{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:08:05Z","timestamp":1794312485115,"version":"4.9.0"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12916-015-0455-8","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T12:58:54Z","timestamp":1441285134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":618,"title":["Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis"],"prefix":"10.1186","volume":"13","author":[{"given":"Anne","family":"Bertrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Kostine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Barnetche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Elise","family":"Truchetet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Schaeverbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"455_CR1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrclinonc.2014.174","volume":"11","author":"SA Rosenberg","year":"2014","unstructured":"Rosenberg SA. Decade in review-cancer immunotherapy: entering the mainstream of cancer treatment. Nat Rev Clin Oncol. 2014;11:630\u20132.","journal-title":"Nat Rev Clin Oncol"},{"key":"455_CR2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nm0303-269","volume":"9","author":"TA Waldmann","year":"2003","unstructured":"Waldmann TA. Immunotherapy: past, present and future. Nat Med. 2003;9:269\u201377.","journal-title":"Nat Med"},{"key":"455_CR3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","volume":"12","author":"DM Pardoll","year":"2012","unstructured":"Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252\u201364.","journal-title":"Nat Rev Cancer"},{"key":"455_CR4","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1002\/cncr.23086","volume":"110","author":"SJ O\u2019Day","year":"2007","unstructured":"O\u2019Day SJ, Hamid O, Urba WJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer. 2007;110:2614\u201327.","journal-title":"Cancer"},{"key":"455_CR5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/1074-7613(95)90125-6","volume":"3","author":"EA Tivol","year":"1995","unstructured":"Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3:541\u20137.","journal-title":"Immunity"},{"key":"455_CR6","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1126\/science.1255904","volume":"345","author":"HS Kuehn","year":"2014","unstructured":"Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, et al. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 2014;345:1623\u20137.","journal-title":"Science"},{"key":"455_CR7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","volume":"363","author":"FS Hodi","year":"2010","unstructured":"Hodi FS, O\u2019Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711\u201323.","journal-title":"N Engl J Med"},{"key":"455_CR8","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1056\/NEJMoa1104621","volume":"364","author":"C Robert","year":"2011","unstructured":"Robert C, Thomas L, Bondarenko I, O\u2019Day S, JW MD, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364:2517\u201326.","journal-title":"N Engl J Med"},{"key":"455_CR9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1634\/theoncologist.12-7-873","volume":"12","author":"A Ribas","year":"2007","unstructured":"Ribas A, Hanson DC, Noe DA, Millham R, Guyot DJ, Bernstein SH, et al. Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer. Oncologist. 2007;12:873\u201383.","journal-title":"Oncologist"},{"key":"455_CR10","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.seminoncol.2010.09.006","volume":"37","author":"L Calabr\u00f2","year":"2010","unstructured":"Calabr\u00f2 L, Danielli R, Sigalotti L, Maio M. Clinical studies with anti-CTLA-4 antibodies in non-melanoma indications. Semin Oncol. 2010;37:460\u20137.","journal-title":"Semin Oncol"},{"key":"455_CR11","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JPT Higgins","year":"2011","unstructured":"Higgins JPT, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.","journal-title":"BMJ"},{"key":"455_CR12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/CMR.0b013e32835c7e68","volume":"23","author":"SG Bernardo","year":"2013","unstructured":"Bernardo SG, Moskalenko M, Pan M, Shah S, Sidhu HK, Sicular S, et al. Elevated rates of transaminitis during ipilimumab therapy for metastatic melanoma. Melanoma Res. 2013;23:47\u201354.","journal-title":"Melanoma Res"},{"key":"455_CR13","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1158\/1078-0432.CCR-10-0569","volume":"16","author":"BC Carthon","year":"2010","unstructured":"Carthon BC, Wolchok JD, Yuan J, Kamat A, Ng Tang DS, Sun J, et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res. 2010;16:2861\u201371.","journal-title":"Clin Cancer Res"},{"key":"455_CR14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/CJI.0b013e31828eed39","volume":"36","author":"S Wilgenhof","year":"2013","unstructured":"Wilgenhof S, Du Four S, Vandenbroucke F, Everaert H, Salmon I, Li\u00e9nard D, et al. Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma. J Immunother. 2013;36:215\u201322.","journal-title":"J Immunother"},{"key":"455_CR15","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1093\/annonc\/mdt027","volume":"24","author":"J Delyon","year":"2013","unstructured":"Delyon J, Mateus C, Lefeuvre D, Lanoy E, Zitvogel L, Chaput N, et al. Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival. Ann Oncol. 2013;24:1697\u2013703.","journal-title":"Ann Oncol"},{"key":"455_CR16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(12)70090-6","volume":"13","author":"K Margolin","year":"2012","unstructured":"Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012;13:459\u201365.","journal-title":"Lancet Oncol"},{"key":"455_CR17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1479-5876-9-204","volume":"9","author":"O Hamid","year":"2011","unstructured":"Hamid O, Schmidt H, Nissan A, Ridolfi L, Aamdal S, Hansson J, et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med. 2011;9:204.","journal-title":"J Transl Med"},{"key":"455_CR18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00262-011-1089-0","volume":"61","author":"R Danielli","year":"2012","unstructured":"Danielli R, Ridolfi R, Chiarion-Sileni V, Queirolo P, Testori A, Plummer R, et al. Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy. Cancer Immunol Immunother. 