{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:15:12Z","timestamp":1783390512159,"version":"3.54.6"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309158\/2023-0"],"award-info":[{"award-number":["309158\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["INCT-EM"],"award-info":[{"award-number":["INCT-EM"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["Cientista do Nosso Estado (CNE) (E-26\/204.045\/2024),"],"award-info":[{"award-number":["Cientista do Nosso Estado (CNE) (E-26\/204.045\/2024),"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The vitellogenin receptor (VgR) mediates yolk protein uptake during follicle development and is essential for embryogenesis in oviparous species. Here, we characterize the single\n                      <jats:italic>Rhodnius prolixus VgR<\/jats:italic>\n                      isoform and uncover an unexpected role in microbial regulation within the reproductive system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The receptor displays a conserved LDLR-like structure and is highly expressed in early oocytes. RNAi-mediated\n                      <jats:italic>VgR<\/jats:italic>\n                      silencing caused defective yolk granule biogenesis, leading to the accumulation of the main yolk protein precursors, Vg and RHBP, in the hemolymph, yet oviposition and fertilization proceeded normally. The resulting eggs were yolk-depleted and non-viable. Remarkably,\n                      <jats:italic>VgR<\/jats:italic>\n                      knockdown reduced bacterial 16S rRNA levels in oocytes while promoting the expansion of several members of the core virome, a phenotype not reproduced by Vg silencing. Neither purified Vg nor changes in immune (defensin) or RNA interference pathways explained the microbial shifts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that VgR influences not only yolk endocytosis but is also associated with changes in microbial composition within developing oocytes. We propose that VgR may contribute to a functional link between yolk endocytic dynamics and microbial homeostasis, thereby affecting the balance of microbial components in the oocyte. This connection broadens the functional context of VgR and provides new insight into how vertical transmission processes may be shaped in this major Chagas disease vector.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12915-026-02622-7","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:42:50Z","timestamp":1778640170000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of vitellogenin receptor function results in yolk depletion, virome expansion, and reduced bacterial load within the oocytes of Rhodnius prolixus"],"prefix":"10.1186","volume":"24","author":[{"given":"Juliana","family":"Amorim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"das Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamara","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Lopes","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonan","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allana","family":"Faria-Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Walter-Nuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Selim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiene","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalysson Vin\u00edcius","family":"de J. C. Baptista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia C.","family":"Atella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella Silva","family":"Laport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Bahia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Logullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela O.","family":"Paiva-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia C.","family":"Gondim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"2622_CR1","unstructured":"WHO. Vector-borne diseases. 2020. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/vector-borne-diseases. Accessed 10 Jun 2022."},{"key":"2622_CR2","doi-asserted-by":"publisher","first-page":"14936","DOI":"10.1073\/pnas.1506226112","volume":"112","author":"RD Mesquita","year":"2015","unstructured":"Mesquita RD, Vionette-Amaral RJ, Lowenberger C, Rivera-Pomar R, Monteiro FA, Minx P, et al. Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection. Proc Natl Acad Sci USA. 2015;112:14936\u201341.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2622_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2022.114030","author":"AB Lange","year":"2022","unstructured":"Lange AB, Leyria J, Orchard I. The hormonal and neural control of egg production in the historically important model insect, Rhodnius prolixus: a review, with new insights in this post-genomic era. Gen Comp Endocrinol. 2022. https:\/\/doi.org\/10.1016\/j.ygcen.2022.114030.","journal-title":"Gen Comp Endocrinol"},{"key":"2622_CR4","unstructured":"Tufail M, Raikhel AS, Takeda M. Biosynthesis and processing of insect vitellogenins. Progress in vitellogenesis. Reproductive biology of invertebrates. 2005;12 Part B:1\u201332."},{"key":"2622_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.en.37.010192.001245","volume":"37","author":"AS Raikhel","year":"1992","unstructured":"Raikhel AS, Dhadialla TS. Accumulation of yolk proteins in insect oocytes. Annu Rev Entomol. 1992;37:217\u201351. https:\/\/doi.org\/10.1146\/annurev.en.37.010192.001245.","journal-title":"Annu Rev Entomol"},{"key":"2622_CR6","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.jinsphys.2008.08.007","volume":"54","author":"M Tufail","year":"2008","unstructured":"Tufail M, Takeda M. Molecular characteristics of insect vitellogenins. J Insect Physiol. 