{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T23:19:22Z","timestamp":1774739962223,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12916-015-0448-7","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T07:20:52Z","timestamp":1442474452000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations"],"prefix":"10.1186","volume":"13","author":[{"given":"Longding","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaojun","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenglun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kien Chai","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kum Thong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Hao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perera","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jielai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixiong","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingfang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"key":"448_CR1","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJM199909233411301","volume":"341","author":"M Ho","year":"1999","unstructured":"Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, et al. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med. 1999;341:929\u201335.","journal-title":"N Engl J Med"},{"key":"448_CR2","doi-asserted-by":"publisher","first-page":"e25662","DOI":"10.1371\/journal.pone.0025662","volume":"6","author":"X Tan","year":"2011","unstructured":"Tan X, Huang X, Zhu S, Chen H, Yu Q, Wang H, et al. The persistent circulation of enterovirus 71 in People\u2019s Republic of China: causing emerging nationwide epidemics since 2008. PLoS One. 2011;6:e25662.","journal-title":"PLoS One"},{"key":"448_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","volume":"26","author":"PC McMinn","year":"2002","unstructured":"McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev. 2002;26:91\u2013107.","journal-title":"FEMS Microbiol Rev"},{"key":"448_CR4","doi-asserted-by":"publisher","first-page":"e775","DOI":"10.1016\/j.ijid.2010.02.2265","volume":"14","author":"E Ma","year":"2010","unstructured":"Ma E, Chan KC, Cheng P, Wong C, Chuang SK. The enterovirus 71 epidemic in 2008--public health implications for Hong Kong. Int J Infect Dis. 2010;14:e775\u201380.","journal-title":"Int J Infect Dis"},{"key":"448_CR5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.47102\/annals-acadmedsg.V38N2p106","volume":"38","author":"LW Ang","year":"2009","unstructured":"Ang LW, Koh BK, Chan KP, Chua LT, James L, Goh KT. Epidemiology and control of hand, foot and mouth disease in Singapore, 2001\u20132007. Ann Acad Med Singapore. 2009;38:106\u201312.","journal-title":"Ann Acad Med Singapore"},{"key":"448_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1743-422X-9-8","volume":"9","author":"W Xu","year":"2012","unstructured":"Xu W, Liu CF, Yan L, Li JJ, Wang LJ, Qi Y, et al. Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications. Virol J. 2012;9:8.","journal-title":"Virol J"},{"key":"448_CR7","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1097\/EDE.0b013e318231d67a","volume":"22","author":"Y Wang","year":"2011","unstructured":"Wang Y, Feng Z, Yang Y, Self S, Gao Y, Longini IM, et al. Hand, foot, and mouth disease in China: patterns of spread and transmissibility. Epidemiology. 2011;22:781\u201392.","journal-title":"Epidemiology"},{"key":"448_CR8","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1056\/NEJMoa1303224","volume":"370","author":"R Li","year":"2014","unstructured":"Li R, Liu L, Mo Z, Wang X, Xia J, Liang Z, et al. An inactivated enterovirus 71 vaccine in healthy children. N Engl J Med. 2014;370:829\u201337.","journal-title":"N Engl J Med"},{"key":"448_CR9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1056\/NEJMoa1304923","volume":"370","author":"F Zhu","year":"2014","unstructured":"Zhu F, Xu W, Xia J, Liang Z, Liu Y, Zhang X, et al. Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China. N Engl J Med. 2014;370:818\u201328.","journal-title":"N Engl J Med"},{"key":"448_CR10","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","volume":"381","author":"FC Zhu","year":"2013","unstructured":"Zhu FC, Meng FY, Li JX, Li XL, Mao QY, Tao H, et al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2013;381:2024\u201332.","journal-title":"Lancet"},{"key":"448_CR11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/INF.0b013e3181cdd178","volume":"29","author":"H Ma","year":"2010","unstructured":"Ma H, He F, Wan J, Jin D, Zhu L, Liu X, et al. Glucocorticoid and pyrazolone treatment of acute fever is a risk factor for critical and life-threatening human enterovirus 71 infection during an outbreak in China, 2008. Pediatr Infect Dis J. 2010;29:524\u20139.","journal-title":"Pediatr Infect Dis J"},{"key":"448_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1442-200x.2004.01868.x","volume":"46","author":"H Shimizu","year":"2004","unstructured":"Shimizu H, Utama A, Onnimala N, Li C, Li-Bi Z, Yu-Jie M, et al. Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Pediatr Int. 2004;46:231\u20135.","journal-title":"Pediatr Int"},{"key":"448_CR13","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","volume":"10","author":"T Solomon","year":"2010","unstructured":"Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis. 2010;10:778\u201390.","journal-title":"Lancet Infect Dis"},{"key":"448_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3201\/eid0707.017703","volume":"7","author":"JS Mackenzie","year":"2001","unstructured":"Mackenzie JS, Chua KB, Daniels PW, Eaton BT, Field HE, Hall RA, et al. Emerging viral diseases of Southeast Asia and the Western Pacific. Emerg Infect Dis. 2001;7:497\u2013504.","journal-title":"Emerg Infect Dis"},{"key":"448_CR15","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.1128\/JCM.00630-09","volume":"47","author":"SW Huang","year":"2009","unstructured":"Huang SW, Hsu YW, Smith DJ, Kiang D, Tsai HP, Lin KH, et al. Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008. J Clin Microbiol. 2009;47:3653\u201362.","journal-title":"J Clin Microbiol"},{"key":"448_CR16","doi-asserted-by":"publisher","first-page":"6269","DOI":"10.1016\/j.vaccine.2011.06.044","volume":"29","author":"C Dong","year":"2011","unstructured":"Dong C, Liu L, Zhao H, Wang J, Liao Y, Zhang X, et al. Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys. Vaccine. 2011;29:6269\u201375.","journal-title":"Vaccine"},{"key":"448_CR17","first-page":"62","volume":"15","author":"F-c Wang","year":"2014","unstructured":"Wang F-c. Epidemiological features of hand-foot-mouth disease in Jingxi county of Guangxi in 2008\u20132012 [Chinese]. Chin Prev Med. 2014;15:62\u20136.","journal-title":"Chin Prev Med"},{"key":"448_CR18","doi-asserted-by":"publisher","first-page":"e88065","DOI":"10.1371\/journal.pone.0088065","volume":"9","author":"YH Xie","year":"2014","unstructured":"Xie YH, Chongsuvivatwong V, Tang Z, McNeil EB, Tan Y. Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi. China PLoS One. 2014;9:e88065.","journal-title":"China PLoS One"},{"key":"448_CR19","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3201\/eid0809.010397","volume":"8","author":"EE Ooi","year":"2002","unstructured":"Ooi EE, Phoon MC, Ishak B, Chan SH. Seroepidemiology of human enterovirus 71. Singapore Emerg Infect Dis. 2002;8:995\u20137.","journal-title":"Singapore Emerg Infect Dis"},{"key":"448_CR20","first-page":"415","volume":"69","author":"B Dai","year":"1991","unstructured":"Dai B, Chen ZH, Liu QC, Wu T, Guo CY, Wang XZ, et al. Duration of immunity following immunization with live measles vaccine: 15 years of observation in Zhejiang Province. China Bull World Health Organ. 1991;69:415\u201323.","journal-title":"China Bull World Health Organ"},{"key":"448_CR21","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1086\/649839","volume":"201","author":"DM Musher","year":"2010","unstructured":"Musher DM, Manof SB, Liss C, McFetridge RD, Marchese RD, Bushnell B, et al. Safety and antibody response, including antibody persistence for 5 years, after primary vaccination or revaccination with pneumococcal polysaccharide vaccine in middle-aged and older adults. J Infect Dis. 2010;201:516\u201324.","journal-title":"J Infect Dis"},{"key":"448_CR22","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1016\/j.vaccine.2007.02.069","volume":"25","author":"C Fraser","year":"2007","unstructured":"Fraser C, Tomassini JE, Xi L, Golm G, Watson M, Giuliano AR, et al. Modeling the long-term antibody response of a human papillomavirus (HPV) virus-like particle (VLP) type 16 prophylactic vaccine. Vaccine. 2007;25:4324\u201333.","journal-title":"Vaccine"},{"key":"448_CR23","doi-asserted-by":"publisher","first-page":"e88","DOI":"10.1542\/peds.109.6.e88","volume":"109","author":"LY Chang","year":"2002","unstructured":"Chang LY, King CC, Hsu KH, Ning HC, Tsao KC, Li CC, et al. Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease\/herpangina in children during an epidemic in Taiwan. Pediatrics. 2002;109:e88.","journal-title":"Pediatrics"},{"key":"448_CR24","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.micinf.2007.06.002","volume":"9","author":"DG Foo","year":"2007","unstructured":"Foo DG, Alonso S, Chow VT, Poh CL. Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide. Microbes Infect. 2007;9:1299\u2013306.","journal-title":"Microbes Infect"},{"key":"448_CR25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.immunol.14.1.333","volume":"14","author":"RM Zinkernagel","year":"1996","unstructured":"Zinkernagel RM, Bachmann MF, Kundig TM, Oehen S, Pirchet H, Hengartner H. On immunological memory. Annu Rev Immunol. 1996;14:333\u201367.","journal-title":"Annu Rev Immunol"},{"key":"448_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.272.5258.54","volume":"272","author":"R Ahmed","year":"1996","unstructured":"Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science. 