{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:51:05Z","timestamp":1784951465863,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12917-019-2052-0","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T14:03:07Z","timestamp":1567087387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of the efficacy of firocoxib (Previcox\u00ae) and grapiprant (Galliprant\u00ae) in an induced model of acute arthritis in dogs"],"prefix":"10.1186","volume":"15","author":[{"given":"Andrea Garc\u00eda","family":"de Salazar Alcal\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Gioda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Dehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-7821","authenticated-orcid":false,"given":"Frederic","family":"Beugnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"2052_CR1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1939-1676.2005.tb02741.x","volume":"19","author":"MS Bergh","year":"2005","unstructured":"Bergh MS, Budsberg SC. The coxib NSAIDs: potential clinical and pharmacological importance in veterinary medicine. J Vet Intern Med. 2005;19:633\u201343.","journal-title":"J Vet Intern Med"},{"issue":"2","key":"2052_CR2","first-page":"127","volume":"7","author":"PD Hanson","year":"2006","unstructured":"Hanson PD, Brooks KC, Case J, Conzemius M, Gordon W, Schuessler J, et al. Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions. Vet Ther. 2006;7(2):127\u201340.","journal-title":"Vet Ther"},{"issue":"6","key":"2052_CR3","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/jvp.12306","volume":"39","author":"LC Rausch-Derra","year":"2016","unstructured":"Rausch-Derra LC, Rhodes L, Freshwater L, Hawks R. Pharmacokinetic comparison of oral tablet and suspension formulations of grapiprant, a novel therapeutic for the pain and inflammation of osteoarthritis in dogs. J Vet Pharmacol Ther. 2016;39(6):566\u201371.","journal-title":"J Vet Pharmacol Ther"},{"issue":"1","key":"2052_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/jvim.12004","volume":"27","author":"DC Brown","year":"2013","unstructured":"Brown DC, Boston RC, Farrar JT. Comparison of force plate gait analysis and owner assessment of pain using the canine brief pain inventory in dogs with osteoarthritis. J Vet Intern Med. 2013;27(1):22\u201330.","journal-title":"J Vet Intern Med"},{"issue":"1","key":"2052_CR5","first-page":"10","volume":"15","author":"C Dauteloup","year":"2017","unstructured":"Dauteloup C, Pichou C, Beugnet F. Assessment of the efficacy of Firocoxib and Robenacoxib in an induced synovitis model of acute arthritis in dogs. Intern J Appl Res Vet Me. 2017;15(1):10\u20138.","journal-title":"Intern J Appl Res Vet Me"},{"issue":"8","key":"2052_CR6","doi-asserted-by":"publisher","first-page":"893","DOI":"10.2460\/ajvr.79.8.893","volume":"79","author":"KC Kennedy","year":"2018","unstructured":"Kennedy KC, Martinez SA, Martinez SE, Tucker RL, Davies NM. Effects of low-level laser therapy on bone healing and signs of pain in dogs following tibial plateau leveling osteotomy. Am J Vet Res. 2018;79(8):893\u2013904.","journal-title":"Am J Vet Res"},{"issue":"1","key":"2052_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.rvsc.2007.02.005","volume":"84","author":"HA Hazewinkel","year":"2008","unstructured":"Hazewinkel HA, van den Brom WE, Theyse LF, Pollmeier M, Hanson PD. Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. Res Vet Sci. 2008;84(1):74\u20139.","journal-title":"Res Vet Sci"},{"issue":"2","key":"2052_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/jvp.12348","volume":"40","author":"LR Borer","year":"2017","unstructured":"Borer LR, Seewald W, Peel JE, King JN. Evaluation of the dose-response relationship of oral robenacoxib in urate crystal-induced acute stifle synovitis in dogs. J Vet Pharmacol Ther. 2017;40(2):148\u201357.","journal-title":"J Vet Pharmacol Ther"},{"issue":"1","key":"2052_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1046\/j.1365-2885.2001.00304.x","volume":"24","author":"PL Toutain","year":"2001","unstructured":"Toutain PL, Cester CC, Haak T, Laroute V. A pharmacokinetic\/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a cox-2 selective nonsteroidal anti-inflammatory drug in the dog. J Vet Pharmacol Ther. 2001;24(1):43\u201355.","journal-title":"J Vet Pharmacol Ther"},{"issue":"4","key":"2052_CR10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2460\/ajvr.2004.65.503","volume":"65","author":"ME McCann","year":"2004","unstructured":"McCann ME, Andersen DR, Zhang D, Brideau C, Black WC, Hanson PD, et al. In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. Am J Vet Res. 2004;65(4):503\u201312.","journal-title":"Am J Vet Res"},{"issue":"1","key":"2052_CR11","first-page":"41","volume":"8","author":"M Drag","year":"2007","unstructured":"Drag M, Kunkle BN, Romano D, Hanson PD. Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. Vet Ther. 2007;8(1):41\u201350.","journal-title":"Vet Ther"},{"key":"2052_CR12","unstructured":"European Medicines Agency. Previcox: Summary of Product Characteristics. 2018. Available at: \n                    https:\/\/www.ema.europa.eu\/documents\/product-information\/previcox-epar-product-information_en.pdf\n                    \n                   Accessed 13 Jan 2019."},{"key":"2052_CR13","unstructured":"European Medicines Agency. Galliprant: Summary of Product Characteristics. 2018. Available at: \n                    https:\/\/www.ema.europa.eu\/documents\/product-information\/galliprant-epar-product-information_en.pdf\n                    \n                   Accessed 13 Jan 2019."},{"issue":"3","key":"2052_CR14","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/jvim.13948","volume":"30","author":"L Rausch-Derra","year":"2016","unstructured":"Rausch-Derra L, Huebner M, Wofford J, Rhodes L. A prospective, randomized, masked, placebo-controlled multisite clinical study of grapiprant, an EP4 prostaglandin receptor antagonist (PRA), in dogs with osteoarthritis. J Vet Intern Med. 2016;30(3):756\u201363.","journal-title":"J Vet Intern Med"},{"issue":"4","key":"2052_CR15","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1111\/vsu.12792","volume":"47","author":"AE Heffernan","year":"2018","unstructured":"Heffernan AE, Katz EM, Sun Y, Rendahl AK, Conzemius MG. Once daily oral extended-release hydrocodone as analgesia following tibial plateau leveling osteotomy in dogs. Vet Surg. 2018;47(4):516\u201323.","journal-title":"Vet Surg"},{"issue":"2","key":"2052_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2460\/javma.243.2.225","volume":"243","author":"Diana Davila","year":"2013","unstructured":"Davila D, Keeshen TP, Evans RB, Conzemius MG. Comparison of the analgesic efficacy of perioperative firocoxib and tramadol administration in dogs undergoing tibial plateau leveling osteotomy. J Am Vet Med Assoc. 201315;243(2):225\u201331.","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"17","key":"2052_CR17","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1136\/vr.159.17.547","volume":"159","author":"M Pollmeier","year":"2006","unstructured":"Pollmeier M, Toulemonde C, Fleishman C, Hanson PD. Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Vet Rec. 2006;159(17):547\u201351.","journal-title":"Vet Rec"},{"key":"2052_CR18","first-page":"114","volume":"8","author":"WG Ryan","year":"2010","unstructured":"Ryan WG, Carithers D, Moldave K, Bell M. Field comparison of canine NSAIDs firacoxib and deracoxib. Intern J Appl Res Vet Med. 2010;8:114\u201323.","journal-title":"Intern J Appl Res Vet Med"}],"updated-by":[{"DOI":"10.1186\/s12917-019-2116-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000}}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-2052-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-019-2052-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-2052-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T23:21:43Z","timestamp":1598570503000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-019-2052-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,29]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2052"],"URL":"https:\/\/doi.org\/10.1186\/s12917-019-2052-0","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s12917-019-2116-1","asserted-by":"object"}]},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,29]]},"assertion":[{"value":"11 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original article [1] contains two mistaken instances of the molecule \u2018fipronil\u2019 in the results. These should instead have stated \u2018firocoxib\u2019.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal housing and care complied with the recommendations of Directive 2010\/63\/EU. The animal facilities Avogadro LS, the study site, have the authorisation number D 31 188 01 obtained from the French Veterinary Authorities and the animal care and use program which approved the study protocol is AAALAC accredited. The study was favourably assessed by the Avogadro LS Animal Ethics Committee and authorized by Merial (now part of Boehringer-Ingelheim) Ethical Committee.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Frederic Beugnet is a salary of Boehringer-Ingelheim. Alia Dehman is working at Hyphen Stat, while all others are working at Avogadro LS, an independent Contract Research Organisation. Previcox is a product of Boehringer-Ingelheim.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"309"}}