2008;54:1447\u201358.","journal-title":"J Insect Physiol"},{"key":"2622_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jinsphys.2008.11.007","volume":"55","author":"M Tufail","year":"2009","unstructured":"Tufail M, Takeda M. Insect vitellogenin\/lipophorin receptors: molecular structures, role in oogenesis, and regulatory mechanisms. J Insect Physiol. 2009;55:88\u2013104.","journal-title":"J Insect Physiol"},{"key":"2622_CR8","unstructured":"Snigirevskaya ES, Raikhel AS. Receptor-mediated endocytosis of yolk proteins in insect oocytes. Progress in vitellogenesis. Reproductive biology of invertebrates. 2005;12 Part B:199\u2013228."},{"key":"2622_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23555","author":"I Ramos","year":"2022","unstructured":"Ramos I, Machado E, Masuda H, Gomes F. Open questions on the functional biology of the yolk granules during embryo development. Mol Reprod Dev. 2022. https:\/\/doi.org\/10.1002\/mrd.23555.","journal-title":"Mol Reprod Dev"},{"key":"2622_CR10","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ibmb.2006.11.007","volume":"37","author":"M Tufail","year":"2007","unstructured":"Tufail M, Takeda M. Molecular cloning and developmental expression pattern of the vitellogenin receptor from the cockroach, Leucophaea maderae. Insect Biochem Mol Biol. 2007;37:235\u201345.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR11","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2583.2005.00570.x","volume":"14","author":"M Tufail","year":"2005","unstructured":"Tufail M, Takeda M. Molecular cloning, characterization and regulation of the cockroach vitellogenin receptor during oogenesis. Insect Mol Biol. 2005;14:389\u2013401.","journal-title":"Insect Mol Biol"},{"key":"2622_CR12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1046\/j.0962-1075.2001.00285.x","volume":"10","author":"K Cho","year":"2001","unstructured":"Cho K, Raikhel AS. Organization and developmental expression of the mosquito vitellogenin receptor gene. Insect Mol Biol. 2001;10:465\u201374.","journal-title":"Insect Mol Biol"},{"key":"2622_CR13","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1091\/mbc.11.2.511","volume":"11","author":"CP Schonbaum","year":"2000","unstructured":"Schonbaum CP, Perrino JJ, Mahowald AP. Regulation of the vitellogenin receptor during Drosophila melanogaster oogenesis. Mol Biol Cell. 2000;11:511\u201321.","journal-title":"Mol Biol Cell"},{"key":"2622_CR14","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/1744-7917.13385","volume":"32","author":"C Wang","year":"2025","unstructured":"Wang C, Bao H, Yan Z, Wang J, Wang S, Li Y. Knockdown of vitellogenin receptor based on minute insect RNA interference methods affects the initial mature egg load in the pest natural enemy Trichogramma dendrolimi. Insect Sci. 2025;32:487\u2013500.","journal-title":"Insect Sci"},{"key":"2622_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/arch.22125","volume":"116","author":"ICdaS Nobre","year":"2024","unstructured":"Nobre ICdaS, Coelho RR, de Souza FMC, Reis MA, Torres JB, Antonino JD. Insights from different reproductive gene knockdowns via RNA interference in the lady beetle Eriopis connexa: establishing a new model for molecular studies on natural enemies. Arch Insect Biochem Physiol. 2024;116:e22125.","journal-title":"Arch Insect Biochem Physiol"},{"key":"2622_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/mec.17214","volume":"33","author":"X Nian","year":"2024","unstructured":"Nian X, Luo Y, He X, Wu S, Li J, Wang D, et al. Infection with \u2018Candidatus Liberibacter asiaticus\u2019 improves the fecundity of Diaphorina citri aiding its proliferation: a win-win strategy. Mol Ecol. 2024;33:e17214.","journal-title":"Mol Ecol"},{"key":"2622_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.995004","volume":"13","author":"Y Lian","year":"2022","unstructured":"Lian Y, Peng S, Jia J, Li J, Wang A, Yang S, et al. Function of Vitellogenin receptor gene in reproductive regulation of Zeugodacus cucurbitae (Coquillett) after short-term high-temperature treatment. Front Physiol. 2022;13:995004.","journal-title":"Front Physiol"},{"key":"2622_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911972","volume":"23","author":"S Han","year":"2022","unstructured":"Han S, Wang D, Song P, Zhang S, He Y. Molecular characterization of vitellogenin and its receptor in Spodoptera frugiperda (JE Smith, 1797), and their function in reproduction of female. Int J Mol Sci. 2022;23:11972.","journal-title":"Int J Mol Sci"},{"key":"2622_CR19","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/jee\/toab224","volume":"115","author":"H Han","year":"2022","unstructured":"Han H, Han S, Qin Q, Chen J, Wang D, He Y. Molecular identification and functional characterization of vitellogenin receptor from Harmonia axyridis (Coleoptera: Coccinellidae). J Econ Entomol. 2022;115:325\u201333.","journal-title":"J Econ Entomol"},{"key":"2622_CR20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2106908118","volume":"118","author":"Y-P Jing","year":"2021","unstructured":"Jing Y-P, Wen X, Li L, Zhang S, Zhang C, Zhou S. The vitellogenin receptor functionality of the migratory locust depends on its phosphorylation by juvenile hormone. Proc Natl Acad Sci USA. 2021;118:e2106908118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2622_CR21","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1742-4658.2005.05066.x","volume":"273","author":"L Ciudad","year":"2006","unstructured":"Ciudad L, Piulachs M, Bell\u00e9s X. Systemic RNAi of the cockroach vitellogenin receptor results in a phenotype similar to that of the Drosophila yolkless mutant. FEBS J. 2006;273:325\u201335.","journal-title":"FEBS J"},{"key":"2622_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106298","author":"Y Sheng","year":"2023","unstructured":"Sheng Y, Chen J, Jiang H, Lu Y, Dong Z, Pang L, et al. The vitellogenin receptor gene contributes to mating and host-searching behaviors in parasitoid wasps. iScience. 