{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:29:00Z","timestamp":1789946940554,"version":"4.0.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"crossref","award":["C2013204130"],"award-info":[{"award-number":["C2013204130"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Healthcare program of Chinese PLA","award":["11BJ227"],"award-info":[{"award-number":["11BJ227"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12917-016-0655-2","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T09:25:26Z","timestamp":1456305926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure"],"prefix":"10.1186","volume":"12","author":[{"given":"Wenyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexia","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"655_CR1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1469-0691.2009.03109.x","volume":"16","author":"F Allerberger","year":"2010","unstructured":"Allerberger F, Wagner M. Listeriosis: a resurgent foodborne infection. Clin Microbiol Infect. 2010;16:16\u201323.","journal-title":"Clin Microbiol Infect"},{"key":"655_CR2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrmicro1413","volume":"4","author":"M Hamon","year":"2006","unstructured":"Hamon M, Bierne H, Cossart P. Listeria monocytogenes: a multifaceted model. Nat Rev Microbiol. 2006;4:423\u201334.","journal-title":"Nat Rev Microbiol"},{"key":"655_CR3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1365-2672.2004.02183.x","volume":"96","author":"KB Gudmundsdottir","year":"2004","unstructured":"Gudmundsdottir KB, Aalbaek B, Sigurdarson S, Gunnarsson E. The diversity of Listeria monocytogenes strains from 10 Icelandic sheep farms. J Appl Microbiol. 2004;96:913\u201321.","journal-title":"J Appl Microbiol"},{"key":"655_CR4","first-page":"173","volume":"337","author":"SB Barbuddhe","year":"2009","unstructured":"Barbuddhe SB, Chakraborty T. Listeria as an enteroinvasive gastrointestinal pathogen. Curr Top Microbiol Immunol. 2009;337:173\u201395.","journal-title":"Curr Top Microbiol Immunol"},{"key":"655_CR5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2958.2002.03176.x","volume":"46","author":"MA Lety","year":"2002","unstructured":"Lety MA, Frehel C, Berche P, Charbit A. Critical role of the N-terminal residues of listeriolysin O in phagosomal escape and virulence of Listeria monocytogenes. Mol Microbiol. 2002;46:367\u201379.","journal-title":"Mol Microbiol"},{"key":"655_CR6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","volume":"21","author":"K Takeda","year":"2003","unstructured":"Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335\u201376.","journal-title":"Annu Rev Immunol"},{"key":"655_CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-immunol-032712-095944","volume":"31","author":"J Moltke Von","year":"2013","unstructured":"Von Moltke J, Ayres JS, Kofoed EM, Chavarr\u00eda-Smith J, Vance RE. Recognition of bacteria by inflammasomes. Annu Rev Immunol. 2013;31:73\u2013106.","journal-title":"Annu Rev Immunol"},{"key":"655_CR8","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/ncomms2608","volume":"4","author":"Z Zhong","year":"2013","unstructured":"Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala F, et al. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun. 2013;4:1611.","journal-title":"Nat Commun"},{"key":"655_CR9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","volume":"39","author":"SS Iyer","year":"2013","unstructured":"Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013;39:311\u201323.","journal-title":"Immunity"},{"key":"655_CR10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","volume":"13","author":"E Latz","year":"2013","unstructured":"Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13:397\u2013411.","journal-title":"Nat Rev Immunol"},{"key":"655_CR11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ni.1864","volume":"11","author":"VA Rathinam","year":"2010","unstructured":"Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010;11:395\u2013402.","journal-title":"Nat Immunol"},{"key":"655_CR12","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","volume":"11","author":"EA Miao","year":"2010","unstructured":"Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol. 2010;11:1136\u201342.","journal-title":"Nat Immunol"},{"key":"655_CR13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0928-8244(02)00449-2","volume":"35","author":"M Abram","year":"2003","unstructured":"Abram M, Schluter D, Vuckovic D, Wraber B, Doric M, Deckert M. Murine model of pregnancy-associated Listeria monocytogenes infection. FEMS Immunol Med Microbiol. 