{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:33:12Z","timestamp":1788348792588,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"DOI":"10.1186\/s12916-024-03759-4","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T15:52:22Z","timestamp":1731513142000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histological, histochemical, and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering"],"prefix":"10.1186","volume":"22","author":[{"given":"Olimpia","family":"Ortiz-Arrabal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Blanco-Elices","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gonz\u00e1lez-Gallardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"S\u00e1nchez-Porras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Etayo-Escanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula \u00c1vila","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Chato-Astrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar-Dar\u00edo","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Garz\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alaminos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"3759_CR1","doi-asserted-by":"publisher","first-page":"671405","DOI":"10.3389\/fphar.2021.671405","volume":"12","author":"V Jhanji","year":"2021","unstructured":"Jhanji V, Billig I, Yam GHF. Cell-free biological approach for corneal stromal wound healing. Front Pharmacol. 2021;12:671405.","journal-title":"Front Pharmacol."},{"key":"3759_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","volume":"134","author":"P Gain","year":"2016","unstructured":"Gain P, Jullienne R, He Z, Aldossary M, Acquart S, Cognasse F, et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol. 2016;134:167\u201373.","journal-title":"JAMA Ophthalmol"},{"key":"3759_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/14712598.2018.1508443","volume":"18","author":"D Bremond-Gignac","year":"2018","unstructured":"Bremond-Gignac D, Copin H, Benkhalifa M. Corneal epithelial stem cells for corneal injury. Expert Opin Biol Ther. 2018;18:997\u20131003.","journal-title":"Expert Opin Biol Ther"},{"key":"3759_CR4","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3390\/ijms22031291","volume":"22","author":"L-P Gu\u00e9rin","year":"2021","unstructured":"Gu\u00e9rin LP, Le-Bel G, Desjardins P, Couture C, Gillard E, Boisselier \u00c9, et al. The human tissue-engineered cornea (hTEC): recent progress. Int J Mol Sci. 2021;22:1291.","journal-title":"Int J Mol Sci"},{"key":"3759_CR5","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1002\/jbm.b.34782","volume":"109","author":"S Leal-Marin","year":"2021","unstructured":"Leal-Marin S, Kern T, Hofmann N, Pogozhykh O, Framme C, B\u00f6rgel M, et al. Human amniotic membrane: a review on tissue engineering, application, and storage. J Biomed Mater Res B Appl Biomater. 2021;109:1198\u2013215.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"3759_CR6","doi-asserted-by":"crossref","unstructured":"Oliveira AC, Garz\u00f3n I, Ionescu AM, Carriel V, Cardona J de la C, Gonz\u00e1lez-Andrades M, et al. Evaluation of small intestine grafts decellularization methods for corneal tissue engineering. PLoS ONE. 2013;8:e66538.","DOI":"10.1371\/journal.pone.0066538"},{"key":"3759_CR7","doi-asserted-by":"publisher","first-page":"1369505","DOI":"10.3389\/fphar.2024.1369505","volume":"15","author":"LM Rodr\u00edguez-Lorenzo","year":"2024","unstructured":"Rodr\u00edguez-Lorenzo LM, Reyes-Ortega F, Griffith M. Editorial: biomaterials used in tissue engineering for the restoration of ocular disorders. Front Pharmacol. 2024;15:1369505.","journal-title":"Front Pharmacol"},{"key":"3759_CR8","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3390\/jfb13040249","volume":"13","author":"R Sklen\u00e1\u0159ov\u00e1","year":"2022","unstructured":"Sklen\u00e1\u0159ov\u00e1 R, Akla N, Latorre MJ, Ulrichov\u00e1 J, Frankov\u00e1 J. Collagen as a biomaterial for skin and corneal wound healing. J Funct Biomater. 