{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:28:26Z","timestamp":1787376506324,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772686 and 31502025"],"award-info":[{"award-number":["31772686 and 31502025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Public Service Sectors Agriculture Research Projects of Ministry of Agriculture of China","award":["201403051-07"],"award-info":[{"award-number":["201403051-07"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12917-019-2071-x","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T13:05:24Z","timestamp":1567775124000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An enhanced expression of hypothalamic neuronal nitric oxide synthase in a rat model of simulated transport stress"],"prefix":"10.1186","volume":"15","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-3496","authenticated-orcid":false,"given":"Yunfei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"issue":"25","key":"2071_CR1","first-page":"6601","volume":"8","author":"NS Minka","year":"2010","unstructured":"Minka NS, Ayo JO. Physiological responses of food animals to road transportation stress. African J Biotechnol. 2010;8(25):6601\u201313.","journal-title":"African J Biotechnol"},{"issue":"Suppl 1","key":"2071_CR2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1023\/B:VERC.0000014211.87613.d9","volume":"27","author":"E Fazio","year":"2003","unstructured":"Fazio E, Ferlazzo A. Evaluation of stress during transport. Vet Res Commun. 2003;27(Suppl 1):519\u201324.","journal-title":"Vet Res Commun"},{"issue":"Suppl 1","key":"2071_CR3","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1023\/B:VERC.0000014210.29852.9a","volume":"27","author":"DM Broom","year":"2003","unstructured":"Broom DM. Causes of poor welfare in large animals during transport. Vet Res Commun. 2003;27(Suppl 1):515\u20138.","journal-title":"Vet Res Commun"},{"issue":"20","key":"2071_CR4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/vr.134.20.513","volume":"134","author":"PD Warriss","year":"1994","unstructured":"Warriss PD, Brown SN. A survey of mortality in slaughter pigs during transport and lairage. Vet Rec. 1994;134(20):513\u20135.","journal-title":"Vet Rec"},{"issue":"1\u20133","key":"2071_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.livsci.2009.06.014","volume":"126","author":"IT Kadim","year":"2009","unstructured":"Kadim IT, Mahgoub O, Al-Marzooqi W, Khalafa S, Al-Sinawib SSH, Al-Amrib IS. Effects of transportation during the hot season and low voltage electrical stimulation on histochemical and meat quality characteristics of sheep longissimus muscle. Livest Sci. 2009;126(1\u20133):154\u201361.","journal-title":"Livest Sci"},{"issue":"1","key":"2071_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.livsci.2006.10.013","volume":"107","author":"NS Minka","year":"2007","unstructured":"Minka NS, Ayo JO. Effects of loading behaviour and road transport stress on traumatic injuries in cattle transported by road during the hot-dry season. Livest Sci. 2007;107(1):91\u20135.","journal-title":"Livest Sci"},{"issue":"1","key":"2071_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1258\/0023677052886493","volume":"39","author":"J Swallow","year":"2005","unstructured":"Swallow J, Anderson D, Buckwell AC, Harris T, Hawkins P, Kirkwood J, Lomas M, Meacham S, Peters A, Prescott M, Owen S, Quest R, Sutcliffe R, Thompson K. Transport working group, laboratory animal science association (LASA). Guidance on the transport of laboratory animals. Lab Anim. 2005;39(1):1\u201339.","journal-title":"Lab Anim"},{"issue":"4","key":"2071_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jveb.2012.10.010","volume":"8","author":"E Fazio","year":"2013","unstructured":"Fazio E, Medica P, Cravana C, Ferlazzo A. Cortisol response to road transport stress in calm and nervous stallions. J Vet Behav. 2013;8(4):231\u20137.","journal-title":"J Vet Behav"},{"issue":"10","key":"2071_CR9","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/nn1003-1011","volume":"6","author":"EA Mayer","year":"2003","unstructured":"Mayer EA, Fanselow MS. Dissecting the components of the central response to stress. Nat Neurosci. 