2012;61:41\u20138.","journal-title":"Cancer Immunol Immunother"},{"key":"455_CR19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1470-2045(09)70334-1","volume":"11","author":"JD Wolchok","year":"2010","unstructured":"Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010;11:155\u201364.","journal-title":"Lancet Oncol"},{"key":"455_CR20","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/annonc\/mdq013","volume":"21","author":"SJ O\u2019Day","year":"2010","unstructured":"O\u2019Day SJ, Maio M, Chiarion-Sileni V, Gajewski TF, Pehamberger H, Bondarenko IN, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann Oncol. 2010;21:1712\u20137.","journal-title":"Ann Oncol"},{"key":"455_CR21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10637-009-9376-8","volume":"29","author":"EM Hersh","year":"2011","unstructured":"Hersh EM, O\u2019Day SJ, Powderly J, Khan KD, Pavlick AC, Cranmer LD, et al. A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-na\u00efve patients with advanced melanoma. Invest New Drugs. 2011;29:489\u201398.","journal-title":"Invest New Drugs"},{"key":"455_CR22","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1158\/1078-0432.CCR-09-1024","volume":"15","author":"J Weber","year":"2009","unstructured":"Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, et al. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res. 2009;15:5591\u20138.","journal-title":"Clin Cancer Res"},{"key":"455_CR23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/CJI.0b013e318156e47e","volume":"30","author":"JC Yang","year":"2007","unstructured":"Yang JC, Hughes M, Kammula U, Royal R, Sherry RM, Topalian SL, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30:825\u201330.","journal-title":"J Immunother"},{"key":"455_CR24","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1158\/1078-0432.CCR-07-0187","volume":"13","author":"SG Downey","year":"2007","unstructured":"Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res. 2007;13:6681\u20138.","journal-title":"Clin Cancer Res"},{"key":"455_CR25","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/cncr.24951","volume":"116","author":"GY Ku","year":"2010","unstructured":"Ku GY, Yuan J, Page DB, Schroeder SEA, Panageas KS, Carvajal RD, et al. Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer. 2010;116:1767\u201375.","journal-title":"Cancer"},{"key":"455_CR26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00262-010-0958-2","volume":"60","author":"AM Giacomo Di","year":"2011","unstructured":"Di Giacomo AM, Danielli R, Calabr\u00f2 L, Bertocci E, Nannicini C, Giannarelli D, et al. Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy). Cancer Immunol Immunother. 2011;60:467\u201377.","journal-title":"Cancer Immunol Immunother"},{"key":"455_CR27","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/CJI.0b013e3181eec14c","volume":"33","author":"RE Royal","year":"2010","unstructured":"Royal RE, Levy C, Turner K, Mathur A, Hughes M, Kammula US, et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother. 2010;33:828\u201333.","journal-title":"J Immunother"},{"key":"455_CR28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/CJI.0b013e31829fb7a2","volume":"36","author":"DT Le","year":"2013","unstructured":"Le DT, Lutz E, Uram JN, Sugar EA, Onners B, Solt S, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother. 2013;36:382\u20139.","journal-title":"J Immunother"},{"key":"455_CR29","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1200\/JCO.2008.16.1927","volume":"26","author":"JS Weber","year":"2008","unstructured":"Weber JS, O\u2019Day S, Urba W, Powderly J, Nichol G, Yellin M, et al. Phase I\/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol. 2008;26:5950\u20136.","journal-title":"J Clin Oncol"},{"key":"455_CR30","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/annonc\/mdt107","volume":"24","author":"SF Slovin","year":"2013","unstructured":"Slovin SF, Higano CS, Hamid O, Tejwani S, Harzstark A, Alumkal JJ, et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I\/II study. Ann Oncol. 2013;24:1813\u201321.","journal-title":"Ann Oncol"},{"key":"455_CR31","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S1470-2045(13)70381-4","volume":"14","author":"L Calabr\u00f2","year":"2013","unstructured":"Calabr\u00f2 L, Morra A, Fonsatti E, Cutaia O, Amato G, Giannarelli D, et al. Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial. Lancet Oncol. 2013;14:1104\u201311.","journal-title":"Lancet Oncol"},{"key":"455_CR32","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1200\/JCO.2010.28.3994","volume":"28","author":"KY Chung","year":"2010","unstructured":"Chung KY, Gore I, Fong L, Venook A, Beck SB, Dorazio P, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol. 2010;28:3485\u201390.","journal-title":"J Clin Oncol"},{"key":"455_CR33","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1158\/1078-0432.CCR-09-2870","volume":"16","author":"C Ralph","year":"2010","unstructured":"Ralph C, Elkord E, Burt DJ, O\u2019Dwyer JF, Austin EB, Stern PL, et al. Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clin Cancer Res. 2010;16:1662\u201372.","journal-title":"Clin Cancer Res"},{"key":"455_CR34","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.1200\/JCO.2005.01.109","volume":"23","author":"A Ribas","year":"2005","unstructured":"Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol. 2005;23:8968\u201377.","journal-title":"J Clin Oncol"},{"key":"455_CR35","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1200\/JCO.2012.44.6112","volume":"31","author":"A Ribas","year":"2013","unstructured":"Ribas A, Kefford R, Marshall MA, Punt CJA, Haanen JB, Marmol M, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013;31:616\u201322.","journal-title":"J Clin Oncol"},{"key":"455_CR36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000353408","volume":"227","author":"A Audemard","year":"2013","unstructured":"Audemard A, de Raucourt S, Miocque S, Comoz F, Giraud JM, Dreno B, et al. Melanoma-associated retinopathy treated with ipilimumab therapy. Dermatology. 