{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:28:15Z","timestamp":1790083695050,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1401221"],"award-info":[{"award-number":["U1401221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470349"],"award-info":[{"award-number":["81470349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400141"],"award-info":[{"award-number":["81400141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621001"],"award-info":[{"award-number":["81621001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81770189"],"award-info":[{"award-number":["81770189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Guangdong Province","award":["2014B020226004"],"award-info":[{"award-number":["2014B020226004"]}]},{"name":"Science and Technology Program of Guangdong Province","award":["2016B030230003"],"award-info":[{"award-number":["2016B030230003"]}]},{"name":"Science and Technology Program of Guangzhou","award":["201707010213"],"award-info":[{"award-number":["201707010213"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12916-019-1393-7","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T01:03:07Z","timestamp":1565571787000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Two dose levels of rabbit antithymocyte globulin as graft-versus-host disease prophylaxis in haploidentical stem cell transplantation: a multicenter randomized study"],"prefix":"10.1186","volume":"17","author":[{"given":"Ren","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"issue":"1","key":"1393_CR1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/bjh.14854","volume":"179","author":"LJ Han","year":"2017","unstructured":"Han LJ, Wang Y, Fan ZP, Huang F, Zhou J, Fu YW, Qu H, Xuan L, Xu N, Ye JY, et al. Haploidentical transplantation compared with matched sibling and unrelated donor transplantation for adults with standard-risk acute lymphoblastic leukaemia in first complete remission. Br J Haematol. 2017;179(1):120\u201330.","journal-title":"Br J Haematol"},{"issue":"14","key":"1393_CR2","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1158\/1078-0432.CCR-15-2335","volume":"22","author":"Y Wang","year":"2016","unstructured":"Wang Y, Liu QF, Xu LP, Liu KY, Zhang XH, Ma X, Wu MQ, Wu DP, Huang XJ. Haploidentical versus matched-sibling transplant in adults with Philadelphia-negative high-risk acute lymphoblastic leukemia: a biologically phase III randomized study. Clin Cancer Res. 2016;22(14):3467\u201376.","journal-title":"Clin Cancer Res"},{"issue":"9","key":"1393_CR3","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1038\/leu.2015.98","volume":"29","author":"A Ruggeri","year":"2015","unstructured":"Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, Blaise D, Bosi A, Huang H, Karakasis D, et al. Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia. Leukemia. 2015;29(9):1891\u2013900.","journal-title":"Leukemia"},{"issue":"9674","key":"1393_CR4","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","volume":"373","author":"JL Ferrara","year":"2009","unstructured":"Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373(9674):1550\u201361.","journal-title":"Lancet"},{"issue":"2","key":"1393_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1053\/j.seminhematol.2016.01.004","volume":"53","author":"YJ Chang","year":"2016","unstructured":"Chang YJ, Huang XJ. Haploidentical stem cell transplantation: anti-thymocyte globulin-based experience. Semin Hematol. 2016;53(2):82\u20139.","journal-title":"Semin Hematol"},{"issue":"2","key":"1393_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3324\/haematol.2016.148510","volume":"102","author":"F Baron","year":"2017","unstructured":"Baron F, Mohty M, Blaise D, Socie G, Labopin M, Esteve J, Ciceri F, Giebel S, Gorin NC, Savani BN, et al. Anti-thymocyte globulin as graft-versus-host disease prevention in the setting of allogeneic peripheral blood stem cell transplantation: a review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Haematologica. 2017;102(2):224\u201334.","journal-title":"Haematologica"},{"issue":"7","key":"1393_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/bmt.2014.19","volume":"49","author":"YJ Chang","year":"2014","unstructured":"Chang YJ, Huang XJ. Haploidentical SCT: the mechanisms underlying the crossing of HLA barriers. Bone Marrow Transplant. 2014;49(7):873\u20139.","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"1393_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13045-017-0480-5","volume":"10","author":"N Santoro","year":"2017","unstructured":"Santoro N, Ruggeri A, Labopin M, Bacigalupo A, Ciceri F, Gulbas Z, Huang H, Afanasyev B, Arcese W, Wu D, et al. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. J Hematol Oncol. 2017;10(1):113.","journal-title":"J Hematol Oncol"},{"issue":"11","key":"1393_CR9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002973","volume":"95","author":"S Yu","year":"2016","unstructured":"Yu S, Fan Q, Sun J, Fan Z, Zhang Y, Jiang Q, Huang F, Xuan L, Dai M, Zhou H, et al. Haploidentical transplantation without in vitro T-cell depletion results in outcomes equivalent to those of contemporaneous matched sibling and unrelated donor transplantation for acute leukemia. Medicine (Baltimore). 