{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:06:26Z","timestamp":1785773186281,"version":"3.56.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12917-014-0281-9","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T10:21:38Z","timestamp":1418293298000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Differential detection of classical swine fever virus challenge strains in C-strain vaccinated pigs"],"prefix":"10.1186","volume":"10","author":[{"given":"Helen E","family":"Everett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bentley S","family":"Crudgington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubukola","family":"Sosan-Soul\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen R","family":"Crooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"issue":"2\u20133","key":"281_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0378-1135(00)00138-3","volume":"73","author":"S Edwards","year":"2000","unstructured":"Edwards S, Fukusho A, Lefevre PC, Lipowski A, Pejsak Z, Roehe P, Westergaard J: Classical swine fever: the global situation. Vet Microbiol. 2000, 73 (2\u20133): 103-119. 10.1016\/S0378-1135(00)00138-3.","journal-title":"Vet Microbiol"},{"issue":"1","key":"281_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetmic.2006.10.003","volume":"119","author":"S Suradhat","year":"2007","unstructured":"Suradhat S, Damrongwatanapokin S, Thanawongnuwech R: Factors critical for successful vaccination against classical swine fever in endemic areas. Vet Microbiol. 2007, 119 (1): 1-9. 10.1016\/j.vetmic.2006.10.003.","journal-title":"Vet Microbiol"},{"key":"281_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virusres.2013.10.025","volume":"179","author":"YL Huang","year":"2014","unstructured":"Huang YL, Deng MC, Wang FI, Huang CC, Chang CY: The challenges of classical swine fever control: modified live and E2 subunit vaccines. Virus Res. 2014, 179: 1-11. 10.1016\/j.virusres.2013.10.025.","journal-title":"Virus Res"},{"issue":"1","key":"281_CR4","doi-asserted-by":"publisher","first-page":"e29310","DOI":"10.1371\/journal.pone.0029310","volume":"7","author":"SP Graham","year":"2012","unstructured":"Graham SP, Everett HE, Haines FJ, Johns HL, Sosan OA, Salguero FJ, Clifford DJ, Steinbach F, Drew TW, Crooke HR: Challenge of pigs with classical swine fever viruses after C-strain vaccination reveals remarkably rapid protection and insights into early immunity. PLoS One. 2012, 7 (1): e29310-10.1371\/journal.pone.0029310.","journal-title":"PLoS One"},{"key":"281_CR5","first-page":"259","volume":"114","author":"JT van Oirschot","year":"2003","unstructured":"van Oirschot JT: Emergency vaccination against classical swine fever. Dev Biol (Basel). 2003, 114: 259-267.","journal-title":"Dev Biol (Basel)"},{"issue":"1\u20132","key":"281_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.vetmic.2008.04.022","volume":"132","author":"S von Ruden","year":"2008","unstructured":"von Ruden S, Staubach C, Kaden V, Hess RG, Blicke J, Kuhne S, Sonnenburg J, Frohlich A, Teuffert J, Moennig V: Retrospective analysis of the oral immunisation of wild boar populations against classical swine fever virus (CSFV) in region Eifel of Rhineland-Palatinate. Vet Microbiol. 2008, 132 (1\u20132): 29-38. 10.1016\/j.vetmic.2008.04.022.","journal-title":"Vet Microbiol"},{"issue":"11\u201312","key":"281_CR7","first-page":"468","volume":"126","author":"A Postel","year":"2013","unstructured":"Postel A, Moennig V, Becher P: Classical swine fever in Europe\u2013the current situation. Berl Munch Tierarztl Wochenschr. 2013, 126 (11\u201312): 468-475.","journal-title":"Berl Munch Tierarztl Wochenschr"},{"issue":"1\u20132","key":"281_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.vetmic.2009.09.044","volume":"142","author":"M Tignon","year":"2010","unstructured":"Tignon M, Kulcsar G, Haegeman A, Barna T, Fabian K, Levai R, Van der Stede Y, Farsang A, Vrancken R, Belak K, Koenen F: Classical swine fever: comparison of oronasal immunisation with CP7E2alf marker and C-strain vaccines in domestic pigs. Vet Microbiol. 