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Given widespread calls for the development of interventions that might improve the uptake and effectiveness of healthcare for this population, this study investigated patient and other stakeholder perspectives regarding an outreach service, delivered by prescribing pharmacists in collaboration with a local voluntary sector provider, within homelessness services and on the street in Glasgow (UK).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The qualitative study involved semi-structured face-to-face interviews with 40 purposively sampled individuals with current or recent experience of homelessness (32 of whom had direct experience of the service and 8 of whom did not), all (<jats:italic>n<\/jats:italic>\u2009=\u20094) staff involved in frontline delivery of the service, and 10 representatives of stakeholder agencies working in partnership with the service and\/or with the same client group. Pseudonymised verbatim interview transcriptions were analysed systematically via thematic and framework analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The service was effective at case finding and engaging with patients who were reluctant to utilise or physically unable to access existing (mainstream or specialist \u2018homeless\u2019) healthcare provision. It helped patients overcome many of the barriers that homeless people commonly face when attempting to access healthcare, enabled immediate diagnosis and prescription of medication, and catalysed and capitalised on windows of opportunity when patients were motivated to address healthcare needs. A number of improvements in health outcomes, including but not limited to medication adherence, were also reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A proactive, informal, flexible, holistic and person-centred outreach service delivered within homelessness service settings and on the street can act as a valuable bridge to both primary and secondary healthcare for people experiencing homelessness who would otherwise \u2018fall through the gaps\u2019 of provision. Prescribing pharmacist input coupled with third sector involvement into healthcare for this vulnerable population allows for the prompt treatment of and\/or prescription for a range of conditions, and offers substantial potential for improving health-related outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12913-020-06013-8","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T11:04:24Z","timestamp":1609758264000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Outreach-based clinical pharmacist prescribing input into the healthcare of people experiencing homelessness: a qualitative investigation"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-6111","authenticated-orcid":false,"given":"Sarah","family":"Johnsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Cuthill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Blenkinsopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"6013_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0140-6736(17)31869-X","volume":"391","author":"RW Aldridge","year":"2018","unstructured":"Aldridge RW, Story A, Hwang SW, Nordentoft M, Luchenski S, Hartwell G, Tweed EJ, Lewer D, Vittal Katikireddi S, Hayward A. 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