1996;272:54\u201360.","journal-title":"Science"},{"key":"448_CR27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1146\/annurev.immunol.22.012703.104527","volume":"22","author":"RM Welsh","year":"2004","unstructured":"Welsh RM, Selin LK, Szomolanyi-Tsuda E. Immunological memory to viral infections. Annu Rev Immunol. 2004;22:711\u201343.","journal-title":"Annu Rev Immunol"},{"key":"448_CR28","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jcv.2011.12.025","volume":"53","author":"M Zeng","year":"2012","unstructured":"Zeng M, El Khatib NF, Tu S, Ren P, Xu S, Zhu Q, et al. Seroepidemiology of enterovirus 71 infection prior to the 2011 season in children in Shanghai. J Clin Virol. 2012;53:285\u20139.","journal-title":"J Clin Virol"},{"key":"448_CR29","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.vaccine.2011.12.081","volume":"30","author":"YL Lin","year":"2012","unstructured":"Lin YL, Yu CI, Hu YC, Tsai TJ, Kuo YC, Chi WK, et al. Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles. Vaccine. 2012;30:1305\u201312.","journal-title":"Vaccine"},{"key":"448_CR30","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1007\/s10875-012-9690-3","volume":"32","author":"Y Liang","year":"2012","unstructured":"Liang Y, Zhou X, Yang E, Pu J, Che Y, Wang J, et al. Analysis of the Th1\/Th2 reaction in the immune response induced by EV71 inactivated vaccine in neonatal rhesus monkeys. J Clin Immunol. 2012;32:1048\u201358.","journal-title":"J Clin Immunol"},{"key":"448_CR31","doi-asserted-by":"publisher","first-page":"e54451","DOI":"10.1371\/journal.pone.0054451","volume":"8","author":"L Liu","year":"2013","unstructured":"Liu L, Zhang Y, Wang J, Zhao H, Jiang L, Che Y, et al. Study of the integrated immune response induced by an inactivated EV71 vaccine. PLoS One. 2013;8:e54451.","journal-title":"PLoS One"},{"key":"448_CR32","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1542\/peds.2008-3645","volume":"124","author":"ME Pichichero","year":"2009","unstructured":"Pichichero ME. Booster vaccinations: can immunologic memory outpace disease pathogenesis? Pediatrics. 2009;124:1633\u201341.","journal-title":"Pediatrics"},{"key":"448_CR33","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","volume":"73","author":"BA Brown","year":"1999","unstructured":"Brown BA, Oberste MS, Alexander Jr JP, Kennett ML, Pallansch MA. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol. 1999;73:9969\u201375.","journal-title":"J Virol"},{"key":"448_CR34","doi-asserted-by":"publisher","first-page":"9386","DOI":"10.1128\/JVI.02856-06","volume":"81","author":"M Arita","year":"2007","unstructured":"Arita M, Nagata N, Iwata N, Ami Y, Suzaki Y, Mizuta K, et al. An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys. J Virol. 2007;81:9386\u201395.","journal-title":"J Virol"},{"key":"448_CR35","doi-asserted-by":"publisher","first-page":"e100545","DOI":"10.1371\/journal.pone.0100545","volume":"9","author":"H Zhang","year":"2014","unstructured":"Zhang H, An D, Liu W, Mao Q, Jin J, Xu L, et al. Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay. PLoS One. 2014;9:e100545.","journal-title":"PLoS One"},{"key":"448_CR36","doi-asserted-by":"publisher","first-page":"e2067","DOI":"10.1371\/journal.pntd.0002067","volume":"7","author":"ML Huang","year":"2013","unstructured":"Huang ML, Chiang PS, Chia MY, Luo ST, Chang LY, Lin TY, et al. Cross-reactive neutralizing antibody responses to enterovirus 71 infections in young children: implications for vaccine development. PLoS Negl Trop Dis. 2013;7:e2067.","journal-title":"PLoS Negl Trop Dis"},{"key":"448_CR37","doi-asserted-by":"publisher","first-page":"e79599","DOI":"10.1371\/journal.pone.0079599","volume":"8","author":"Q Mao","year":"2013","unstructured":"Mao Q, Cheng T, Zhu F, Li J, Wang Y, Li Y, et al. The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy Chinese infants and children. PLoS One. 2013;8:e79599.","journal-title":"PLoS One"},{"key":"448_CR38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3201\/eid0904.020395","volume":"9","author":"MJ Cardosa","year":"2003","unstructured":"Cardosa MJ, Perera D, Brown BA, Cheon D, Chan HM, Chan KP, et al. Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes. Emerg Infect Dis. 2003;9:461\u20138.","journal-title":"Emerg Infect Dis"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-015-0448-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12916-015-0448-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-015-0448-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T06:34:40Z","timestamp":1691994880000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-015-0448-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,17]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["448"],"URL":"https:\/\/doi.org\/10.1186\/s12916-015-0448-7","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,17]]},"article-number":"226"}}