{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:21:49Z","timestamp":1791897709048,"version":"4.3.4"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302293"],"award-info":[{"award-number":["82302293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62473082"],"award-info":[{"award-number":["62473082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62036003"],"award-info":[{"award-number":["62036003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology foundation of Sichuan Province","award":["2024NSFSC1782"],"award-info":[{"award-number":["2024NSFSC1782"]}]},{"name":"Medical-Engineering Cooperation Funds from University of Electronic Science and Technology of China","award":["ZYGX2021YGLH201"],"award-info":[{"award-number":["ZYGX2021YGLH201"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC2009906"],"award-info":[{"award-number":["2022YFC2009906"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["ZYGX2022YGRH008"],"award-info":[{"award-number":["ZYGX2022YGRH008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med"],"DOI":"10.1186\/s12916-025-04099-7","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:02:33Z","timestamp":1746183753000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Normative structural connectome constrains spreading transient brain activity in generalized epilepsy"],"prefix":"10.1186","volume":"23","author":[{"given":"Jie","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"issue":"4","key":"4099_CR1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/epi.13670","volume":"58","author":"RS Fisher","year":"2017","unstructured":"Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh\u00e9 SL, Peltola J, Roulet PE. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522\u201330.","journal-title":"Epilepsia"},{"issue":"3","key":"4099_CR2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208076","volume":"102","author":"O Devinsky","year":"2024","unstructured":"Devinsky O, Elder C, Sivathamboo S, Scheffer IE, Koepp MJ. Idiopathic generalized epilepsy: misunderstandings, challenges, and opportunities. Neurology. 2024;102(3): e208076.","journal-title":"Neurology"},{"issue":"2","key":"4099_CR3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","volume":"29","author":"Y-F Zang","year":"2007","unstructured":"Zang Y-F, He Y, Zhu C-Z, Cao Q-J, Sui M-Q, Liang M, Tian L-X, Jiang T-Z, Wang Y-F. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev. 2007;29(2):83\u201391.","journal-title":"Brain Dev"},{"key":"4099_CR4","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s11434-016-1201-0","volume":"61","author":"W Liao","year":"2016","unstructured":"Liao W, Wang J, Xu T, Zhang Z, Ji G-J, Xu Q, Wang Z, Yang F, Zuo X-N, Qiu A. Altered relationship between thickness and intrinsic activity amplitude in generalized tonic\u2013clonic seizures. Sci Bull. 2016;61:1865\u201375.","journal-title":"Sci Bull"},{"issue":"5","key":"4099_CR5","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.eplepsyres.2014.03.003","volume":"108","author":"Z Wang","year":"2014","unstructured":"Wang Z, Zhang Z, Liao W, Xu Q, Zhang J, Lu W, Jiao Q, Chen G, Feng J, Lu G. Frequency-dependent amplitude alterations of resting-state spontaneous fluctuations in idiopathic generalized epilepsy. Epilepsy Res. 2014;108(5):853\u201360.","journal-title":"Epilepsy Res"},{"key":"4099_CR6","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.nicl.2014.10.008","volume":"6","author":"ML McGill","year":"2014","unstructured":"McGill ML, Devinsky O, Wang X, Quinn BT, Pardoe H, Carlson C, Butler T, Kuzniecky R, Thesen T. Functional neuroimaging abnormalities in idiopathic generalized epilepsy. NeuroImage Clin. 2014;6:455\u201362.","journal-title":"NeuroImage Clin"},{"issue":"2","key":"4099_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/WCO.0b013e32835ee5b8","volume":"26","author":"J Engel","year":"2013","unstructured":"Engel J, Thompson PM, Stern JM, Staba RJ, Bragin A, Mody I. Connectomics and epilepsy. Curr Opin Neurol. 2013;26(2):186\u201394.","journal-title":"Curr Opin Neurol"},{"issue":"47","key":"4099_CR8","doi-asserted-by":"publisher","first-page":"eabc6457","DOI":"10.1126\/sciadv.abc6457","volume":"6","author":"S Lariviere","year":"2020","unstructured":"Lariviere S, Rodr\u00edguez-Cruces R, Royer J, Caligiuri ME, Gambardella A, Concha L, Keller SS, Cendes F, Yasuda C, Bonilha L. Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study. Sci Adv. 2020;6(47):eabc6457.","journal-title":"Sci Adv"},{"issue":"3","key":"4099_CR9","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nrn3901","volume":"16","author":"A Fornito","year":"2015","unstructured":"Fornito A, Zalesky A, Breakspear M. The connectomics of brain disorders. Nat Rev Neurosci. 2015;16(3):159\u201372.","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"4099_CR10","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41583-019-0177-6","volume":"20","author":"MP Van den Heuvel","year":"2019","unstructured":"Van den Heuvel MP, Sporns O. A cross-disorder connectome landscape of brain dysconnectivity. Nat Rev Neurosci. 2019;20(7):435\u201346.","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"4099_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrn3887","volume":"16","author":"J Brettschneider","year":"2015","unstructured":"Brettschneider J, Tredici KD, Lee VMY, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci. 2015;16(2):109\u201320.","journal-title":"Nat Rev Neurosci"},{"issue":"22","key":"4099_CR12","doi-asserted-by":"publisher","first-page":"e2290","DOI":"10.1212\/WNL.0000000000207277","volume":"100","author":"F Agosta","year":"2023","unstructured":"Agosta F, Spinelli EG, Basaia S, Cividini C, Falbo F, Pavone C, Riva N, Canu E, Castelnovo V, Magnani G. Functional connectivity from disease epicenters in frontotemporal dementia. Neurology. 2023;100(22):e2290\u2013303.","journal-title":"Neurology"},{"issue":"8","key":"4099_CR13","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.biopsych.2019.09.031","volume":"87","author":"G Shafiei","year":"2020","unstructured":"Shafiei G, Markello RD, Makowski C, Talpalaru A, Kirschner M, Devenyi GA, Guma E, Hagmann P, Cashman NR, Lepage M. Spatial patterning of tissue volume loss in schizophrenia reflects brain network architecture. Biol Psychiatry. 2020;87(8):727\u201335.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"4099_CR14","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.1038\/s41467-022-32420-y","volume":"13","author":"JY Hansen","year":"2022","unstructured":"Hansen JY, Shafiei G, Vogel JW, Smart K, Bearden CE, Hoogman M, Franke B, Van Rooij D, Buitelaar J, McDonald CR. Local molecular and global connectomic contributions to cross-disorder cortical abnormalities. Nat Commun. 2022;13(1):4682.","journal-title":"Nat Commun"},{"issue":"5","key":"4099_CR15","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.biopsych.2023.08.003","volume":"95","author":"J Li","year":"2024","unstructured":"Li J, Long Z, Sheng W, Du L, Qiu J, Chen H, Liao W. Transcriptomic similarity informs neuromorphic deviations in depression biotypes. Biol Psychiatry. 2024;95(5):414\u201325.","journal-title":"Biol Psychiatry"},{"issue":"12","key":"4099_CR16","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1001\/jamapsychiatry.2023.3293","volume":"80","author":"S Chopra","year":"2023","unstructured":"Chopra S, Segal A, Oldham S, Holmes A, Sabaroedin K, Orchard ER, Francey SM, O\u2019Donoghue B, Cropley V, Nelson B. Network-based spreading of gray matter changes across different stages of psychosis. JAMA Psychiat. 2023;80(12):1246\u201357.","journal-title":"JAMA Psychiat"},{"issue":"8","key":"4099_CR17","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nrn2416","volume":"9","author":"WW Lytton","year":"2008","unstructured":"Lytton WW. Computer modelling of epilepsy. Nat Rev Neurosci. 2008;9(8):626\u201337.","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"4099_CR18","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/s41583-023-00731-8","volume":"24","author":"JW Vogel","year":"2023","unstructured":"Vogel JW, Corriveau-Lecavalier N, Franzmeier N, Pereira JB, Brown JA, Maass A, Botha H, Seeley WW, Bassett DS, Jones DT. Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight. Nat Rev Neurosci. 2023;24(10):620\u201339.","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"4099_CR19","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41583-023-00718-5","volume":"24","author":"C Seguin","year":"2023","unstructured":"Seguin C, Sporns O, Zalesky A. Brain network communication: concepts, models and applications. Nat Rev Neurosci. 2023;24(9):557\u201374.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"4099_CR20","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/s41467-024-44863-6","volume":"15","author":"X Liang","year":"2024","unstructured":"Liang X, Sun L, Liao X, Lei T, Xia M, Duan D, Zeng Z, Li Q, Xu Z, Men W. Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence. Nat Commun. 