{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:50:14Z","timestamp":1791139814585,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12917-014-0274-8","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T15:03:19Z","timestamp":1416841399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Insights into potential pathogenesis mechanisms associated with Campylobacter jejuni-induced abortion in ewes"],"prefix":"10.1186","volume":"10","author":[{"given":"Yasser M","family":"Sanad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwonil","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Kashoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issmat I","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehia M","family":"Saif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gireesh","family":"Rajashekara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"274_CR1","doi-asserted-by":"publisher","first-page":"7409","DOI":"10.1128\/AEM.69.12.7409-7413.2003","volume":"69","author":"FM Colles","year":"2003","unstructured":"Colles FM, Jones K, Harding RM, Maiden MC: Genetic diversity of Campylobacter jejuni isolates from farm animals and the farm environment. Appl Environ Microbiol. 2003, 69: 7409-7413. 10.1128\/AEM.69.12.7409-7413.2003.","journal-title":"Appl Environ Microbiol"},{"key":"274_CR2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2460\/ajvr.1996.57.02.163","volume":"57","author":"WJ Delong","year":"1996","unstructured":"Delong WJ, Jaworski MD, Ward AC: Antigenic and restriction enzyme analysis of Campylobacter spp. associated with abortion in sheep. Am J Vet Res. 1996, 57: 163-167.","journal-title":"Am J Vet Res"},{"key":"274_CR3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1177\/104063879300500316","volume":"5","author":"CA Kirkbride","year":"1993","unstructured":"Kirkbride CA: Diagnoses in 1,784 ovine abortions and stillbirths. J Vet Diagn Invest. 1993, 5: 398-402. 10.1177\/104063879300500316.","journal-title":"J Vet Diagn Invest"},{"key":"274_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0021-9975(05)80046-5","volume":"111","author":"MB Skirrow","year":"1994","unstructured":"Skirrow MB: Diseases due to Campylobacter, Helicobacter and related bacteria. J Comp Pathol. 1994, 111: 113-149. 10.1016\/S0021-9975(05)80046-5.","journal-title":"J Comp Pathol"},{"key":"274_CR5","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1128\/JCM.00031-08","volume":"46","author":"O Sahin","year":"2008","unstructured":"Sahin O, Plummer PJ, Jordan DM, Sulaj K, Pereira S, Robbe-Austerman S, Wang L, Yaeger MJ, Hoffman LJ, Zhang Q: Emergence of a tetracycline-resistant Campylobacter jejuni clone associated with outbreaks of ovine abortion in the United States. J Clin Microbiol. 2008, 46: 1663-1671. 10.1128\/JCM.00031-08.","journal-title":"J Clin Microbiol"},{"key":"274_CR6","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1128\/JCM.00355-14","volume":"52","author":"Z Wu","year":"2014","unstructured":"Wu Z, Sippy R, Sahin O, Plummer P, Vidal A, Newell D, Zhang Q: Genetic diversity and antimicrobial susceptibility of Campylobacter jejuni isolates associated with sheep abortion in the United States and Great Britain. J Clin Microbiol. 2014, 52: 1853-1861. 10.1128\/JCM.00355-14.","journal-title":"J Clin Microbiol"},{"key":"274_CR7","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1128\/JCM.06167-11","volume":"50","author":"O Sahin","year":"2012","unstructured":"Sahin O, Fitzgerald C, Stroika S, Zhao S, Sippy RJ, Kwan P, Plummer PJ, Han J, Yaeger MJ, Zhang Q: Molecular evidence for zoonotic transmission of an emergent, highly pathogenic Campylobacter jejuni clone in the United States. J Clin Microbiol. 2012, 50: 680-687. 10.1128\/JCM.06167-11.","journal-title":"J Clin Microbiol"},{"key":"274_CR8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/030098588702400509","volume":"24","author":"OR Hedstrom","year":"1987","unstructured":"Hedstrom OR, Sonn RJ, Lassen ED, Hultgren BD, Crisman RO, Smith BB, Snyder SP: Pathology of Campylobacter jejuni abortion in sheep. Vet Pathol. 