{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:24:22Z","timestamp":1793874262230,"version":"4.6.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Swiss Bernese Mountain Dog Club"},{"name":"Swiss Army \u2013 Logistic Base of the Army \u2013 Centre of Competence Veterinary Service and Army Animals"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12917-016-0782-9","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T09:40:06Z","timestamp":1469439606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Life expectancy and causes of death in Bernese mountain dogs in Switzerland"],"prefix":"10.1186","volume":"12","author":[{"given":"Michael","family":"Klopfenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menga","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Geissb\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"782_CR1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0167-5877(03)00010-2","volume":"58","author":"HF Proschowsky","year":"2003","unstructured":"Proschowsky HF, Rugbjerg H, Ersb\u00f8ll AK. Mortality of purebred and mixed-breed dogs in Denmark. Prev Vet Med. 2003;58:63\u201374.","journal-title":"Prev Vet Med"},{"key":"782_CR2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/vr.b4808","volume":"166","author":"LB Br\u00f8nden","year":"2010","unstructured":"Br\u00f8nden LB, Nielsen SS, Toft N, Kristensen AT. Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark. Vet Rec. 2010;166:586\u201390.","journal-title":"Vet Rec"},{"issue":"25","key":"782_CR3","first-page":"187","volume":"2011","author":"Fleming JM, Creevy KE, Promislow DEL: Mortality in North American dogs from 1984 to","year":"2004","unstructured":"Fleming JM, Creevy KE, Promislow DEL: Mortality in North American dogs from 1984 to. An Investigation into age-, size-, and breed-related causes of death. J Vet Intern Med. 2004;2011(25):187\u201398.","journal-title":"J Vet Intern Med"},{"key":"782_CR4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.tvjl.2013.09.062","volume":"198","author":"S Erich","year":"2013","unstructured":"Erich S, Rutteman G, Teske E. Causes of death and the impact of histiocytic sarcoma on the life expectancy of the Dutch population of Bernese mountain dogs and flat-coated retrievers. Vet J. 2013;198:678\u201383.","journal-title":"Vet J"},{"key":"782_CR5","unstructured":"Eichelberg H, Seine R. Lebenserwartung und Todesursachen bei Hunden I. Zur Situation bei Mischlingen und verschiedenen Rassehunden. Berliner und M\u00fcnchner Tier\u00e4rtzliche Wochenschrift. 1996;109:292\u2013303."},{"key":"782_CR6","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/vr.145.22.625","volume":"145","author":"AR Michell","year":"1999","unstructured":"Michell AR. Longevity of British breeds of dog and its relationships with sex, size, cardiovascular variables and disease. Vet Rec. 1999;145:625\u201330.","journal-title":"Vet Rec"},{"key":"782_CR7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/vr.b4756","volume":"166","author":"L Nielsen","year":"2010","unstructured":"Nielsen L, Andreasen SN, Andersen SD, Kristensen AT. Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. Vet Rec. 2010;166:199\u2013202.","journal-title":"Vet Rec"},{"issue":"3","key":"782_CR8","doi-asserted-by":"crossref","first-page":"B171","DOI":"10.1093\/gerona\/52A.3.B171","volume":"52A","author":"GJ Patronek","year":"1997","unstructured":"Patronek GJ, Waters DJ, Glickman LT. Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol. 1997;52A(3):B171\u20138.","journal-title":"J Gerontol"},{"key":"782_CR9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.rvsc.2006.06.005","volume":"82","author":"KA Greer","year":"2007","unstructured":"Greer KA, Canterberry SC, Murphy KE. Statistical analysis regarding the effects of height and weight on life span of the domestic dog. Res Vet Sci. 2007;82:208\u201314.","journal-title":"Res Vet Sci"},{"key":"782_CR10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tvjl.2013.09.020","volume":"198","author":"DG O\u2019Neill","year":"2013","unstructured":"O\u2019Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Longevity and mortality of owned dogs in England. Vet J. 2013;198:638\u201343.","journal-title":"Vet J"},{"key":"782_CR11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1354\/vp.39-1-74","volume":"39","author":"VK Affolter","year":"2002","unstructured":"Affolter VK, Moore PF. Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. Vet Pathol. 2002;39:74\u201383.","journal-title":"Vet Pathol"},{"issue":"1","key":"782_CR12","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/jhered\/esp039","volume":"100","author":"J Abadie","year":"2009","unstructured":"Abadie J, H\u00e9dan B, Cadieu E, De Brito C, Devauchelle P, Bourgain C, Parker HG, Vaysse A, Margaritte-Jeannin P, Galibert F, Ostrander E, Andr\u00e9 C. Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered. 2009;100(1):S19\u201327.","journal-title":"J Hered"},{"key":"782_CR13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1748-5827.1995.tb02838.x","volume":"36","author":"G Padgett","year":"1995","unstructured":"Padgett G, Madewell BR, Keller ET, Jodar L, Packard M. Inheritance of histiocytosis in Bernese mountain dogs. J Small Anim Pract. 1995;36:93\u20138.","journal-title":"J Small Anim Pract"},{"key":"782_CR14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1024\/0036-7281.148.6.281","volume":"148","author":"E Voegeli","year":"2006","unstructured":"Voegeli E, Welle M, Hauser B, Dolf G, Fl\u00fcckiger M. Das histiozyt\u00e4re Sarkom beim Berner Sennenhund in der Schweiz: Eine retrospektive Studie \u00fcber seine genetische Pr\u00e4disposition. Schweizerisches Arch f\u00fcr Tierheilkd. 2006;148:281\u20138.","journal-title":"Schweizerisches Arch f\u00fcr Tierheilkd"},{"key":"782_CR15","unstructured":"Verordnung des BLV \u00fcber den Tierschutz beim Z\u00fcchten. In Swiss Fed Food Saf Vet Off; 2014:1\u201311. https:\/\/www.admin.ch\/opc\/search\/?lang=de&language%5B%5D=de&product%5B%5D=oc&text=Tierschutz+beim+Z%C3%BCchten&lang=de ."},{"key":"782_CR16","first-page":"1","volume":"23","author":"M Rossetti","year":"2011","unstructured":"Rossetti M, Doherr M, Geissb\u00fchler U. Morbidity and mortality in Bernese mountain dogs with pedigree born in Switzerland in 2001 and 2002. Dr Diss Univ Berne. 2011;23:1\u201346.","journal-title":"Dr Diss Univ Berne"},{"key":"782_CR17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/cc2955","volume":"8","author":"V Bewick","year":"2004","unstructured":"Bewick V, Cheek L, Ball J. Statistics review 12: survival analysis. Crit Care. 2004;8:389\u201394.","journal-title":"Crit Care"},{"key":"782_CR18","first-page":"283","volume":"18","author":"WP Berdal","year":"1994","unstructured":"Berdal WP, Moe L, Glattre E. Demographic characteristics of Bernese mountain dogs in Norway. Kenya Vet. 1994;18:283.","journal-title":"Kenya Vet"},{"key":"782_CR19","unstructured":"Report from the Kennel Club \/ British Small Animal Veterinary Association Scientific Committee: summary results of the purebred dog health survey for Bernese mountain dogs [http:\/\/www.thekennelclub.org.uk\/vets-researchers\/purebred-dog-health-survey-results\/]"},{"issue":"1","key":"782_CR20","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jcpa.2009.10.008","volume":"142","author":"BN Bonnett","year":"2010","unstructured":"Bonnett BN, Egenvall A. Age Patterns of Disease and Death in Insured Swedish Dogs, Cats and Horses. J Comp Pathol. 