{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:14:06Z","timestamp":1784182446420,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biol"],"DOI":"10.1186\/s12915-026-02643-2","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:55:03Z","timestamp":1779371703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating microRNAs reveal egg-brain crosstalk and a brain-predominant microRNA linked to the onset of the next reproductive cycle in iteroparous salmonids"],"prefix":"10.1186","volume":"24","author":[{"given":"Mariana","family":"Roza de Abreu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Lagarde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Milhade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goro","family":"Yoshizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violette","family":"Thermes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-8227","authenticated-orcid":false,"given":"Julien","family":"Bobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"2643_CR1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ygcen.2009.05.022","volume":"165","author":"E Lubzens","year":"2010","unstructured":"Lubzens E, Young G, Bobe J, Cerd\u00e0 J. Oogenesis in teleosts: how eggs are formed. Gen Comp Endocrinol. 2010;165:367\u201389. https:\/\/doi.org\/10.1016\/j.ygcen.2009.05.022.","journal-title":"Gen Comp Endocrinol"},{"key":"2643_CR2","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ygcen.2009.02.011","volume":"165","author":"J Bobe","year":"2010","unstructured":"Bobe J, Labb\u00e9 C. Egg and sperm quality in fish. Gen Comp Endocrinol. 2010;165:535\u201348. https:\/\/doi.org\/10.1016\/j.ygcen.2009.02.011.","journal-title":"Gen Comp Endocrinol"},{"key":"2643_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60118-2","volume":"14","author":"A Gueho","year":"2024","unstructured":"Gueho A, \u017barski D, Rime H, Gu\u00e9vel B, Com E, Lavigne R, et al. Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish. Sci Rep. 2024;14:9651. https:\/\/doi.org\/10.1038\/s41598-024-60118-2.","journal-title":"Sci Rep"},{"key":"2643_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","volume":"173","author":"DP Bartel","year":"2018","unstructured":"Bartel DP. Metazoan MicroRNAs. Cell. 2018;173:20\u201351. https:\/\/doi.org\/10.1016\/j.cell.2018.03.006.","journal-title":"Cell"},{"key":"2643_CR5","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/jcp.27127","volume":"234","author":"R Ojha","year":"2019","unstructured":"Ojha R, Nandani R, Pandey RK, Mishra A, Prajapati VK. Emerging role of circulating microRNA in the diagnosis of human infectious diseases. J Cell Physiol. 2019;234:1030\u201343. https:\/\/doi.org\/10.1002\/jcp.27127.","journal-title":"J Cell Physiol"},{"key":"2643_CR6","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.3892\/ijo.2012.1647","volume":"41","author":"A Allegra","year":"2012","unstructured":"Allegra A, Alonci A, Campo S, Penna G, Petrungaro A, Gerace D, et al. Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review). Int J Oncol. 2012;41:1897\u2013912. https:\/\/doi.org\/10.3892\/ijo.2012.1647.","journal-title":"Int J Oncol"},{"key":"2643_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.mrfmmm.2011.03.004","volume":"717","author":"A Etheridge","year":"2011","unstructured":"Etheridge A, Lee I, Hood L, Galas D, Wang K. Extracellular microRNA: a new source of biomarkers. Mutat Res Fundam Mol Mech Mutagen. 2011;717:85\u201390. https:\/\/doi.org\/10.1016\/j.mrfmmm.2011.03.004.","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"key":"2643_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-01163-5","volume":"19","author":"E Cardona","year":"2021","unstructured":"Cardona E, Guyomar C, Desvignes T, Montfort J, Guendouz S, Postlethwait JH, et al. Circulating miRNA repertoire as a biomarker of metabolic and reproductive states in rainbow trout. BMC Biol. 2021;19:235. https:\/\/doi.org\/10.1186\/s12915-021-01163-5.","journal-title":"BMC Biol"},{"key":"2643_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1677\/joe.0.1630087","volume":"163","author":"J Chyb","year":"1999","unstructured":"Chyb J, Mikolajczyk T, Breton B. Post-ovulatory secretion of pituitary gonadotropins GtH I and GtH II in the rainbow trout (Oncorhynchus mykiss): regulation by steroids and possible role of non-steroidal gonadal factors. J Endocrinol. 1999;163:87\u201397. https:\/\/doi.org\/10.1677\/joe.0.1630087.","journal-title":"J Endocrinol"},{"key":"2643_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007593","volume":"14","author":"S Gay","year":"2018","unstructured":"Gay S, Bugeon J, Bouchareb A, Henry L, Delahaye C, Legeai F, et al. MiR-202 controls female fecundity by regulating medaka oogenesis. PLoS Genet. 