2003;6(10):1011\u20132.","journal-title":"Nat Neurosci"},{"issue":"1","key":"2071_CR10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ydbio.2004.01.024","volume":"269","author":"J Chen","year":"2004","unstructured":"Chen J, Tu Y, Moon C, Matarazzo V, Palmer AM, Ronnett GV. The localization of neuronal nitric oxide synthase may influence its role in neuronal precursor proliferation and synaptic maintenance. Dev Biol. 2004;269(1):165\u201382.","journal-title":"Dev Biol"},{"issue":"1","key":"2071_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.expneurol.2004.07.010","volume":"190","author":"X Jiang","year":"2004","unstructured":"Jiang X, Mu D, Manabat C, Koshy AA, Christen S, T\u00e4uber MG, Vexler ZS, Ferriero DM. Differential vulnerability of immature murine neurons to oxygen-glucose deprivation. Exp Neurol. 2004;190(1):224\u201332.","journal-title":"Exp Neurol"},{"issue":"6","key":"2071_CR12","doi-asserted-by":"publisher","first-page":"C1566","DOI":"10.1152\/ajpcell.00367.2007","volume":"294","author":"H Wang","year":"2008","unstructured":"Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PM, Ziolo MT. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. Am J Physiol Cell Physiol. 2008;294(6):C1566\u201375.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"26","key":"2071_CR13","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1016\/j.lfs.2003.10.037","volume":"74","author":"Z Yuan","year":"2004","unstructured":"Yuan Z, Liu B, Yuan L, Zhang Y, Dong X, Lu J. Evidence of nuclear localization of neuronal nitric oxide synthase in cultured astrocytes of rats. Life Sci. 2004;74(26):3199\u2013209.","journal-title":"Life Sci"},{"issue":"2","key":"2071_CR14","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1073\/pnas.87.2.682","volume":"87","author":"DS Bredt","year":"1990","unstructured":"Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A. 1990;87(2):682\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"2071_CR15","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.1073\/pnas.91.10.4214","volume":"91","author":"JL Dinerman","year":"1994","unstructured":"Dinerman JL, Dawson TM, Schell MJ, Snowman A, Snyder SH. Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc Natl Acad Sci U S A. 1994;91(10):4214\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2\u20133","key":"2071_CR16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.pbiomolbio.2003.11.015","volume":"84","author":"JE Stern","year":"2004","unstructured":"Stern JE. Nitric oxide and homeostatic control: an intercellular signalling molecule contributing to autonomic and neuroendocrine integration? Prog Biophys Mol Biol. 2004;84(2\u20133):197\u2013215.","journal-title":"Prog Biophys Mol Biol"},{"issue":"2","key":"2071_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.rvsc.2014.01.008","volume":"96","author":"C Wan","year":"2014","unstructured":"Wan C, Yin P, Xu X, Liu M, He S, Song S, Liu F, Xu J. Effect of simulated transport stress on the rat small intestine: a morphological and gene expression study. Res Vet Sci. 2014;96(2):355\u201364.","journal-title":"Res Vet Sci"},{"issue":"2","key":"2071_CR18","doi-asserted-by":"publisher","first-page":"197","DOI":"10.15302\/J-FASE-2018245","volume":"6","author":"S Zheng","year":"2019","unstructured":"Zheng S, Zhu J, Li J, Zhang S, Ma Y. Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels. Front Agr Sci Eng. 2019;6(2):197\u2013205.","journal-title":"Front Agr Sci Eng"},{"key":"2071_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10253890.2019.1625328","volume":"11","author":"L Wang","year":"2019","unstructured":"Wang L, Han D, Yin P, Teng K, Xu J, Ma Y. Decreased tryptophan hydroxylase 2 mRNA and protein expression, decreased brain serotonin concentrations, and anxiety-like behavioral changes in a rat model of simulated transport stress. Stress. 2019;11:1\u201311.","journal-title":"Stress"},{"key":"2071_CR20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/cne.901130304","volume":"113","author":"J de Groot","year":"1959","unstructured":"de Groot J. The rat hypothalamus in stereotaxic coordinates. J Comp Neurol. 