2010, 142 (1\u20132): 59-68. 10.1016\/j.vetmic.2009.09.044.","journal-title":"Vet Microbiol"},{"issue":"1\u20132","key":"281_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.vetmic.2013.12.002","volume":"169","author":"S Blome","year":"2014","unstructured":"Blome S, Gabriel C, Schmeiser S, Meyer D, Meindl-Bohmer A, Koenen F, Beer M: Efficacy of marker vaccine candidate CP7_E2alf against challenge with classical swine fever virus isolates of different genotypes. Vet Microbiol. 2014, 169 (1\u20132): 8-17. 10.1016\/j.vetmic.2013.12.002.","journal-title":"Vet Microbiol"},{"issue":"1","key":"281_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1586\/erv.09.130","volume":"9","author":"A Uttenthal","year":"2010","unstructured":"Uttenthal A, Parida S, Rasmussen TB, Paton DJ, Haas B, Dundon WG: Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza. Expert Rev Vaccines. 2010, 9 (1): 73-87. 10.1586\/erv.09.130.","journal-title":"Expert Rev Vaccines"},{"issue":"1","key":"281_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jviromet.2009.03.003","volume":"159","author":"L Liu","year":"2009","unstructured":"Liu L, Hoffmann B, Baule C, Beer M, Belak S, Widen F: Two real-time RT-PCR assays of classical swine fever virus, developed for the genetic differentiation of naturally infected from vaccinated wild boars. J Virol Methods. 2009, 159 (1): 131-133. 10.1016\/j.jviromet.2009.03.003.","journal-title":"J Virol Methods"},{"issue":"3\u20134","key":"281_CR12","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.vetmic.2012.07.046","volume":"161","author":"A Aebischer","year":"2013","unstructured":"Aebischer A, Muller M, Hofmann MA: Two newly developed E(rns)-based ELISAs allow the differentiation of Classical Swine Fever virus-infected from marker-vaccinated animals and the discrimination of pestivirus antibodies. Vet Microbiol. 2013, 161 (3\u20134): 274-285. 10.1016\/j.vetmic.2012.07.046.","journal-title":"Vet Microbiol"},{"issue":"1","key":"281_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1135(01)00321-2","volume":"81","author":"J Lorena","year":"2001","unstructured":"Lorena J, Barlic-Maganja D, Lojkic M, Madic J, Grom J, Cac Z, Roic B, Terzic S, Lojkic I, Polancec D, Cajavec S: Classical swine fever virus (C strain) distribution in organ samples of inoculated piglets. Vet Microbiol. 2001, 81 (1): 1-8. 10.1016\/S0378-1135(01)00321-2.","journal-title":"Vet Microbiol"},{"issue":"3\u20134","key":"281_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.vetmic.2006.10.034","volume":"120","author":"P Koenig","year":"2007","unstructured":"Koenig P, Hoffmann B, Depner KR, Reimann I, Teifke JP, Beer M: Detection of classical swine fever vaccine virus in blood and tissue samples of pigs vaccinated either with a conventional C-strain vaccine or a modified live marker vaccine. Vet Microbiol. 2007, 120 (3\u20134): 343-351. 10.1016\/j.vetmic.2006.10.034.","journal-title":"Vet Microbiol"},{"issue":"2\u20134","key":"281_CR15","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.vetmic.2012.10.030","volume":"162","author":"PL Eble","year":"2013","unstructured":"Eble PL, Geurts Y, Quak S, Moonen-Leusen HW, Blome S, Hofmann MA, Koenen F, Beer M, Loeffen WL: Efficacy of chimeric Pestivirus vaccine candidates against classical swine fever: protection and DIVA characteristics. Vet Microbiol. 2013, 162 (2\u20134): 437-446. 10.1016\/j.vetmic.2012.10.030.","journal-title":"Vet Microbiol"},{"issue":"2\u20134","key":"281_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.vetmic.2009.11.020","volume":"143","author":"V Kaden","year":"2010","unstructured":"Kaden V, Lange E, Kuster H, Muller T, Lange B: An update on safety studies on the attenuated \"RIEMSER Schweinepestoralvakzine\" for vaccination of wild boar against classical swine fever. Vet Microbiol. 