2016;95(11):e2973.","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"1393_CR10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/bmt.2013.191","volume":"49","author":"Y Wang","year":"2014","unstructured":"Wang Y, Fu HX, Liu DH, Xu LP, Zhang XH, Chang YJ, Chen YH, Wang FR, Sun YQ, Tang FF, et al. Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial. Bone Marrow Transplant. 2014;49(3):426\u201333.","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"1393_CR11","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1038\/bmt.2015.148","volume":"50","author":"L Binkert","year":"2015","unstructured":"Binkert L, Medinger M, Halter JP, Heim D, Gerull S, Holbro A, Lengerke C, Weisser M, Passweg JR. Lower dose anti-thymocyte globulin for GvHD prophylaxis results in improved survival after allogeneic stem cell transplantation. Bone Marrow Transplant. 2015;50(10):1331\u20136.","journal-title":"Bone Marrow Transplant"},{"issue":"15","key":"1393_CR12","first-page":"2881","volume":"123","author":"YJ Chang","year":"2017","unstructured":"Chang YJ, Wang Y, Mo XD, Zhang XH, Xu LP, Yan CH, Chen H, Chen YH, Chen Y, Han W, et al. Optimal dose of rabbit thymoglobulin in conditioning regimens for unmanipulated, haploidentical, hematopoietic stem cell transplantation: long-term outcomes of a prospective randomized trial. Cancer-Am Cancer Soc. 2017;123(15):2881\u201392.","journal-title":"Cancer-Am Cancer Soc"},{"issue":"6","key":"1393_CR13","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1182\/blood-2014-03-563130","volume":"124","author":"Y Wang","year":"2014","unstructured":"Wang Y, Chang YJ, Xu LP, Liu KY, Liu DH, Zhang XH, Chen H, Han W, Chen YH, Wang FR, et al. Who is the best donor for a related HLA haplotype-mismatched transplant? Blood. 2014;124(6):843\u201350.","journal-title":"Blood"},{"issue":"22","key":"1393_CR14","doi-asserted-by":"publisher","first-page":"32579","DOI":"10.18632\/oncotarget.8691","volume":"7","author":"L Xuan","year":"2016","unstructured":"Xuan L, Fan Z, Zhang Y, Zhou H, Huang F, Dai M, Nie D, Lin D, Xu N, Guo X, et al. Sequential intensified conditioning followed by prophylactic DLI could reduce relapse of refractory acute leukemia after allo-HSCT. Oncotarget. 2016;7(22):32579\u201391.","journal-title":"Oncotarget"},{"key":"1393_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1756-8722-5-46","volume":"5","author":"L Xuan","year":"2012","unstructured":"Xuan L, Huang F, Fan Z, Zhou H, Zhang X, Yu G, Zhang Y, Liu C, Sun J, Liu Q. Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies. J Hematol Oncol. 2012;5:46.","journal-title":"J Hematol Oncol"},{"issue":"5","key":"1393_CR16","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1139274","volume":"5","author":"X Jiang","year":"2016","unstructured":"Jiang X, Xu L, Zhang Y, Huang F, Liu D, Sun J, Song C, Liang X, Fan Z, Zhou H, et al. Rituximab-based treatments followed by adoptive cellular immunotherapy for biopsy-proven EBV-associated post-transplant lymphoproliferative disease in recipients of allogeneic hematopoietic stem cell transplantation. Oncoimmunology. 2016;5(5):e1139274.","journal-title":"Oncoimmunology"},{"issue":"7","key":"1393_CR17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/ajh.23452","volume":"88","author":"Q Liu","year":"2013","unstructured":"Liu Q, Xuan L, Liu H, Huang F, Zhou H, Fan Z, Zhao K, Wu M, Xu L, Zhai X, et al. Molecular monitoring and stepwise preemptive therapy for Epstein-Barr virus viremia after allogeneic stem cell transplantation. Am J Hematol. 2013;88(7):550\u20135.","journal-title":"Am J Hematol"},{"issue":"1","key":"1393_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1399-3062.2012.00722.x","volume":"15","author":"XH Luo","year":"2013","unstructured":"Luo XH, Huang XJ, Li D, Liu KY, Xu LP, Liu DH. Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood\/bone marrow mixed grafts. Transpl Infect Dis. 2013;15(1):22\u201333.","journal-title":"Transpl Infect Dis"},{"issue":"3","key":"1393_CR19","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1182\/blood.V102.3.839","volume":"102","author":"S Chakrabarti","year":"2003","unstructured":"Chakrabarti S, Milligan DW, Pillay D, Mackinnon S, Holder K, Kaur N, McDonald D, Fegan CD, Waldmann H, Hale G, et al. Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation. Blood. 2003;102(3):839\u201342.","journal-title":"Blood"},{"issue":"6","key":"1393_CR20","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, Thomas ED. 1994 consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15(6):825\u20138.","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"1393_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.blre.2005.01.007","volume":"20","author":"ME Horwitz","year":"2006","unstructured":"Horwitz ME, Sullivan KM. Chronic graft-versus-host disease. Blood Rev. 2006;20(1):15\u201327.","journal-title":"Blood Rev"},{"issue":"4","key":"1393_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/bmt.2008.162","volume":"42","author":"P Ljungman","year":"2008","unstructured":"Ljungman P, de la Camara R, Cordonnier C, Einsele H, Engelhard D, Reusser P, Styczynski J, Ward K. Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant. 2008;42(4):227\u201340.","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"1393_CR23","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/TP.0b013e31829d38af","volume":"96","author":"L Xuan","year":"2013","unstructured":"Xuan L, Jiang X, Sun J, Zhang Y, Huang F, Fan Z, Guo X, Dai M, Liu C, Yu G, et al. Spectrum of Epstein-Barr virus-associated diseases in recipients of allogeneic hematopoietic stem cell transplantation. Transplantation. 