2024;15(1):784.","journal-title":"Nat Commun"},{"issue":"6","key":"4099_CR21","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.neuron.2015.05.035","volume":"86","author":"B Mi\u0161i\u0107","year":"2015","unstructured":"Mi\u0161i\u0107 B, Betzel RF, Nematzadeh A, Goni J, Griffa A, Hagmann P, Flammini A, Ahn Y-Y, Sporns O. Cooperative and competitive spreading dynamics on the human connectome. Neuron. 2015;86(6):1518\u201329.","journal-title":"Neuron"},{"issue":"6","key":"4099_CR22","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","volume":"73","author":"A Raj","year":"2012","unstructured":"Raj A, Kuceyeski A, Weiner M. A network diffusion model of disease progression in dementia. Neuron. 2012;73(6):1204\u201315.","journal-title":"Neuron"},{"issue":"5","key":"4099_CR23","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/ana.25706","volume":"87","author":"JM Meier","year":"2020","unstructured":"Meier JM, van Der Burgh HK, Nitert AD, Bede P, de Lange SC, Hardiman O, van den Berg LH, van den Heuvel MP. Connectome-based propagation model in amyotrophic lateral sclerosis. Ann Neurol. 2020;87(5):725\u201338.","journal-title":"Ann Neurol"},{"issue":"1","key":"4099_CR24","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s42003-020-0958-5","volume":"3","author":"Y Weng","year":"2020","unstructured":"Weng Y, Larivi\u00e8re S, Caciagli L, Vos de Wael R, Rodr\u00edguez-Cruces R, Royer J, Xu Q, Bernasconi N, Bernasconi A, Thomas Yeo B. Macroscale and microcircuit dissociation of focal and generalized human epilepsies. Commun Biol. 2020;3(1):244.","journal-title":"Commun Biol"},{"issue":"2","key":"4099_CR25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neuroimage.2009.01.055","volume":"46","author":"BC Bernhardt","year":"2009","unstructured":"Bernhardt BC, Rozen DA, Worsley KJ, Evans AC, Bernasconi N, Bernasconi A. Thalamo\u2013cortical network pathology in idiopathic generalized epilepsy: insights from MRI-based morphometric correlation analysis. Neuroimage. 2009;46(2):373\u201381.","journal-title":"Neuroimage"},{"key":"4099_CR26","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fneur.2015.00252","volume":"6","author":"JL Novak","year":"2015","unstructured":"Novak JL, Miller PR, Markovic D, Meymandi SK, DeGiorgio CM. Risk assessment for sudden death in epilepsy: the SUDEP-7 inventory. Front Neurol. 2015;6:252.","journal-title":"Front Neurol"},{"issue":"5","key":"4099_CR27","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/epi.17551","volume":"64","author":"GM Duma","year":"2023","unstructured":"Duma GM, Danieli A, Mento G, Vitale V, Opipari RS, Jirsa V, Bonanni P, Sorrentino P. Altered spreading of neuronal avalanches in temporal lobe epilepsy relates to cognitive performance: A resting-state hdEEG study. Epilepsia. 2023;64(5):1278\u201388.","journal-title":"Epilepsia"},{"issue":"1","key":"4099_CR28","doi-asserted-by":"publisher","first-page":"fcad348","DOI":"10.1093\/braincomms\/fcad348","volume":"6","author":"GM Duma","year":"2024","unstructured":"Duma GM, Pellegrino G, Rabuffo G, Danieli A, Antoniazzi L, Vitale V, Scotto Opipari R, Bonanni P, Sorrentino P. Altered spread of waves of activities at large scale is influenced by cortical thickness organization in temporal lobe epilepsy: a magnetic resonance imaging\u2013high-density electroencephalography study. Brain Commun. 2024;6(1):fcad348.","journal-title":"Brain Commun"},{"issue":"1","key":"4099_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/practneurol-2017-001827","volume":"18","author":"S Baxendale","year":"2018","unstructured":"Baxendale S. Neuropsychological assessment in epilepsy. Pract Neurol. 2018;18(1):43\u20138.","journal-title":"Pract Neurol"},{"issue":"2","key":"4099_CR30","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","volume":"62","author":"B Fischl","year":"2012","unstructured":"Fischl B. FreeSurfer Neuroimage. 2012;62(2):774\u201381.","journal-title":"FreeSurfer Neuroimage"},{"issue":"6","key":"4099_CR31","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1093\/cercor\/bhy123","volume":"29","author":"R Kong","year":"2019","unstructured":"Kong R, Li J, Orban C, Sabuncu MR, Liu H, Schaefer A, Sun N, Zuo X-N, Holmes AJ, Eickhoff SB. Spatial topography of individual-specific cortical networks predicts human cognition, personality, and emotion. Cereb Cortex. 