{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:14:55Z","timestamp":1764080095973,"version":"3.28.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"DOI":"10.1186\/s12916-024-03724-1","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:01:55Z","timestamp":1730991715000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["ANXA4 restricts HBV replication by inhibiting autophagic degradation of MCM2 in chronic hepatitis B"],"prefix":"10.1186","volume":"22","author":[{"given":"Luo","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"3724_CR1","doi-asserted-by":"crossref","unstructured":"Mohsen N, Haidong W, Rafael L, et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385(9963):117\u201371.","DOI":"10.1016\/S0140-6736(14)61682-2"},{"issue":"9959","key":"3724_CR2","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/S0140-6736(14)60220-8","volume":"384","author":"C Tr\u00e9po","year":"2014","unstructured":"Tr\u00e9po C, Chan HLY, Lok A. Hepatitis B virus infection. Lancet. 2014;384(9959):2053\u201363.","journal-title":"Lancet"},{"issue":"5","key":"3724_CR3","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3390\/v16050724","volume":"16","author":"DA Asandem","year":"2024","unstructured":"Asandem DA, Segbefia SP, Kusi KA, Bonney JHK. Hepatitis B virus infection: a mini review. Viruses. 2024;16(5):724.","journal-title":"Viruses"},{"issue":"12","key":"3724_CR4","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1136\/gutjnl-2023-330691","volume":"72","author":"Z Liu","year":"2023","unstructured":"Liu Z, Lin C, Mao X, Guo C, Suo C, Zhu D, et al. Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people. Gut. 2023;72(12):2354\u201363.","journal-title":"Gut"},{"key":"3724_CR5","doi-asserted-by":"crossref","unstructured":"Jose-Abrego A, Roman S, Laguna-Meraz S, Panduro A. Host and HBV interactions and their potential impact on clinical outcomes. Pathogens (Basel, Switzerland). 2023;12(9):1146.","DOI":"10.3390\/pathogens12091146"},{"issue":"1","key":"3724_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1054\/bjoc.2000.1311","volume":"83","author":"EK Han","year":"2000","unstructured":"Han EK, Tahir SK, Cherian SP, Collins N, Ng SC. Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. Br J Cancer. 2000;83(1):83\u20138.","journal-title":"Br J Cancer"},{"issue":"2","key":"3724_CR7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/sj.bjc.6604128","volume":"98","author":"R Duncan","year":"2008","unstructured":"Duncan R, Carpenter B, Main LC, Telfer C, Murray GI. Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer. 2008;98(2):426\u201333.","journal-title":"Br J Cancer"},{"issue":"11","key":"3724_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080359","volume":"8","author":"T Mogami","year":"2013","unstructured":"Mogami T, Yokota N, Asai-Sato M, Yamada R, Koizume S, Sakuma Y, et al. Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. PLoS ONE. 2013;8(11): e80359.","journal-title":"PLoS ONE"},{"key":"3724_CR9","volume":"36","author":"CE Creutz","year":"2023","unstructured":"Creutz CE. Expression of bovine annexin A4 in E. coli rescues cytokinesis blocked by beta-lactam antibiotics. Biochem Biophys Rep. 2023;36: 101553.","journal-title":"Biochem Biophys Rep"},{"key":"3724_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12953-017-0114-4","volume":"15","author":"S Katrinli","year":"2016","unstructured":"Katrinli S, Ozdil K, Sahin A, Ozturk O, Kir G, Baykal AT, et al. Proteomic profiling of HBV infected liver biopsies with different fibrotic stages. Proteome Sci. 2016;15:7.","journal-title":"Proteome Sci"},{"issue":"1","key":"3724_CR11","doi-asserted-by":"publisher","first-page":"10879","DOI":"10.1038\/s41598-022-14830-6","volume":"12","author":"A Mu\u00f1oz-Prieto","year":"2022","unstructured":"Mu\u00f1oz-Prieto A, Rubi\u0107 I, Gonzalez-Sanchez JC, Kule\u0161 J, Mart\u00ednez-Subiela S, Cer\u00f3n JJ, et al. Saliva changes in composition associated to COVID-19: a preliminary study. Sci Rep. 2022;12(1):10879.","journal-title":"Sci Rep"},{"issue":"10","key":"3724_CR12","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1080\/15548627.2017.1343770","volume":"13","author":"A Kuma","year":"2017","unstructured":"Kuma A, Komatsu M, Mizushima N. Autophagy-monitoring and autophagy-deficient mice. Autophagy. 