1987, 24: 419-426.","journal-title":"Vet Pathol"},{"key":"274_CR9","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.2460\/ajvr.70.10.1269","volume":"70","author":"ER Burrough","year":"2009","unstructured":"Burrough ER, Sahin O, Plummer PJ, Zhang Q, Yaeger MJ: Pathogenicity of an emergent, ovine abortifacient Campylobacter jejuni clone orally inoculated into pregnant guinea pigs. Am J Vet Res. 2009, 70: 1269-1276. 10.2460\/ajvr.70.10.1269.","journal-title":"Am J Vet Res"},{"key":"274_CR10","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.3382\/ps.2008-00010","volume":"87","author":"M Denis","year":"2008","unstructured":"Denis M, Rose V, Huneau-Sala\u00fcn A, Balaine L, Salvat G: Diversity of pulsed-field gel electrophoresis profiles of Campylobacter jejuni and Campylobacter coli from broiler chickens in France. Poult Sci. 2008, 87: 1662-1671. 10.3382\/ps.2008-00010.","journal-title":"Poult Sci"},{"key":"274_CR11","doi-asserted-by":"publisher","first-page":"e25778","DOI":"10.1371\/journal.pone.0025778","volume":"6","author":"YM Sanad","year":"2011","unstructured":"Sanad YM, Kassem II, Abley M, Gebreyes W, LeJeune JT, Rajashekara G: Genotypic and phenotypic properties of cattle-associated Campylobacter and their implications to public health in the USA. PLoS One. 2011, 6: e25778-10.1371\/journal.pone.0025778.","journal-title":"PLoS One"},{"key":"274_CR12","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1128\/JCM.39.5.1889-1894.2001","volume":"39","author":"ER Ribot","year":"2001","unstructured":"Ribot ER, Fitzgerald C, Kubota K, Swaminathan B, Barrett D: Rapid pulsed-field gel electrophoresis protocol for subtyping of Campylobacter jejuni . J Clin Microbiol. 2001, 39: 1889-1894. 10.1128\/JCM.39.5.1889-1894.2001.","journal-title":"J Clin Microbiol"},{"key":"274_CR13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1089\/fpd.2012.1293","volume":"10","author":"YM Sanad","year":"2013","unstructured":"Sanad YM, Closs G, Kumar A, LeJeune JT, Rajashekara G: Molecular epidemiology and public health relevance of Campylobacter isolated from dairy cattle and European starlings in Ohio, USA. Foodborne Pathog Dis. 2013, 10: 229-236. 10.1089\/fpd.2012.1293.","journal-title":"Foodborne Pathog Dis"},{"key":"274_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1128\/JCM.39.1.14-23.2001","volume":"39","author":"KE Dingle","year":"2001","unstructured":"Dingle KE, Colles FM, Wareing DRA, Ure R, Fox AJ, Bolton FE, Bootsma HJ, Willems RJL, Urwin R, Maiden MCJ: Multilocus sequence typing system for Campylobacter jejuni . J Clin Microbiol. 2001, 39: 14-23. 10.1128\/JCM.39.1.14-23.2001.","journal-title":"J Clin Microbiol"},{"key":"274_CR15","first-page":"677","volume":"20","author":"VA Miller","year":"1959","unstructured":"Miller VA, Jensen R, Gilroy JJ: Bacteremia in pregnant sheep following oral administration of Vibrio fetus . Am J Vet Res. 1959, 20: 677-679.","journal-title":"Am J Vet Res"},{"key":"274_CR16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1128\/JCM.38.1.286-291.2000","volume":"38","author":"J Engberg","year":"2000","unstructured":"Engberg J, On SLW, Harrington CS, Gerner-Smidt P: Prevalence of Campylobacter, Arcobacter, Helicobacter, and Sutterella spp. in human fecal samples as estimated by a reevaluation of isolation methods for campylobacters. J Clin Microbiol. 2000, 38: 286-291.","journal-title":"J Clin Microbiol"},{"key":"274_CR17","doi-asserted-by":"publisher","first-page":"13681","DOI":"10.1128\/JVI.01702-07","volume":"81","author":"K Jung","year":"2007","unstructured":"Jung K, Alekseev KP, Zhang X, Cheon DS, Vlasova AN, Saif LJ: Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus. J Virol. 2007, 81: 13681-13693. 10.1128\/JVI.01702-07.","journal-title":"J Virol"},{"key":"274_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-61779-860-3_5","volume":"887","author":"K Kyrylkova","year":"2012","unstructured":"Kyrylkova K, Kyryachenko S, Leid M, Kioussi C: Detection of apoptosis by TUNEL assay. Methods Mol Biol. 2012, 887: 41-47. 