2019;29(6):2533\u201351.","journal-title":"Cereb Cortex"},{"key":"4099_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.117831","volume":"230","author":"Y Meng","year":"2021","unstructured":"Meng Y, Yang S, Chen H, Li J, Xu Q, Zhang Q, Lu G, Zhang Z, Liao W. Systematically disrupted functional gradient of the cortical connectome in generalized epilepsy: Initial discovery and independent sample replication. Neuroimage. 2021;230: 117831.","journal-title":"Neuroimage"},{"key":"4099_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116960","volume":"218","author":"S Yang","year":"2020","unstructured":"Yang S, Meng Y, Li J, Li B, Fan Y-S, Chen H, Liao W. The thalamic functional gradient and its relationship to structural basis and cognitive relevance. Neuroimage. 2020;218: 116960.","journal-title":"Neuroimage"},{"key":"4099_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuroimage.2013.05.041","volume":"80","author":"DC Van Essen","year":"2013","unstructured":"Van Essen DC, Smith SM, Barch DM, Behrens TE, Yacoub E, Ugurbil K, Consortium W-MH. The WU-Minn human connectome project: an overview. Neuroimage. 2013;80:62\u201379 https:\/\/db.humanconnectome.org\/.","journal-title":"Neuroimage"},{"key":"4099_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116137","volume":"202","author":"J-D Tournier","year":"2019","unstructured":"Tournier J-D, Smith R, Raffelt D, Tabbara R, Dhollander T, Pietsch M, Christiaens D, Jeurissen B, Yeh C-H, Connelly A. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019;202: 116137.","journal-title":"Neuroimage"},{"issue":"9","key":"4099_CR36","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","volume":"28","author":"A Schaefer","year":"2018","unstructured":"Schaefer A, Kong R, Gordon EM, Laumann TO, Zuo X-N, Holmes AJ, Eickhoff SB, Yeo BT. Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI. Cereb Cortex. 2018;28(9):3095\u2013114.","journal-title":"Cereb Cortex"},{"issue":"2","key":"4099_CR37","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1162\/netn_a_00075","volume":"3","author":"RF Betzel","year":"2019","unstructured":"Betzel RF, Griffa A, Hagmann P, Mi\u0161i\u0107 B. Distance-dependent consensus thresholds for generating group-representative structural brain networks. Netw Neurosci. 2019;3(2):475\u201396.","journal-title":"Netw Neurosci"},{"issue":"1","key":"4099_CR38","doi-asserted-by":"publisher","first-page":"5737","DOI":"10.1038\/s41598-020-62832-z","volume":"10","author":"S Brodoehl","year":"2020","unstructured":"Brodoehl S, Gaser C, Dahnke R, Witte OW, Klingner CM. Surface-based analysis increases the specificity of cortical activation patterns and connectivity results. Sci Rep. 2020;10(1):5737.","journal-title":"Sci Rep"},{"issue":"3","key":"4099_CR39","first-page":"1125","volume":"103","author":"BT Yeo","year":"2011","unstructured":"Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Z\u00f6llei L, Polimeni JR. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol. 2011;103(3):1125\u201365.","journal-title":"J Neurophysiol"},{"key":"4099_CR40","doi-asserted-by":"crossref","unstructured":"Mesulam MM. Principles of behavioral and cognitive neurology. Oxford University Press, 2000.","DOI":"10.1093\/oso\/9780195134759.001.0001"},{"key":"4099_CR41","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.neuroimage.2018.05.070","volume":"178","author":"AF Alexander-Bloch","year":"2018","unstructured":"Alexander-Bloch AF, Shou H, Liu S, Satterthwaite TD, Glahn DC, Shinohara RT, Vandekar SN, Raznahan A. On testing for spatial correspondence between maps of human brain structure and function. Neuroimage. 2018;178:540\u201351.","journal-title":"Neuroimage"},{"issue":"1","key":"4099_CR42","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/cercor\/bhx249","volume":"28","author":"F V\u00e1\u0161a","year":"2018","unstructured":"V\u00e1\u0161a F, Seidlitz J, Romero-Garcia R, Whitaker KJ, Rosenthal G, V\u00e9rtes PE, Shinn M, Alexander-Bloch A, Fonagy P, Dolan RJ. Adolescent tuning of association cortex in human structural brain networks. Cereb Cortex. 2018;28(1):281\u201394.","journal-title":"Cereb Cortex"},{"issue":"9","key":"4099_CR43","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/s41593-018-0195-0","volume":"21","author":"JB Burt","year":"2018","unstructured":"Burt JB, Demirta\u015f M, Eckner WJ, Navejar NM, Ji JL, Martin WJ, Bernacchia A, Anticevic A, Murray JD. Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography. Nat Neurosci. 2018;21(9):1251\u20139.","journal-title":"Nat Neurosci"},{"issue":"7416","key":"4099_CR44","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nature11405","volume":"489","author":"MJ Hawrylycz","year":"2012","unstructured":"Hawrylycz MJ, Lein ES, Bongaarts AL, Shen EH, Ng L, Miller JA, Van De Lagemaat LN, Smith KA, Ebbert A, Riley ZL. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391\u20139.\u00a0https:\/\/human.brain-map.org\/.","journal-title":"Nature"},{"key":"4099_CR45","doi-asserted-by":"publisher","first-page":"e72129","DOI":"10.7554\/eLife.72129","volume":"10","author":"RD Markello","year":"2021","unstructured":"Markello RD, Arnatkeviciute A, Poline JB, Fulcher BD, Fornito A, Misic B. Standardizing workflows in imaging transcriptomics with the abagen toolbox. eLife. 2021;10:e72129.","journal-title":"eLife"},{"issue":"1","key":"4099_CR46","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1038\/s41467-018-07524-z","volume":"9","author":"C Tilae","year":"2018","unstructured":"Tilae C. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nat Commun. 2018;9(1):5269.","journal-title":"Nat Commun"},{"issue":"1","key":"4099_CR47","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1038\/s41467-022-31730-5","volume":"13","author":"S Larivi\u00e8re","year":"2022","unstructured":"Larivi\u00e8re S, Royer J, Rodr\u00edguez-Cruces R, Paquola C, Caligiuri ME, Gambardella A, Concha L, Keller SS, Cendes F, Yasuda CL. Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression. Nat Commun. 2022;13(1):4320.","journal-title":"Nat Commun"},{"issue":"4","key":"4099_CR48","doi-asserted-by":"publisher","first-page":"fcae231","DOI":"10.1093\/braincomms\/fcae231","volume":"6","author":"GM Duma","year":"2024","unstructured":"Duma GM, Cuozzo S, Wilson L, Danieli A, Bonanni P, Pellegrino G. Excitation\/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent. Brain Commun. 2024;6(4):fcae231.","journal-title":"Brain Commun"},{"issue":"3","key":"4099_CR49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2020574118","volume":"118","author":"A Goulas","year":"2021","unstructured":"Goulas A, Changeux J-P, Wagstyl K, Amunts K, Palomero-Gallagher N, Hilgetag CC. The natural axis of transmitter receptor distribution in the human cerebral cortex. P Natl Acad Sci Usa. 2021;118(3): e2020574118.","journal-title":"P Natl Acad Sci Usa"},{"issue":"11","key":"4099_CR50","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1038\/s41593-022-01186-3","volume":"25","author":"JY Hansen","year":"2022","unstructured":"Hansen JY, Shafiei G, Markello RD, Smart K, Cox SM, N\u00f8rgaard M, Beliveau V, Wu Y, Gallezot J-D, Aumont \u00c9. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. Nat Neurosci. 2022;25(11):1569\u201381 https:\/\/github.com\/netneurolab\/hansen_receptors.","journal-title":"Nat Neurosci"},{"issue":"4","key":"4099_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000678","volume":"18","author":"K Wagstyl","year":"2020","unstructured":"Wagstyl K, Larocque S, Cucurull G, Lepage C, Cohen JP, Bludau S, Palomero-Gallagher N, Lewis LB, Funck T, Spitzer H. BigBrain 3D atlas of cortical layers: Cortical and laminar thickness gradients diverge in sensory and motor cortices. PLoS Biol. 2020;18(4): e3000678.","journal-title":"PLoS Biol"},{"issue":"5","key":"4099_CR52","doi-asserted-by":"publisher","first-page":"e3000284","DOI":"10.1371\/journal.pbio.3000284","volume":"17","author":"C Paquola","year":"2019","unstructured":"Paquola C, Vos De Wael R, Wagstyl K, Bethlehem RA, Hong SJ, Seidlitz J, Bullmore ET, Evans AC, Misic B, Margulies DS. Microstructural and functional gradients are increasingly dissociated in transmodal cortices. PLoS Biol. 2019;17(5):e3000284.","journal-title":"PLoS Biol"},{"issue":"6139","key":"4099_CR53","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1126\/science.1235381","volume":"340","author":"K Amunts","year":"2013","unstructured":"Amunts K, Lepage C, Borgeat L, Mohlberg H, Dickscheid T, Rousseau M-\u00c9, Bludau S, Bazin P-L, Lewis LB, Oros-Peusquens A-M. BigBrain: an ultrahigh-resolution 3D human brain model. Science. 2013;340(6139):1472\u20135 https:\/\/bigbrainwarp.readthedocs.io.","journal-title":"Science."},{"key":"4099_CR54","doi-asserted-by":"publisher","first-page":"e70119","DOI":"10.7554\/eLife.70119","volume":"10","author":"C Paquola","year":"2021","unstructured":"Paquola C, Royer J, Lewis LB, Lepage C, Glatard T, Wagstyl K, DeKraker J, Toussaint PJ, Valk SL, Collins L. The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging. eLife. 2021;10:e70119.","journal-title":"eLife"},{"key":"4099_CR55","first-page":"1","volume":"17","author":"U Gr\u00f6mping","year":"2007","unstructured":"Gr\u00f6mping U. Relative importance for linear regression in R: the package relaimpo. J Stat Softw. 