{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:11:30Z","timestamp":1767175890509,"version":"build-2238731810"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mast cell tumours are the most common cutaneous neoplasms in dogs. Other primary sites include visceral organs, such as the gastrointestinal tract, liver, or spleen\n                      <jats:bold>,<\/jats:bold>\n                      and the oral cavity. Frequent metastatic sites include the local lymph nodes, skin, spleen, liver and bone marrow. The thorax is rarely affected by metastatic disease and no such cases have been reported in dogs.\n                    <\/jats:p>\n                    <jats:p>Mast cell tumours are usually not considered as a differential diagnosis for lung and intrathoracic chest wall masses in dogs. Chest wall tumours can be primary tumours of the ribs and sternum, an invasion of adjacent tumours into the chest wall, and metastasis from distant tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases presentation<\/jats:title>\n                    <jats:p>A German Shepherd dog presented with a history of persistent cough and a large mass involving the thoracic wall and a small round pulmonary mass. The dog had a history of mammary tumours that were surgically excised. Thoracoscopy revealed a thoracic wall mass involving the internal intercostal muscle and a small mass in the left cranial lung lobe. Cytology and histopathology of the intrathoracic mass confirmed the large mass as a mast cell tumour and the small mass as a carcinoma. Cytology of the sternal lymph nodes showed no involvement. The dog received toceranib for 3\u2009months, which failed to alleviate persistent cough. Radiology indicated that the large mass had a partial response to toceranib. The dog was euthanasied.<\/jats:p>\n                    <jats:p>\n                      A Maltese dog presented with a history of chronic regurgitation and cough\n                      <jats:bold>,<\/jats:bold>\n                      and a large mass involving the left caudal lung lobe. Cytology and histopathology of mass confirmed a mast cell tumour. The dog received toceranib for 2\u2009months. Radiology indicated that the large mass had no response to toceranib. The dog was euthanasied. Confirmation of lungs mast cell tumour and the absence of any other Mast cell tumour was achieved by postmortem examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The cases discussed are two unusual presentations of intrathoracic mast cell tumours, in the absence of cutaneous mast cell tumours, in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12917-019-1950-5","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T09:07:11Z","timestamp":1560762431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Presumptive primary intrathoracic mast cell tumours in two dogs"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-9547","authenticated-orcid":false,"given":"Juan Carlos","family":"Cartagena-Albertus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoaneta","family":"Moise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Moya-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"C\u00e1mara-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Alberto","family":"Montoya-Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"1950_CR1","first-page":"361","volume":"17","author":"AP Davies","year":"1981","unstructured":"Davies AP, Hayden DW, Perman V. Noncutaneous systemic mastocytosis and mast cell leukemia in a dog: case report and literature review. J Am Anim Hosp Assoc. 1981;17:361\u20138.","journal-title":"J Am Anim Hosp Assoc"},{"key":"1950_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/vco.12071","volume":"14","author":"JW Elliott","year":"2016","unstructured":"Elliott JW, Cripps P, Blackwood L. Canine oral mucosal mast cell tumours. Vet Comp Oncol. 2016;14:101\u201311.","journal-title":"Vet Comp Oncol"},{"key":"1950_CR3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/B978-1-4377-2362-5.00020-7","volume-title":"Small Animal Clinical Oncology","author":"CA London","year":"2013","unstructured":"London CA, Thamm DH. Mast cell tumors. In: Withrow SJ, MacEwen EG, editors. Small Animal Clinical Oncology. 5th ed. Philadelphia: Saunders; 2013. p. 335\u201355.","edition":"5"},{"key":"1950_CR4","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2460\/javma.2000.216.222","volume":"216","author":"T Takahashi","year":"2000","unstructured":"Takahashi T, Kadosawa T, Nagase M, et al. Visceral mast cell tumors in dogs: 10 cases (1982-1997). J Am Vet Med Assoc. 2000;216:222\u20136.","journal-title":"J Am Vet Med Assoc"},{"key":"1950_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1365-3164.2008.00694.x","volume":"19","author":"MM Welle","year":"2008","unstructured":"Welle MM, Bley CR, Howard J. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol. 2008;19:321\u201339.","journal-title":"Vet Dermatol"},{"issue":"2","key":"1950_CR6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1292\/jvms.62.187","volume":"62","author":"Yoshiaki HIKASA","year":"2000","unstructured":"Hikasa Y, Morita T, Futaoka Y, et al. Connective tissue-type mast cell leukemia in a dog. J Vet Med Sci. 2000;62:187\u201390.","journal-title":"Journal of Veterinary Medical Science"},{"key":"1950_CR7","first-page":"453","volume-title":"Small Animal Clinical Oncology","author":"RB Rebhun","year":"2013","unstructured":"Rebhun RB, Culp WTN. Pulmonary neoplasia. In: Withrow SJ, MacEwen EG, editors. Small Animal Clinical Oncology. 5th ed. Philadelphia: Saunders; 2013. p. 453\u201362.","edition":"5"},{"key":"1950_CR8","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/j.1939-1676.2003.tb02433.x","volume":"17","author":"T Ishiguro","year":"2003","unstructured":"Ishiguro T, Kadosawa T, Takagi S, et al. Relationship of disease progression and plasma histamine concentrations in 11 dogs with mast cell tumors. J Vet Intern Med. 2003;17:194\u20138.","journal-title":"J Vet Intern Med"},{"key":"1950_CR9","first-page":"435","volume":"27","author":"MJ Pollack","year":"1991","unstructured":"Pollack MJ, Flanders JA, Johnson RC. Disseminated malignant mastocytoma in a dog. J Am Anim Hosp Assoc. 1991;27:435\u201340.","journal-title":"J Am Anim Hosp Assoc"},{"issue":"6","key":"1950_CR10","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1177\/030098587901600605","volume":"16","author":"J. R. Duncan","year":"1979","unstructured":"Duncan JR, Prasse KW. Cytology of canine cutaneous round cell tumors. Mast cell tumor, histiocytoma, lymphosarcoma and transmissible venereal tumor. Vet Pathol. 1979;16:673\u20139.","journal-title":"Veterinary Pathology"},{"issue":"6","key":"1950_CR11","first-page":"591","volume":"58","author":"O Campbell","year":"2017","unstructured":"Campbell O, de Lorimier LP, Beauregard G. Presumptive primary pulmonary mast cell tumor in 2 dogs. Can Vet J. 2017;58(6):591\u20136.","journal-title":"Can Vet J"},{"key":"1950_CR12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1740-8261.2011.01839.x","volume":"52","author":"AP Book","year":"2011","unstructured":"Book AP, Fidel J, Wills T. Correlation of ultrasound findings, liver and spleen cytology, and prognosis in the clinical staging of high metastatic risk canine mast cell tumors. Vet Radiol Ultrasound. 2011;52:548\u201354.","journal-title":"Vet Radiol Ultrasound"},{"key":"1950_CR13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2460\/javma.1999.215.03.355","volume":"215","author":"PM McManus","year":"1999","unstructured":"McManus PM. Frequency and severity of mastocytemia in dogs with and without mast cell tumors: 120 cases (1995-1997). J Am Vet Med Assoc. 1999;215:355\u20137.","journal-title":"J Am Vet Med Assoc"},{"key":"1950_CR14","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1740-8261.1998.tb01645.x","volume":"39","author":"DR Spann","year":"1998","unstructured":"Spann DR, Sellon RK, Thrall DE. Computed tomographic diagnosis: use of computed tomography to distinguish a pulmonary mass from alveolar disease. Vet Radiol Ultrasound. 1998;39:532\u20135.","journal-title":"Vet Radiol Ultrasound."},{"key":"1950_CR15","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1939-1676.1990.tb03116.x","volume":"4","author":"LE Fox","year":"1990","unstructured":"Fox LE, Rosenthal RC, Twedt DC. Plasma histamine and gastrin concentrations in 17 dogs with mast cell tumors. J Vet Intern Med. 1990;4:242\u20136.","journal-title":"J Vet Intern Med"}],"updated-by":[{"DOI":"10.1186\/s12917-021-02852-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000}}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-1950-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-019-1950-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-1950-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T17:11:36Z","timestamp":1721409096000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-019-1950-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1950"],"URL":"https:\/\/doi.org\/10.1186\/s12917-019-1950-5","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"20 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12917-021-02852-7","URL":"https:\/\/doi.org\/10.1186\/s12917-021-02852-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"\u2018Not applicable\u2019.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consents from the owners of the dogs were obtained for the publication of this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"204"}}