2013;227:146\u20139.","journal-title":"Dermatology"},{"key":"455_CR37","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.3747\/co.20.1265","volume":"20","author":"H Assi","year":"2013","unstructured":"Assi H, Wilson KS. Immune toxicities and long remission duration after ipilimumab therapy for metastatic melanoma: two illustrative cases. Curr Oncol Tor Ont. 2013;20:e165\u2013169.","journal-title":"Curr Oncol Tor Ont"},{"key":"455_CR38","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/CMR.0000000000000017","volume":"23","author":"S Pintova","year":"2013","unstructured":"Pintova S, Sidhu H, Friedlander PA, Holcombe RF. Sweet\u2019s syndrome in a patient with metastatic melanoma after ipilimumab therapy. Melanoma Res. 2013;23:498\u2013501.","journal-title":"Melanoma Res"},{"key":"455_CR39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/01.cji.0000178913.41256.06","volume":"28","author":"JA Blansfield","year":"2005","unstructured":"Blansfield JA, Beck KE, Tran K, Yang JC, Hughes MS, Kammula US, et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother. 2005;28:593\u20138.","journal-title":"J Immunother"},{"key":"455_CR40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/CMR.0b013e32832e0bff","volume":"19","author":"KC Kaehler","year":"2009","unstructured":"Kaehler KC, Egberts F, Lorigan P, Hauschild A. Anti-CTLA-4 therapy-related autoimmune hypophysitis in a melanoma patient. Melanoma Res. 2009;19:333\u20134.","journal-title":"Melanoma Res"},{"key":"455_CR41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s12032-010-9794-7","volume":"29","author":"ZR Barnard","year":"2012","unstructured":"Barnard ZR, Walcott BP, Kahle KT, Nahed BV, Coumans JV. Hyponatremia associated with ipilimumab-induced hypophysitis. Med Oncol. 2012;29:374\u20137.","journal-title":"Med Oncol"},{"key":"455_CR42","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/practneurol-2012-000447","volume":"13","author":"I Bot","year":"2013","unstructured":"Bot I, Blank CU, Boogerd W, Brandsma D. Neurological immune-related adverse events of ipilimumab. Pract Neurol. 2013;13:278\u201380.","journal-title":"Pract Neurol"},{"key":"455_CR43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1530\/EJE-10-0833","volume":"164","author":"L Min","year":"2011","unstructured":"Min L, Vaidya A, Becker C. Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy. Eur J Endocrinol. 2011;164:303\u20137.","journal-title":"Eur J Endocrinol"},{"key":"455_CR44","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1097\/RLU.0b013e3182639765","volume":"38","author":"B Hiel Van der","year":"2013","unstructured":"Van der Hiel B, Blank CU, Haanen JBAG, Stokkel MPM. Detection of early onset of hypophysitis by (18)F-FDG PET-CT in a patient with advanced stage melanoma treated with ipilimumab. Clin Nucl Med. 2013;38:e182\u2013184.","journal-title":"Clin Nucl Med"},{"key":"455_CR45","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1055\/s-0033-1355337","volume":"121","author":"A Lammert","year":"2013","unstructured":"Lammert A, Schneider HJ, Bergmann T, Benck U, Kr\u00e4mer BK, G\u00e4rtner R, et al. Hypophysitis caused by ipilimumab in cancer patients: hormone replacement or immunosuppressive therapy. Exp Clin Endocrinol Diabetes. 2013;121:581\u20137.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"455_CR46","first-page":"315","volume":"66","author":"L Anderson","year":"2013","unstructured":"Anderson L, Bhatia V. Ipilimumab immune-related adverse reactions: a case report. S D Med. 2013;66:315\u20137.","journal-title":"S D Med"},{"key":"455_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-12-0167","volume":"167","author":"A Juszczak","year":"2012","unstructured":"Juszczak A, Gupta A, Karavitaki N, Middleton MR, Grossman AB. Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review. Eur J Endocrinol. 2012;167:1\u20135.","journal-title":"Eur J Endocrinol"},{"key":"455_CR48","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.3174\/ajnr.A1623","volume":"30","author":"KJ Carpenter","year":"2009","unstructured":"Carpenter KJ, Murtagh RD, Lilienfeld H, Weber J, Murtagh FR. Ipilimumab-induced hypophysitis: MR imaging findings. AJNR Am J Neuroradiol. 2009;30:1751\u20133.","journal-title":"AJNR Am J Neuroradiol"},{"key":"455_CR49","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2012.47.5095","volume":"31","author":"DR Minor","year":"2013","unstructured":"Minor DR, Bunker SR, Doyle J. Lymphocytic vasculitis of the uterus in a patient with melanoma receiving ipilimumab. J Clin Oncol. 2013;31, e356.","journal-title":"J Clin Oncol"},{"key":"455_CR50","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1210\/jc.2006-2484","volume":"92","author":"SA Shaw","year":"2007","unstructured":"Shaw SA, Camacho LH, McCutcheon IE, Waguespack SG. Transient hypophysitis after cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. J Clin Endocrinol Metab. 2007;92:1201\u20132.","journal-title":"J Clin Endocrinol Metab"},{"key":"455_CR51","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4158\/EP11273.OR","volume":"18","author":"L Min","year":"2012","unstructured":"Min L, Vaidya A, Becker C. Association of ipilimumab therapy for advanced melanoma with secondary adrenal insufficiency: a case series. Endocr Pract. 2012;18:351\u20135.","journal-title":"Endocr Pract"},{"key":"455_CR52","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1007\/s12032-010-9606-0","volume":"28","author":"K Harmankaya","year":"2011","unstructured":"Harmankaya K, Erasim C, Koelblinger C, Ibrahim R, Hoos A, Pehamberger H, et al. Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy. Med Oncol. 2011;28:1140\u20134.","journal-title":"Med Oncol"},{"key":"455_CR53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1188\/11.CJON.393-403","volume":"15","author":"B Ledezma","year":"2011","unstructured":"Ledezma B, Binder S, Hamid O. Atypical clinical response patterns to ipilimumab. Clin J Oncol Nurs. 2011;15:393\u2013403.","journal-title":"Clin J Oncol Nurs"},{"key":"455_CR54","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/MCG.0b013e31828f1d51","volume":"47","author":"KA Mitchell","year":"2013","unstructured":"Mitchell KA, Kluger H, Sznol M, Hartman DJ. Ipilimumab-induced perforating colitis. J Clin Gastroenterol. 2013;47:781\u20135.","journal-title":"J Clin Gastroenterol"},{"key":"455_CR55","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1007\/s10620-009-0839-8","volume":"55","author":"JD Lord","year":"2010","unstructured":"Lord JD, Hackman RC, Moklebust A, Thompson JA, Higano CS, Chielens D, et al. Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells. Dig Dis Sci. 2010;55:1396\u2013405.","journal-title":"Dig Dis Sci"},{"key":"455_CR56","doi-asserted-by":"crossref","first-page":"298, 504, 505","DOI":"10.1053\/j.gastro.2012.01.042","volume":"143","author":"C Koch","year":"2012","unstructured":"Koch C, Paetzold S, Trojan J. Enterocolitis in a patient being treated with ipilimumab for metastatic melanoma. Gastroenterology. 2012;143:298, 504, 505.","journal-title":"Gastroenterology"},{"key":"455_CR57","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/cbr.2008.0607","volume":"24","author":"DR Minor","year":"2009","unstructured":"Minor DR, Chin K, Kashani-Sabet M. Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immune-related colitis. Cancer Biother Radiopharm. 2009;24:321\u20135.","journal-title":"Cancer Biother Radiopharm"},{"key":"455_CR58","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3109\/0284186X.2012.682630","volume":"51","author":"M Slingerland","year":"2012","unstructured":"Slingerland M, Nortier JWR, Veenendaal RA, Kapiteijn E. Severe colitis while responding to ipilimumab in metastatic melanoma. Acta Oncol. 2012;51:805\u20137.","journal-title":"Acta Oncol"},{"key":"455_CR59","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1002\/ibd.22846","volume":"19","author":"A Garc\u00eda-Varona","year":"2013","unstructured":"Garc\u00eda-Varona A, Odze RD, Makrauer F. Lymphocytic colitis secondary to ipilimumab treatment. Inflamm Bowel Dis. 2013;19:E15\u201316.","journal-title":"Inflamm Bowel Dis"},{"key":"455_CR60","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/RLU.0b013e318248549a","volume":"37","author":"A Lyall","year":"2012","unstructured":"Lyall A, Vargas HA, Carvajal RD, Ulaner G. Ipilimumab-induced colitis on FDG PET\/CT. Clin Nucl Med. 2012;37:629\u201330.","journal-title":"Clin Nucl Med"},{"key":"455_CR61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/01720610-201108000-00017","volume":"24","author":"A Tsiaras","year":"2011","unstructured":"Tsiaras A. Case of the month. Autoimmune colitis secondary to CTLA-4 blockade. JAAPA. 2011;24:68.","journal-title":"JAAPA"},{"key":"455_CR62","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/CMR.0b013e32835fb524","volume":"23","author":"C Pag\u00e8s","year":"2013","unstructured":"Pag\u00e8s C, Gornet JM, Monsel G, Allez M, Bertheau P, Bagot M, et al. Ipilimumab-induced acute severe colitis treated by infliximab. Melanoma Res. 2013;23:227\u201330.","journal-title":"Melanoma Res"},{"key":"455_CR63","doi-asserted-by":"crossref","first-page":"W468","DOI":"10.2214\/AJR.12.9751","volume":"200","author":"KW Kim","year":"2013","unstructured":"Kim KW, Ramaiya NH, Krajewski KM, Shinagare AB, Howard SA, Jagannathan JP, et al. Ipilimumab-associated colitis: CT findings. Am J Roentgenol. 2013;200:W468\u2013474.","journal-title":"Am J Roentgenol"},{"key":"455_CR64","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s10620-012-2140-5","volume":"57","author":"DE Kleiner","year":"2012","unstructured":"Kleiner DE, Berman D. Pathologic changes in ipilimumab-related hepatitis in patients with metastatic melanoma. Dig Dis Sci. 2012;57:2233\u201340.","journal-title":"Dig Dis Sci"},{"key":"455_CR65","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1200\/JCO.2010.32.2206","volume":"29","author":"KD Chmiel","year":"2011","unstructured":"Chmiel KD, Suan D, Liddle C, Nankivell B, Ibrahim R, Bautista C, et al. Resolution of severe ipilimumab-induced hepatitis after antithymocyte globulin therapy. J Clin Oncol. 2011;29:e237\u2013240.","journal-title":"J Clin Oncol"},{"key":"455_CR66","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00262-008-0642-y","volume":"58","author":"AM Giacomo Di","year":"2009","unstructured":"Di Giacomo AM, Danielli R, Guidoboni M, Calabr\u00f2 L, Carlucci D, Miracco C, et al. Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases. Cancer Immunol Immunother. 2009;58:1297\u2013306.","journal-title":"Cancer Immunol Immunother"},{"key":"455_CR67","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.mayocp.2013.01.015","volume":"88","author":"NM Gentile","year":"2013","unstructured":"Gentile NM, D\u2019Souza A, Fujii LL, Wu T-T, Murray JA. Association between ipilimumab and celiac disease. Mayo Clin Proc. 2013;88:414\u20137.","journal-title":"Mayo Clin Proc"},{"key":"455_CR68","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/annonc\/mdr028","volume":"22","author":"S Wilgenhof","year":"2011","unstructured":"Wilgenhof S, Neyns B. Anti-CTLA-4 antibody-induced Guillain-Barr\u00e9 syndrome in a melanoma patient. Ann Oncol. 2011;22:991\u20133.","journal-title":"Ann Oncol"},{"key":"455_CR69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/CJI.0b013e31827807dd","volume":"36","author":"C Gaudy-Marqueste","year":"2013","unstructured":"Gaudy-Marqueste C, Monestier S, Franques J, Cantais E, Richard M-A, Grob J-J. A severe case of ipilimumab-induced Guillain-Barr\u00e9 syndrome revealed by an occlusive enteric neuropathy: a differential diagnosis for ipilimumab-induced colitis. J Immunother. 2013;36:77\u20138.","journal-title":"J Immunother"},{"key":"455_CR70","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/neuonc\/nou001","volume":"16","author":"B Liao","year":"2014","unstructured":"Liao B, Shroff S, Kamiya-Matsuoka C, Tummala S. Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma. Neuro Oncol. 2014;16:589\u201393.","journal-title":"Neuro Oncol"},{"key":"455_CR71","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1017\/S0317167100007939","volume":"36","author":"G Hunter","year":"2009","unstructured":"Hunter G, Voll C, Robinson CA. Autoimmune inflammatory myopathy after treatment with ipilimumab. Can J Neurol Sci. 2009;36:518\u201320.","journal-title":"Can J Neurol Sci"},{"key":"455_CR72","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.annder.2013.02.029","volume":"140","author":"M Lecouflet","year":"2013","unstructured":"Lecouflet M, Verschoore M, Giard C, Gohier P, Le Corre Y, Milea D, et al. Orbital myositis associated with ipilimumab. Ann Dermatol V\u00e9n\u00e9r\u00e9ologie. 2013;140:448\u201351.","journal-title":"Ann Dermatol V\u00e9n\u00e9r\u00e9ologie"},{"key":"455_CR73","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/CJI.0b013e318193a206","volume":"32","author":"S Bhatia","year":"2009","unstructured":"Bhatia S, Huber BR, Upton MP, Thompson JA. Inflammatory enteric neuropathy with severe constipation after ipilimumab treatment for melanoma: a case report. J Immunother. 