were analysed. Individual and lifestyle confounders were controlled for using mixed-models repeated-measures analyses, and logistic regression analyses were applied to identify predictors of the decrease in life satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety per cent (947\/1052) responded at least once, and 42% (450\/1052) responded at all four times. Work-related predictors of higher life satisfaction in the adjusted model were work\u2013home stress (\u03b2\u00a0=\u2009\u2212\u20090.20, 95% confidence interval [CI]\u2009=\u2009\u2212\u20090.25 to \u2212\u20090.16,<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), perceived job demands (\u03b2\u00a0=\u2009\u2212\u20090.10, CI\u2009=\u2009\u2212\u20090.15 to \u2212\u20090.05,<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), and colleague support (\u03b2\u00a0=\u20090.05, CI\u2009=\u20090.04 to 0.07,<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). The new adjusted individual predictors that we identified included female gender, reality weakness trait, and problematic drinking behaviour. Neuroticism trait and low colleague support predicted a decrease in life satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Work\u2013home stress, perceived job demands, and colleague support were the most important predictors of life satisfaction related to doctors\u2019 work. When personality traits were controlled for, female doctors were more satisfied with their life than male doctors. These findings suggest that improving work-related factors with targeted interventions, including a supportive work environment, may increase life satisfaction among doctors.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12913-019-4599-7","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T04:28:23Z","timestamp":1571804903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Life satisfaction in Norwegian medical doctors: a 15-year longitudinal study of work-related predictors"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-7530","authenticated-orcid":false,"given":"Javed Iqbal","family":"Mahmood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti St\u00f8en","family":"Grotmol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tesli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Moum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reidar","family":"Tyssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"4599_CR1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s12529-015-9473-3","volume":"22","author":"RA Scheepers","year":"2015","unstructured":"Scheepers RA, Boerebach BC, Arah OA, Heineman MJ, Lombarts KM. 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