2003;35:177\u201382.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"655_CR14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.reprotox.2008.07.007","volume":"26","author":"EA Irvin","year":"2008","unstructured":"Irvin EA, Williams D, Voss KA, Smith MA. Listeria monocytogenes infection in pregnant guinea pigs is associated with maternal liver necrosis, a decrease in maternal serum TNF-alpha concentrations, and an increase in placental apoptosis. Reprod Toxicol. 2008;26:123\u20139.","journal-title":"Reprod Toxicol"},{"key":"655_CR15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/1933719109349962","volume":"17","author":"T Nagamatsu","year":"2010","unstructured":"Nagamatsu T, Schust DJ. Review: The Immunomodulatory Roles of Macrophages at the Maternal-Fetal Interface. Reprod Sci. 2010;17:209\u201318.","journal-title":"Reprod Sci"},{"key":"655_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1447-0756.2008.00963.x","volume":"35","author":"K Koga","year":"2009","unstructured":"Koga K, Aldo PB, Mor G. Toll-like receptors and pregnancy: trophoblast as modulators of the immune response. J Obstet Gynaecol Res. 2009;35:191\u2013202.","journal-title":"J Obstet Gynaecol Res"},{"key":"655_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0897.2006.00446.x","volume":"57","author":"S Fest","year":"2007","unstructured":"Fest S, Aldo PB, Abrahams VM, Visintin I, Alvero A, Chen R, et al. Trophoblast- macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol. 2007;57:55\u201366.","journal-title":"Am J Reprod Immunol"},{"key":"655_CR18","first-page":"149","volume":"122","author":"G Mor","year":"2006","unstructured":"Mor G, Straszewski-Chavez SL, Abrahams VM. Macrophage-trophoblast interactions. Methods Mol Med. 2006;122:149\u201363.","journal-title":"Methods Mol Med"},{"key":"655_CR19","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.4049\/jimmunol.181.3.2028","volume":"181","author":"S Machata","year":"2008","unstructured":"Machata S, Tchatalbachev S, Mohamed W, Jansch L, Hain T, Chakraborty T. Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation. J Immunol. 2008;181:2028\u201335.","journal-title":"J Immunol"},{"key":"655_CR20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","volume":"410","author":"F Hayashi","year":"2001","unstructured":"Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410:1099\u2013103.","journal-title":"Nature"},{"key":"655_CR21","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4049\/jimmunol.0901346","volume":"184","author":"K Meixenberger","year":"2010","unstructured":"Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, et al. Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3. J Immunol. 2010;184:922\u201330.","journal-title":"J Immunol"},{"key":"655_CR22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-010-9425-2","volume":"30","author":"J Wu","year":"2010","unstructured":"Wu J, Fernandes-Alnemri T, Alnemri ES. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J Clin Immunol. 2010;30:693\u2013702.","journal-title":"J Clin Immunol"},{"key":"655_CR23","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/eji.201040425","volume":"40","author":"S Kim","year":"2010","unstructured":"Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, et al. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol. 2010;40:1545\u201351.","journal-title":"Eur J Immunol"},{"key":"655_CR24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/emboj.2012.274","volume":"31","author":"Z Abdullah","year":"2012","unstructured":"Abdullah Z, Schlee M, Roth S, Mraheil MA, Barchet W, B\u00f6ttcher J, et al. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO Journal. 2012;31:153\u201364.","journal-title":"EMBO Journal"},{"key":"655_CR25","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1128\/IAI.01143-09","volume":"78","author":"SR Dewamitta","year":"2010","unstructured":"Dewamitta SR, Nomura T, Kawamura I, Hara H, Tsuchiya K, Kurenuma T, et al. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes. Infect Immun. 