2009;32:203\u20135.","journal-title":"J Immunother"},{"key":"455_CR74","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1200\/JCO.2011.38.7886","volume":"30","author":"M Maur","year":"2012","unstructured":"Maur M, Tomasello C, Frassoldati A, Dieci MV, Barbieri E, Conte P. Posterior reversible encephalopathy syndrome during ipilimumab therapy for malignant melanoma. J Clin Oncol. 2012;30:e76\u201378.","journal-title":"J Clin Oncol"},{"key":"455_CR75","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/mus.23830","volume":"48","author":"G Manousakis","year":"2013","unstructured":"Manousakis G, Koch J, Sommerville RB, El-Dokla A, Harms MB, Al-Lozi MT, et al. Multifocal radiculoneuropathy during ipilimumab treatment of melanoma. Muscle Nerve. 2013;48:440\u20134.","journal-title":"Muscle Nerve"},{"key":"455_CR76","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1007\/s10637-011-9787-1","volume":"30","author":"F Bompaire","year":"2012","unstructured":"Bompaire F, Mateus C, Taillia H, De Greslan T, Lahutte M, Sallansonnet-Froment M, et al. Severe meningo-radiculo-neuritis associated with ipilimumab. Invest New Drugs. 2012;30:2407\u201310.","journal-title":"Invest New Drugs"},{"key":"455_CR77","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/RLU.0b013e31828da691","volume":"39","author":"L Gilardi","year":"2013","unstructured":"Gilardi L, Colandrea M, Vassallo S, Travaini LL, Paganelli G. Ipilimumab-induced immunomediated adverse events: possible pitfalls in (18)F-FDG PET\/CT interpretation. Clin Nucl Med. 2013;39:472\u20134.","journal-title":"Clin Nucl Med"},{"key":"455_CR78","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1016\/j.jaad.2013.07.028","volume":"69","author":"RB Reule","year":"2013","unstructured":"Reule RB, North JP. Cutaneous and pulmonary sarcoidosis-like reaction associated with ipilimumab. J Am Acad Dermatol. 2013;69:e272\u2013273.","journal-title":"J Am Acad Dermatol"},{"key":"455_CR79","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1200\/JCO.2011.39.3298","volume":"30","author":"G Berthod","year":"2012","unstructured":"Berthod G, Lazor R, Letovanec I, Romano E, Noirez L, Mazza Stalder J, et al. Pulmonary sarcoid-like granulomatosis induced by ipilimumab. J Clin Oncol. 2012;30:e156\u2013159.","journal-title":"J Clin Oncol"},{"key":"455_CR80","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1183\/09031936.00107912","volume":"41","author":"C Tissot","year":"2013","unstructured":"Tissot C, Carsin A, Freymond N, Pacheco Y, Devouassoux G. Sarcoidosis complicating anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody biotherapy. Eur Respir J. 2013;41:246\u20137.","journal-title":"Eur Respir J"},{"key":"455_CR81","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1200\/JCO.2011.37.9693","volume":"30","author":"WV Vogel","year":"2012","unstructured":"Vogel WV, Guislain A, Kvistborg P, Schumacher TNM, Haanen JBAG, Blank CU. Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission. J Clin Oncol. 2012;30:e7\u2013e10.","journal-title":"J Clin Oncol"},{"key":"455_CR82","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000161122","volume":"218","author":"A Eckert","year":"2009","unstructured":"Eckert A, Schoeffler A, Dalle S, Phan A, Kiakouama L, Thomas L. Anti-CTLA4 monoclonal antibody induced sarcoidosis in a metastatic melanoma patient. Dermatololy. 2009;218:69\u201370.","journal-title":"Dermatololy"},{"key":"455_CR83","first-page":"9","volume":"8","author":"J Sun","year":"2008","unstructured":"Sun J, Schiffman J, Raghunath A, Ng Tang D, Chen H, Sharma P. Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy. Cancer Immun. 2008;8:9.","journal-title":"Cancer Immun"},{"key":"455_CR84","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1378\/chest.12-1467","volume":"143","author":"IZ Barjaktarevic","year":"2013","unstructured":"Barjaktarevic IZ, Qadir N, Suri A, Santamauro JT, Stover D. Organizing pneumonia as a side effect of ipilimumab treatment of melanoma. Chest. 2013;143:858\u201361.","journal-title":"Chest"},{"key":"455_CR85","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMc0904283","volume":"361","author":"F Fadel","year":"2009","unstructured":"Fadel F, El Karoui K, Knebelmann B. Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med. 2009;361:211\u20132.","journal-title":"N Engl J Med"},{"key":"455_CR86","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00262-008-0627-x","volume":"58","author":"IO Gordon","year":"2009","unstructured":"Gordon IO, Wade T, Chin K, Dickstein J, Gajewski TF. Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma. Cancer Immunol Immunother. 2009;58:1351\u20133.","journal-title":"Cancer Immunol Immunother"},{"key":"455_CR87","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/CJI.0b013e31819aa40b","volume":"32","author":"M Akhtari","year":"2009","unstructured":"Akhtari M, Waller EK, Jaye DL, Lawson DH, Ibrahim R, Papadopoulos NE, et al. Neutropenia in a patient treated with ipilimumab (anti-CTLA-4 antibody). J Immunother. 2009;32:322\u20134.","journal-title":"J Immunother"},{"key":"455_CR88","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/1078155211411001","volume":"18","author":"S Ahmad","year":"2012","unstructured":"Ahmad S, Lewis M, Corrie P, Iddawela M. Ipilimumab-induced thrombocytopenia in a patient with metastatic melanoma. J Oncol Pharm Pract. 2012;18:287\u201392.","journal-title":"J Oncol Pharm Pract"},{"key":"455_CR89","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1056\/NEJMc1110923","volume":"365","author":"J Delyon","year":"2011","unstructured":"Delyon J, Mateus C, Lambert T. Hemophilia A induced by ipilimumab. N Engl J Med. 2011;365:1747\u20138.","journal-title":"N Engl J Med"},{"key":"455_CR90","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/art.38282","volume":"66","author":"BL Goldstein","year":"2014","unstructured":"Goldstein BL, Gedmintas L, Todd DJ. Drug-associated polymyalgia rheumatica\/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of CTLA-4. Arthritis Rheumatol. 