2018;14:e1007593. https:\/\/doi.org\/10.1371\/journal.pgen.1007593.","journal-title":"PLoS Genet"},{"key":"2643_CR11","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1093\/nar\/gkad1154","volume":"52","author":"S Janati-Idrissi","year":"2024","unstructured":"Janati-Idrissi S, de Abreu MR, Guyomar C, de Mello F, Nguyen T, Mechkouri N, et al. Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production. Nucleic Acids Res. 2024;52:738\u201354. https:\/\/doi.org\/10.1093\/nar\/gkad1154.","journal-title":"Nucleic Acids Res"},{"key":"2643_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2505-9","volume":"17","author":"A Juanchich","year":"2016","unstructured":"Juanchich A, Bardou P, Ru\u00e9 O, Gabillard J-C, Gaspin C, Bobe J, et al. Characterization of an extensive rainbow trout miRNA transcriptome by next generation sequencing. BMC Genomics. 2016;17:164. https:\/\/doi.org\/10.1186\/s12864-016-2505-9.","journal-title":"BMC Genomics"},{"key":"2643_CR13","unstructured":"Juanchich A, Gabillard J-C, Guiguen Y, Bobe J. NCBI SRA. 2013. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA227065."},{"key":"2643_CR14","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1007\/s10571-023-01362-4","volume":"43","author":"SK Yadav","year":"2023","unstructured":"Yadav SK, Jauhari A, Singh N, Pandey A, Sarkar S, Pandey S, et al. Transcriptomics and proteomics approach for the identification of altered blood microRNAs and plasma proteins in Parkinson\u2019s disease. Cell Mol Neurobiol. 2023;43:3527\u201353. https:\/\/doi.org\/10.1007\/s10571-023-01362-4.","journal-title":"Cell Mol Neurobiol"},{"key":"2643_CR15","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1007\/s11033-022-07188-5","volume":"49","author":"S Ghafouri-Fard","year":"2022","unstructured":"Ghafouri-Fard S, Hussen BM, Abak A, Taheri M, Jalili Khoshnoud R. Aberrant expression of miRNAs in epilepsy. Mol Biol Rep. 2022;49:5057\u201374. https:\/\/doi.org\/10.1007\/s11033-022-07188-5.","journal-title":"Mol Biol Rep"},{"key":"2643_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neuroscience.2015.07.045","volume":"305","author":"RJ Chen","year":"2015","unstructured":"Chen RJ, Kelly G, Sengupta A, Heydendael W, Nicholas B, Beltrami S, et al. MicroRNAs as biomarkers of resilience or vulnerability to stress. Neuroscience. 2015;305:36\u201348. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.07.045.","journal-title":"Neuroscience"},{"key":"2643_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msac004","volume":"39","author":"T Desvignes","year":"2022","unstructured":"Desvignes T, Bardou P, Montfort J, Sydes J, Guyomar C, George S, et al. FishmiRNA: an evolutionarily supported microRNA annotation and expression database for ray-finned fishes. Mol Biol Evol. 2022;39:msac004. https:\/\/doi.org\/10.1093\/molbev\/msac004.","journal-title":"Mol Biol Evol"},{"key":"2643_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.aquaculture.2003.08.019","volume":"231","author":"S Aegerter","year":"2004","unstructured":"Aegerter S, Jalabert B. Effects of post-ovulatory oocyte ageing and temperature on egg quality and on the occurrence of triploid fry in rainbow trout, Oncorhynchus mykiss. Aquaculture. 2004;231:59\u201371. https:\/\/doi.org\/10.1016\/j.aquaculture.2003.08.019.","journal-title":"Aquaculture"},{"key":"2643_CR19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0044-8486(84)90032-2","volume":"43","author":"J Springate","year":"1984","unstructured":"Springate J, Bromage N, Elliott J, Hudson D. The timing of ovulation and stripping and their effects on the rates of fertilization and survival to eying, hatch and swim-up in the rainbow-trout (Salmo gairdneri R). Aquaculture. 1984;43:313\u201322. https:\/\/doi.org\/10.1016\/0044-8486(84)90032-2.","journal-title":"Aquaculture"},{"key":"2643_CR20","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/mrd.20361","volume":"72","author":"S Aegerter","year":"2005","unstructured":"Aegerter S, Jalabert B, Bobe J. Large scale real-time PCR analysis of mRNA abundance in rainbow trout eggs in relationship with egg quality and post-ovulatory ageing. Mol Reprod Dev. 2005;72:377\u201385. https:\/\/doi.org\/10.1002\/mrd.20361.","journal-title":"Mol Reprod Dev"},{"key":"2643_CR21","doi-asserted-by":"publisher","first-page":"9360","DOI":"10.1093\/nar\/gkae694","volume":"52","author":"H Seitz","year":"2024","unstructured":"Seitz H. A new perspective on microRNA-guided gene regulation specificity, and its potential generalization to transcription factors and RNA-binding proteins. Nucleic Acids Res. 2024;52:9360\u20138. https:\/\/doi.org\/10.1093\/nar\/gkae694.","journal-title":"Nucleic Acids Res"},{"key":"2643_CR22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.18388\/pb.2021_515","volume":"70","author":"V Ambros","year":"2024","unstructured":"Ambros V. MicroRNA-mediated gene regulation and the resilience of multicellular animals. Postepy Biochem. 