2010, 143 (2\u20134): 133-138. 10.1016\/j.vetmic.2009.11.020.","journal-title":"Vet Microbiol"},{"issue":"1\u20132","key":"281_CR17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jviromet.2009.02.002","volume":"158","author":"I Leifer","year":"2009","unstructured":"Leifer I, Depner K, Blome S, Le Potier MF, Le Dimna M, Beer M, Hoffmann B: Differentiation of C-strain \"Riems\" or CP7_E2alf vaccinated animals from animals infected by classical swine fever virus field strains using real-time RT-PCR. J Virol Methods. 2009, 158 (1\u20132): 114-122. 10.1016\/j.jviromet.2009.02.002.","journal-title":"J Virol Methods"},{"issue":"1\u20132","key":"281_CR18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jviromet.2010.03.004","volume":"166","author":"I Leifer","year":"2010","unstructured":"Leifer I, Everett H, Hoffmann B, Sosan O, Crooke H, Beer M, Blome S: Escape of classical swine fever C-strain vaccine virus from detection by C-strain specific real-time RT-PCR caused by a point mutation in the primer-binding site. J Virol Methods. 2010, 166 (1\u20132): 98-100. 10.1016\/j.jviromet.2010.03.004.","journal-title":"J Virol Methods"},{"issue":"3-4","key":"281_CR19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.vetmic.2011.05.039","volume":"153","author":"S Blome","year":"2011","unstructured":"Blome S, Gabriel C, Staubach C, Leifer I, Strebelow G, Beer M: Genetic differentiation of infected from vaccinated animals after implementation of an emergency vaccination strategy against classical swine fever in wild boar. Vet Microbiol. 2011, 153 (3-4): 373-376. 10.1016\/j.vetmic.2011.05.039.","journal-title":"Vet Microbiol"},{"issue":"2","key":"281_CR20","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jviromet.2011.05.003","volume":"175","author":"L Liu","year":"2011","unstructured":"Liu L, Xia H, Everett H, Sosan O, Crooke H, Meindl-Bohmer A, Qiu HJ, Moennig V, Belak S, Widen F: A generic real-time TaqMan assay for specific detection of lapinized Chinese vaccines against classical swine fever. J Virol Methods. 2011, 175 (2): 170-174. 10.1016\/j.jviromet.2011.05.003.","journal-title":"J Virol Methods"},{"issue":"2","key":"281_CR21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.rvsc.2014.06.010","volume":"97","author":"F Widen","year":"2014","unstructured":"Widen F, Everett H, Blome S, Fernandez Pinero J, Uttenthal A, Cortey M, von Rosen T, Tignon M, Liu L: Comparison of two real-time RT-PCR assays for differentiation of C-strain vaccinated from classical swine fever infected pigs and wild boars. Res Vet Sci. 2014, 97 (2): 455-457. 10.1016\/j.rvsc.2014.06.010.","journal-title":"Res Vet Sci"},{"issue":"1\u20133","key":"281_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetmic.2007.04.046","volume":"126","author":"JJ Zhao","year":"2008","unstructured":"Zhao JJ, Cheng D, Li N, Sun Y, Shi Z, Zhu QH, Tu C, Tong GZ, Qiu HJ: Evaluation of a multiplex real-time RT-PCR for quantitative and differential detection of wild-type viruses and C-strain vaccine of Classical swine fever virus. Vet Microbiol. 2008, 126 (1\u20133): 1-10. 10.1016\/j.vetmic.2007.04.046.","journal-title":"Vet Microbiol"},{"issue":"3","key":"281_CR23","first-page":"226","volume":"70","author":"HS Cho","year":"2006","unstructured":"Cho HS, Park SJ, Park NY: Development of a reverse-transcription polymerase chain reaction assay with fluorogenic probes to discriminate Korean wild-type and vaccine isolates of Classical swine fever virus. Can J Vet Res. 2006, 70 (3): 226-229.","journal-title":"Can J Vet Res"},{"issue":"1","key":"281_CR24","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jviromet.2010.10.025","volume":"171","author":"XJ Zhang","year":"2011","unstructured":"Zhang XJ, Han QY, Sun Y, Belak S, Liu L, Qiu HJ: Development of a loop-mediated isothermal amplification for visual detection of the HCLV vaccine against classical swine fever in China. J Virol Methods. 