2022;13:249.","journal-title":"J Funct Biomater"},{"key":"3759_CR9","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/gels9050431","volume":"9","author":"Y Lyu","year":"2023","unstructured":"Lyu Y, Liu Y, He H, Wang H. Application of silk-fibroin-based hydrogels in tissue engineering. Gels. 2023;9:431.","journal-title":"Gels"},{"key":"3759_CR10","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1002\/term.2951","volume":"13","author":"L Rico-S\u00e1nchez","year":"2019","unstructured":"Rico-S\u00e1nchez L, Garz\u00f3n I, Gonz\u00e1lez-Andrades M, Ru\u00edz-Garc\u00eda A, Punzano M, Lizana-Moreno A, et al. Successful development and clinical translation of a novel anterior lamellar artificial cornea. J Tissue Eng Regen Med. 2019;13:2142\u201354.","journal-title":"J Tissue Eng Regen Med"},{"key":"3759_CR11","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1177\/11206721221150065","volume":"33","author":"F Tavakkoli","year":"2023","unstructured":"Tavakkoli F, Eleiwa TK, Elhusseiny AM, Damala M, Rai AK, Cheraqpour K, et al. Corneal stem cells niche and homeostasis impacts in regenerative medicine; concise review. Eur J Ophthalmol. 2023;33:1536\u201352.","journal-title":"Eur J Ophthalmol"},{"key":"3759_CR12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/bioengineering10010111","volume":"10","author":"M Soleimani","year":"2023","unstructured":"Soleimani M, Cheraqpour K, Koganti R, Baharnoori SM, Djalilian AR. Concise review: bioengineering of limbal stem cell niche. Bioengineering (Basel). 2023;10:111.","journal-title":"Bioengineering (Basel)"},{"key":"3759_CR13","doi-asserted-by":"crossref","unstructured":"Garz\u00f3n I, Chato-Astrain J, Gonz\u00e1lez-Gallardo C, Ionescu A, Cardona J de la C, Mateu M, et al. Long-term in vivo evaluation of orthotypical and heterotypical bioengineered human corneas. Front Bioeng Biotechnol. 2020;8:681.","DOI":"10.3389\/fbioe.2020.00681"},{"key":"3759_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114612","volume":"162","author":"C Gonz\u00e1lez-Gallardo","year":"2023","unstructured":"Gonz\u00e1lez-Gallardo C, Mart\u00ednez-Atienza J, Mataix B, Mu\u00f1oz-\u00c1vila JI, Daniel Mart\u00ednez-Rodr\u00edguez J, Medialdea S, et al. Successful restoration of corneal surface integrity with a tissue-engineered allogeneic implant in severe keratitis patients. Biomed Pharmacother. 2023;162: 114612.","journal-title":"Biomed Pharmacother"},{"key":"3759_CR15","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/term.178","volume":"3","author":"M Gonz\u00e1lez-Andrades","year":"2009","unstructured":"Gonz\u00e1lez-Andrades M, Garz\u00f3n I, Gasc\u00f3n MI, Mu\u00f1oz-Avila JI, S\u00e1nchez-Quevedo MC, Campos A, et al. Sequential development of intercellular junctions in bioengineered human corneas. J Tissue Eng Regen Med. 2009;3:442\u20139.","journal-title":"J Tissue Eng Regen Med"},{"key":"3759_CR16","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1167\/iovs.14-14304","volume":"55","author":"I Garz\u00f3n","year":"2014","unstructured":"Garz\u00f3n I, Mart\u00edn-Piedra MA, Alfonso-Rodr\u00edguez C, Gonz\u00e1lez-Andrades M, Carriel V, Mart\u00ednez-G\u00f3mez C, et al. Generation of a biomimetic human artificial cornea model using Wharton\u2019s jelly mesenchymal stem cells. Invest Ophthalmol Vis Sci. 2014;55:4073\u201383.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3759_CR17","doi-asserted-by":"publisher","first-page":"1124995","DOI":"10.3389\/fbioe.2023.1124995","volume":"11","author":"C Blanco-Elices","year":"2023","unstructured":"Blanco-Elices C, Morales-\u00c1lvarez C, Chato-Astrain J, Gonz\u00e1lez-Gallardo C, \u00c1vila-Fern\u00e1ndez P, Campos F, et al. Development of stromal differentiation patterns in heterotypical models of artificial corneas generated by tissue engineering. Front Bioeng Biotechnol. 2023;11:1124995.","journal-title":"Front Bioeng Biotechnol."},{"key":"3759_CR18","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1016\/j.jmbbm.2011.06.013","volume":"4","author":"AM Ionescu","year":"2011","unstructured":"Ionescu AM, Alaminos M, de la Cruz Cardona J, de Dios Garc\u00eda-L\u00f3pez Dur\u00e1n J, Gonz\u00e1lez-Andrades M, Ghinea R, et al. Investigating a novel nanostructured fibrin-agarose biomaterial for human cornea tissue engineering: rheological properties. J Mech Behav Biomed Mater. 2011;4:1963\u201373.","journal-title":"J Mech Behav Biomed Mater."},{"key":"3759_CR19","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1097\/ICO.0b013e3181ca3650","volume":"29","author":"AM Ionescu","year":"2010","unstructured":"Ionescu AM, de la Cruz CJ, Gonz\u00e1lez-Andrades M, Alaminos M, Campos A, Hita E, et al. UV absorbance of a bioengineered corneal stroma substitute in the 240\u2013400 nm range. Cornea. 