2010;78:1884\u201394.","journal-title":"Infect Immun"},{"key":"655_CR26","first-page":"431","volume":"12","author":"RK Sharma","year":"1998","unstructured":"Sharma RK. Mouse trophoblastic cell lines: I--Relationship between invasive potential and TGF-beta 1. In Vivo. 1998;12:431\u201340.","journal-title":"In Vivo"},{"key":"655_CR27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","volume":"9","author":"V Hornung","year":"2008","unstructured":"Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008;9:847\u201356.","journal-title":"Nat Immunol"},{"key":"655_CR28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","volume":"464","author":"P Duewell","year":"2010","unstructured":"Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464:1357\u201361.","journal-title":"Nature"},{"key":"655_CR29","first-page":"19688","volume":"283","author":"N Nabavi","year":"2008","unstructured":"Nabavi N, Urukova Y, Cardelli M, Aubin JE, Harrison RE. Lysosome dispersion in osteoblasts accommodates enhanced collagen production during differentiation. J Biol Chem. 2008;283:19688\u201390.","journal-title":"J Biol Chem."},{"key":"655_CR30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10753-013-9759-z","volume":"37","author":"X Li","year":"2014","unstructured":"Li X, Zhong F. Nickel induces interleukin-1\u03b2 secretion via the NLRP3-ASC-caspase-1 pathway. Inflammation. 2014;37:457\u201366.","journal-title":"Inflammation."},{"key":"655_CR31","doi-asserted-by":"crossref","first-page":"e25046","DOI":"10.1371\/journal.pone.0025046","volume":"6","author":"M Tachibana","year":"2011","unstructured":"Tachibana M, Hashino M, Nishida T, Shimizu T, Watarai M. Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion. PloS One. 2011;6:e25046.","journal-title":"PloS One."},{"key":"655_CR32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000074300","volume":"134","author":"G Chaouat","year":"2004","unstructured":"Chaouat G, Ledee-Bataitle N, Dubanchet S, Zourbas S, Sandra O, Martal J. THI\/TH2 paradigm in pregnancy: paradigm lost? Cytokines in pregnantcy\/early abortion: reexamining the THI\/TH2 paradigm. Int Arch Allergy Immunol. 2004;134:93\u2013119.","journal-title":"Int Arch Allergy Immunol."},{"key":"655_CR33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/10647440500147885","volume":"13","author":"K Deb","year":"2005","unstructured":"Deb K, Chaturvedi MM, Jaiswal YK. Gram-negative bacterial LPS induced poor uterine receptivity and implantation failure in mouse: alterations in IL-1beta expression in the preimplantation embryo and uterine horns. Infect Dis Obstet Gynecol. 2005;13:125\u201333.","journal-title":"Infect Dis Obstet Gynecol."},{"key":"655_CR34","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S1995-7645(13)60178-9","volume":"6","author":"F Hua","year":"2013","unstructured":"Hua F, Li CH, Wang H, Xu HG. Relationship between expression of COX-2, TNF-\u03b1, IL-6 and autoimmune-type recurrent miscarriage. Asian Pac J Trop Med. 2013;6:990\u20134.","journal-title":"Asian Pac J Trop Med."},{"key":"655_CR35","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1210\/en.2003-0063","volume":"144","author":"B Madhappan","year":"2003","unstructured":"Madhappan B, Kempuraj D, Christodoulou S, Tsapikidis S, Boucher W, Karagiannis V, et al. High levels of intra-uterine corticotropin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions. Endocrinology. 2003;144:2285\u201390.","journal-title":"Endocrinology."},{"key":"655_CR36","doi-asserted-by":"crossref","first-page":"679","DOI":"10.4049\/jimmunol.156.2.679","volume":"156","author":"HW Rogers","year":"1996","unstructured":"Rogers HW, Callery MP, Deck B, Unanue ER. Listeria monocytogenes induces apoptosis of infected hepatocytes. J Immunol. 1996;156:679\u201384.","journal-title":"J Immunol."},{"key":"655_CR37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reprotox.2014.01.005","volume":"45","author":"W Li","year":"2014","unstructured":"Li W, Han D, Liang S, Zhong Z, Li X, Wen J, et al. Molecular mechanism for the effects of E. coli heat-labile enterotoxin on mouse embryo survival. Reprod Toxicol. 2014;45:31\u20138.","journal-title":"Reprod Toxicol"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-016-0655-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:32:22Z","timestamp":1692232342000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1746-6148\/12\/36"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,24]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["655"],"URL":"https:\/\/doi.org\/10.1186\/s12917-016-0655-2","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,24]]},"article-number":"36"}}