{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:26:43Z","timestamp":1790792803623,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["G049919"],"award-info":[{"award-number":["G049919"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12917-017-0986-7","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T13:31:01Z","timestamp":1488375061000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characteristics of extended-spectrum \u03b2-lactamase\u2013producing Escherichia coli isolated from fecal samples of piglets with diarrhea in central and southern Taiwan in 2015"],"prefix":"10.1186","volume":"13","author":[{"given":"Wan-Chen","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Sheng","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"986_CR1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2460\/javma.1986.188.10.1144","volume":"188","author":"LG Biehl","year":"1986","unstructured":"Biehl LG, Hoefling DC. Diagnosis, treatment, and prevention of diarrhea in 7-to 14-day-old pigs. J Am Vet Med Assoc. 1986;188:1144\u20136.","journal-title":"J Am Vet Med Assoc"},{"key":"986_CR2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.drup.2012.12.001","volume":"16","author":"SN Seiffert","year":"2013","unstructured":"Seiffert SN, Hilty M, Perreten V, Endimiani A. Extended-spectrum cephalosporin-resistant gram-negative organisms in livestock; an emerging problem for human health. Drug Resist Updat. 2013;16:22\u201345.","journal-title":"Drug Resist Updat"},{"key":"986_CR3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/CMR.00002-11","volume":"24","author":"BM Marshall","year":"2011","unstructured":"Marshall BM, Levy SB. Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev. 2011;24:718\u201333.","journal-title":"Clin Microbiol Rev"},{"key":"986_CR4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","volume":"54","author":"K Bush","year":"2010","unstructured":"Bush K, Jacoby GA. Updated functional classification of \u03b2-lactamases. Antimicrob Agents Chemother. 2010;54:969\u201376.","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl. 1","key":"986_CR5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1469-0691.2007.01854.x","volume":"14","author":"M Gniadkowski","year":"2008","unstructured":"Gniadkowski M. Evolution of extended-spectrum \u03b2-lactamase by mutation. Clin Microbiol Infect. 2008;14 Suppl 1:11\u201332.","journal-title":"Clin Microbiol Infect"},{"key":"986_CR6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","volume":"8","author":"JD Pitout","year":"2008","unstructured":"Pitout JD, Laupland KB. Extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8:159\u201366.","journal-title":"Lancet Infect Dis"},{"key":"986_CR7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1574-6976.2009.00198.x","volume":"34","author":"A Smet","year":"2010","unstructured":"Smet A, Martel A, Persoons D, Dewulf J, Heyndrickx M, Herman L, Haesebrouck F, Butaye P. Broad-spectrum \u03b2-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health. FEMS Microbiol Rev. 2010;34:295\u2013316.","journal-title":"FEMS Microbiol Rev"},{"key":"986_CR8","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1469-0691.2012.03850.x","volume":"18","author":"C Ewers","year":"2012","unstructured":"Ewers C, Bethe A, Semmler T, Guenther S, Wieler LH. Extended-spectrum \u03b2-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective. Clin Microbiol Infect. 2012;18:646\u201355.","journal-title":"Clin Microbiol Infect"},{"key":"986_CR9","unstructured":"Su Y, Yu CY, Tsai Y, Wang SH, Lee C, Chu C. Fluoroquinolone-resistant and extended-spectrum beta-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan. J Microbiol Immunol Infect. 2014. doi: 1016\/j.jmii.2014.1010.1003."},{"issue":"5","key":"986_CR10","first-page":"395","volume":"23","author":"HK Shieh","year":"1997","unstructured":"Shieh HK. The FMD, situiation in Taiwan. J Chin Soc Vet Sci. 1997;23(5):395\u2013402.","journal-title":"J Chin Soc Vet Sci"},{"key":"986_CR11","volume-title":"Performance standards for antimicrobial susceptibility testing: twenty-first informational supplement M100-21","author":"CLSI","year":"2011","unstructured":"CLSI. Performance standards for antimicrobial susceptibility testing: twenty-first informational supplement M100-21. Wayne, PA, USA: CLSI; 2011."