2024;70:62\u201370. https:\/\/doi.org\/10.18388\/pb.2021_515.","journal-title":"Postepy Biochem"},{"key":"2643_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2024.740589","volume":"583","author":"IA Johnston","year":"2024","unstructured":"Johnston IA, Kent MP, Boudinot P, Looseley M, Bargelloni L, Faggion S, et al. Advancing fish breeding in aquaculture through genome functional annotation. Aquaculture. 2024;583:740589. https:\/\/doi.org\/10.1016\/j.aquaculture.2024.740589.","journal-title":"Aquaculture"},{"key":"2643_CR24","doi-asserted-by":"publisher","unstructured":"Baudement M-O, Morata DP, Gillard GB, Dewari PS, Gundappa MK, Podgorniak T, et al. Salmonids reveal principles of regulatory evolution following autotetraploidization. 2025;:2025.12.18.695160. https:\/\/doi.org\/10.64898\/2025.12.18.695160.","DOI":"10.64898\/2025.12.18.695160"},{"key":"2643_CR25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/j.1095-8649.1991.tb04403.x","volume":"39","author":"N Jonsson","year":"1991","unstructured":"Jonsson N, Jonsson B, Hansen LP. Energetic cost of spawning in male and female Atlantic salmon (Salmo salar L.). J Fish Biol. 1991;39:739\u201344. https:\/\/doi.org\/10.1111\/j.1095-8649.1991.tb04403.x.","journal-title":"J Fish Biol"},{"key":"2643_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2023.111510","volume":"285","author":"LE Jenkins","year":"2023","unstructured":"Jenkins LE, Medeiros LR, Cervantes DL, Nagler JJ, Pierce AL. Effects of post-spawning ration restriction on reproductive development and the growth hormone\/insulin-like growth factor-1 axis in female rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol A Mol Integr Physiol. 2023;285:111510. https:\/\/doi.org\/10.1016\/j.cbpa.2023.111510.","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"2643_CR27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ygcen.2013.09.005","volume":"194","author":"LK Caldwell","year":"2013","unstructured":"Caldwell LK, Pierce AL, Nagler JJ. Metabolic endocrine factors involved in spawning recovery and rematuration of iteroparous female rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol. 2013;194:124\u201332. https:\/\/doi.org\/10.1016\/j.ygcen.2013.09.005.","journal-title":"Gen Comp Endocrinol"},{"key":"2643_CR28","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/s0016-6480(89)80041-3","volume":"74","author":"A de Mones","year":"1989","unstructured":"de Mones A, Fostier A, Cauty C, Jalabert B. Ovarian early postovulatory development and oestrogen production in rainbow trout (Salmo gairdneri R.) from a spring-spawning strain. Gen Comp Endocrinol. 1989;74:431\u201341. https:\/\/doi.org\/10.1016\/s0016-6480(89)80041-3.","journal-title":"Gen Comp Endocrinol"},{"key":"2643_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202506492","volume":"12","author":"Z Liu","year":"2025","unstructured":"Liu Z, Zhang N, Wen Z, Wang H, Li T, Ma R, et al. Genomic insights into the origin, high fecundity and environmental adaptation of Hu sheep. Adv Sci (Weinh). 2025;12:e06492. https:\/\/doi.org\/10.1002\/advs.202506492.","journal-title":"Adv Sci (Weinh)"},{"key":"2643_CR30","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/age.13437","volume":"55","author":"C Li","year":"2024","unstructured":"Li C, Wang X, Li H, Ahmed Z, Luo Y, Qin M, et al. Whole-genome resequencing reveals diversity and selective signals in the Wuxue goat. Anim Genet. 2024;55:575\u201387. https:\/\/doi.org\/10.1111\/age.13437.","journal-title":"Anim Genet"},{"key":"2643_CR31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.theriogenology.2022.09.005","volume":"193","author":"TF Martins","year":"2022","unstructured":"Martins TF, Braga Magalh\u00e3es AF, Verardo LL, Santos GC, Silva Fernandes AA, Gomes Vieira JI, et al. Functional analysis of litter size and number of teats in pigs: from GWAS to post-GWAS. Theriogenology. 