2007;17:1\u201327.","journal-title":"J Stat Softw"},{"issue":"10","key":"4099_CR56","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1001\/jamaneurol.2019.1708","volume":"76","author":"M Galovic","year":"2019","unstructured":"Galovic M, van Dooren VQ, Postma TS, Vos SB, Caciagli L, Borz\u00ec G, Rosillo JC, Vuong KA, de Tisi J, Nachev P. Progressive cortical thinning in patients with focal epilepsy. JAMA Neurol. 2019;76(10):1230\u20139.","journal-title":"JAMA Neurol"},{"issue":"11","key":"4099_CR57","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1093\/brain\/awad284","volume":"146","author":"F Xiao","year":"2023","unstructured":"Xiao F, Caciagli L, Wandschneider B, Sone D, Young AL, Vos SB, Winston GP, Zhang Y, Liu W, An D. Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference. Brain. 2023;146(11):4702\u201316.","journal-title":"Brain"},{"issue":"3","key":"4099_CR58","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1002\/epi4.12781","volume":"8","author":"H Pei","year":"2023","unstructured":"Pei H, Ma S, Yan W, Liu Z, Wang Y, Yang Z, Li Q, Yao D, Jiang S, Luo C. Functional and structural networks decoupling in generalized tonic\u2013clonic seizures and its reorganization by drugs. Epilepsia Open. 2023;8(3):1038\u201348.","journal-title":"Epilepsia Open"},{"key":"4099_CR59","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3389\/fneur.2019.00488","volume":"10","author":"HJ Jo","year":"2019","unstructured":"Jo HJ, Kenney-Jung DL, Balzekas I, Welker KM, Jones DT, Croarkin PE, Benarroch EE, Worrell GA. Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy. Front Neurol. 2019;10:488.","journal-title":"Front Neurol"},{"issue":"10","key":"4099_CR60","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.3174\/ajnr.A4373","volume":"36","author":"R Bharath","year":"2015","unstructured":"Bharath R, Sinha S, Panda R, Raghavendra K, George L, Chaitanya G, Gupta A, Satishchandra P. Seizure frequency can alter brain connectivity: evidence from resting-state fMRI. Am J Neuroradiol. 2015;36(10):1890\u20138.","journal-title":"Am J Neuroradiol"},{"issue":"7","key":"4099_CR61","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1038\/s41596-022-00696-5","volume":"17","author":"S Rutherford","year":"2022","unstructured":"Rutherford S, Kia SM, Wolfers T, Fraza C, Zabihi M, Dinga R, Berthet P, Worker A, Verdi S, Ruhe HG. The normative modeling framework for computational psychiatry. Nat Protoc. 2022;17(7):1711\u201334.","journal-title":"Nat Protoc"},{"issue":"6","key":"4099_CR62","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1038\/s41380-024-02442-7","volume":"29","author":"F Georgiadis","year":"2024","unstructured":"Georgiadis F, Larivi\u00e8re S, Glahn D, Hong LE, Kochunov P, Mowry B, Loughland C, Pantelis C, Henskens FA, Green MJ. Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study. Mol Psychiatry. 2024;29(6):1869\u201381.","journal-title":"Mol Psychiatry"},{"issue":"10","key":"4099_CR63","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1093\/brain\/awr223","volume":"134","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, Liao W, Chen H, Mantini D, Ding J-R, Xu Q, Wang Z, Yuan C, Chen G, Jiao Q. Altered functional\u2013structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain. 2011;134(10):2912\u201328.","journal-title":"Brain"},{"issue":"1","key":"4099_CR64","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12857","volume":"49","author":"J Li","year":"2023","unstructured":"Li J, Keller SS, Seidlitz J, Chen H, Li B, Weng Y, Meng Y, Yang S, Xu Q, Zhang Q. Cortical morphometric vulnerability to generalised epilepsy reflects chromosome-and cell type-specific transcriptomic signatures. Neuropath Appl Neuro. 2023;49(1): e12857.","journal-title":"Neuropath Appl Neuro"},{"issue":"21","key":"4099_CR65","doi-asserted-by":"publisher","first-page":"E4880","DOI":"10.1073\/pnas.1720186115","volume":"115","author":"RF Betzel","year":"2018","unstructured":"Betzel RF, Bassett DS. Specificity and robustness of long-distance connections in weighted, interareal connectomes. P Natl Acad Sci Usa. 2018;115(21):E4880\u20139.","journal-title":"P Natl Acad Sci Usa"},{"issue":"8","key":"4099_CR66","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41583-022-00601-9","volume":"23","author":"F V\u00e1\u0161a","year":"2022","unstructured":"V\u00e1\u0161a F, Mi\u0161i\u0107 B. Null models in network neuroscience. Nat Rev Neurosci. 