10.1007\/978-1-61779-860-3_5.","journal-title":"Methods Mol Biol"},{"key":"274_CR19","first-page":"1544","volume":"7","author":"Y Rao","year":"2008","unstructured":"Rao Y, Lee Y, Jarjoura D, Ruppert AS, Liu CG, Hsu JC, Hagan JP: A comparison of normalization techniques for microRNA microarray data. Stat Appl Genet Mol Biol. 2008, 7: 1544-6115.","journal-title":"Stat Appl Genet Mol Biol"},{"key":"274_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003, 4: 249-264. 10.1093\/biostatistics\/4.2.249.","journal-title":"Biostatistics"},{"key":"274_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1214\/07-AOAS102","volume":"1","author":"A Gordon","year":"2007","unstructured":"Gordon A, Glazko G, Qiu X, Yakovlev A: Control of the mean number of false discoveries, Bonferroni and stability of multiple testing. Ann Appl Stat. 2007, 1: 179-190. 10.1214\/07-AOAS102.","journal-title":"Ann Appl Stat"},{"key":"274_CR22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1242\/dev.126.4.723","volume":"126","author":"M Koutsourakis","year":"1999","unstructured":"Koutsourakis M, Lanngeveld A, Patient R, Beddington R, Grosveld F: The transcription factor GATA6 is essential for early extraembryonic development. Development. 1999, 126: 723-732.","journal-title":"Development"},{"key":"274_CR23","first-page":"2622","volume":"7","author":"R Zhao","year":"2006","unstructured":"Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA: GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2006, 7: 2622-2631.","journal-title":"Mol Cell Biol"},{"key":"274_CR24","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0925-4773(01)00423-3","volume":"106","author":"C Millet","year":"2001","unstructured":"Millet C, Lemaire P, Orsetti B, Guglielmi P, Fran\u00e7ois V: The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities. Mech Dev. 2001, 106: 85-96. 10.1016\/S0925-4773(01)00423-3.","journal-title":"Mech Dev"},{"key":"274_CR25","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1101\/gad.843800","volume":"14","author":"S Nef","year":"2000","unstructured":"Nef S, Parada LF: Hormones in male sexual development. Genes Dev. 2000, 14: 3075-3086. 10.1101\/gad.843800.","journal-title":"Genes Dev"},{"key":"274_CR26","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1084\/jem.20040104","volume":"200","author":"CG Lee","year":"2004","unstructured":"Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA: Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med. 2004, 200: 377-389. 10.1084\/jem.20040104.","journal-title":"J Exp Med"},{"key":"274_CR27","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9378(99)70227-9","volume":"180","author":"E Hirsch","year":"1999","unstructured":"Hirsch E, Blanchard R, Mehta SP: Differential fetal and maternal contributions to the cytokine milieu in a murine model of infection induced preterm birth. Am J Obstet Gynecol. 1999, 180: 429-434. 10.1016\/S0002-9378(99)70227-9.","journal-title":"Am J Obstet Gynecol"},{"key":"274_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0020-7292(02)00016-4","volume":"77","author":"H Fukuda","year":"2002","unstructured":"Fukuda H, Masuzaki H, Ishimaru T: Interleukin-6 and interleukin-1 receptor antagonist in amniotic fluid and cord blood in patients with pre-term, premature rupture of the membranes. Int J Gynecol Obstet. 2002, 77: 123-129. 10.1016\/S0020-7292(02)00016-4.","journal-title":"Int J Gynecol Obstet"},{"key":"274_CR29","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.1210\/en.2010-0063","volume":"151","author":"SA Robertson","year":"2010","unstructured":"Robertson SA, Christiaens I, Dorian CL, Zaragoza DB, Care AS, Banks AM, Olson DM: Interleukin-6 is an essential determinant of on-time parturition in the mouse. Endocrinology. 2010, 151: 3996-4006. 10.1210\/en.2010-0063.","journal-title":"Endocrinology"},{"key":"274_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1600-065X.2011.01055.x","volume":"244","author":"JM Hildebrand","year":"2011","unstructured":"Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA: Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011, 244: 55-74. 