{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T03:59:08Z","timestamp":1763179148410,"version":"3.37.3"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Flea bite is considered to be the main cause of allergic dermatitis in cats. There is a need for treatments able to control clinical signs of allergic dermatitis associated with flea bite in cats.<\/jats:p>\n                <jats:p>This was an open pre-treatment versus post-treatment clinical field study. All cats included in the study presented pruritus, skin lesions or other evidence compatible with flea infestation. Skin lesions were assessed (using SCORFAD) at days 0, 28, 56 and 84 whereas pruritus severity was assessed (using PVAS) at days 0, 15, 28, 56 and 84. On day 0, The fluralaner (280\u2009mg\/ml) product (Bravecto\u00ae spot-on for cats) was supplied in pipettes containing 0.4, 0.89 and 1.79\u2009ml for cats of 1.2\u20132.8\u2009kg, &gt;\u20092.8\u20136.25\u2009kg and\u2009&gt;\u20096.25\u201312.5\u2009kg body weight, respectively. The other animals living in the same household also received fluralaner. Based on cytological examination at day 0, oral amoxicillin and clavulanic acid was prescribed for 21\u2009days if indicated. For cats presenting intense pruritus and discomfort at day 0, oral prednisolone at 0.5\u2009mg\/kg was prescribed for 3\u2009days.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During the study all cats, except for one (cat number 10), improved significantly. Post-treatment median SCORFAD scores at all evaluations were significantly different from the pre-treatment score on day 0 (<jats:italic>P<\/jats:italic> values &lt;\u20090.002 for all three post treatment examination days) with a score reduction of 49% on day 28, 79% on day 56 and 87% on day 84. The PVAS score decreased significantly over the study period for all cats but one (cat number 10). Post-treatment median PVAS scores at all evaluations were significantly different from the pre-treatment PVAS score on day 0 (<jats:italic>P<\/jats:italic> value &lt;\u20090.002 for all four post-treatment days) with a reduction of 46% on day 15, 67% on day 28, 82% on day 56 and 92% on day 84. No adverse reaction or other health issue was reported during the study.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A single topical treatment with fluralaner results in a significant reduction of flea bite allergic dermatitis clinical signs in cats over the subsequent 12\u2009weeks without any additional environmental treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-019-2081-8","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T08:04:22Z","timestamp":1570781062000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Open field study on the efficacy of fluralaner topical solution for long-term control of flea bite allergy dermatitis in client owned cats in Ile-de-France region"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3440-1270","authenticated-orcid":false,"given":"Amaury","family":"Briand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle","family":"Cochet-Faivre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Pr\u00e9laud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Hubinois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"2081_CR1","first-page":"410","volume-title":"Muller & Kirk\u2019s small animal dermatology","author":"WH Miller","year":"2013","unstructured":"Miller WH, Griffin CE, Campbell KL. Feline fleabite hypersensitivity. In: Miller WH, Griffin CE, Campbell KL, editors. Muller & Kirk\u2019s small animal dermatology. 7th ed. St Louis: Elsevier; 2013. p. 410\u20132.","edition":"7"},{"key":"2081_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ibmb.2013.11.009","volume":"45","author":"M Gassel","year":"2014","unstructured":"Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod \u03b3-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal\/acaricidal activity. Insect Biochem Mol Biol. 2014;45:111\u201324.","journal-title":"Insect Biochem Mol Biol"},{"key":"2081_CR3","unstructured":"Dongus H. Bravecto\u00ae fu\u0308r die Katze: Innovative Zecken- und Flohbeka\u0308mpfung mit 12 Wochen Wirksamkeit. Sonderdruck Aus Kleintiermedizin. 2016;1:196\u20138."},{"issue":"1","key":"2081_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13071-017-1972-4","volume":"10","author":"C Meadows","year":"2017","unstructured":"Meadows C, Guerino F, Sun F. A randomized, blinded, controlled USA field study to assess the use of fluralaner topical solution in controlling feline flea infestations. Parasit Vectors. 2017;10(1):37.","journal-title":"Parasit Vectors"},{"issue":"1","key":"2081_CR5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s13071-018-2995-1","volume":"11","author":"MW Dryden","year":"2018","unstructured":"Dryden MW, Canfield MS, Bocon C, Phan L, Niedfeldt E, Kinnon A, et al. In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA. Parasit Vectors. 2018;11(1):422.","journal-title":"Parasit Vectors"},{"key":"2081_CR6","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1365-3164.2012.01071.x","volume":"23","author":"J Steffan","year":"2012","unstructured":"Steffan J, Olivry T, Forster SL, et al. Responsiveness and validity of the SCORFAD, an extent and severity scale for feline hyper-sensitivity dermatitis. Vet Dermatol. 