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However, their biological functions and underlying mechanisms in hypoxia adaptation remain largely unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Here, we established a correlation between a Chr3q29-derived lncRNA gene and tongue squamous carcinoma (TSCC) by genome-wide analyses. Using RACE, we determined that two novel variants of this lncRNA gene are generated in TSCC, namely\n                      <jats:italic>LINC00887_TSCC_short<\/jats:italic>\n                      (\n                      <jats:italic>887S<\/jats:italic>\n                      ) and\n                      <jats:italic>LINC00887_TSCC_long<\/jats:italic>\n                      (\n                      <jats:italic>887L<\/jats:italic>\n                      ). RNA-sequencing in\n                      <jats:italic>887S<\/jats:italic>\n                      or\n                      <jats:italic>887L<\/jats:italic>\n                      loss-of-function cells identified their common downstream target as\n                      <jats:italic>Carbonic Anhydrase IX<\/jats:italic>\n                      (\n                      <jats:italic>CA9<\/jats:italic>\n                      ), a gene known to be upregulated by hypoxia during tumor progression. Mechanistically, our results showed that the hypoxia-augmented\n                      <jats:italic>887S<\/jats:italic>\n                      and constitutively expressed\n                      <jats:italic>887L<\/jats:italic>\n                      functioned in opposite directions on tumor progression through the common target\n                      <jats:italic>CA9<\/jats:italic>\n                      . Upon normoxia,\n                      <jats:italic>887S<\/jats:italic>\n                      and\n                      <jats:italic>887L<\/jats:italic>\n                      interacted. Upon hypoxia, the two variants were separated. Each RNA recognized and bound to their responsive DNA cis-acting elements on\n                      <jats:italic>CA9<\/jats:italic>\n                      promoter:\n                      <jats:italic>887L<\/jats:italic>\n                      activated\n                      <jats:italic>CA9<\/jats:italic>\n                      \u2019s transcription through recruiting HIF1\u03b1, while\n                      <jats:italic>887S<\/jats:italic>\n                      suppressed\n                      <jats:italic>CA9<\/jats:italic>\n                      through DNMT1-mediated DNA methylation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We provided hypoxia-permitted functions of two antagonistic lncRNA variants to fine control the hypoxia adaptation through CA9.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12915-021-01112-2","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T05:03:15Z","timestamp":1630990995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression"],"prefix":"10.1186","volume":"19","author":[{"given":"Tao","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangxiao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxi","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Peng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-3425","authenticated-orcid":false,"given":"Xiangting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"1112_CR1","first-page":"298","volume":"128","author":"WG Kaelin Jr","year":"2017","unstructured":"Kaelin WG Jr. The VHL tumor suppressor gene: insights into oxygen sensing and cancer. 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