{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T08:33:59Z","timestamp":1719218039632},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n A recent cohort study among Papua New Guinean women surprisingly showed iron deficiency during pregnancy to be associated with increased birth weight. These findings seemingly contradict previous trial evidence that iron supplementation leads to increased birth weight, particularly in iron-deficient women, and hence require explanation.<\/jats:p>\n <\/jats:sec>\n \n Main text<\/jats:title>\n We have re-analysed data from a previous trial in Kenya and demonstrated that, because women who were initially iron deficient respond better to iron supplementation, they show an increase in birthweight. There is evidence that this benefit is decreased in iron-replete women, possibly due to the adverse effects of haemoconcentration that can impair oxygen and nutrient transfer across the placenta. The Papua New Guinean results might be explained by a similar differential response to the iron supplements that they all received.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Antenatal iron supplementation should ideally be administered in conjunction with measures to prevent, diagnose and treat malaria given the propensity of pathogenic microorganisms to proliferate in iron-supplemented individuals. However, even where services to prevent and treat malaria are poor, current evidence supports the conclusion that the benefits of universal iron supplementation outweigh its risks.<\/jats:p>\n Please see related article: https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-018-1146-z<\/jats:ext-link>.<\/jats:p>\n Please see related article: https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-019-1376-8<\/jats:ext-link>.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12916-019-1375-9","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T01:02:47Z","timestamp":1564102967000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antenatal iron supplementation and birth weight in conditions of high exposure to infectious diseases"],"prefix":"10.1186","volume":"17","author":[{"given":"Hans","family":"Verhoef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin N.","family":"Mwangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Cerami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Prentice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"1375_CR1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12916-018-1146-z","volume":"16","author":"FJI Fowkes","year":"2018","unstructured":"Fowkes FJI, Moore KA, Opi DH, Simpson JA, Langham F, Stanisic DI, Ura A, King CL, Siba PM, Mueller I, Rogerson SJ, Beeson JG. Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study. BMC Med. 2018;16:156.","journal-title":"BMC Med"},{"key":"1375_CR2","unstructured":"World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. Geneva: WHO; 2016. \n http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/250796\/9789241549912-eng.pdf?sequence=1\n \n . Accessed 24 Oct 2018."},{"key":"1375_CR3","doi-asserted-by":"publisher","unstructured":"Pe\u00f1a-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015;(7). Art. No.: CD004736. \n https:\/\/doi.org\/10.1002\/14651858.CD004736.pub5\n \n .","DOI":"10.1002\/14651858.CD004736.pub5"},{"key":"1375_CR4","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1001\/jama.2015.9496","volume":"314","author":"MN Mwangi","year":"2015","unstructured":"Mwangi MN, Roth JM, Smit MR, Trijsburg L, Mwangi AM, Demir AY, Wielders JP, Mens PF, Verweij JJ, Cox SE, Prentice AM, Brouwer ID, Savelkoul HF, Andang'o PE, Verhoef H. Effect of daily antenatal iron supplementation on Plasmodium infection in Kenyan women: a randomized clinical trial. JAMA. 2015;314:1009\u201320.","journal-title":"JAMA"},{"key":"1375_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0029-7844(96)00095-6","volume":"88","author":"PG Whittaker","year":"1996","unstructured":"Whittaker PG. Serial hematologic changes and pregnancy outcome. Obstet Gynecol. 1996;88:33\u20139.","journal-title":"Obstet Gynecol"},{"key":"1375_CR6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12936-018-2509-9","volume":"17","author":"NJ White","year":"2018","unstructured":"White NJ. Anaemia and malaria. Malaria J. 2018;17:371.","journal-title":"Malaria J"},{"key":"1375_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1136\/bmj.310.6978.489","volume":"310","author":"P Steer","year":"1995","unstructured":"Steer P, Alam MA, Wadsworth J, Welch A. Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. BMJ. 1995;310:489\u201391.","journal-title":"BMJ."},{"key":"1375_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16896-z","volume":"7","author":"MM Goheen","year":"2017","unstructured":"Goheen MM, Bah A, Wegm\u00fcller R, Verhoef H, Darboe B, Danso E, Prentice AM, Cerami C. Host iron status and erythropoietic response to iron supplementation determines susceptibility to the RBC stage of falciparum malaria during pregnancy. Sci Rep. 2017;7:17674.","journal-title":"Sci Rep"},{"key":"1375_CR9","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/bjh.14584","volume":"177","author":"MN Mwangi","year":"2017","unstructured":"Mwangi MN, Prentice AM, Verhoef H. Safety and benefits of antenatal oral iron supplementation in low-income countries: a review. Br J Haematol. 2017;177:884\u201395.","journal-title":"Br J Haematol"},{"key":"1375_CR10","doi-asserted-by":"publisher","first-page":"k3165","DOI":"10.1136\/bmj.k3165","volume":"362","author":"S-R Pasricha","year":"2018","unstructured":"Pasricha S-R, Armitage AE, Prentice AM, Drakesmith H. Reducing anaemia in low income countries: control of infection is essential. BMJ. 2018;362:k3165.","journal-title":"BMJ"},{"key":"1375_CR11","unstructured":"World Health Organization. World malaria report 2017. Geneva: WHO; 2017. \n http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/259492\/9789241565523-eng.pdf?sequence=1\n \n . Accessed 24 Oct 2018."}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-019-1375-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12916-019-1375-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-019-1375-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T13:40:40Z","timestamp":1600263640000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-019-1375-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1375"],"URL":"https:\/\/doi.org\/10.1186\/s12916-019-1375-9","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,26]]},"assertion":[{"value":"31 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"London School of Hygiene and Tropical Medicine and Wageningen University have jointly applied for a patent for the invention relating to an iron supplement for use in the treatment and\/or prevention of low infant birth weight, which lists Hans Verhoef as the inventor. No other disclosures were reported.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"146"}}