2012;23:410\u20137.","journal-title":"Vet Dermatol"},{"key":"2081_CR7","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13071-016-1463-z","volume":"9","author":"O Crosaz","year":"2016","unstructured":"Crosaz O, Chapelle E, Cochet-Faivre N, Ka D, Hubinois C, Guillot J. Open field study on the efficacy of oral fluralaner for long-term control of flea allergy dermatitis in client-owned dogs in Ile-de-France region. Parasit Vectors. 2016;9:174.","journal-title":"Parasit Vectors"},{"key":"2081_CR8","series-title":"International Scholarly Research Notices","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/484308","volume-title":"Efficacy of Spinosad tablets administered to a colony of 15 indoor cats naturally infested with fleas","author":"M-C Cadiergues","year":"2014","unstructured":"Cadiergues M-C, Pressanti C. Efficacy of Spinosad tablets administered to a colony of 15 indoor cats naturally infested with fleas. International Scholarly Research Notices 2014."},{"issue":"6","key":"2081_CR9","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1365-3164.2008.00717.x","volume":"19","author":"AD Lowe","year":"2008","unstructured":"Lowe AD, Campbell KL, Graves T. Glucocorticoids in the cat. Vet Dermatol. 2008;19(6):340\u20137.","journal-title":"Vet Dermatol"},{"issue":"1","key":"2081_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s13071-018-2927-0","volume":"11","author":"S Ranjan","year":"2018","unstructured":"Ranjan S, Young D, Sun F. A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment. Parasit Vectors. 2018;11(1):385.","journal-title":"Parasit Vectors"},{"key":"2081_CR11","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/s13071-018-3043-x","volume":"11","author":"R Lavan","year":"2018","unstructured":"Lavan R, Armstrong R, Burgio F, Tunceli K. Duration of annual canine flea and tick protection provided by dog owners in Spain. Parasit Vectors. 2018;11:458.","journal-title":"Parasit Vectors"},{"key":"2081_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0965-4","volume":"8","author":"MW Dryden","year":"2015","unstructured":"Dryden MW, Smith V, Bennett T, Math L, Kallman J, Heaney K, Sun F. Efficacy of fluralaner flavored chews (Bravecto) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production. Parasit Vectors. 2015;8:364.","journal-title":"Parasit Vectors"},{"key":"2081_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1365-3164.2008.00728.x","volume":"20","author":"J Rybn\u00edcek","year":"2009","unstructured":"Rybn\u00edcek J, Lau-Gillard PJ, Harvey R, Hill PB. Further validation of a pruritus severity scale for use in dogs. Vet Dermatol. 2009;20:115\u201322.","journal-title":"Vet Dermatol"},{"key":"2081_CR14","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1186\/s13071-018-3175-z","volume":"11","author":"N Rohdich","year":"2018","unstructured":"Rohdich N, Zschiesche E, Wolf O, Loehlein W, Pobel T, Jos\u00e9 Gil M, Roepke KA. Field effectiveness and safety of fluralaner plus moxidectin (Bravecto\u00ae plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats. Parasit Vectors. 2018;11:598.","journal-title":"Parasit Vectors"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-2081-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-019-2081-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-019-2081-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T23:14:38Z","timestamp":1602285278000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-019-2081-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2081"],"URL":"https:\/\/doi.org\/10.1186\/s12917-019-2081-8","relation":{},"ISSN":["1746-6148"],"issn-type":[{"type":"electronic","value":"1746-6148"}],"subject":[],"published":{"date-parts":[[2019,10,11]]},"assertion":[{"value":"12 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in compliance with local and national regulations. All cat owners (or delegates) were required to sign an informed consent form prior to any cat being enrolled into the study.The study was approved, including ethical review, under the Merck Animal Health Standard Operating Procedure for market support studies. This Standard Operating Procedure does not include a systematic review by our internal Ethical Committee. For clinical studies with on-label use of an approved animal drug and written owner informed consent without further investigation as it was the case for this study, this Procedure does not require any supplementary ethical review. The approval is based on the detailed protocol showing that all animals recruited only passed a classical clinical examination and were all treated against external parasites during the whole study. There is no difference between the treatment of the cats included in the study and cat visiting the vet in a classical context. That is also why the French local regulation does not require any complementary review.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The owners gave a written consent for their cat\u2019s clinical details along with any identifying images to be published in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The study was funded by MSD Sant\u00e9 Animale, 7 Rue Olivier de Serres - Angers Technopole, Beaucouz\u00e9, France. CH and RA are current employees of MSD, AB works at ADVETIA Veterinary hospital and Alfort Veterinary School and was contracted by MSD Sant\u00e9 Animale to conduct the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"337"}}