10.1111\/j.1600-065X.2011.01055.x.","journal-title":"Immunol Rev"},{"key":"274_CR31","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.1128\/IAI.72.7.3855-3862.2004","volume":"72","author":"T Yajima","year":"2004","unstructured":"Yajima T, Nishimura H, Saito K, Kuwano H, Yoshikai Y: Overexpression of interleukin-15 increases susceptibility to lipopolysaccharide induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin. Infect Immun. 2004, 72: 3855-3862. 10.1128\/IAI.72.7.3855-3862.2004.","journal-title":"Infect Immun"},{"key":"274_CR32","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/nm1615","volume":"13","author":"Z Orinska","year":"2007","unstructured":"Orinska Z, Maurer M, Mirghomizadeh F, Bulanova E, Metz M, Nashkevich N, Schiemann F, Schulmistrat J, Budagian V, Giron-Michel J, Brandt E, Paus R, Bulfone-Paus S: IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med. 2007, 13: 927-934. 10.1038\/nm1615.","journal-title":"Nat Med"},{"key":"274_CR33","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1189\/jlb.0912442","volume":"93","author":"AJ Lee","year":"2013","unstructured":"Lee AJ, Kandiah N, Karimi K, Clark DA, Ashkar AA: Interleukin-15 is required for maximal lipopolysaccharide-induced abortion. J Leukoc Biol. 2013, 93: 905-912. 10.1189\/jlb.0912442.","journal-title":"J Leukoc Biol"},{"key":"274_CR34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1600-0897.2010.00879.x","volume":"64","author":"B Toth","year":"2010","unstructured":"Toth B, Haufe T, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U: Placental interleukin- 15 expression in recurrent miscarriage. Am J Reprod Immunol. 2010, 64: 402-410. 10.1111\/j.1600-0897.2010.00879.x.","journal-title":"Am J Reprod Immunol"},{"key":"274_CR35","doi-asserted-by":"publisher","first-page":"118","DOI":"10.5603\/FHC.2012.0017","volume":"50","author":"TE Deftereou","year":"2012","unstructured":"Deftereou TE, Lambropoulou M, Chatzaki E, Koffa M, Ypsilantis P, Pagonopoulou O, Grammatikopoulou I, Papadopoulos E, Papalambros A, Kontomanolis E, Papadopoulos N: Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: a histochemical and immunohistochemical study. Folia Histochem Cytobiol. 2012, 50: 118-124. 10.5603\/FHC.2012.0017.","journal-title":"Folia Histochem Cytobiol"},{"key":"274_CR36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.biochem.69.1.217","volume":"69","author":"A Strassr","year":"2000","unstructured":"Strassr A, O\u2019Connor L, Dixit VM: Apoptosis signaling. Annu Rev Biochem. 2000, 69: 217-245. 10.1146\/annurev.biochem.69.1.217.","journal-title":"Annu Rev Biochem"},{"key":"274_CR37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s00404-005-0028-8","volume":"273","author":"HM Tanir","year":"2005","unstructured":"Tanir HM, Sener T, Artan S, Kaytaz B, Sahin-Mutlu F, Ozen ME: Programmed cell death (apoptosis) in placentas from normal pregnancy and pregnancy complicated by term and preterm premature rupture of membranes. Arch Gynecol Obstet. 2005, 273: 98-103. 10.1007\/s00404-005-0028-8.","journal-title":"Arch Gynecol Obstet"},{"key":"274_CR38","doi-asserted-by":"publisher","first-page":"4384","DOI":"10.1128\/IAI.68.8.4384-4390.2000","volume":"68","author":"DJ Bacon","year":"2000","unstructured":"Bacon DJ, Alm RA, Burr DH, Hu L, Kopecko DJ, Ewing CP, Trust TJ, Guerry P: Involvement of a plasmid in virulence of Campylobacter jejuni 81-176. Infect Immun. 2000, 68: 4384-4390. 10.1128\/IAI.68.8.4384-4390.2000.","journal-title":"Infect Immun"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-014-0274-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-014-0274-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-014-0274-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-014-0274-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T04:46:47Z","timestamp":1717562807000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-014-0274-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["274"],"URL":"https:\/\/doi.org\/10.1186\/s12917-014-0274-8","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,25]]},"assertion":[{"value":"10 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"274"}}