1959;113:389\u2013400.","journal-title":"J Comp Neurol"},{"key":"2071_CR21","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2007","unstructured":"Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 6th ed. London: Academic; 2007.","edition":"6"},{"issue":"2","key":"2071_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/ilar.41.2.59","volume":"41","author":"WS Stokes","year":"2000","unstructured":"Stokes WS. Reducing unrelieved pain and distress in laboratory animals using humane endpoints. ILAR J. 2000;41(2):59\u201361.","journal-title":"ILAR J"},{"issue":"4","key":"2071_CR23","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1093\/ilar.47.4.364","volume":"47","author":"JA Obernier","year":"2006","unstructured":"Obernier JA, Baldwin RL. Establishing an appropriate period of acclimatization following transportation of laboratory animals. ILAR J. 2006;47(4):364\u20139.","journal-title":"ILAR J"},{"issue":"5","key":"2071_CR24","doi-asserted-by":"publisher","first-page":"485","DOI":"10.2174\/187152706778559336","volume":"5","author":"A Armario","year":"2006","unstructured":"Armario A. The hypothalamic-pituitary-adrenal axis: what can it tell us about stressors? CNS Neurol Disord Drug Target. 2006;5(5):485\u2013501.","journal-title":"CNS Neurol Disord Drug Target"},{"issue":"2","key":"2071_CR25","first-page":"155","volume":"62","author":"RC Gaillard","year":"2001","unstructured":"Gaillard RC. Interaction between the hypothalamo-pituitary-adrenal axis and the immunological system. Ann Endocrinol (Paris). 2001;62(2):155\u201363.","journal-title":"Ann Endocrinol (Paris)"},{"issue":"24","key":"2071_CR26","doi-asserted-by":"publisher","first-page":"6250","DOI":"10.1523\/JNEUROSCI.5219-07.2008","volume":"28","author":"L Lo Iacono","year":"2008","unstructured":"Lo Iacono L, Gross C. Alpha-Ca2+\/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. J Neurosci. 2008;28(24):6250\u20137.","journal-title":"J Neurosci"},{"issue":"9","key":"2071_CR27","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1176\/appi.ajp.160.9.1554","volume":"160","author":"CL Raison","year":"2003","unstructured":"Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry. 2003;160(9):1554\u201365.","journal-title":"Am J Psychiatry"},{"issue":"1\u20133","key":"2071_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0301-0511(01)00092-8","volume":"57","author":"U Ehlert","year":"2001","unstructured":"Ehlert U, Gaab J, Heinrichs M. Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus\u2013pituitary\u2013adrenal axis. Biol Psychol. 2001;57(1\u20133):141\u201352.","journal-title":"Biol Psychol"},{"issue":"8","key":"2071_CR29","doi-asserted-by":"publisher","first-page":"856","DOI":"10.14202\/vetworld.2016.856-861","volume":"9","author":"E Fazio","year":"2016","unstructured":"Fazio E, Medica P, Cravana C, Ferlazzo AA. Pituitary-adrenocortical adjustments to transport stress in horses with previous different handling and transport conditions. Vet World. 2016;9(8):856\u201361.","journal-title":"Vet World"},{"issue":"8","key":"2071_CR30","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.pnpbp.2005.08.006","volume":"29","author":"JP Herman","year":"2005","unstructured":"Herman JP, Ostrander MM, Mueller NK, Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuro-Psychopharmacol Biol Psychiatry. 2005;29(8):1201\u201313.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"1\u20132","key":"2071_CR31","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0006-8993(00)02950-4","volume":"886","author":"BS McEwen","year":"2000","unstructured":"McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 2000;886(1\u20132):172\u201389.","journal-title":"Brain Res"},{"issue":"1","key":"2071_CR32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0018-506X(02)00026-0","volume":"43","author":"GE Wood","year":"2003","unstructured":"Wood GE, Young LT, Reagan LP, McEwen BS. Acute and chronic restraint stress alter the incidence of social conflict in male rats. Horm Behav. 2003;43(1):205\u201313.","journal-title":"Horm Behav"},{"issue":"4","key":"2071_CR33","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","volume":"53","author":"C Tsigos","year":"2002","unstructured":"Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res. 2002;53(4):865\u201371.","journal-title":"J Psychosom Res"},{"key":"2071_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/bs.vh.2016.09.004","volume":"103","author":"A Kumar","year":"2017","unstructured":"Kumar A, Chanana P. Role of nitric oxide in stress-induced anxiety: from pathophysiology to therapeutic target. Vitam Horm. 2017;103:147\u201367.","journal-title":"Vitam Horm"},{"issue":"5","key":"2071_CR35","first-page":"353","volume":"10","author":"CK Kim","year":"1998","unstructured":"Kim CK, Rivier C. Influence of nitric oxide synthase inhibitors on the ACTH and cytokine responses to peripheral immune signals. J Neuroendocrinol. 