2011, 171 (1): 200-205. 10.1016\/j.jviromet.2010.10.025.","journal-title":"J Virol Methods"},{"issue":"9","key":"281_CR25","first-page":"251","volume":"147","author":"T Sandvik","year":"2000","unstructured":"Sandvik T, Drew T, Paton D: CSF virus in East Anglia: where from?. Vet Rec. 2000, 147 (9): 251.","journal-title":"Vet Rec"},{"issue":"6","key":"281_CR26","first-page":"236","volume":"107","author":"S Parchariyanon","year":"2000","unstructured":"Parchariyanon S, Inui K, Damrongwatanapokin S, Pinyochon W, Lowings P, Paton D: Sequence analysis of E2 glycoprotein genes of classical swine fever viruses: identification of a novel genogroup in Thailand. Dtsch Tierarztl Wochenschr. 2000, 107 (6): 236-238.","journal-title":"Dtsch Tierarztl Wochenschr"},{"issue":"1\u20132","key":"281_CR27","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jviromet.2005.05.030","volume":"130","author":"B Hoffmann","year":"2005","unstructured":"Hoffmann B, Beer M, Schelp C, Schirrmeier H, Depner K: Validation of a real-time RT-PCR assay for sensitive and specific detection of classical swine fever. J Virol Methods. 2005, 130 (1\u20132): 36-44. 10.1016\/j.jviromet.2005.05.030.","journal-title":"J Virol Methods"},{"issue":"6","key":"281_CR28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/j.1439-0450.2004.00766.x","volume":"51","author":"V Kaden","year":"2004","unstructured":"Kaden V, Lange E, Riebe R, Lange B: Classical swine fever virus Strain 'C': how long is it detectable after oral vaccination?. J Vet Med B Infect Dis Vet Public Health. 2004, 51 (6): 260-262. 10.1111\/j.1439-0450.2004.00766.x.","journal-title":"J Vet Med B Infect Dis Vet Public Health"},{"issue":"1\u20132","key":"281_CR29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jviromet.2009.04.029","volume":"160","author":"YL Huang","year":"2009","unstructured":"Huang YL, Pang VF, Pan CH, Chen TH, Jong MH, Huang TS, Jeng CR: Development of a reverse transcription multiplex real-time PCR for the detection and genotyping of classical swine fever virus. J Virol Methods. 2009, 160 (1\u20132): 111-118. 10.1016\/j.jviromet.2009.04.029.","journal-title":"J Virol Methods"},{"issue":"1\u20132","key":"281_CR30","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.vetmic.2009.09.039","volume":"142","author":"H Everett","year":"2010","unstructured":"Everett H, Salguero FJ, Graham SP, Haines F, Johns H, Clifford D, Nunez A, La Rocca SA, Parchariyanon S, Steinbach F, Drew T, Crooke H: Characterisation of experimental infections of domestic pigs with genotype 2.1 and 3.3 isolates of classical swine fever virus. Vet Microbiol. 2010, 142 (1\u20132): 26-33. 10.1016\/j.vetmic.2009.09.039.","journal-title":"Vet Microbiol"},{"issue":"1\u20132","key":"281_CR31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.vetmic.2009.09.040","volume":"142","author":"SP Graham","year":"2010","unstructured":"Graham SP, Everett HE, Johns HL, Haines FJ, La Rocca SA, Khatri M, Wright IK, Drew T, Crooke HR: Characterisation of virus-specific peripheral blood cell cytokine responses following vaccination or infection with classical swine fever viruses. Vet Microbiol. 2010, 142 (1\u20132): 34-40. 10.1016\/j.vetmic.2009.09.040.","journal-title":"Vet Microbiol"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12917-014-0281-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-014-0281-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-014-0281-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-014-0281-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:53:25Z","timestamp":1630565605000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-014-0281-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["281"],"URL":"https:\/\/doi.org\/10.1186\/s12917-014-0281-9","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"24 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"281"}}