2010;142(1):S33\u20138.","journal-title":"J Comp Pathol"},{"key":"782_CR21","unstructured":"Report from the Kennel Club \/ British Small Animal Veterinary Association Scientific Committee Summary results of the Purebred Dog Health Survey for all breeds [http:\/\/www.thekennelclub.org.uk\/vets-researchers\/purebred-dog-health-survey-results\/]"},{"key":"782_CR22","volume-title":"Untersuchungen zur H\u00e4ufigkeit und klinischem Erscheinungsbild des histiozyt\u00e4ren Sarkoms beim Berner Sennenhund unter besonderer Ber\u00fccksichtigung zytologischer Knochenmarkanalysen","author":"C Coenen","year":"2009","unstructured":"Coenen C. Untersuchungen zur H\u00e4ufigkeit und klinischem Erscheinungsbild des histiozyt\u00e4ren Sarkoms beim Berner Sennenhund unter besonderer Ber\u00fccksichtigung zytologischer Knochenmarkanalysen. Giessen: Justus-Liebig-Universit\u00e4t Giessen; 2009."},{"key":"782_CR23","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1939-1676.2008.0133.x","volume":"22","author":"DF Merlo","year":"2008","unstructured":"Merlo DF, Rossi L, Pellegrino C, Ceppi M, Cardellino U, Capurro C, Ratto A, Sambucco PL, Sestito V, Tanara G, Bocchini V. Cancer incidence in pet dogs: findings of the Animal Tumor Registry of Genoa, Italy. J Vet Intern Med. 2008;22:976\u201384.","journal-title":"J Vet Intern Med"},{"key":"782_CR24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/jvim.12317","volume":"28","author":"R Zeng","year":"2014","unstructured":"Zeng R, Coates JR, Johnson GC, Hansen L, Awano T, Kolicheski A, Ivansson E, Perloski M, Lindblad-Toh K, O\u2019Brien DP, Guo J, Katz ML, Johnson GS. Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy. J Vet Intern Med. 2014;28:515\u201321.","journal-title":"J Vet Intern Med"},{"key":"782_CR25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1177\/030098589403100403","volume":"31","author":"G Minkus","year":"1994","unstructured":"Minkus G, Breuer W, Wanke R, Reusch C, Leuterer G, Brem G, Hermanns W. Familial nephropathy in Bernese mountain dogs. Vet Pathol. 1994;31:421\u20138.","journal-title":"Vet Pathol"},{"key":"782_CR26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/vr.134.16.411","volume":"134","author":"C Reusch","year":"1994","unstructured":"Reusch C, Hoerauf A, Lechner J, Kirsch M, Leuterer G, Minkus G, Brem G. A new familial glomerulonephropathy in Bernese mountain dogs. Vet Rec. 1994;134:411\u20135.","journal-title":"Vet Rec"},{"key":"782_CR27","doi-asserted-by":"crossref","first-page":"B403","DOI":"10.1093\/gerona\/51A.6.B403","volume":"51A","author":"Y Li","year":"1996","unstructured":"Li Y, Deeb B, Pendergrass W, Wolf N. Cellular proliferative capacity and life span in small and large dogs. J Gerontol Ser A Biol Sci Med Sci. 1996;51A:B403\u20138.","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"key":"782_CR28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jez.b.21116","volume":"308B","author":"F Galis","year":"2007","unstructured":"Galis F, van der Sluijs I, Van Dooren TJM, Metz JAJ, Nussbaumer M. Do large dogs die young? J Exp Zool (Mol Dev Evol). 2007;308B:119\u201326.","journal-title":"J Exp Zool (Mol Dev Evol)"},{"key":"782_CR29","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/669665","volume":"181","author":"C Kraus","year":"2013","unstructured":"Kraus C, Pavard S, Promislow DEL. The size\u2013life Span trade-off decomposed: Why large dogs die young. Am Nat. 2013;181:492\u2013505.","journal-title":"Am Nat"},{"key":"782_CR30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12917-015-0544-0","volume":"11","author":"FC Hostettler","year":"2015","unstructured":"Hostettler FC, Wiener DJ, Welle MM, Posthaus H, Geissb\u00fchler U. Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven Bernese mountain dogs with histiocytic sarcoma. BMC Vet Res. 2015;11:229.","journal-title":"BMC Vet Res"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-016-0782-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T15:06:37Z","timestamp":1498316797000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-016-0782-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["782"],"URL":"https:\/\/doi.org\/10.1186\/s12917-016-0782-9","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]},"article-number":"153"}}