2023. https:\/\/doi.org\/10.1016\/j.isci.2023.106298.","journal-title":"iScience"},{"key":"2622_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008516","volume":"14","author":"J Leyria","year":"2020","unstructured":"Leyria J, Orchard I, Lange AB. What happens after a blood meal? A transcriptome analysis of the main tissues involved in egg production in Rhodnius prolixus, an insect vector of Chagas disease. PLoS Negl Trop Dis. 2020;14:e0008516.","journal-title":"PLoS Negl Trop Dis"},{"key":"2622_CR24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s41579-025-01164-z","volume":"23","author":"M Kaltenpoth","year":"2025","unstructured":"Kaltenpoth M, Fl\u00f3rez LV, Vigneron A, Dirksen P, Engl T. Origin and function of beneficial bacterial symbioses in insects. Nat Rev Microbiol. 2025;23:551\u201367. https:\/\/doi.org\/10.1038\/s41579-025-01164-z.","journal-title":"Nat Rev Microbiol"},{"key":"2622_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1017\/S1742758411000014","volume":"31","author":"J Rodr\u00edguez","year":"2011","unstructured":"Rodr\u00edguez J, Pav\u00eda P, Montilla M, Puerta CJ. Identifying triatomine symbiont Rhodococcus rhodnii as intestinal bacteria from Rhodnius ecuadoriensis (Hemiptera: Reduviidae) laboratory insects. Int J Trop Insect Sci. 2011;31:34\u20137. https:\/\/doi.org\/10.1017\/S1742758411000014.","journal-title":"Int J Trop Insect Sci"},{"key":"2622_CR26","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1098\/rspb.2012.1208","volume":"279","author":"B Longdon","year":"2012","unstructured":"Longdon B, Jiggins FM. Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone? Proc R Soc B Biol Sci. 2012;279:3889\u201398. https:\/\/doi.org\/10.1098\/rspb.2012.1208.","journal-title":"Proc R Soc B Biol Sci"},{"key":"2622_CR27","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1002\/ps.5256","volume":"75","author":"K He","year":"2019","unstructured":"He K, Lin K, Ding S, Wang G, Li F. The vitellogenin receptor has an essential role in vertical transmission of rice stripe virus during oogenesis in the small brown plant hopper. Pest Manag Sci. 2019;75:1370\u201382. https:\/\/doi.org\/10.1002\/ps.5256.","journal-title":"Pest Manag Sci"},{"key":"2622_CR28","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0312","author":"Y Huo","year":"2019","unstructured":"Huo Y, Yu Y, Liu Q, Liu D, Zhang M, Liang J, et al. Rice stripe virus hitchhikes the vector insect vitellogenin ligand-receptor pathway for ovary entry. Philosophical Transactions of the Royal Society B: Biological Sciences. 2019. https:\/\/doi.org\/10.1098\/rstb.2018.0312.","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"2622_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009780","author":"TF De Brito","year":"2021","unstructured":"De Brito TF, Coelho VL, Cardoso MA, De Abreu Brito IA, Berni MA, Zenk FL, et al. Transovarial transmission of a core virome in the Chagas disease vector Rhodnius prolixus. PLoS Pathog. 2021. https:\/\/doi.org\/10.1371\/journal.ppat.1009780.","journal-title":"PLoS Pathog"},{"key":"2622_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2024.104221","volume":"176","author":"A Macedo-Silva","year":"2025","unstructured":"Macedo-Silva A, Rios T, Ramos I, Majerowicz D. Lipophorin receptor knockdown reduces hatchability of kissing bug Rhodnius prolixus eggs. Insect Biochem Mol Biol. 2025;176:104221. https:\/\/doi.org\/10.1016\/j.ibmb.2024.104221.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR31","doi-asserted-by":"publisher","unstructured":"PH Vieira L Bomfim GC Atella H Masuda I Ramos 2018 Silencing of RpATG6 impaired the yolk accumulation and the biogenesis of the yolk organelles in the insect vector R. prolixus PLoS Negl Trop Dishttps:\/\/doi.org\/10.1371\/journal.pntd.0006507","DOI":"10.1371\/journal.pntd.0006507"},{"key":"2622_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2023.159442","volume":"1869","author":"DS Ar\u00eades","year":"2024","unstructured":"Ar\u00eades DS, Rios T, Carvalho-Kelly LF, Braz V, Araripe LO, Bruno RV, et al. Deficiency of Brummer lipase disturbs lipid mobilization and locomotion, and impairs reproduction due to defects in the eggshell ultrastructure in the insect vector Rhodnius prolixus. Biochim Biophys Acta Mol Cell Biol Lipids. 2024;1869:159442.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2622_CR33","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.bbalip.2016.12.004","volume":"1862","author":"M Alves-Bezerra","year":"2017","unstructured":"Alves-Bezerra M, Ramos IB, De Paula IF, Maya-Monteiro CM, Klett EL, Coleman RA, et al. Deficiency of glycerol-3-phosphate acyltransferase 1 decreases triacylglycerol storage and induces fatty acid oxidation in insect fat body. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2017;1862:324\u201336. https:\/\/doi.org\/10.1016\/j.bbalip.2016.12.004.","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"2622_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158851","volume":"1866","author":"G Silva-Oliveira","year":"2021","unstructured":"Silva-Oliveira G, De Paula IF, Medina JM, Alves-Bezerra M, Gondim KC. Insulin receptor deficiency reduces lipid synthesis and reproductive function in the insect Rhodnius prolixus. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:158851.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2622_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/finsc.2023.1167889","volume":"3","author":"I Orchard","year":"2023","unstructured":"Orchard I, Al-Dailami AN, Leyria J, Lange AB. Malpighian tubules of Rhodnius prolixus: more than post-prandial diuresis. Front Insect Sci. 2023;3:1167889.","journal-title":"Front Insect Sci"},{"key":"2622_CR36","doi-asserted-by":"crossref","unstructured":"Leyria J. Endocrine factors modulating vitellogenesis and oogenesis in insects: An update. Mol Cell Endocrinol. 2024;:112211.","DOI":"10.1016\/j.mce.2024.112211"},{"key":"2622_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213832","author":"J Leyria","year":"2022","unstructured":"Leyria J, Orchard I, Lange AB. Impact of JH signaling on reproductive physiology of the classical insect model, Rhodnius prolixus. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms232213832.","journal-title":"Int J Mol Sci"},{"key":"2622_CR38","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.244830","volume":"225","author":"SAM Benrabaa","year":"2022","unstructured":"Benrabaa SAM, Orchard I, Lange AB. The role of ecdysteroid in the regulation of ovarian growth and oocyte maturation in Rhodnius prolixus, a vector of Chagas disease. J Exp Biol. 2022;225:jeb244830.","journal-title":"J Exp Biol"},{"key":"2622_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283286","volume":"18","author":"S Benrabaa","year":"2023","unstructured":"Benrabaa S, Orchard I, Lange AB. A critical role for ecdysone response genes in regulating egg production in adult female Rhodnius prolixus. PLoS ONE. 2023;18:e0283286.","journal-title":"PLoS ONE"},{"key":"2622_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010007","volume":"24","author":"J Leyria","year":"2022","unstructured":"Leyria J, Benrabaa S, Nouzova M, Noriega FG, Tose LV, Fernandez-Lima F, et al. Crosstalk between nutrition, insulin, juvenile hormone, and ecdysteroid signaling in the classical insect model, Rhodnius prolixus. Int J Mol Sci. 2022;24:7.","journal-title":"Int J Mol Sci"},{"key":"2622_CR41","first-page":"543","volume":"15","author":"H Masuda","year":"1985","unstructured":"Masuda H, Oliveira PL. Characterization of vitellin and vitellogenin of Rhodnius prolixus. Identification of phosphorilated compounds in the molecule. Insect Biochem Mol Biol. 1985;15:543\u201350.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR42","first-page":"10897","volume":"270","author":"PL Oliveira","year":"1995","unstructured":"Oliveira PL, Kawooya JK, Ribeiro JM, Meyer T, Poorman R, Alves EW, et al. A heme-binding protein from hemolymph and oocytes of the blood-sucking insect, Rhodnius prolixus. Isolation and characterization J Biol Chem. 1995;270:10897\u2013901.","journal-title":"Isolation and characterization J Biol Chem"},{"key":"2622_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1520-6327(1998)39:4<133::aid-arch1>3.0.co;2-d","author":"EA Machado","year":"1998","unstructured":"Machado EA, Oliveira PL, Moreira MF, De Souza W, Masuda H. Uptake of Rhodnius heme-binding protein (RHBP) by the ovary of Rhodnius prolixus. Arch Insect Biochem Physiol. 1998. https:\/\/doi.org\/10.1002\/(sici)1520-6327(1998)39:4%3c133::aid-arch1%3e3.0.co;2-d.","journal-title":"Arch Insect Biochem Physiol"},{"key":"2622_CR44","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0020-1790(89)90086-3","volume":"19","author":"K Gondim","year":"1989","unstructured":"Gondim K, Oliveira P, Coelho H, Masuda H. Lipophorin from Rhodnius prolixus: purification and partial characterization. Insect Biochem. 1989;19:153\u201361.","journal-title":"Insect Biochem"},{"key":"2622_CR45","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0022-1910(89)90032-2","volume":"35","author":"KC Gondim","year":"1989","unstructured":"Gondim KC, Oliveira PL, Masuda H. Lipophorin and o\u00f6genesis in Rhodnius prolixus: transfer of phospholipids. J Insect Physiol. 1989;35:19\u201327. https:\/\/doi.org\/10.1016\/0022-1910(89)90032-2.","journal-title":"J Insect Physiol"},{"key":"2622_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0965-1748(94)90123-6","volume":"24","author":"FS Faria","year":"1994","unstructured":"Faria FS, Garcia ES, Goldenberg S. Synthesis of a haemolymph hexamerin by the fat body and testis of Rhodnius prolixus. Insect Biochem Mol Biol. 1994;24:59\u201367.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR47","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/S0965-1748(02)00074-7","volume":"32","author":"GO Paiva-Silva","year":"2002","unstructured":"Paiva-Silva GO, Sorgine MHF, Benedetti CE, Meneghini R, Almeida IC, Machado EA, et al. On the biosynthesis of Rhodnius prolixus heme-binding protein. Insect Biochem Mol Biol. 2002;32:1533\u201341. https:\/\/doi.org\/10.1016\/S0965-1748(02)00074-7.