2014;66:768\u20139.","journal-title":"Arthritis Rheumatol"},{"key":"455_CR91","first-page":"4607","volume":"32","author":"PM Forde","year":"2012","unstructured":"Forde PM, Rock K, Wilson G, O\u2019Byrne KJ. Ipilimumab-induced immune-related renal failure \u2013 a case report. Anticancer Res. 2012;32:4607\u20138.","journal-title":"Anticancer Res"},{"key":"455_CR92","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1001\/archderm.142.2.166","volume":"142","author":"SH Jaber","year":"2006","unstructured":"Jaber SH, Cowen EW, Haworth LR, Booher SL, Berman DM, Rosenberg SA, et al. Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent. Arch Dermatol. 2006;142:166\u201372.","journal-title":"Arch Dermatol"},{"key":"455_CR93","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.jaad.2012.12.963","volume":"69","author":"K Minkis","year":"2013","unstructured":"Minkis K, Garden BC, Wu S, Pulitzer MP, Lacouture ME. The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis. J Am Acad Dermatol. 2013;69:e121\u2013128.","journal-title":"J Am Acad Dermatol"},{"key":"455_CR94","volume-title":"Hypophysite lymphocytaire. Endocrinologie-Nutrition, 10-023-D-10","author":"J Salenave","year":"2007","unstructured":"Salenave J, Chanson P, Young J. Hypophysite lymphocytaire. Endocrinologie-Nutrition, 10-023-D-10. Paris: Elsevier Masson SAS; 2007."},{"key":"455_CR95","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1200\/JCO.2005.04.5716","volume":"24","author":"KE Beck","year":"2006","unstructured":"Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 2006;24:2283\u20139.","journal-title":"J Clin Oncol"},{"key":"455_CR96","doi-asserted-by":"crossref","first-page":"abstract 8583","DOI":"10.1200\/jco.2011.29.15_suppl.8583","volume":"29","author":"R Ibrahim","year":"2011","unstructured":"Ibrahim R, Berman DM, DePril V, Humphrey T, Chen M, Messina M, et al. Ipilimumab safety profile: summary of findings from completed trials in advanced melanoma. J Clin Oncol. 2011;29:abstract 8583.","journal-title":"J Clin Oncol"},{"key":"455_CR97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053745","volume":"8","author":"CJ Voskens","year":"2013","unstructured":"Voskens CJ, Goldinger SM, Loquai C, Robert C, Kaehler KC, Berking C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLoS One. 2013;8, e53745.","journal-title":"PLoS One"},{"key":"455_CR98","first-page":"30","volume":"28","author":"BA Teply","year":"2014","unstructured":"Teply BA, Lipson EJ. Identification and management of toxicities from immune checkpoint-blocking drugs. Oncology (Williston Park). 2014;28:30\u20138.","journal-title":"Oncology (Williston Park)"},{"key":"455_CR99","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1093\/annonc\/mdt291","volume":"24","author":"D McDermott","year":"2013","unstructured":"McDermott D, Haanen J, Chen T-T, Lorigan P, O\u2019Day S. MDX010-20 Investigators. Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20). Ann Oncol. 2013;24:2694\u20138.","journal-title":"Ann Oncol"},{"key":"455_CR100","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/annonc\/mdu441","volume":"25","author":"C Lebb\u00e9","year":"2014","unstructured":"Lebb\u00e9 C, Weber JS, Maio M, Neyns B, Harmankaya K, Hamid O, et al. Survival follow-up and ipilimumab retreatment of patients with advanced melanoma who received ipilimumab in prior phase II studies. Ann Oncol. 2014;25:2277\u201384.","journal-title":"Ann Oncol"},{"key":"455_CR101","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/bjc.2014.126","volume":"110","author":"V Chiarion-Sileni","year":"2014","unstructured":"Chiarion-Sileni V, Pigozzo J, Ascierto PA, Simeone E, Maio M, Calabr\u00f2 L, et al. Ipilimumab retreatment in patients with pretreated advanced melanoma: the expanded access programme in Italy. Br J Cancer. 2014;110:1721\u20136.","journal-title":"Br J Cancer"},{"key":"455_CR102","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1158\/1078-0432.CCR-12-3080","volume":"19","author":"C Robert","year":"2013","unstructured":"Robert C, Schadendorf D, Messina M, Hodi FS, O\u2019Day S. MDX010-20 investigators. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res. 2013;19:2232\u20139.","journal-title":"Clin Cancer Res"},{"key":"455_CR103","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/EJE-14-0845","volume":"172","author":"F Albarel","year":"2015","unstructured":"Albarel F, Gaudy C, Castinetti F, Carr\u00e9 T, Morange I, Conte-Devolx B, et al. Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma. Eur J Endocrinol. 2015;172:195\u2013204.","journal-title":"Eur J Endocrinol"},{"key":"455_CR104","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1200\/JCO.2005.06.205","volume":"23","author":"P Attia","year":"2005","unstructured":"Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol. 2005;23:6043\u201353.","journal-title":"J Clin Oncol"},{"key":"455_CR105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/CCO.0b013e328341edff","volume":"23","author":"MG Bouwhuis","year":"2011","unstructured":"Bouwhuis MG, Ten Hagen TLM, Suciu S, Eggermont AM. Autoimmunity and treatment outcome in melanoma. Curr Opin Oncol. 2011;23:170\u20136.","journal-title":"Curr Opin Oncol"},{"key":"455_CR106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1440-1711.1999.00795.x","volume":"77","author":"KD McCoy","year":"1999","unstructured":"McCoy KD, Le Gros G. The role of CTLA-4 in the regulation of T cell immune responses. Immunol Cell Biol. 1999;77:1\u201310.","journal-title":"Immunol Cell Biol"},{"key":"455_CR107","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-065X.2009.00775.x","volume":"229","author":"H Bour-Jordan","year":"2009","unstructured":"Bour-Jordan H, Bluestone JA. Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev. 2009;229:41\u201366.","journal-title":"Immunol Rev"},{"key":"455_CR108","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.20130579","volume":"210","author":"TR Simpson","year":"2013","unstructured":"Simpson TR, Li F, Montalvo-Ortiz W, Sepulveda MA, Bergerhoff K, Arce F, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med. 2013;210:1695\u2013710.","journal-title":"J Exp Med"},{"key":"455_CR109","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/cei.12367","volume":"177","author":"A Picchianti Diamanti","year":"2014","unstructured":"Picchianti Diamanti A, Rosado MM, Scarsella M, Germano V, Giorda E, Cascioli S, et al. Abatacept (cytotoxic T lymphocyte antigen 4-immunoglobulin) improves B cell function and regulatory T cell inhibitory capacity in rheumatoid arthritis patients non-responding to anti-tumour necrosis factor-\u03b1 agents. Clin Exp Immunol. 