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Applying Australian-specific data, these estimates were used to further calculate the total number of associated deaths and incident cases of severe AS per annum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on an overall point prevalence of 1.48\u2009% among those aged\u2009\u2265\u200955 years, we estimate that a minimum of 97,000 Australians are living with severe AS. With a 2-fold increased risk of mortality without undergoing aortic valve replacement (AVR), more than half of these individuals (\u223c56,000) will die within 5-years. From a clinical management perspective, among those with concurrent symptoms (68.3\u2009%, 66,500 [95\u2009% CI 59,000\u201374,000] cases) more than half (58.4\u2009%, 38,800 [95\u2009% CI 35,700\u2009\u2212\u200942,000] cases) would be potentially considered for surgical AVR (SAVR) - comprising 2,400, 5,400 and 31,000 cases assessed as high-, medium- or low peri-operative mortality risk, respectively. A further 17,000\/27,700 (41.6\u2009% [95\u2009% CI 11,600\u2009\u2212\u200922,600]) of such individuals would be potentially considered to a transthoracic AVR (TAVR). During the subsequent 5-year period (2020\u20132024), each year, we estimate an additional 9,300 Australians aged\u2009\u2265\u200960 years will subsequently develop severe AS (6,300 of whom will experience concurrent symptoms). Of these symptomatic cases, an estimated 3,700 and 1,600 cases\/annum, will be potentially suitable for SAVR and TAVR, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest there is likely to be a substantive burden of individuals living with severe AS in Australia. Many of these cases may not have been diagnosed and\/or received appropriate treatment (based on the evidence-based application of SAVR and TAVR) to reduce their high-risk of subsequent mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12913-021-06843-0","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T20:02:34Z","timestamp":1628625754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Uncovering the treatable burden of severe aortic stenosis in Australia: current and future projections within an ageing population"],"prefix":"10.1186","volume":"21","author":[{"given":"Geoff","family":"Strange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Scalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Playford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"issue":"12","key":"6843_CR1","doi-asserted-by":"publisher","first-page":"e67-e492","DOI":"10.1161\/CIR.0000000000000558","volume":"137","author":"EJ Benjamin","year":"2018","unstructured":"Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al. 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