2022;193:157\u201366. https:\/\/doi.org\/10.1016\/j.theriogenology.2022.09.005.","journal-title":"Theriogenology"},{"key":"2643_CR32","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1261\/rna.754207","volume":"13","author":"S Ro","year":"2007","unstructured":"Ro S, Song R, Park C, Zheng H, Sanders KM, Yan W. Cloning and expression profiling of small RNAs expressed in the mouse ovary. RNA. 2007;13:2366\u201380. https:\/\/doi.org\/10.1261\/rna.754207.","journal-title":"RNA"},{"key":"2643_CR33","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1101\/gr.093054.109","volume":"19","author":"J Armisen","year":"2009","unstructured":"Armisen J, Gilchrist MJ, Wilczynska A, Standart N, Miska EA. Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis. Genome Res. 2009;19:1766\u201375. https:\/\/doi.org\/10.1101\/gr.093054.109.","journal-title":"Genome Res"},{"key":"2643_CR34","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1159\/000341378","volume":"6","author":"TT Bizuayehu","year":"2012","unstructured":"Bizuayehu TT, Babiak J, Norberg B, Fernandes JMO, Johansen SD, Babiak I. Sex-biased miRNA expression in Atlantic halibut (Hippoglossus hippoglossus) brain and gonads. Sex Dev. 2012;6:257\u201366. https:\/\/doi.org\/10.1159\/000341378.","journal-title":"Sex Dev"},{"issue":"5","key":"2643_CR35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1095\/biolreprod.112.105361","volume":"88","author":"A Juanchich","year":"2013","unstructured":"Juanchich A, Le Cam A, Montfort J, Guiguen Y, Bobe J. Identification of differentially expressed miRNAs and their potential targets during fish ovarian development. Biol Reprod. 2013;88:128. https:\/\/doi.org\/10.1095\/biolreprod.112.105361.","journal-title":"Biol Reprod"},{"key":"2643_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40361-8","volume":"9","author":"T Desvignes","year":"2019","unstructured":"Desvignes T, Batzel P, Sydes J, Eames BF, Postlethwait JH. miRNA analysis with Prost! reveals evolutionary conservation of organ-enriched expression and post-transcriptional modifications in three-spined stickleback and zebrafish. Sci Rep. 2019;9:3913. https:\/\/doi.org\/10.1038\/s41598-019-40361-8.","journal-title":"Sci Rep"},{"key":"2643_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/biolre\/iox160","volume":"98","author":"Q-L Wong","year":"2018","unstructured":"Wong Q-L, Sun M-A, Lau S-W, Parsania C, Zhou S, Zhong S, et al. Identification and characterization of a specific 13-miRNA expression signature during follicle activation in the zebrafish ovary. Biol Reprod. 2018;98:42\u201353. https:\/\/doi.org\/10.1093\/biolre\/iox160.","journal-title":"Biol Reprod"},{"key":"2643_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","volume":"17","author":"M Martin","year":"2011","unstructured":"Martin M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnetjournal. 2011;17:10\u20132. https:\/\/doi.org\/10.14806\/ej.17.1.200.","journal-title":"EMBnetjournal"},{"key":"2643_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"2643_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v025.i01","volume":"25","author":"S L\u00ea","year":"2008","unstructured":"L\u00ea S, Josse J, Husson F. FactoMineR: an R package for multivariate analysis. J Stat Softw. 2008;25:1\u201318. https:\/\/doi.org\/10.18637\/jss.v025.i01.","journal-title":"J Stat Softw"},{"key":"2643_CR41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005","author":"V Agarwal","year":"2015","unstructured":"Agarwal V, Bell GW, Nam J-W, Bartel DP. Predicting effective microRNA target sites in mammalian mRNAs. Elife. 2015. https:\/\/doi.org\/10.7554\/eLife.05005.","journal-title":"Elife"},{"key":"2643_CR42","unstructured":"AQUAFAANG. ENA. 2022. https:\/\/www.ebi.ac.uk\/ena\/browser\/view\/PRJEB57191."},{"key":"2643_CR43","unstructured":"Cardona E, Bobe J. NCBI SRA. 2021. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA693437."}],"container-title":["BMC Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12915-026-02643-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12915-026-02643-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12915-026-02643-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:57:39Z","timestamp":1784181459000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12915-026-02643-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2643"],"URL":"https:\/\/doi.org\/10.1186\/s12915-026-02643-2","relation":{},"ISSN":["1741-7007"],"issn-type":[{"value":"1741-7007","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"5 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Experiments and procedures were fully compliant with French and European animal welfare policies and followed guidelines of the INRAE LPGP Institutional Animal Care and Use Ethical Committee, which specifically approved this study under reference # T-2019\u201326.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"166"}}