2010;29:895\u20138.","journal-title":"Cornea"},{"key":"3759_CR20","doi-asserted-by":"crossref","unstructured":"Cardona J de la C, Ionescu A-M, G\u00f3mez-Sotomayor R, Gonz\u00e1lez-Andrades M, Campos A, Alaminos M, et al. Transparency in a fibrin and fibrin-agarose corneal stroma substitute generated by tissue engineering. Cornea. 2011;30:1428\u201335.","DOI":"10.1097\/ICO.0b013e31821bdfd4"},{"key":"3759_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00418-018-1701-x","volume":"151","author":"A Vela-Romera","year":"2019","unstructured":"Vela-Romera A, Carriel V, Mart\u00edn-Piedra MA, Aneiros-Fern\u00e1ndez J, Campos F, Chato-Astrain J, et al. Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis. Histochem Cell Biol. 2019;151:57\u201373.","journal-title":"Histochem Cell Biol"},{"key":"3759_CR22","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.jpedsurg.2013.01.056","volume":"48","author":"F Mart\u00edn-Cano","year":"2013","unstructured":"Mart\u00edn-Cano F, Garz\u00f3n I, Mara\u00f1\u00e9s C, Liceras E, Mart\u00edn-Piedra MA, Ruiz-Montes AM, et al. Histological and immunohistochemical changes in the rat oral mucosa used as an autologous urethral graft. J Pediatr Surg. 2013;48:1557\u201364.","journal-title":"J Pediatr Surg"},{"key":"3759_CR23","doi-asserted-by":"publisher","first-page":"S175","DOI":"10.1016\/j.joen.2020.06.026","volume":"46","author":"A Bakopoulou","year":"2020","unstructured":"Bakopoulou A. Prospects of advanced therapy medicinal products-based therapies in regenerative dentistry: current status, comparison with global trends in medicine, and future perspectives. J Endod. 2020;46:S175\u201388.","journal-title":"J Endod"},{"key":"3759_CR24","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1167\/iovs.07-0707","volume":"49","author":"JH Mathew","year":"2008","unstructured":"Mathew JH, Bergmanson JPG, Doughty MJ. Fine structure of the interface between the anterior limiting lamina and the anterior stromal fibrils of the human cornea. Invest Ophthalmol Vis Sci. 2008;49:3914\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3759_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-02969-7","author":"KM Meek","year":"2024","unstructured":"Meek KM, Knupp C, Lewis PN, Morgan SR, Hayes S. Structural control of corneal transparency, refractive power and dynamics. Eye (Lond). 2024. https:\/\/doi.org\/10.1038\/s41433-024-02969-7.","journal-title":"Eye (Lond)"},{"key":"3759_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/ICU.0000000000000489","volume":"29","author":"SH Yun","year":"2018","unstructured":"Yun SH, Chernyak D. Brillouin microscopy: assessing ocular tissue biomechanics. Curr Opin Ophthalmol. 2018;29:299\u2013305.","journal-title":"Curr Opin Ophthalmol"},{"key":"3759_CR27","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.exer.2015.01.014","volume":"132","author":"SD Hanlon","year":"2015","unstructured":"Hanlon SD, Behzad AR, Sakai LY, Burns AR. Corneal stroma microfibrils. Exp Eye Res. 2015;132:198\u2013207.","journal-title":"Exp Eye Res"},{"key":"3759_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2019.09.001","volume":"72","author":"S Werner","year":"2020","unstructured":"Werner S, Keller L, Pantel K. Epithelial keratins: biology and implications as diagnostic markers for liquid biopsies. Mol Aspects Med. 2020;72: 100817.","journal-title":"Mol Aspects Med"},{"key":"3759_CR29","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.stemcr.2020.09.006","volume":"15","author":"M Fernanda de Mello Costa","year":"2020","unstructured":"Fernanda de Mello Costa M, Weiner AI, Vaughan AE. Basal-like progenitor cells: a review of dysplastic alveolar regeneration and remodeling in lung repair. Stem Cell Reports. 2020;15:1015\u201325.","journal-title":"Stem Cell Reports."},{"key":"3759_CR30","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.semcdb.2007.09.015","volume":"19","author":"JV Jester","year":"2008","unstructured":"Jester JV. Corneal crystallins and the development of cellular transparency. Semin Cell Dev Biol. 2008;19:82\u201393.","journal-title":"Semin Cell Dev Biol"},{"key":"3759_CR31","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/601731","volume":"2015","author":"T Ramos","year":"2015","unstructured":"Ramos T, Scott D, Ahmad S. An update on ocular surface epithelial stem cells: cornea and conjunctiva. Stem Cells Int. 2015;2015: 601731.","journal-title":"Stem Cells Int"},{"key":"3759_CR32","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1167\/iovs.06-0574","volume":"47","author":"S Yoshida","year":"2006","unstructured":"Yoshida S, Shimmura S, Kawakita T, Miyashita H, Den S, Shimazaki J, et al. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci. 2006;47:4780\u20136.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3759_CR33","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.exer.2005.02.016","volume":"81","author":"U Schl\u00f6tzer-Schrehardt","year":"2005","unstructured":"Schl\u00f6tzer-Schrehardt U, Kruse FE. Identification and characterization of limbal stem cells. Exp Eye Res. 2005;81:247\u201364.","journal-title":"Exp Eye Res"},{"key":"3759_CR34","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s12015-013-9481-0","volume":"10","author":"B Shaharuddin","year":"2014","unstructured":"Shaharuddin B, Harvey I, Ahmad S, Ali S, Meeson A. Characterisation of human limbal side population cells isolated using an optimised protocol from an immortalised epithelial cell line and primary limbal cultures. Stem Cell Rev Rep. 2014;10:240\u201350.","journal-title":"Stem Cell Rev Rep"},{"key":"3759_CR35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/cells8040347","volume":"8","author":"RM Gouveia","year":"2019","unstructured":"Gouveia RM, Vajda F, Wibowo JA, Figueiredo F, Connon CJ. YAP, \u0394Np63, and \u03b2-catenin signaling pathways are involved in the modulation of corneal epithelial stem cell phenotype induced by substrate stiffness. Cells. 2019;8:347.","journal-title":"Cells"},{"key":"3759_CR36","doi-asserted-by":"publisher","first-page":"963689724124199","DOI":"10.1177\/09636897241241992","volume":"33","author":"A Hopkinson","year":"2024","unstructured":"Hopkinson A, Notara M, Cursiefen C, Sidney LE. Increased anti-inflammatory therapeutic potential and progenitor marker expression of corneal mesenchymal stem cells cultured in an optimized propagation medium. Cell Transplant. 2024;33:9636897241241992.","journal-title":"Cell Transplant"},{"key":"3759_CR37","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000375110","volume":"53","author":"KS Na","year":"2015","unstructured":"Na KS, Mok JW, Joo C-K. Ex vivo human corneal epithelial cell expansion from a xeno-feeder-free system. Ophthalmic Res. 2015;53:217\u201324.","journal-title":"Ophthalmic Res"},{"key":"3759_CR38","doi-asserted-by":"publisher","first-page":"11387","DOI":"10.1073\/pnas.1919394117","volume":"117","author":"BR Seo","year":"2020","unstructured":"Seo BR, Chen X, Ling L, Song YH, Shimpi AA, Choi S, et al. Collagen microarchitecture mechanically controls myofibroblast differentiation. Proc Natl Acad Sci U S A. 2020;117:11387\u201398.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3759_CR39","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/sctm.17-0003","volume":"7","author":"G Pellegrini","year":"2018","unstructured":"Pellegrini G, Ardig\u00f2 D, Milazzo G, Iotti G, Guatelli P, Pelosi D, et al. Navigating market authorization: the path Holoclar took to become the first stem cell product approved in the European Union. Stem Cells Transl Med. 2018;7:146\u201354.","journal-title":"Stem Cells Transl Med"},{"key":"3759_CR40","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.3390\/cells12202458","volume":"12","author":"L Nureen","year":"2023","unstructured":"Nureen L, Di Girolamo N. Limbal epithelial stem cells in the diabetic cornea. Cells. 2023;12:2458.","journal-title":"Cells"},{"key":"3759_CR41","doi-asserted-by":"publisher","unstructured":"Alaminos M. Quantitative results of the analysis of human native and bioengineered tissues corresponding to the work \u201cHistological, histochemical and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering.\u201d 2024. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.10845879.","DOI":"10.5281\/zenodo.10845879"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-024-03759-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12916-024-03759-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-024-03759-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T16:21:21Z","timestamp":1731514881000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-024-03759-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3759"],"URL":"https:\/\/doi.org\/10.1186\/s12916-024-03759-4","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"7 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"531"}}