2017;13(10):1619\u201328.","journal-title":"Autophagy"},{"key":"3724_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00601","volume":"10","author":"R Xue","year":"2019","unstructured":"Xue R, Yang J, Jia L, Zhu X, Wu J, Zhu Y, et al. Mitofusin2, as a protective target in the liver, controls the balance of apoptosis and autophagy in acute-on-chronic liver failure. Front Pharmacol. 2019;10: 601.","journal-title":"Front Pharmacol"},{"issue":"9","key":"3724_CR14","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1073\/pnas.0911373107","volume":"107","author":"D Sir","year":"2010","unstructured":"Sir D, Tian Y, Chen W-l, Ann DK, Yen T-SB, Ou J-HJ. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci U S A. 2010;107(9):4383\u20138.","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"24","key":"3724_CR15","doi-asserted-by":"publisher","first-page":"13453","DOI":"10.1128\/JVI.06064-11","volume":"85","author":"Y Tian","year":"2011","unstructured":"Tian Y, Sir D, Kuo C-F, Ann DK, Ou J-HJ. Autophagy required for hepatitis B virus replication in transgenic mice. J Virol. 2011;85(24):13453\u20136.","journal-title":"J Virol."},{"issue":"2","key":"3724_CR16","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cell.2004.11.046","volume":"120","author":"JJ Lum","year":"2005","unstructured":"Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005;120(2):237\u201348.","journal-title":"Cell"},{"issue":"36","key":"3724_CR17","doi-asserted-by":"publisher","first-page":"31582","DOI":"10.1074\/jbc.M506736200","volume":"280","author":"J Onodera","year":"2005","unstructured":"Onodera J, Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem. 2005;280(36):31582\u20136.","journal-title":"J Biol Chem"},{"key":"3724_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/srep09730","volume":"5","author":"AM Yakoub","year":"2015","unstructured":"Yakoub AM, Shukla D. Autophagy stimulation abrogates herpes simplex virus-1 infection. Sci Rep. 2015;5: 9730.","journal-title":"Sci Rep"},{"issue":"11","key":"3724_CR19","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1080\/15548627.2015.1091911","volume":"11","author":"M Granato","year":"2015","unstructured":"Granato M, Santarelli R, Filardi M, Gonnella R, Farina A, Torrisi MR, et al. The activation of KSHV lytic cycle blocks autophagy in PEL cells. Autophagy. 2015;11(11):1978\u201386.","journal-title":"Autophagy"},{"issue":"12","key":"3724_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006784","volume":"13","author":"Q Long","year":"2017","unstructured":"Long Q, Yan R, Hu J, Cai D, Mitra B, Kim ES, et al. The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. PLoS Pathog. 2017;13(12): e1006784.","journal-title":"PLoS Pathog"},{"key":"3724_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105601","volume":"213","author":"J Zheng","year":"2023","unstructured":"Zheng J, Deng Y, Wei Z, Zou H, Wen X, Cai J, et al. Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions. Antiviral Res. 2023;213: 105601.","journal-title":"Antiviral Res"},{"issue":"2","key":"3724_CR22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1152\/physrev.00030.2001","volume":"82","author":"V Gerke","year":"2002","unstructured":"Gerke V, Moss SE. Annexins: from structure to function. Physiol Rev. 2002;82(2):331\u201371.","journal-title":"Physiol Rev"},{"issue":"1","key":"3724_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0304-4157(94)90019-1","volume":"1197","author":"P Raynal","year":"1994","unstructured":"Raynal P, Pollard HB. Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim Biophys Acta. 1994;1197(1):63\u201393.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"3724_CR24","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.3390\/ijms14022652","volume":"14","author":"MA Lizarbe","year":"2013","unstructured":"Lizarbe MA, Barrasa JI, Olmo N, Gavilanes F, Turnay J. Annexin-phospholipid interactions. Functional implications. Int J Mol Sci. 2013;14(2):2652\u201383.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3724_CR25","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.3390\/ijms19061781","volume":"19","author":"S Schloer","year":"2018","unstructured":"Schloer S, Pajonczyk D, Rescher U. Annexins in translational research: hidden treasures to be found. Int J Mol Sci. 2018;19(6):1781.