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006507","volume":"12","author":"PH Vieira","year":"2018","unstructured":"Vieira PH, Bomfim L, Atella GC, Masuda H, Ramos I. Silencing of RpATG6 impaired the yolk accumulation and the biogenesis of the yolk organelles in the insect vector R. prolixus. PLoS Negl Trop Dis. 2018;12:e0006507. https:\/\/doi.org\/10.1371\/journal.pntd.0006507.","journal-title":"PLoS Negl Trop Dis"},{"key":"2622_CR49","doi-asserted-by":"publisher","first-page":"29323","DOI":"10.1074\/jbc.M113.504985","volume":"288","author":"AB Walter-Nuno","year":"2013","unstructured":"Walter-Nuno AB, Oliveira MP, Oliveira MF, Gon\u00e7alves RL, Ramos IB, Koerich LB, et al. Silencing of maternal heme-binding protein causes embryonic mitochondrial dysfunction and impairs embryogenesis in the blood sucking insect Rhodnius prolixus. J Biol Chem. 2013;288:29323\u201332.","journal-title":"J Biol Chem"},{"key":"2622_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1142433","author":"E de Almeida","year":"2023","unstructured":"de Almeida E, Dittz U, Pereira J, Walter-Nuno AB, Paiva-Silva GO, Lacerda-Abreu MA, et al. Functional characterization of maternally accumulated hydrolases in the mature oocytes of the vector Rhodnius prolixus reveals a new protein phosphatase essential for the activation of the yolk mobilization and embryo development. Front Physiol. 2023. https:\/\/doi.org\/10.3389\/fphys.2023.1142433.","journal-title":"Front Physiol"},{"key":"2622_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009760","author":"PH Vieira","year":"2021","unstructured":"Vieira PH, Benjamim CF, Atella G, Ramos I. VPS38\/UVRAG and ATG14, the variant regulatory subunits of the ATG6\/Beclin1-PI3K complexes, are crucial for the biogenesis of the yolk organelles and are transcriptionally regulated in the oocytes of the vector Rhodnius prolixus. PLoS Negl Trop Dis. 2021. https:\/\/doi.org\/10.1371\/journal.pntd.0009760.","journal-title":"PLoS Negl Trop Dis"},{"key":"2622_CR52","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1017\/S1751731119003355","volume":"14","author":"M Morini","year":"2020","unstructured":"Morini M, Lafont AG, Maugars G, Baloche S, Dufour S, Asturiano JF, et al. Identification and stable expression of vitellogenin receptor through vitellogenesis in the European eel. Animal. 2020;14:1213\u201322. https:\/\/doi.org\/10.1017\/S1751731119003355.","journal-title":"Animal"},{"key":"2622_CR53","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1006\/bbrc.1996.1040","volume":"224","author":"K Okabayashi","year":"1996","unstructured":"Okabayashi K, Shoji H, Nakamura T, Hashimoto O, Asashima M, Sugino H. cDNA cloning and expression of the Xenopus laevis vitellogenin receptor. Biochem Biophys Res Commun. 1996;224:406\u201313.","journal-title":"Biochem Biophys Res Commun"},{"key":"2622_CR54","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/BF00174046","volume":"41","author":"CA Bidwell","year":"1995","unstructured":"Bidwell CA, Carlson DM. Characterization of vitellogenin from white sturgeon, Acipenser transmontanus. J Mol Evol. 1995;41:104\u201312.","journal-title":"J Mol Evol"},{"key":"2622_CR55","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/imb.12873","volume":"33","author":"X Liu","year":"2024","unstructured":"Liu X, Liu C, Feng Y, Guo X, Zhang L, Wang M, et al. Male vitellogenin regulates gametogenesis through a testis-enriched big protein in Chrysopa pallens. Insect Mol Biol. 2024;33:17\u201328.","journal-title":"Insect Mol Biol"},{"key":"2622_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00618","author":"RD Mitchell","year":"2019","unstructured":"Mitchell RD, Sonenshine DE, P\u00e9rez De Le\u00f3n AA. Vitellogenin receptor as a target for tick control: a mini-review. Front Physiol. 2019. https:\/\/doi.org\/10.3389\/fphys.2019.00618.","journal-title":"Front Physiol"},{"key":"2622_CR57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003949","author":"Y Huo","year":"2014","unstructured":"Huo Y, Liu W, Zhang F, Chen X, Li L, Liu Q, et al. Transovarial transmission of a plant virus is mediated by vitellogenin of its insect vector. PLoS Pathog. 2014. https:\/\/doi.org\/10.1371\/journal.ppat.1003949.","journal-title":"PLoS Pathog"},{"key":"2622_CR58","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01142-20","author":"Q Mao","year":"2020","unstructured":"Mao Q, Wu W, Huang L, Yi G, Jia D, Chen Q, et al. Insect bacterial symbiont-mediated vitellogenin uptake into oocytes to support egg development. MBio. 2020. https:\/\/doi.org\/10.1128\/mBio.01142-20.","journal-title":"MBio"},{"key":"2622_CR59","doi-asserted-by":"publisher","first-page":"547","DOI":"10.4161\/viru.28367","volume":"5","author":"D Freitak","year":"2014","unstructured":"Freitak D, Schmidtberg H, Dickel F, Lochnit G, Vogel H, Vilcinskas A. The maternal transfer of bacteria can mediate trans-generational immune priming in insects. Virulence. 2014;5:547\u201354. https:\/\/doi.org\/10.4161\/viru.28367.","journal-title":"Virulence"},{"key":"2622_CR60","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.biocel.2010.11.003","volume":"43","author":"S Zhang","year":"2011","unstructured":"Zhang S, Wang S, Li H, Li L. Vitellogenin, a multivalent sensor and an antimicrobial effector. Int J Biochem Cell Biol. 2011;43:303\u20135. https:\/\/doi.org\/10.1016\/j.biocel.2010.11.003.","journal-title":"Int J Biochem Cell Biol"},{"key":"2622_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2025.104301","volume":"180","author":"J Pereira","year":"2025","unstructured":"Pereira J, Rios T, Amorim J, Faria-Reis A, de Almeida E, Neves M, et al. Functional characterization of vitellogenin unveils novel roles in RHBP uptake and lifespan regulation in the insect vector Rhodnius prolixus. Insect Biochem Mol Biol. 2025;180:104301.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01189","author":"CS Vieira","year":"2018","unstructured":"Vieira CS, Moreira OC, Batista KKS, Ratcliffe NA, Castro DP, Azambuja P. The NF-\u03baB inhibitor, IMD-0354, affects immune gene expression, bacterial microbiota and Trypanosoma cruzi infection in Rhodnius prolixus midgut. Front Physiol. 