},{"key":"986_CR12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.vetmic.2010.01.018","volume":"144","author":"BW Shaheen","year":"2010","unstructured":"Shaheen BW, Oyarzabal OA, Boothe DM. The role of class 1 and 2 integrons in mediating antimicrobial resistance among canine and feline clinical E. coli isolates from the US. Vet Microbiol. 2010;144:363\u201370.","journal-title":"Vet Microbiol"},{"key":"986_CR13","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1365-2958.2006.05172.x","volume":"60","author":"T Wirth","year":"2006","unstructured":"Wirth T, Falush D, Lan R, Colles F, Mensa P, Wieler LH, Karch H, Reeves PR, Maiden MCJ, Ochman H, et al. Sex and virulence in Escherichia coli: an evolutionary perspective. Mol Microbiol. 2006;60:1136\u201351.","journal-title":"Mol Microbiol"},{"key":"986_CR14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1472-765X.2010.02945.x","volume":"51","author":"R Saito","year":"2010","unstructured":"Saito R, Koyano S, Nagai R, Okamura N, Moriya K, JKoike K. Evaluation of a chromogenic agar medium for the detection of extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae. Lett Appl Microbiol. 2010;51:704\u20136.","journal-title":"Lett Appl Microbiol"},{"key":"986_CR15","first-page":"1103","volume":"6","author":"G Xu","year":"2015","unstructured":"Xu G, An W, Wang H, Zhang X. Prevalence and characteristics of extended-spectrum \u03b2-lactamase genes in Escherichia coli isolated from piglets with post-weaning diarrhea in Heilongjiang province, China. Front Microbiol. 2015;6:1103.","journal-title":"Front Microbiol"},{"key":"986_CR16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijantimicag.2011.12.001","volume":"39","author":"H Zheng","year":"2012","unstructured":"Zheng H, Zeng Z, Chen S, Liu Y, Yao Q, Deng Y, Chen X, Lv L, Zhuo C, Chen Z, et al. Prevalence and characterisation of CTX-M \u03b2-lactamases amongst Escherichia coli isolates from healthy food animals in China. Int J Antimicrob Agents. 2012;39:305\u201310.","journal-title":"Int J Antimicrob Agents"},{"key":"986_CR17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/lam.12043","volume":"56","author":"TR Whitehead","year":"2013","unstructured":"Whitehead TR, Cotta MA. Stored swine manure and swine faeces as reservoirs of antibiotic resistance genes. Lett Appl Microbiol. 2013;56:264\u20137.","journal-title":"Lett Appl Microbiol"},{"key":"986_CR18","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1128\/JCM.42.7.2902-2906.2004","volume":"42","author":"SH Jeong","year":"2004","unstructured":"Jeong SH, Bae IK, Lee JH, Sohn SG, Kang GH, Jeon GJ, Kim YH, Jeong BC, Lee SH. Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a korean nationwide survey. J Clin Microbiol. 2004;42:2902\u20136.","journal-title":"J Clin Microbiol"},{"key":"986_CR19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.diagmicrobio.2007.06.007","volume":"59","author":"EDV Romero","year":"2007","unstructured":"Romero EDV, Padilla TP, Hern\u00e1ndez AH, Grande RP, V\u00e1zquez MF, Garc\u00eda IG, Garc\u00eda-Rodr\u00edguez JA, Bellido JLM. Prevalence of clinical isolates of Escherichia coli and Klebsiella spp. producing multiple extended-spectrum \u03b2-lactamases. Diagn Microbiol Infect Dis. 2007;59:433\u20137.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"986_CR20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/jac\/dkq004","volume":"65","author":"C Ewers","year":"2010","unstructured":"Ewers C, Grobbel M, Stamm I, Kopp PA, Diehl I, Semmler T, Fruth A, Beutlich J, Guerra B, Wieler LH, et al. Emergence of human pandemic O25: H4-ST131 CTX-M-15 extended-spectrum- \u03b2-lactamase-producing Escherichia coli among companion animals. J Antimicrob Chemother. 