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The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise evidence on the association of platelet activation in HIV-infected patients on successful treatment.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Electronic databases were searched from inception until November 2019. Studies were included if the primary or secondary outcome of the study was to assess platelet activation in HIV-infected patients on ART. The primary outcome of this review included the levels of platelet activation. The pooled effect estimates were calculated using a random-effects meta-analysis model.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We identified 30 studies comprising of 2325 participants. The pooled estimates showed elevated levels of platelet activation in treatment-na\u00efve HIV-infected patients compared to uninfected controls (Hedges\u2019 <jats:italic>g<\/jats:italic> 2.00 [95%CI 1.05, 2.94]; <jats:italic>z<\/jats:italic>\u00a0=\u20094.12, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001). These remained elevated despite successful ART (Hedges\u2019 <jats:italic>g<\/jats:italic> 2.05 [95%CI 0.58, 3.52]; <jats:italic>z<\/jats:italic>\u00a0=\u20092.71, <jats:italic>p<\/jats:italic>\u00a0=\u20090.0067).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The levels of platelet activation are elevated in treatment-na\u00efve HIV-infected patients, and these persist during successful ART. Further studies should assess the clinical relevance of monitoring the levels of platelet activation in HIV-infected patients on ART.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12916-020-01801-9","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T04:06:03Z","timestamp":1605672363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8846-1992","authenticated-orcid":false,"given":"Bongani B.","family":"Nkambule","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuyolwethu","family":"Mxinwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibusiso","family":"Mkandla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinashe","family":"Mutize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabelo","family":"Mokgalaboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawanda M.","family":"Nyambuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phiwayinkosi V.","family":"Dludla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"issue":"8","key":"1801_CR1","doi-asserted-by":"publisher","first-page":"e349","DOI":"10.1016\/S2352-3018(17)30066-8","volume":"4","author":"A Trickey","year":"2017","unstructured":"Trickey A, May MT, Vehreschild J-J, Obel N, Gill MJ, Crane HM, et al. 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