2014;177:630\u201340.","journal-title":"Clin Exp Immunol"},{"key":"455_CR110","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1126\/science.1195568","volume":"330","author":"YK Lee","year":"2010","unstructured":"Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science. 2010;330:1768\u201373.","journal-title":"Science"},{"key":"455_CR111","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40425-014-0035-z","volume":"2","author":"C Kyi","year":"2014","unstructured":"Kyi C, Carvajal RD, Wolchok JD, Postow MA. Ipilimumab in patients with melanoma and autoimmune disease. J Immunother Cancer. 2014;2:35.","journal-title":"J Immunother Cancer"},{"key":"455_CR112","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00262-014-1607-y","volume":"63","author":"M Pedersen","year":"2014","unstructured":"Pedersen M, Andersen R, N\u00f8rgaard P, Jacobsen S, Thielsen P, Thor Straten P, et al. Successful treatment with ipilimumab and interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease. Cancer Immunol Immunother. 2014;63:1341\u20136.","journal-title":"Cancer Immunol Immunother"},{"key":"455_CR113","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1200\/JCO.2013.49.2314","volume":"32","author":"EJ Lipson","year":"2014","unstructured":"Lipson EJ, Bodell MA, Kraus ES, Sharfman WH. Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. J Clin Oncol. 2014;32:e69\u201371.","journal-title":"J Clin Oncol"},{"key":"455_CR114","unstructured":"Bristol-Myers Squibb. YERVOY (ipilimumab): immune-mediated adverse reaction management guide. 2011. https:\/\/www.hcp.yervoy.com\/pdf\/731US15BR00848-01-01_DIGITAL%20_YERVOY%20AR%20Management%20Guide_AFP_7%208%2015_CMKY.pdf"},{"key":"455_CR115","doi-asserted-by":"crossref","first-page":"857519","DOI":"10.1155\/2013\/857519","volume":"2013","author":"A Tarhini","year":"2013","unstructured":"Tarhini A. Immune-mediated adverse events associated with ipilimumab ctla-4 blockade therapy: the underlying mechanisms and clinical management. Scientifica. 2013;2013:857519.","journal-title":"Scientifica"},{"key":"455_CR116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jaad.2014.02.035","volume":"71","author":"ME Lacouture","year":"2014","unstructured":"Lacouture ME, Wolchok JD, Yosipovitch G, K\u00e4hler KC, Busam KJ, Hauschild A. Ipilimumab in patients with cancer and the management of dermatologic adverse events. J Am Acad Dermatol. 2014;71:161\u20139.","journal-title":"J Am Acad Dermatol"},{"key":"455_CR117","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3109\/07357907.2013.793699","volume":"31","author":"P Queirolo","year":"2013","unstructured":"Queirolo P, Morabito A, Laurent S, Lastraioli S, Piccioli P, Ascierto PA, et al. Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: a pilot study. Cancer Invest. 2013;31:336\u201345.","journal-title":"Cancer Invest"},{"key":"455_CR118","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/CJI.0b013e31817fd8f3","volume":"31","author":"WB Breunis","year":"2008","unstructured":"Breunis WB, Tarazona-Santos E, Chen R, Kiley M, Rosenberg SA, Chanock SJ. Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade. J Immunother. 2008;31:586\u201390.","journal-title":"J Immunother"},{"key":"455_CR119","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1056\/NEJMoa1406498","volume":"371","author":"A Snyder","year":"2014","unstructured":"Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189\u201399.","journal-title":"N Engl J Med"},{"key":"455_CR120","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00262-013-1418-6","volume":"62","author":"AM Giacomo Di","year":"2013","unstructured":"Di Giacomo AM, Calabr\u00f2 L, Danielli R, Fonsatti E, Bertocci E, Pesce I, et al. Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10 mg\/kg within an expanded access programme. Cancer Immunol Immunother. 2013;62:1021\u20138.","journal-title":"Cancer Immunol Immunother"},{"key":"455_CR121","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4049\/jimmunol.1302455","volume":"193","author":"NK Vudattu","year":"2014","unstructured":"Vudattu NK, Waldron-Lynch F, Truman LA, Deng S, Preston-Hurlburt P, Torres R, et al. Humanized mice as a model for aberrant responses in human T cell immunotherapy. J Immunol. 2014;193:587\u201396.","journal-title":"J Immunol"},{"key":"455_CR122","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/1752-1947-8-240","volume":"8","author":"E Simeone","year":"2014","unstructured":"Simeone E, Grimaldi AM, Esposito A, Curvietto M, Palla M, Paone M, et al. Serious haematological toxicity during and after ipilimumab treatment: a case series. J Med Case Reports. 2014;8:240.","journal-title":"J Med Case Reports"},{"key":"455_CR123","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/CJI.0000000000000041","volume":"37","author":"P Rusquec Du","year":"2014","unstructured":"Du Rusquec P, Saint-Jean M, Brocard A, Peuvrel L, Khammari A, Qu\u00e9reux G, et al. Ipilimumab-induced autoimmune pancytopenia in a case of metastatic melanoma. J Immunother. 2014;37:348\u201350.","journal-title":"J Immunother"},{"key":"455_CR124","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10637-014-0092-7","volume":"32","author":"H Izzedine","year":"2014","unstructured":"Izzedine H, Gueutin V, Gharbi C, Mateus C, Robert C, Routier E, et al. Kidney injuries related to ipilimumab. Invest New Drugs. 2014;32:769\u201373.","journal-title":"Invest New Drugs"},{"issue":"5","key":"455_CR125","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/bjd.13058","volume":"171","author":"J Munoz","year":"2014","unstructured":"Munoz J, Guillot B, Girard C, Dereure O, Du-Thanh A. First report of ipilimumab-induced Grover disease. Br J Dermatol. 2014;171(5):1236\u20137.","journal-title":"Br J Dermatol"},{"key":"455_CR126","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1016\/j.jaad.2013.11.022","volume":"70","author":"RL Kyllo","year":"2014","unstructured":"Kyllo RL, Parker MK, Rosman I, Musiek AC. Ipilimumab-associated Sweet syndrome in a patient with high-risk melanoma. J Am Acad Dermatol. 2014;70:e85\u201386.