2010;65:651\u201360.","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"986_CR21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5604\/01.3001.0009.2124","volume":"64","author":"M Rzewuska","year":"2015","unstructured":"Rzewuska M, Stefanska I, Kizerwetter-Swida M, Chrobak-Chmiel D, Szczygielska P, Lesniak M, Binek M. Characterization of extended-spectrum-\u03b2-lactamases produced by Escherichia coli strains isolated from dogs in Poland. Pol J Microbiol. 2015;64(3):285\u20138.","journal-title":"Pol J Microbiol"},{"issue":"1","key":"986_CR22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/1040841X.2012.691460","volume":"39","author":"WH Zhao","year":"2013","unstructured":"Zhao WH, Hu ZQ. Epidemiology and genetics of CTX-M extended-spectrum \u03b2-lactamases in Gram-negative bacteria. Crit Rev Microbiol. 2013;39(1):79\u2013101.","journal-title":"Crit Rev Microbiol"},{"key":"986_CR23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/AAC.48.1.1-14.2004","volume":"48","author":"R Bonnet","year":"2004","unstructured":"Bonnet R. Growing group of extended-spectrum betya-lactamases: the CTX-M enzymes. Antimicrob Agents Chemother. 2004;48:11\u20134.","journal-title":"Antimicrob Agents Chemother"},{"key":"986_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/fpd.2012.1245","volume":"10","author":"MD Tamang","year":"2013","unstructured":"Tamang MD, Nam HM, Kim SR, Chae MH, Jang GC, Jung SC, Lim SK. Prevalence and molecular characterization of CTX-M \u03b2-lactamase-producing Escherichia coli isolated from healthy swine and cattle. Foodborne Pathog Dis. 2013;10:13\u201320.","journal-title":"Foodborne Pathog Dis"},{"key":"986_CR25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.diagmicrobio.2007.02.005","volume":"58","author":"P Kiratisin","year":"2007","unstructured":"Kiratisin P, Apisarnthanarak A, Saifon P, Laesripa C, Kitphati R, Mundy LM. The emergence of a novel ceftazidime-resistant CTX-M extended-spectrum beta-lactamase, CTX-M-55, in both community-onset and hospital-acquired infections in Thailand. Diagn Microbiol Infect Dis. 2007;58:349\u201355.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"986_CR26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1186\/s12879-014-0659-0","volume":"14","author":"J Zhang","year":"2014","unstructured":"Zhang J, Zheng B, Zhao L, Wei Z, Ji J, Li L, Xiao Y. Nationwide high prevalence of CTX-M and an increase of CTX-M-55 in Escherichia coli isolated from patients with community-onset infections in Chinese county hospitals. BMC Infect Dis. 2014;14:659\u201369.","journal-title":"BMC Infect Dis"},{"key":"986_CR27","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1128\/AAC.00589-15","volume":"59","author":"E Riccobono","year":"2007","unstructured":"Riccobono E, Di Pilato V, Di Maggio T, Revollo C, Bartoloni A, Pallecchi L, Rossolini GM. Characterization of IncI1 sequence type 71 epidemic plasmid lineage responsible for the recent dissemination of CTX-M-65 extended-spectrum beta-lactamase in the Bolivian Chaco region. Antimicrob Agents Chemother. 2007;59:5340\u20137.","journal-title":"Antimicrob Agents Chemother"},{"key":"986_CR28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1746-6148-8-21","volume":"8","author":"N Geser","year":"2012","unstructured":"Geser N, Stephan R, H\u00e4chler H. Occurrence and characteristics of extended-spectrum \u03b2-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk. BMC Vet Res. 2012;8:21.","journal-title":"BMC Vet Res"},{"key":"986_CR29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mib.2014.05.017","volume":"19","author":"MD Barton","year":"2014","unstructured":"Barton MD. Impact of antibiotic use in the swine industry. Curr Opin Microbiol. 2014;19:9\u201315.","journal-title":"Curr Opin Microbiol"},{"key":"986_CR30","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1128\/AAC.00354-08","volume":"52","author":"LM Cavaco","year":"2008","unstructured":"Cavaco LM, Abatih E, Aarestrup FM, Guardabassi L. Selection and persistence of CTX-M-producing Escherichia coli in the intestinal flora of pigs treated with amoxicillin, ceftiofur, or cefquinome. Antimicrob Agents Chemother. 