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3724_CR26","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s41467-024-45954-0","volume":"15","author":"V Gerke","year":"2024","unstructured":"Gerke V, Gavins FNE, Geisow M, Grewal T, Jaiswal JK, Nylandsted J, et al. Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics. Nat Commun. 2024;15(1):1574.","journal-title":"Nat Commun"},{"issue":"1","key":"3724_CR27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0042-6822(90)90280-5","volume":"179","author":"P Roingeard","year":"1990","unstructured":"Roingeard P, Romet-Lemonne JL, Leturcq D, Goudeau A, Essex M. Hepatitis B virus core antigen (HBc Ag) accumulation in an HBV nonproducer clone of HepG2-transfected cells is associated with cytopathic effect. Virology. 1990;179(1):113\u201320.","journal-title":"Virology"},{"issue":"3","key":"3724_CR28","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s00109-005-0014-4","volume":"84","author":"D Schmid","year":"2006","unstructured":"Schmid D, Dengjel J, Schoor O, Stevanovic S, M\u00fcnz C. Autophagy in innate and adaptive immunity against intracellular pathogens. J Mol Med (Berl). 2006;84(3):194\u2013202.","journal-title":"J Mol Med (Berl)"},{"issue":"6","key":"3724_CR29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.chom.2009.05.016","volume":"5","author":"V Deretic","year":"2009","unstructured":"Deretic V, Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe. 2009;5(6):527\u201349.","journal-title":"Cell Host Microbe"},{"issue":"16","key":"3724_CR30","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMra2022774","volume":"383","author":"N Mizushima","year":"2020","unstructured":"Mizushima N, Levine B. Autophagy in human diseases. N Engl J Med. 2020;383(16):1564\u201376.","journal-title":"N Engl J Med"},{"issue":"8","key":"3724_CR31","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","volume":"24","author":"J Debnath","year":"2023","unstructured":"Debnath J, Gammoh N, Ryan KM. Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 2023;24(8):560\u201375.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"3724_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030156","volume":"3","author":"WT Jackson","year":"2005","unstructured":"Jackson WT, Giddings TH, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, et al. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 2005;3(5): e156.","journal-title":"PLoS Biol"},{"issue":"11","key":"3724_CR33","doi-asserted-by":"publisher","first-page":"10136","DOI":"10.1074\/jbc.M306124200","volume":"279","author":"E Prentice","year":"2004","unstructured":"Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR. Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem. 2004;279(11):10136\u201341.","journal-title":"J Biol Chem"},{"issue":"4","key":"3724_CR34","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/hep.22464","volume":"48","author":"D Sir","year":"2008","unstructured":"Sir D, Chen W-L, Choi J, Wakita T, Yen TSB, Ou J-HJ. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology. 2008;48(4):1054\u201361.","journal-title":"Hepatology"},{"issue":"Pt 2","key":"3724_CR35","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1099\/vir.0.005355-0","volume":"90","author":"M Panyasrivanit","year":"2009","unstructured":"Panyasrivanit M, Khakpoor A, Wikan N, Smith DR. Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes. J Gen Virol. 2009;90(Pt 2):448\u201356.","journal-title":"J Gen Virol"},{"key":"3724_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117206","volume":"242","author":"L Zhang","year":"2020","unstructured":"Zhang L. Autophagy in hepatitis B or C virus infection: an incubator and a potential therapeutic target. Life Sci. 2020;242: 117206.","journal-title":"Life Sci"},{"key":"3724_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.796664","volume":"11","author":"C Matsui","year":"2021","unstructured":"Matsui C, Yuliandari P, Deng L, Abe T, Shoji I. The role of chaperone-mediated autophagy in hepatitis C virus-induced pathogenesis. Front Cell Infect Microbiol. 2021;11: 796664.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"3724_CR38","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13045-020-00936-9","volume":"13","author":"C Chung","year":"2020","unstructured":"Chung C, Seo W, Silwal P, Jo E-K. Crosstalks between inflammasome and autophagy in cancer. J Hematol Oncol. 2020;13(1):100.