2022;23(8):493\u2013504.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"4099_CR67","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12916-023-02935-2","volume":"21","author":"S Jiang","year":"2023","unstructured":"Jiang S, Huang H, Zhou J, Li H, Duan M, Yao D, Luo C. Progressive trajectories of schizophrenia across symptoms, genes, and the brain. Bmc Med. 2023;21(1):237.","journal-title":"Bmc Med"},{"issue":"4","key":"4099_CR68","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1528-1167.2011.03385.x","volume":"53","author":"F Benuzzi","year":"2012","unstructured":"Benuzzi F, Mirandola L, Pugnaghi M, Farinelli V, Tassinari CA, Capovilla G, Cantalupo G, Beccaria F, Nichelli P, Meletti S. Increased cortical BOLD signal anticipates generalized spike and wave discharges in adolescents and adults with idiopathic generalized epilepsies. Epilepsia. 2012;53(4):622\u201330.","journal-title":"Epilepsia"},{"issue":"3","key":"4099_CR69","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1111\/epi.14663","volume":"60","author":"C Tangwiriyasakul","year":"2019","unstructured":"Tangwiriyasakul C, Perani S, Abela E, Carmichael DW, Richardson MP. Sensorimotor network hypersynchrony as an endophenotype in families with genetic generalized epilepsy: a resting-state functional magnetic resonance imaging study. Epilepsia. 2019;60(3):e14\u20139.","journal-title":"Epilepsia"},{"issue":"42","key":"4099_CR70","doi-asserted-by":"publisher","first-page":"15236","DOI":"10.1073\/pnas.0504935102","volume":"102","author":"J Gotman","year":"2005","unstructured":"Gotman J, Grova C, Bagshaw A, Kobayashi E, Aghakhani Y, Dubeau F. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. P Natl Acad Sci Usa. 2005;102(42):15236\u201340.","journal-title":"P Natl Acad Sci Usa"},{"issue":"6","key":"4099_CR71","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1093\/brain\/awr098","volume":"134","author":"C Vollmar","year":"2011","unstructured":"Vollmar C, O\u2019Muircheartaigh J, Barker GJ, Symms MR, Thompson P, Kumari V, Duncan JS, Janz D, Richardson MP, Koepp MJ. Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study. Brain. 2011;134(6):1710\u20139.","journal-title":"Brain"},{"issue":"4","key":"4099_CR72","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14672","volume":"30","author":"S Jiang","year":"2024","unstructured":"Jiang S, Wang Y, Pei H, Li H, Chen J, Yao Y, Li Q, Yao D, Luo C. Brain activation and connection across resting and motor-task states in patients with generalized tonic\u2013clonic seizures. CNS Neurosci Ther. 2024;30(4): e14672.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"4099_CR73","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/epi.16759","volume":"62","author":"S Yang","year":"2021","unstructured":"Yang S, Zhang Z, Chen H, Meng Y, Li J, Li Z, Xu Q, Zhang Q, Fan YS, Lu G. Temporal variability profiling of the default mode across epilepsy subtypes. Epilepsia. 2021;62(1):61\u201373.","journal-title":"Epilepsia"},{"issue":"1","key":"4099_CR74","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1038\/s41467-024-46651-8","volume":"15","author":"J Xia","year":"2024","unstructured":"Xia J, Liu C, Li J, Meng Y, Yang S, Chen H, Liao W. Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets. Nat Commun. 2024;15(1):2289.","journal-title":"Nat Commun"},{"issue":"9","key":"4099_CR75","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1093\/brain\/awad117","volume":"146","author":"LE Sainburg","year":"2023","unstructured":"Sainburg LE, Janson AP, Johnson GW, Jiang JW, Rogers BP, Chang C, Englot DJ, Morgan VL. Structural disconnection relates to functional changes after temporal lobe epilepsy surgery. Brain. 2023;146(9):3913\u201322.","journal-title":"Brain"},{"key":"4099_CR76","doi-asserted-by":"publisher","first-page":"102604","DOI":"10.1016\/j.pneurobio.2024.102604","volume":"236","author":"K Xie","year":"2024","unstructured":"Xie K, Royer J, Larivi\u00e8re S, Rodriguez-Cruces R, Fr\u00e4ssle S, Cabalo DG, Ngo A, DeKraker J, Auer H, Tavakol S. Atypical connectome topography and signal flow in temporal lobe epilepsy. Prog Neurobiol. 2024;236:102604.","journal-title":"Prog Neurobiol"},{"issue":"1","key":"4099_CR77","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41392-021-00728-8","volume":"6","author":"J Kang","year":"2021","unstructured":"Kang J, Brajanovski N, Chan KT, Xuan J, Pearson RB, Sanij E. Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy. Signal Transduction Targeted Ther. 2021;6(1):323.","journal-title":"Signal Transduction Targeted Ther"},{"key":"4099_CR78","doi-asserted-by":"publisher","first-page":"106848","DOI":"10.1016\/j.yebeh.2019.106848","volume":"104","author":"L Zhu","year":"2020","unstructured":"Zhu L, Chen L, Xu P, Lu D, Dai S, Zhong L, Han Y, Zhang M, Xiao B, Chang L. Genetic and molecular basis of epilepsy-related cognitive dysfunction. Epilepsy Behav. 2020;104:106848.","journal-title":"Epilepsy Behav"},{"key":"4099_CR79","doi-asserted-by":"publisher","first-page":"118826","DOI":"10.1016\/j.lfs.2020.118826","volume":"265","author":"E Akyuz","year":"2021","unstructured":"Akyuz E, Polat AK, Eroglu E, Kullu I, Angelopoulou E, Paudel YN. Revisiting the role of neurotransmitters in epilepsy: An updated review. Life Sci. 2021;265:118826.","journal-title":"Life Sci"},{"issue":"9","key":"4099_CR80","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1093\/brain\/awad125","volume":"146","author":"J Royer","year":"2023","unstructured":"Royer J, Larivi\u00e8re S, Rodriguez-Cruces R, Cabalo DG, Tavakol S, Auer H, Ngo A, Park BY, Paquola C, Smallwood J. Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy. Brain. 2023;146(9):3923\u201337.","journal-title":"Brain"},{"issue":"1","key":"4099_CR81","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/s41467-021-21943-5","volume":"12","author":"J Li","year":"2021","unstructured":"Li J, Seidlitz J, Suckling J, Fan F, Ji G-J, Meng Y, Yang S, Wang K, Qiu J, Chen H. Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures. Nat Commun. 2021;12(1):1647.","journal-title":"Nat Commun"},{"issue":"3","key":"4099_CR82","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1148\/radiol.13131638","volume":"271","author":"G-J Ji","year":"2014","unstructured":"Ji G-J, Zhang Z, Xu Q, Zang Y-F, Liao W, Lu G. Generalized tonic-clonic seizures: aberrant interhemispheric functional and anatomical connectivity. Radiology. 2014;271(3):839\u201347.","journal-title":"Radiology"},{"issue":"11","key":"4099_CR83","first-page":"1597","volume":"157","author":"P Gloor","year":"1997","unstructured":"Gloor P, Guberman AH. The temporal lobe & limbic system. Can Med Assoc J. 1997;157(11):1597.","journal-title":"Can Med Assoc J"},{"issue":"2","key":"4099_CR84","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.tics.2020.11.006","volume":"25","author":"D Pitcher","year":"2021","unstructured":"Pitcher D, Ungerleider LG. Evidence for a third visual pathway specialized for social perception. Trends Cognit Sci. 2021;25(2):100\u201310.","journal-title":"Trends Cognit Sci"},{"issue":"2","key":"4099_CR85","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1162\/netn_a_00237","volume":"6","author":"R Rodriguez-Cruces","year":"2022","unstructured":"Rodriguez-Cruces R, Royer J, Larivi\u00e8re S, Bassett DS, Caciagli L, Bernhardt BC. Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies. Netw Neurosci. 2022;6(2):320\u201338.","journal-title":"Netw Neurosci"},{"issue":"12","key":"4099_CR86","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.1002\/hbm.23323","volume":"37","author":"R Li","year":"2016","unstructured":"Li R, Liao W, Li Y, Yu Y, Zhang Z, Lu G, Chen H. Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic-clonic seizure. Hum Brain Mapp. 2016;37(12):4487\u201399.","journal-title":"Hum Brain Mapp"},{"issue":"11","key":"4099_CR87","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/s41592-022-01625-w","volume":"19","author":"RD Markello","year":"2022","unstructured":"Markello RD, Hansen JY, Liu Z-Q, Bazinet V, Shafiei G, Su\u00e1rez LE, Blostein N, Seidlitz J, Baillet S, Satterthwaite TD. Neuromaps: structural and functional interpretation of brain maps. Nat Methods. 2022;19(11):1472\u20139.","journal-title":"Nat Methods"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-025-04099-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12916-025-04099-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12916-025-04099-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T13:15:54Z","timestamp":1746191754000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-025-04099-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4099"],"URL":"https:\/\/doi.org\/10.1186\/s12916-025-04099-7","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the medical ethics committee of Jinling Hospital, School of Medicine, Nanjing University, China (approval number: 2014GJJ-056). Written informed consent was obtained from all participants in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"258"}}