2018. https:\/\/doi.org\/10.3389\/fphys.2018.01189.","journal-title":"Front Physiol"},{"key":"2622_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1398-4","author":"CS Vieira","year":"2016","unstructured":"Vieira CS, Waniek PJ, Castro DP, Mattos DP, Moreira OC, Azambuja P. Impact of Trypanosoma cruzi on antimicrobial peptide gene expression and activity in the fat body and midgut of Rhodnius prolixus. Parasit Vectors. 2016. https:\/\/doi.org\/10.1186\/s13071-016-1398-4.","journal-title":"Parasit Vectors"},{"key":"2622_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-232","author":"CS Vieira","year":"2014","unstructured":"Vieira CS, Waniek PJ, Mattos DP, Castro DP, Mello CB, Ratcliffe NA, et al. Humoral responses in Rhodnius prolixus: bacterial feeding induces differential patterns of antibacterial activity and enhances mRNA levels of antimicrobial peptides in the midgut. Parasit Vectors. 2014. https:\/\/doi.org\/10.1186\/1756-3305-7-232.","journal-title":"Parasit Vectors"},{"key":"2622_CR65","doi-asserted-by":"publisher","unstructured":"Vieira CS, Mattos DP, Waniek PJ, Santangelo JM, Figueiredo MB, Gumiel M, et al. Rhodnius prolixus interaction with Trypanosoma rangeli: Modulation of the immune system and microbiota population. Parasit Vectors. 2015;8. https:\/\/doi.org\/10.1186\/s13071-015-0736-2.","DOI":"10.1186\/s13071-015-0736-2"},{"key":"2622_CR66","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/j.1365-2583.2011.01107.x","volume":"20","author":"R Ursic\u2010Bedoya","year":"2011","unstructured":"Ursic\u2010Bedoya R, Buchhop J, Joy JB, Durvasula R, Lowenberger C. Prolixicin: a novel antimicrobial peptide isolated from Rhodnius prolixus with differential activity against bacteria and Trypanosoma cruzi. Insect Mol Biol. 2011;20:775\u201386.","journal-title":"Insect Mol Biol"},{"key":"2622_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-2-33","volume":"2","author":"ES Garcia","year":"2009","unstructured":"Garcia ES, Castro DP, Figueiredo MB, Genta FA, Azambuja P. Trypanosoma rangeli: a new perspective for studying the modulation of immune reactions of Rhodnius prolixus. Parasit Vectors. 2009;2:33.","journal-title":"Parasit Vectors"},{"key":"2622_CR68","doi-asserted-by":"publisher","unstructured":"Vieira C, Mattos D, Waniek P, Santangelo J, Figueiredo M, Gumiel M, et al. Rhodnius prolixus interaction with Trypanosoma rangeli: modulation of the immune system and microbiota population. Parasit Vectors. 2015;8. https:\/\/doi.org\/10.1186\/s13071-015-0736-2.","DOI":"10.1186\/s13071-015-0736-2"},{"key":"2622_CR69","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13071-015-0736-2","volume":"8","author":"CS Vieira","year":"2015","unstructured":"Vieira CS, Mattos DP, Waniek PJ, Santangelo JM, Figueiredo MB, Gumiel M, et al. Rhodnius prolixus interaction with Trypanosoma rangeli: modulation of the immune system and microbiota population. Parasit Vectors. 2015;8:135.","journal-title":"Parasit Vectors"},{"key":"2622_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.598526","volume":"10","author":"A Rolandelli","year":"2021","unstructured":"Rolandelli A, Nascimento AEC, Silva LS, Rivera-Pomar R, Guarneri AA. Modulation of IMD, Toll, and Jak\/STAT immune pathways genes in the fat body of Rhodnius prolixus during Trypanosoma rangeli infection. Front Cell Infect Microbiol. 2021;10:598526.","journal-title":"Front Cell Infect Microbiol"},{"key":"2622_CR71","doi-asserted-by":"publisher","first-page":"1435447","DOI":"10.3389\/fphys.2024.1435447","volume":"15","author":"SB Pereira","year":"2024","unstructured":"Pereira SB, de Mattos DP, Gonzalez MS, Mello CB, Azambuja P, de Castro DP, et al. Immune signaling pathways in Rhodnius prolixus in the context of Trypanosoma rangeli infection: cellular and humoral immune responses and microbiota modulation. Front Physiol. 2024;15:1435447.","journal-title":"Front Physiol"},{"key":"2622_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2023.107032","author":"DLM Nunes","year":"2023","unstructured":"Nunes DLM, Carvalho-Araujo MF, Silva-Cabral S, Rios T, Chagas-Lima AC, de Sousa G, et al. Lipid metabolism dynamic in triatomine Rhodnius prolixus during acute Trypanosoma rangeli infection. Acta Trop. 2023. https:\/\/doi.org\/10.1016\/j.actatropica.2023.107032.","journal-title":"Acta Trop"},{"key":"2622_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2019.00166","author":"KCF Lidani","year":"2019","unstructured":"Lidani KCF, Andrade FA, Bavia L, Damasceno FS, Beltrame MH, Messias-Reason IJ, et al. Chagas disease: from discovery to a worldwide health problem. J Phys Oceanogr. 2019. https:\/\/doi.org\/10.3389\/fpubh.2019.00166.","journal-title":"J Phys Oceanogr"},{"key":"2622_CR74","doi-asserted-by":"publisher","unstructured":"G\u00f3mez-Ochoa SA, Rojas LZ, Echeverr\u00eda LE, Muka T, Franco OH. Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study. Glob Heart. 