{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:39:59Z","timestamp":1764603599109,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of this disease is rarely reported in the veterinary literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 5-week-old, male entire Husky cross puppy presented for a one-day history of abnormal neurological behaviour (circling, ataxia, vocalization and obtund mentation). The puppy was euthanized shortly after presentation due to rapid deterioration. Histopathology raised concerns for Canine Adenovirus 1 (CAdV-1) based on vasculitis in the brain and intranuclear inclusion bodies in endothelial cell and hepatocytes; immunohistochemistry on brain tissue confirmed CAdV-1 infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This report discusses possible routes of infection and manifestations of adenovirus infections causing neurologic signs. It also provides a timely reminder that CAdV-1 should be considered a differential in unvaccinated dogs that present with neurological signs. Further studies are required to better understand the neurotrophic tendencies of this virus.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-019-2173-5","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T17:03:49Z","timestamp":1574355829000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Canine adenovirus type 1 causing neurological signs in a 5-week-old puppy"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-0715","authenticated-orcid":false,"given":"Samuel J.","family":"Hornsey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Philibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale L.","family":"Godson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth C. R.","family":"Snead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"2173_CR1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/B978-1-4377-0795-3.00018-1","volume-title":"Canine and feline infectious diseases","author":"JE Sykes","year":"2014","unstructured":"Sykes JE. Chapter 18 - infectious canine hepatitis. In: Sykes JE, editor. Canine and feline infectious diseases. Saint Louis: W.B. Saunders; 2014. p. 182\u20136."},{"key":"2173_CR2","doi-asserted-by":"crossref","unstructured":"Williams ES, Barker IK. Adenoviral Diseases. Infectious diseases of wild mammals. 3rd ed.. ed. Ames: Ames : Iowa State University Press; 2001.","DOI":"10.1002\/9780470344880"},{"key":"2173_CR3","unstructured":"Cabasso VJ. Infectious canine hepatitis [virus, foxes, dogs and skunks]. 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The animal remained under the care of an RCVS registered veterinary surgeon for the duration of its treatment.The animal was owned by the Saskatchewan Society for the Prevention of Cruelty to Animals (SPCA). Consent was obtained to allow the Veterinary Medical Centre to perform diagnostic testing, and provide treatment, consent was also obtained to perform euthanasia and necropsy.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent for publication has been obtained from the Saskatchewan Society for the Prevention of Cruelty to Animals (SPCA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"418"}}