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"3724_CR39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/hep.22581","volume":"49","author":"H Tang","year":"2009","unstructured":"Tang H, Da L, Mao Y, Li Y, Li D, Xu Z, et al. Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression. Hepatology. 2009;49(1):60\u201371.","journal-title":"Hepatology"},{"issue":"30","key":"3724_CR40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201927119","volume":"119","author":"JYK Chu","year":"2022","unstructured":"Chu JYK, Chuang Y-C, Tsai K-N, Pantuso J, Ishida Y, Saito T, et al. Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release. Proc Natl Acad Sci U S A. 2022;119(30): e2201927119.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3724_CR41","doi-asserted-by":"publisher","first-page":"2261556","DOI":"10.1080\/22221751.2023.2261556","volume":"12","author":"Z Zhao","year":"2023","unstructured":"Zhao Z, Wei Z, Zheng J, Li Z, Zou H, Wen X, et al. Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways. Emerg Microbes Infect. 2023;12(2):2261556.","journal-title":"Emerg Microbes Infect"},{"key":"3724_CR42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.lfs.2018.04.051","volume":"205","author":"M Xie","year":"2018","unstructured":"Xie M, Yang Z, Liu Y, Zheng M. The role of HBV-induced autophagy in HBV replication and HBV related-HCC. Life Sci. 2018;205:107\u201312.","journal-title":"Life Sci"},{"key":"3724_CR43","doi-asserted-by":"crossref","unstructured":"Lin Y, Zhao Z, Huang A, Lu M. Interplay between cellular autophagy and hepatitis B virus replication: a systematic review. Cells. 2020;9(9):2101.","DOI":"10.3390\/cells9092101"},{"issue":"30","key":"3724_CR44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201927119","volume":"119","author":"JYK Chu","year":"2022","unstructured":"Chu JYK, Chuang YC, Tsai KN, Pantuso J, Ishida Y, Saito T, et al. Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release. Proc Natl Acad Sci U S A. 2022;119(30): e2201927119.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"3724_CR45","doi-asserted-by":"publisher","first-page":"5561","DOI":"10.7150\/thno.85390","volume":"13","author":"H Zhou","year":"2023","unstructured":"Zhou H, Yan L, Huang H, Li X, Xia Q, Zheng L, et al. Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury via ANXA1 SUMOylation in microglia. Theranostics. 2023;13(15):5561\u201383.\u00a0","journal-title":"Theranostics"},{"issue":"4","key":"3724_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30537","volume":"125","author":"NY Kim","year":"2024","unstructured":"Kim NY, Mohan CD, Sethi G, Ahn KS. Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells. J Cell Biochem. 2024;125(4): e30537.","journal-title":"J Cell Biochem"},{"key":"3724_CR47","doi-asserted-by":"publisher","first-page":"155512","DOI":"10.1016\/j.phymed.2024.155512","volume":"128","author":"XH Wang","year":"2024","unstructured":"Wang XH, Shen CP, Wang TT, Huang Y, Jin Y, Zhou MY, et al. Shikonin suppresses rheumatoid arthritis by inducing apoptosis and autophagy via modulation of the AMPK\/mTOR\/ULK-1 signaling pathway. Phytomedicine. 2024;128:155512.","journal-title":"Phytomedicine"},{"issue":"12","key":"3724_CR48","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1634\/stemcells.2007-0483","volume":"25","author":"SC Pruitt","year":"2007","unstructured":"Pruitt SC, Bailey KJ, Freeland A. Reduced Mcm2 expression results in severe stem\/progenitor cell deficiency and cancer. Stem Cells. 2007;25(12):3121\u201332.","journal-title":"Stem Cells"},{"key":"3724_CR49","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.2147\/OTT.S169002","volume":"11","author":"W Wu","year":"2018","unstructured":"Wu W, Wang X, Shan C, Li Y, Li F. Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma. Onco Targets Ther. 2018;11:5025\u201334.","journal-title":"Onco Targets Ther"},{"issue":"9","key":"3724_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001110","volume":"6","author":"C-H Chuang","year":"2010","unstructured":"Chuang C-H, Wallace MD, Abratte C, Southard T, Schimenti JC. Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. PLoS Genet. 2010;6(9): e1001110.","journal-title":"PLoS Genet"},{"issue":"1","key":"3724_CR51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41392-023-01316-8","volume":"8","author":"Y Yang","year":"2023","unstructured":"Yang Y, Yan Y, Yin J, Tang N, Wang K, Huang L, et al. O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner. Signal Transduct Target Ther. 2023;8(1):63.","journal-title":"Signal Transduct Target Ther"},{"key":"3724_CR52","doi-asserted-by":"crossref","unstructured":"Rankin BD, Rankin S. The MCM2\u20137 complex: roles beyond DNA unwinding. Biology. 