2008;52:3612\u20136.","journal-title":"Antimicrob Agents Chemother"},{"key":"986_CR31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/jac\/dks427","volume":"68","author":"Y Agers\u00f8","year":"2013","unstructured":"Agers\u00f8 Y, Aarestrup FM. Voluntary ban on cephalosporin use in Danish pig production has effectively reduced extended-spectrum cephalosporinase-producing Escherichia coli in slaughter pigs. J Antimicrob Chemother. 2013;68:569\u201372.","journal-title":"J Antimicrob Chemother"},{"key":"986_CR32","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1128\/AAC.44.10.2709-2714.2000","volume":"44","author":"V Leflon-Guibout","year":"2000","unstructured":"Leflon-Guibout V, Speldooren V, Heym B, Nicolas-Chanoine M-H. Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla TEM genes. Antimicrob Agents Chemother. 2000;44:2709\u201314.","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"986_CR33","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/AEM.03222-15","volume":"82","author":"PA Chen","year":"2016","unstructured":"Chen PA, Hung CH, Huang PC, Chen JR, Huang IF, Chen WL, Chiou YH, Hung WY, Wang JL, Cheng MF. Characteristics of CTX-M extended-spectrum \u03b2-lactamase-producing Escherichia coli strains isolated from multiple rivers in Southern Taiwan. Appl Environ Microbiol. 2016;82(6):1889\u201397.","journal-title":"Appl Environ Microbiol"},{"key":"986_CR34","doi-asserted-by":"crossref","first-page":"e0143326","DOI":"10.1371\/journal.pone.0143326","volume":"10","author":"C Dahms","year":"2015","unstructured":"Dahms C, H\u00fcbner N, Kossow A, Mellmann A, Dittmann K, Kramer A. Occurrence of ESBL-producing Escherichia coli in livestock and farm workers in Mecklenburg-Western Pomerania, Germany. PLoS One. 2015;10:e0143326.","journal-title":"PLoS One"},{"key":"986_CR35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.mimet.2005.03.018","volume":"63","author":"A Carattoli","year":"2005","unstructured":"Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods. 2005;63:219\u201328.","journal-title":"J Microbiol Methods"},{"key":"986_CR36","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/jac\/dkq347","volume":"65","author":"L Villa","year":"2010","unstructured":"Villa L, Garc\u00eda-Fern\u00e1ndez A, Fortini D, Carattoli A. Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants. J Antimicrob Chemother. 2010;65:2518\u201329.","journal-title":"J Antimicrob Chemother"},{"key":"986_CR37","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1073\/pnas.75.8.3737","volume":"75","author":"JG Stucliffe","year":"1978","unstructured":"Stucliffe JG. Nucleotide-sequence of ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A. 1978;75:3737\u201341.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"986_CR38","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1128\/JCM.43.9.4486-4491.2005","volume":"43","author":"JH Chia","year":"2005","unstructured":"Chia JH, Chu C, Su LH, Chiu CH, Kuo AJ, Sun CF, Wu TL. Development of a multiplex PCR and SHV melting-curve mutation detection system for detection of some SHV and CTX-M-lactamases of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae in Taiwan. J Clin Microbiol. 2005;43:4486\u201391.","journal-title":"J Clin Microbiol"},{"key":"986_CR39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jinf.2006.01.014","volume":"54","author":"Y Yu","year":"2007","unstructured":"Yu Y, Ji S, Chen Y, Zhou W, Wei Z, Li L, Ma Y. Resistance of strains producing extended-spectrum \u03b2-lactamases and genotype distribution in China. J Infect. 2007;54:53\u20137.","journal-title":"J Infect"},{"key":"986_CR40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","volume":"57","author":"N Woodford","year":"2006","unstructured":"Woodford N, fagan EJ, Ellington MJ. Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum \u03b2-lactamases. J Antimicrob Chemother. 2006;57:154\u20135.","journal-title":"J Antimicrob Chemother"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-017-0986-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T22:20:52Z","timestamp":1750026052000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-017-0986-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["986"],"URL":"https:\/\/doi.org\/10.1186\/s12917-017-0986-7","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"article-number":"66"}}