{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:22:49Z","timestamp":1791325369013,"version":"4.3.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["USDA 2013-41480-21001"],"award-info":[{"award-number":["USDA 2013-41480-21001"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Certara, Inc."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12917-016-0884-4","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T12:03:27Z","timestamp":1479470607000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach"],"prefix":"10.1186","volume":"12","author":[{"given":"Zhoumeng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cuneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan D.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Tell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayna","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim E.","family":"Riviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-201X","authenticated-orcid":false,"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"884_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9781118872819","volume-title":"Strategies for reducing drug and chemical residues in food animals: international approaches to residue avoidance, management, and testing","author":"RE Baynes","year":"2014","unstructured":"Baynes RE, Riviere JE. Strategies for reducing drug and chemical residues in food animals: international approaches to residue avoidance, management, and testing. Hoboken: John Wiley & Sons, Inc; 2014. p. 1\u2013334."},{"key":"884_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.fct.2015.12.020","volume":"88","author":"RE Baynes","year":"2016","unstructured":"Baynes RE, Dedonder K, Kissell L, Mzyk D, Marmulak T, Smith G, Tell L, Gehring R, Davis J, Riviere JE. Health concerns and management of select veterinary drug residues. Food Chem Toxicol. 2016;88:112\u201322.","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"884_CR3","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1365-2885.2010.01261.x","volume":"34","author":"KA Clothier","year":"2011","unstructured":"Clothier KA, Leavens T, Griffith RW, Wetzlich SE, Baynes RE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus). J Vet Pharmacol Ther. 2011;34(5):448\u201354.","journal-title":"J Vet Pharmacol Ther"},{"issue":"5","key":"884_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1365-2885.2010.01178.x","volume":"33","author":"KA Clothier","year":"2010","unstructured":"Clothier KA, Jordan DM, Loynachan AT, Griffith RW. Safety evaluation of tulathromycin use in the caprine species: tulathromycin toxicity assessment in goats. J Vet Pharmacol Ther. 2010;33(5):499\u2013502.","journal-title":"J Vet Pharmacol Ther"},{"issue":"5","key":"884_CR5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/jvp.12311","volume":"39","author":"Z Lin","year":"2016","unstructured":"Lin Z, Gehring R, Mochel JP, Lav\u00e9 T, Riviere JE. Mathematical modeling and simulation in animal health. Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment. J Vet Pharmacol Ther. 2016;39(5):421\u201338.","journal-title":"J Vet Pharmacol Ther"},{"issue":"3","key":"884_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/jvp.12278","volume":"39","author":"JE Riviere","year":"2015","unstructured":"Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical modeling and simulation in animal health. Part I: moving beyond pharmacokinetics. J Vet Pharmacol Ther. 2015;39(3):213\u201323.","journal-title":"J Vet Pharmacol Ther"},{"key":"884_CR7","doi-asserted-by":"publisher","first-page":"27907","DOI":"10.1038\/srep27907","volume":"6","author":"Z Lin","year":"2016","unstructured":"Lin Z, Vahl CI, Riviere JE. Human food safety implications of variation in food animal drug metabolism. Sci Rep. 2016;6:27907.","journal-title":"Sci Rep"},{"issue":"3","key":"884_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.rvsc.2010.06.025","volume":"90","author":"G Young","year":"2011","unstructured":"Young G, Smith GW, Leavens TL, Wetzlich SE, Baynes RE, Mason SE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats. Res Vet Sci. 2011;90(3):477\u20139.","journal-title":"Res Vet Sci"},{"issue":"10","key":"884_CR9","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.2460\/ajvr.73.10.1634","volume":"73","author":"J Romanet","year":"2012","unstructured":"Romanet J, Smith GW, Leavens TL, Baynes RE, Wetzlich SE, Riviere JE, Tell LA. Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats. Am J Vet Res. 2012;73(10):1634\u201340.","journal-title":"Am J Vet Res"},{"issue":"2","key":"884_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2885.2011.01304.x","volume":"35","author":"TL Leavens","year":"2012","unstructured":"Leavens TL, Tell LA, Clothier KA, Griffith RW, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats. J Vet Pharmacol Ther. 2012;35(2):121\u201331.","journal-title":"J Vet Pharmacol Ther"},{"issue":"7","key":"884_CR11","doi-asserted-by":"publisher","first-page":"424","DOI":"10.5455\/vetworld.2012.424-428","volume":"5","author":"K Abo-EI-Sooud","year":"2012","unstructured":"Abo-EI-Sooud K, Afifi NA, Abd-EI-Aty AM. Pharmacokinetics and bioavailability of tulathromycin following intravenous, intramuscular and subcutaneous administrations in healthy rabbits. Vet World. 2012;5(7):424\u20138.","journal-title":"Vet World"},{"issue":"2","key":"884_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/jvp.12071","volume":"37","author":"B Grismer","year":"2014","unstructured":"Grismer B, Rowe JD, Carlson J, Wetzlich SE, Tell LA. Pharmacokinetics of tulathromycin in plasma and milk samples after a single subcutaneous injection in lactating goats (Capra hircus). J Vet Pharmacol Ther. 2014;37(2):205\u20138.","journal-title":"J Vet Pharmacol Ther"},{"issue":"8","key":"884_CR13","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1021\/jf0351624","volume":"52","author":"D Galer","year":"2004","unstructured":"Galer D, Hessong S, Beato B, Risk J, Inskeep P, Weerasinghe C, Schneider RP, Langer C, LaPerle J, Renouf D, et al. An analytical method for the analysis of tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung. J Agric Food Chem. 2004;52(8):2179\u201391.","journal-title":"J Agric Food Chem"},{"issue":"26","key":"884_CR14","doi-asserted-by":"publisher","first-page":"7555","DOI":"10.1021\/jf034880n","volume":"51","author":"PL Boner","year":"2003","unstructured":"Boner PL, Liu DD, Feely WF, Robinson RA, Wu J. Determination of flunixin in edible bovine tissues using liquid chromatography coupled with tandem mass spectrometry. J Agric Food Chem. 2003;51(26):7555\u20139.","journal-title":"J Agric Food Chem"},{"issue":"4","key":"884_CR15","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1002\/jps.24341","volume":"104","author":"M Li","year":"2015","unstructured":"Li M, Gehring R, Lin Z, Riviere J. A framework for meta-analysis of veterinary drug pharmacokinetic data using mixed effect modeling. J Pharm Sci. 2015;104(4):1230\u20139.","journal-title":"J Pharm Sci"},{"issue":"5","key":"884_CR16","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/BF01061728","volume":"5","author":"LB Sheiner","year":"1977","unstructured":"Sheiner LB, Rosenberg B, Marathe VV. Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. J Pharmacokinet Biopharm. 1977;5(5):445\u201379.","journal-title":"J Pharmacokinet Biopharm"},{"issue":"1","key":"884_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.taap.2013.08.010","volume":"273","author":"Z Lin","year":"2013","unstructured":"Lin Z, Fisher JW, Wang R, Ross MK, Filipov NM. Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling. Toxicol Appl Pharmacol. 2013;273(1):140\u201358.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"884_CR18","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1080\/19440049.2014.938363","volume":"31","author":"TL Leavens","year":"2014","unstructured":"Leavens TL, Tell LA, Kissell LW, Smith GW, Smith DJ, Wagner SA, Shelver WL, Wu H, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(9):1506\u201321.","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess"},{"issue":"19","key":"884_CR19","doi-asserted-by":"publisher","first-page":"8844","DOI":"10.1021\/jf801747u","volume":"56","author":"PA Martos","year":"2008","unstructured":"Martos PA, Lehotay SJ, Shurmer B. Ultratrace analysis of nine macrolides, including tulathromycin A (Draxxin), in edible animal tissues with minicolumn liquid chromatography tandem mass spectrometry. J Agric Food Chem. 2008;56(19):8844\u201350.","journal-title":"J Agric Food Chem"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-016-0884-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-016-0884-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-016-0884-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T23:53:40Z","timestamp":1692575620000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-016-0884-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["884"],"URL":"https:\/\/doi.org\/10.1186\/s12917-016-0884-4","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,18]]},"assertion":[{"value":"30 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"258"}}