2024;13(4):258.","DOI":"10.3390\/biology13040258"},{"key":"3724_CR53","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.biochem.68.1.649","volume":"68","author":"BK Tye","year":"1999","unstructured":"Tye BK. MCM proteins in DNA replication. Annu Rev Biochem. 1999;68:649\u201386.","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"3724_CR54","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0167-4781(98)00033-5","volume":"1398","author":"SE Kearsey","year":"1998","unstructured":"Kearsey SE, Labib K. MCM proteins: evolution, properties, and role in DNA replication. Biochim Biophys Acta. 1998;1398(2):113\u201336.","journal-title":"Biochim Biophys Acta"},{"issue":"18","key":"3724_CR55","doi-asserted-by":"publisher","first-page":"10085","DOI":"10.1073\/pnas.181347998","volume":"98","author":"B Chaudhuri","year":"2001","unstructured":"Chaudhuri B, Xu H, Todorov I, Dutta A, Yates JL. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus. Proc Natl Acad Sci U S A. 2001;98(18):10085\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3724_CR56","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1128\/MMBR.00019-09","volume":"73","author":"ML Bochman","year":"2009","unstructured":"Bochman ML, Schwacha A. The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev. 2009;73(4):652\u201383.","journal-title":"Microbiol Mol Biol Rev"},{"key":"3724_CR57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0065-3527(05)65002-6","volume":"65","author":"AM Boguszewska-Chachulska","year":"2005","unstructured":"Boguszewska-Chachulska AM, Haenni A-L. RNA viruses redirect host factors to better amplify their genome. Adv Virus Res. 2005;65:29\u201361.","journal-title":"Adv Virus Res"},{"issue":"5","key":"3724_CR58","doi-asserted-by":"publisher","first-page":"610","DOI":"10.4149\/neo_2023_230517N265","volume":"70","author":"Y Chu","year":"2023","unstructured":"Chu Y, Jin X, Guo X. MCM2 promotes the stemness of endometrial cancer cells via the Akt\/\u03b2-catenin pathway. Neoplasma. 2023;70(5):610\u201320.","journal-title":"Neoplasma"},{"issue":"5","key":"3724_CR59","first-page":"805","volume":"40","author":"L Martin","year":"2007","unstructured":"Martin L. The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. J Biochem Mol Biol. 2007;40(5):805\u201313.","journal-title":"J Biochem Mol Biol"},{"issue":"8","key":"3724_CR60","doi-asserted-by":"publisher","first-page":"5941","DOI":"10.1074\/jbc.M109.039925","volume":"285","author":"S Pankiv","year":"2010","unstructured":"Pankiv S, Lamark T, Bruun JA, \u00d8vervatn A, Bj\u00f8rk\u00f8y G, Johansen T. Nucleocytoplasmic shuttling of p62\/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J Biol Chem. 2010;285(8):5941\u201353.","journal-title":"J Biol Chem"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-024-03724-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12916-024-03724-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-024-03724-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T16:03:15Z","timestamp":1730995395000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-024-03724-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3724"],"URL":"https:\/\/doi.org\/10.1186\/s12916-024-03724-1","relation":{},"ISSN":["1741-7015"],"issn-type":[{"type":"electronic","value":"1741-7015"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"15 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol for the study with clinical samples was approved by the Medical Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University (approval number: 20210228701). Informed consent was obtained from all participants involved in the study. The experimental animals were inspected and approved by the Institutional Animal Care and Use Committee of South China Agricultural University (approval number: 2022d051).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have given their consent for publication of this manuscript. We confirm that all necessary approvals have been obtained and that the manuscript does not violate any confidentiality agreements or rights.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"521"}}