2013;96(6):560\u20136.","journal-title":"Transplantation"},{"key":"1393_CR24","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1756-8722-6-94","volume":"6","author":"R Lin","year":"2013","unstructured":"Lin R, Liu Q. Diagnosis and treatment of viral diseases in recipients of allogeneic hematopoietic stem cell transplantation. J Hematol Oncol. 2013;6:94.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"1393_CR25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/01.TP.0000133513.29923.44","volume":"78","author":"M Remberger","year":"2004","unstructured":"Remberger M, Svahn BM, Mattsson J, Ringden O. Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem-cell transplantation. Transplantation. 2004;78(1):122\u20137.","journal-title":"Transplantation"},{"issue":"11","key":"1393_CR26","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1016\/j.bbmt.2009.07.006","volume":"15","author":"M Hamadani","year":"2009","unstructured":"Hamadani M, Blum W, Phillips G, Elder P, Andritsos L, Hofmeister C, O'Donnell L, Klisovic R, Penza S, Garzon R, et al. Improved nonrelapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced-intensity conditioning allogeneic transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2009;15(11):1422\u201330.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"5","key":"1393_CR27","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/bmt.2012.3","volume":"47","author":"R Devillier","year":"2012","unstructured":"Devillier R, Crocchiolo R, Castagna L, Furst S, El CJ, Faucher C, Prebet T, Etienne A, Chabannon C, Vey N, et al. The increase from 2.5 to 5 mg\/kg of rabbit anti-thymocyte-globulin dose in reduced intensity conditioning reduces acute and chronic GVHD for patients with myeloid malignancies undergoing allo-SCT. Bone Marrow Transplant. 2012;47(5):639\u201345.","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"1393_CR28","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1182\/blood.V98.10.2942","volume":"98","author":"A Bacigalupo","year":"2001","unstructured":"Bacigalupo A, Lamparelli T, Bruzzi P, Guidi S, Alessandrino PE, di Bartolomeo P, Oneto R, Bruno B, Barbanti M, Sacchi N, et al. Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood. 2001;98(10):2942\u20137.","journal-title":"Blood"},{"issue":"2","key":"1393_CR29","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1182\/blood-2002-12-3629","volume":"102","author":"M Mohty","year":"2003","unstructured":"Mohty M, Bay JO, Faucher C, Choufi B, Bilger K, Tournilhac O, Vey N, Stoppa AM, Coso D, Chabannon C, et al. Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin-based reduced-intensity preparative regimen. Blood. 2003;102(2):470\u20136.","journal-title":"Blood"},{"issue":"8","key":"1393_CR30","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/S1470-2045(17)30417-5","volume":"18","author":"F Locatelli","year":"2017","unstructured":"Locatelli F, Bernardo ME, Bertaina A, Rognoni C, Comoli P, Rovelli A, Pession A, Fagioli F, Favre C, Lanino E, et al. Efficacy of two different doses of rabbit anti-T-lymphocyte globulin to prevent graft-versus-host disease in children with haematological malignancies transplanted from an unrelated donor: a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2017;18(8):1126\u201336.","journal-title":"Lancet Oncol"},{"key":"1393_CR31","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1186\/s12967-015-0748-x","volume":"13","author":"J Liu","year":"2015","unstructured":"Liu J, Xu LP, Bian Z, Chang YJ, Wang Y, Zhang XH, Huang XJ. Differential impact of two doses of antithymocyte globulin conditioning on lymphocyte recovery upon haploidentical hematopoietic stem cell transplantation. J Transl Med. 2015;13:391.","journal-title":"J Transl Med"},{"issue":"7","key":"1393_CR32","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/sj.bmt.1703680","volume":"30","author":"M Duval","year":"2002","unstructured":"Duval M, Pedron B, Rohrlich P, Legrand F, Faye A, Lescoeur B, Bensaid P, Larchee R, Sterkers G, Vilmer E. Immune reconstitution after haematopoietic transplantation with two different doses of pre-graft antithymocyte globulin. Bone Marrow Transplant. 2002;30(7):421\u20136.","journal-title":"Bone Marrow Transplant"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-019-1393-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12916-019-1393-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-019-1393-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T12:48:29Z","timestamp":1664110109000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-019-1393-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1393"],"URL":"https:\/\/doi.org\/10.1186\/s12916-019-1393-7","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]},"assertion":[{"value":"4 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the local ethics committee review board ([2013] EC- NO. 037), and written informed consent was obtained from the donors and recipients in accordance with the Declaration of Helsinki before the initiation of the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Participants\u2019 consent was not obtained, but the presented data are anonymised, and risk of identification is low.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"156"}}