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This demanding work environment leads to burnout and exhaustion among nurses. Understanding the specific factors leading to these issues is critical for adequately supporting nurses and informing policymakers. Currently, little is known about the unique factors associated with burnout and emotional exhaustion among nurses in South Africa. Furthermore, whether these factors can be predicted using demographic data alone is unclear. Machine learning has recently been proven to solve complex problems and accurately predict outcomes in medical settings. In this study, supervised machine learning models were developed to identify the factors that most strongly predict nurses reporting feelings of burnout and experiencing emotional exhaustion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The PyCaret 3.3 package was used to develop classification machine learning models on 1165 collected survey responses from nurses across South Africa in medical-surgical units. The models were evaluated on their accuracy score, Area Under the Curve (AUC) score and confusion matrix performance. Additionally, the accuracy score of models using demographic data alone was compared to the full survey data models. The features with the highest predictive power were extracted from both the full survey data and demographic data models for comparison. Descriptive statistical analysis was used to analyse survey data according to the highest predictive factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The gradient booster classifier (GBC) model had the highest accuracy score for predicting both self-reported feelings of burnout (75.8%) and emotional exhaustion (76.8%) from full survey data. For demographic data alone, the accuracy score was 60.4% and 68.5%, respectively, for predicting self-reported feelings of burnout and emotional exhaustion. Fatigue was the factor with the highest predictive power for self-reported feelings of burnout and emotional exhaustion. Nursing staff\u2019s confidence in management was the second highest predictor for feelings of burnout whereas management who listens to employees was the second highest predictor for emotional exhaustion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Supervised machine learning models can accurately predict self-reported feelings of burnout or emotional exhaustion among nurses in South Africa from full survey data but not from demographic data alone. The models identified fatigue rating, confidence in management and management who listens to employees as the most important factors to address to prevent these issues among nurses in South Africa.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12913-024-12184-5","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:27:43Z","timestamp":1735604863000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A machine learning model to predict the risk factors causing feelings of burnout and emotional exhaustion amongst nursing staff in South Africa"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-706X","authenticated-orcid":false,"given":"Maria Magdalena","family":"Van Zyl-Cilli\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-9933","authenticated-orcid":false,"given":"Jacoba H.","family":"B\u00fchrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-2148","authenticated-orcid":false,"given":"Alwiena J.","family":"Blignaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-484X","authenticated-orcid":false,"given":"Derya","family":"Demirtas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-0926","authenticated-orcid":false,"given":"Siedine K.","family":"Coetzee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"12184_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-019-7566-7","volume":"19","author":"BW Dubale","year":"2019","unstructured":"Dubale BW, Friedman LE, Chemali Z, Denninger JW, Mehta DH, Alem A, et al. 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