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"455_CR127","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jamadermatol.2014.2233","volume":"151","author":"S Sheik Ali","year":"2015","unstructured":"Sheik Ali S, Goddard AL, Luke JJ, Donahue H, Todd DJ, Werchniak A, et al. Drug-associated dermatomyositis following ipilimumab therapy: a novel immune-mediated adverse event associated with cytotoxic T-lymphocyte antigen 4 blockade. JAMA Dermatol. 2015;151(2):195\u20139.","journal-title":"JAMA Dermatol"},{"key":"455_CR128","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1684\/ejd.2014.2297","volume":"24","author":"BM Rudolph","year":"2014","unstructured":"Rudolph BM, Staib F, Von Stebut E, Hainz M, Grabbe S, Loquai C. Neutrophilic disease of the skin and intestines after ipilimumab treatment for malignant melanoma \u2013 simultaneous occurrence of pyoderma gangrenosum and colitis. Eur J Dermatol. 2014;24:268\u20139.","journal-title":"Eur J Dermatol"},{"key":"455_CR129","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3109\/01676830.2014.949792","volume":"33","author":"E McElnea","year":"2014","unstructured":"McElnea E, N\u00ed Mh\u00e9al\u00f3id A, Moran S, Kelly R, Fulcher T. Thyroid-like ophthalmopathy in a euthyroid patient receiving ipilimumab. Orbit Amst Neth. 2014;33:424\u20137.","journal-title":"Orbit Amst Neth"},{"issue":"3","key":"455_CR130","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1097\/IOP.0000000000000081","volume":"31","author":"AD Henderson","year":"2015","unstructured":"Henderson AD, Thomas DA. A case report of orbital inflammatory syndrome secondary to ipilimumab. Ophthal Plast Reconstr Surg. 2015;31(3):e68\u201370.","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"455_CR131","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/IOP.0000000000000033","volume":"30","author":"GE Borodic","year":"2014","unstructured":"Borodic GE, Hinkle D. Ipilimumab-induced orbital inflammation resembling Graves disease with subsequent development of systemic hyperthyroidism from CTLA-4 receptor suppression. Ophthal Plast Reconstr Surg. 2014;30:83.","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"455_CR132","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.6004\/jnccn.2014.0105","volume":"12","author":"NN Nallapaneni","year":"2014","unstructured":"Nallapaneni NN, Mourya R, Bhatt VR, Malhotra S, Ganti AK, Tendulkar KK. Ipilimumab-induced hypophysitis and uveitis in a patient with metastatic melanoma and a history of ipilimumab-induced skin rash. J Natl Compr Cancer Netw. 2014;12:1077\u201381.","journal-title":"J Natl Compr Cancer Netw"},{"key":"455_CR133","doi-asserted-by":"crossref","unstructured":"Johnson DB, Saranga-Perry V, Lavin PJM, Burnette WB, Clark SW, Uskavitch DR, et al. Myasthenia gravis induced by ipilimumab in patients with metastatic melanoma. J Clin Oncol. 2014. Ahead of print.","DOI":"10.1200\/JCO.2013.51.1683"},{"issue":"6","key":"455_CR134","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1200\/JCO.2013.49.7735","volume":"33","author":"JJ Luke","year":"2015","unstructured":"Luke JJ, Lezcano C, Hodi FS, Murphy GF. Antitumor granuloma formation by CD4+ T cells in a patient with rapidly progressive melanoma experiencing spiking fevers, neuropathy, and other immune-related toxicity after treatment with ipilimumab. J Clin Oncol. 2015;33(6):e32\u20135.","journal-title":"J Clin Oncol"},{"key":"455_CR135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.clineuro.2014.06.011","volume":"125","author":"Y Chodakiewitz","year":"2014","unstructured":"Chodakiewitz Y, Brown S, Boxerman JL, Brody JM, Rogg JM. Ipilimumab treatment associated pituitary hypophysitis: clinical presentation and imaging diagnosis. Clin Neurol Neurosurg. 2014;125:125\u201330.","journal-title":"Clin Neurol Neurosurg"},{"key":"455_CR136","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1210\/jc.2014-2306","volume":"99","author":"AT Faje","year":"2014","unstructured":"Faje AT, Sullivan R, Lawrence D, Tritos NA, Fadden R, Klibanski A, et al. Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma. J Clin Endocrinol Metab. 2014;99:4078\u201385.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"455_CR137","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s12020-014-0199-9","volume":"47","author":"J Marlier","year":"2014","unstructured":"Marlier J, Cocquyt V, Brochez L, Van Belle S, Kruse V. Ipilimumab, not just another anti-cancer therapy: hypophysitis as side effect illustrated by four case-reports. Endocrine. 2014;47(3):878\u201383.","journal-title":"Endocrine"},{"key":"455_CR138","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2478\/pjs-2014-0017","volume":"86","author":"P Dilling","year":"2014","unstructured":"Dilling P, Walczak J, Pikiel P, Kruszewski WJ. Multiple colon perforation as a fatal complication during treatment of metastatic melanoma with ipilimumab \u2013 case report. Pol Przegl Chir. 2014;86:94\u20136.","journal-title":"Pol Przegl Chir"},{"issue":"3","key":"455_CR139","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/RLU.0000000000000606","volume":"40","author":"RA Raad","year":"2015","unstructured":"Raad RA, Pavlick A, Kannan R, Friedman KP. Ipilimumab-induced hepatitis on 18F-FDG PET\/CT in a patient with malignant melanoma. Clin Nucl Med. 2015;40(3):258\u20139.","journal-title":"Clin Nucl Med"},{"key":"455_CR140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000362614","volume":"37","author":"KP Murphy","year":"2014","unstructured":"Murphy KP, Kennedy MP, Barry JE, O\u2019Regan KN, Power DG. New-onset mediastinal and central nervous system sarcoidosis in a patient with metastatic melanoma undergoing CTLA4 monoclonal antibody treatment. Oncol Res Treat. 2014;37:351\u20133.","journal-title":"Oncol Res Treat"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-015-0455-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12916-015-0455-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-015-0455-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T06:12:28Z","timestamp":1653113548000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-015-0455-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,4]]},"references-count":140,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["455"],"URL":"https:\/\/doi.org\/10.1186\/s12916-015-0455-8","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,4]]},"article-number":"211"}}