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The vulnerability of mossy cells in TLE is well known in animal models as well as in patients; however, the mechanisms leading to cellular death is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Transient receptor potential melastatin 4 (TRPM4) is a Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -activated non-selective cation channel regulating diverse physiological functions of excitable cells. Here, we identified that TRPM4 is present in hilar mossy cells and regulates their intrinsic electrophysiological properties including spontaneous activity and action potential dynamics. Furthermore, we showed that TRPM4 contributes to mossy cells death following status epilepticus and therefore modulates seizure susceptibility and epilepsy-related memory deficits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results provide evidence for the role of TRPM4 in MC excitability both in physiological and pathological conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12915-023-01604-3","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:03:03Z","timestamp":1682506983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy"],"prefix":"10.1186","volume":"21","author":[{"given":"Laura","family":"Mundrucz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9la","family":"Kecsk\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Henn-Mike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"K\u00f3bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Buz\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Vennekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-0476","authenticated-orcid":false,"given":"Mikl\u00f3s","family":"Kecsk\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"issue":"13","key":"1604_CR1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1056\/NEJMra022308","volume":"349","author":"BS Chang","year":"2003","unstructured":"Chang BS, Lowenstein DH. 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