1998;10(5):353\u201362.","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"2071_CR36","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bbr.2012.07.037","volume":"235","author":"HY Joung","year":"2012","unstructured":"Joung HY, Jung EY, Kim K, Lee MS, Her S, Shim I. The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat. Behav Brain Res. 2012;235(2):176\u201381.","journal-title":"Behav Brain Res"},{"issue":"2","key":"2071_CR37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0006-8993(93)91739-F","volume":"605","author":"A Costa","year":"1993","unstructured":"Costa A, Trainer P, Besser M, Grossman A. Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Res. 1993;605(2):187\u201392.","journal-title":"Brain Res"},{"issue":"11","key":"2071_CR38","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.3390\/ijms18102224","volume":"18","author":"DN Joseph","year":"2017","unstructured":"Joseph DN, Whirledge S. Stress and the HPA axis: balancing homeostasis and fertility. Int J Mol Sci. 2017;18(11):2224.","journal-title":"Int J Mol Sci"},{"key":"2071_CR39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jchemneu.2016.08.007","volume":"78","author":"E Badowska-Szalewska","year":"2016","unstructured":"Badowska-Szalewska E, Ludkiewicz B, Krawczyk R, Morys J. Exposure to mild stress and brain derived neurotrophin factor (BDNF) immunoreactivity in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei: comparison between aged and adult rats. J Chem Neuroanat. 2016;78:57\u201364.","journal-title":"J Chem Neuroanat"},{"issue":"17","key":"2071_CR40","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1113\/JP275669","volume":"596","author":"EW Salter","year":"2018","unstructured":"Salter EW, Sunstrum JK, Matovic S, Inoue W. Chronic stress dampens excitatory synaptic gain in the paraventricular nucleus of the hypothalamus. J Physiol. 2018;596(17):4157\u201372.","journal-title":"J Physiol"},{"issue":"2","key":"2071_CR41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","volume":"22","author":"JK Elmquist","year":"1999","unstructured":"Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999;22(2):221\u201332.","journal-title":"Neuron"},{"key":"2071_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0079-6123(08)63055-1","volume":"87","author":"AD Loewy","year":"1991","unstructured":"Loewy AD. Forebrain nuclei involved in autonomic control. Prog Brain Res. 1991;87:253\u201368.","journal-title":"Prog Brain Res"},{"issue":"11","key":"2071_CR43","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/0306-4522(80)90040-8","volume":"5","author":"WE Armstrong","year":"1980","unstructured":"Armstrong WE, Warach S, Hatton GI, McNeill TH. Subnuclei in the rat hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis. Neuroscience. 1980;5(11):1931\u201358.","journal-title":"Neuroscience"},{"key":"2071_CR44","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0079-6123(08)63052-6","volume":"87","author":"LW Swanson","year":"1991","unstructured":"Swanson LW. Biochemical switching in hypothalamic circuits mediating responses to stress. Prog Brain Res. 1991;87:181\u2013200.","journal-title":"Prog Brain Res"},{"key":"2071_CR45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0079-6123(08)61167-X","volume":"92","author":"LW Swanson","year":"1992","unstructured":"Swanson LW. Spatiotemporal patterns of transcription factor gene expression accompanying the development and plasticity of cell phenotypes in the neuroendocrine system. Prog Brain Res. 1992;92:97\u2013113.","journal-title":"Prog Brain Res"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-2071-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-019-2071-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-2071-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T23:06:43Z","timestamp":1599260803000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-019-2071-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,6]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2071"],"URL":"https:\/\/doi.org\/10.1186\/s12917-019-2071-x","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,6]]},"assertion":[{"value":"17 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All efforts were made to minimize suffering of each animal used in this study. All animal procedures conformed to the National Institutes of Health guidelines and were approved by the Institutional Animal Care and Use Committee of China Agricultural University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they consent for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"323"}}