2022;17. https:\/\/doi.org\/10.5334\/GH.1150.","DOI":"10.5334\/GH.1150"},{"key":"2622_CR75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002594","volume":"8","author":"JMC Ribeiro","year":"2014","unstructured":"Ribeiro JMC, Genta FA, Sorgine MHF, Logullo R, Mesquita RD, Paiva-Silva GO, et al. An insight into the transcriptome of the digestive tract of the bloodsucking bug, Rhodnius prolixus. PLoS Negl Trop Dis. 2014;8:27. https:\/\/doi.org\/10.1371\/journal.pntd.0002594.","journal-title":"PLoS Negl Trop Dis"},{"key":"2622_CR76","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.ibmb.2011.06.004","volume":"41","author":"MN Medeiros","year":"2011","unstructured":"Medeiros MN, Logullo R, Ramos IB, Sorgine MHF, Paiva-Silva GO, Mesquita RD, et al. Transcriptome and gene expression profile of ovarian follicle tissue of the triatomine bug Rhodnius prolixus. Insect Biochem Mol Biol. 2011;41:823\u201331. https:\/\/doi.org\/10.1016\/j.ibmb.2011.06.004.","journal-title":"Insect Biochem Mol Biol"},{"key":"2622_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81387-1","author":"VL Coelho","year":"2021","unstructured":"Coelho VL, de Brito TF, de Abreu Brito IA, Cardoso MA, Berni MA, Araujo HMM, et al. Analysis of ovarian transcriptomes reveals thousands of novel genes in the insect vector Rhodnius prolixus. Sci Rep. 2021. https:\/\/doi.org\/10.1038\/s41598-021-81387-1.","journal-title":"Sci Rep"},{"key":"2622_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-67932-4","volume":"10","author":"J Leyria","year":"2020","unstructured":"Leyria J, Orchard I, Lange AB. Transcriptomic analysis of regulatory pathways involved in female reproductive physiology of Rhodnius prolixus under different nutritional states. Sci Rep. 2020;10:1\u201316.","journal-title":"Sci Rep"},{"issue":"Suppl 5","key":"2622_CR79","doi-asserted-by":"publisher","first-page":"S475","DOI":"10.33549\/physiolres.935221","volume":"72","author":"D Kodrik","year":"2023","unstructured":"Kodrik D, Frydrychov\u00e1 R\u010c, Hlavkova D, Habu\u0161tov\u00e1 OS, \u0160t\u011brbov\u00e1 H. Unusual functions of insect vitellogenins: minireview. Physiol Res. 2023;72(Suppl 5):S475.","journal-title":"Physiol Res"},{"key":"2622_CR80","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ygcen.2005.02.009","volume":"142","author":"M-P Tu","year":"2005","unstructured":"Tu M-P, Yin C-M, Tatar M. Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster. Gen Comp Endocrinol. 2005;142:347\u201356.","journal-title":"Gen Comp Endocrinol"},{"key":"2622_CR81","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1046\/j.1474-9728.2002.00010.x","volume":"1","author":"M Tu","year":"2002","unstructured":"Tu M, Epstein D, Tatar M. The demography of slow aging in male and female Drosophila mutant for the insulin\u2010receptor substrate homologue chico. Aging Cell. 2002;1:75\u201380.","journal-title":"Aging Cell"},{"key":"2622_CR82","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0531-5565(00)00238-2","volume":"36","author":"M Tatar","year":"2001","unstructured":"Tatar M, Yin C-M. Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms. Exp Gerontol. 2001;36:723\u201338.","journal-title":"Exp Gerontol"},{"key":"2622_CR83","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tem.2004.11.003","volume":"16","author":"EB Dubrovsky","year":"2005","unstructured":"Dubrovsky EB. Hormonal cross talk in insect development. Trends Endocrinol Metab. 2005;16:6\u201311.","journal-title":"Trends Endocrinol Metab"},{"key":"2622_CR84","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1080\/01688170.1984.10510107","volume":"7","author":"M Lamy","year":"1984","unstructured":"Lamy M. Vitellogenesis, vitellogenin and vitellin in the males of insects: a review. Int J Invertebr Reprod Dev. 1984;7:311\u201321.","journal-title":"Int J Invertebr Reprod Dev"},{"key":"2622_CR85","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.tree.2006.10.008","volume":"22","author":"LG Harshman","year":"2007","unstructured":"Harshman LG, Zera AJ. The cost of reproduction: the devil in the details. Trends Ecol Evol. 2007;22:80\u20136.","journal-title":"Trends Ecol Evol"},{"key":"2622_CR86","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213832","volume":"23","author":"J Leyria","year":"2022","unstructured":"Leyria J, Orchard I, Lange AB. Impact of JH signaling on reproductive physiology of the classical insect model, Rhodnius prolixus. Int J Mol Sci. 2022;23:13832.","journal-title":"Int J Mol Sci"},{"key":"2622_CR87","doi-asserted-by":"publisher","unstructured":"Yoth M, Maupetit-M\u00e9houas S, Akkouche A, Gueguen N, Bertin B, Jensen S, et al. Reactivation of a somatic errantivirus and germline invasion in Drosophila ovaries. Nat Commun. 2023;14. https:\/\/doi.org\/10.1038\/s41467-023-41733-5.","DOI":"10.1038\/s41467-023-41733-5"},{"key":"2622_CR88","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1742-4690-3-25","volume":"3","author":"E Brasset","year":"2006","unstructured":"Brasset E, Taddei AR, Arnaud F, Faye B, Fausto AM, Mazzini M, et al. Viral particles of the endogenous retrovirus ZAM from Drosophila melanogaster use a pre-existing endosome\/exosome pathway for transfer to the oocyte. Retrovirology. 2006;3:25.","journal-title":"Retrovirology"},{"key":"2622_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nmicrobiol.2017.25","volume":"2","author":"D Jia","year":"2017","unstructured":"Jia D, Mao Q, Chen Y, Liu Y, Chen Q, Wu W, et al. Insect symbiotic bacteria harbour viral pathogens for transovarial transmission. Nat Microbiol. 2017;2:1\u20137.","journal-title":"Nat Microbiol"},{"key":"2622_CR90","doi-asserted-by":"publisher","first-page":"6746","DOI":"10.1073\/pnas.1701720114","volume":"114","author":"J Wei","year":"2017","unstructured":"Wei J, He Y-Z, Guo Q, Guo T, Liu Y-Q, Zhou X-P, et al. Vector development and vitellogenin determine the transovarial transmission of begomoviruses. Proc Natl Acad Sci USA. 2017;114:6746\u201351.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2622_CR91","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.virol.2019.03.009","volume":"531","author":"Q Guo","year":"2019","unstructured":"Guo Q, Shu Y-N, Liu C, Chi Y, Liu Y-Q, Wang X-W. Transovarial transmission of tomato yellow leaf curl virus by seven species of the Bemisia tabaci complex indigenous to China: not all whiteflies are the same. Virology. 2019;531:240\u20137.","journal-title":"Virology"},{"key":"2622_CR92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005015","volume":"11","author":"H Salmela","year":"2015","unstructured":"Salmela H, Amdam GV, Freitak D. Transfer of immunity from mother to offspring is mediated via egg-yolk protein vitellogenin. PLoS Pathog. 2015;11:e1005015.","journal-title":"PLoS Pathog"},{"key":"2622_CR93","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1139\/z80-222","volume":"58","author":"E Huebner","year":"1980","unstructured":"Huebner E, Injeyan H. Patency of the follicular epithelium in Rhodnius prolixus: a reexamination of the hormone response and technique refinement. Can J Zool. 1980;58:1617\u201325.","journal-title":"Can J Zool"},{"issue":"Pt 16","key":"2622_CR94","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1242\/jeb.01089","volume":"207","author":"CS Bjornsson","year":"2004","unstructured":"Bjornsson CS, Huebner E. Extracellular H+ dynamics during oogenesis in Rhodnius prolixus ovarioles. J Exp Biol. 2004;207(Pt 16):2835\u201344.","journal-title":"J Exp Biol"},{"key":"2622_CR95","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22995","author":"R Nunes-da-fonseca","year":"2017","unstructured":"Nunes-da-fonseca R, Berni M, Pane A, Araujo HM. Rhodnius prolixus\u202f: from classical physiology to modern developmental biology. Genesis. 2017. https:\/\/doi.org\/10.1002\/dvg.22995.","journal-title":"Genesis"},{"key":"2622_CR96","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402\u20138.","journal-title":"Methods"},{"key":"2622_CR97","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55:611\u201322. https:\/\/doi.org\/10.1373\/clinchem.2008.112797.","journal-title":"Clin Chem"},{"key":"2622_CR98","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0003-2697(81)90136-6","volume":"110","author":"CR Merril","year":"1981","unstructured":"Merril CR, Dunau ML, Goldman D. A rapid sensitive silver stain for polypeptides in polyacrylamide gels. Anal Biochem. 1981;110:201\u20137.","journal-title":"Anal Biochem"},{"key":"2622_CR99","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265\u201375.","journal-title":"J Biol Chem"},{"key":"2622_CR100","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.imbio.2008.10.003","volume":"214","author":"QH Liu","year":"2009","unstructured":"Liu QH, Zhang SC, Li ZJ, Gao CR. Characterization of a pattern recognition molecule vitellogenin from carp (Cyprinus carpio). Immunobiology. 2009;214:257\u201367. https:\/\/doi.org\/10.1016\/j.imbio.2008.10.003.","journal-title":"Immunobiology"},{"key":"2622_CR101","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.jinsphys.2004.04.007","volume":"50","author":"Y Fan","year":"2004","unstructured":"Fan Y, Schal C, Vargo EL, Bagn\u00e8res A-G. Characterization of termite lipophorin and its involvement in hydrocarbon transport. J Insect Physiol. 2004;50:609\u201320.","journal-title":"J Insect Physiol"},{"key":"2622_CR102","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/arch.21080","volume":"82","author":"D Majerowicz","year":"2013","unstructured":"Majerowicz D, Cezimbra MP, Alves-Bezerra M, Entringer PF, Atella GC, Sola-Penna M, et al. Rhodnius Prolixus Lipophorin: Lipid Composition And Effect Of High Temperature On Physiological Role. Arch Insect Biochem Physiol. 2013;82:129\u201340. https:\/\/doi.org\/10.1002\/arch.21080.","journal-title":"Arch Insect Biochem Physiol"},{"key":"2622_CR103","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1002\/mrd.20560","volume":"73","author":"IB Ramos","year":"2006","unstructured":"Ramos IB, Miranda K, de Souza W, Machado EA. Calcium-regulated fusion of yolk granules during early embryogenesis of Periplaneta americana. Mol Reprod Dev. 2006;73:1247\u201354.","journal-title":"Mol Reprod Dev"},{"issue":"Pt 1","key":"2622_CR104","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1242\/jeb.02652","volume":"210","author":"IB Ramos","year":"2007","unstructured":"Ramos IB, Miranda K, de Souza W, Oliveira DMP, Lima aPCa, Sorgine MHF, et al. Calcium-regulated fusion of yolk granules is important for yolk degradation during early embryogenesis of Rhodnius prolixus Stahl. J Exp Biol. 2007;210(Pt 1):138\u201348. https:\/\/doi.org\/10.1242\/jeb.02652.","journal-title":"J Exp Biol"}],"container-title":["BMC Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12915-026-02622-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12915-026-02622-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12915-026-02622-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:02:21Z","timestamp":1783389741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12915-026-02622-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":104,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2622"],"URL":"https:\/\/doi.org\/10.1186\/s12915-026-02622-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.64898\/2025.12.05.692514","asserted-by":"object"}]},"ISSN":["1741-7007"],"issn-type":[{"value":"1741-7007","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"8 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments involving animals were conducted in accordance with Brazilian national guidelines for the care and use of laboratory animals and were approved by the Ethics Committee on the Use of Animals of the Universidade Federal do Rio de Janeiro (CEUA-UFRJ), under protocol number CEUA #123\/22.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"151"}}