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In Canada, <jats:italic>Salmonella<\/jats:italic> is commonly found on swine farms and the increasing concern about drug use and antimicrobial resistance associated with <jats:italic>Salmonella<\/jats:italic> has promoted research into alternative control methods, including selecting for pig genotypes associated with resistance to <jats:italic>Salmonella.<\/jats:italic> The objective of this study was to identify single-nucleotide variants in the pig genome associated with <jats:italic>Salmonella<\/jats:italic> susceptibility using a genome-wide association approach. Repeated blood and fecal samples were collected from 809 pigs in 14 groups on farms and tonsils and lymph nodes were collected at slaughter. Sera were analyzed for <jats:italic>Salmonella<\/jats:italic> IgG antibodies by ELISA and feces and tissues were cultured for <jats:italic>Salmonella<\/jats:italic>. Pig DNA was genotyped using a custom 54\u2009K single-nucleotide variant oligo array and logistic mixed-models used to identify SNVs associated with IgG seropositivity, shedding, and tissue colonization.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Variants in\/near <jats:italic>PTPRJ<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20090.0000066), <jats:italic>ST6GALNAC3<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20090.0000099), and <jats:italic>DCDC2C<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20093, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0000086) were associated with susceptibility to <jats:italic>Salmonella<\/jats:italic>, while variants near <jats:italic>AKAP12<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20093, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0000358) and in <jats:italic>RALGAPA2<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20090.0000760) may be associated with susceptibility.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Further study of the variants and genes identified may improve our understanding of neutrophil recruitment, intracellular killing of bacteria, and\/or susceptibility to <jats:italic>Salmonella<\/jats:italic> and may help future efforts to reduce <jats:italic>Salmonella<\/jats:italic> on-farm through genetic approaches.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-020-02344-0","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T11:35:32Z","timestamp":1589542532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of single-nucleotide variants associated with susceptibility to Salmonella in pigs using a genome-wide association approach"],"prefix":"10.1186","volume":"16","author":[{"given":"Corinne H.","family":"Schut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolvahab","family":"Farzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell S.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret H.","family":"Ainslie-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Friendship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3116-9111","authenticated-orcid":false,"given":"Brandon N.","family":"Lillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"issue":"7","key":"2344_CR1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1089\/fpd.2012.1389","volume":"10","author":"MK Thomas","year":"2013","unstructured":"Thomas MK, Murray R, Flockhart L, Pintar K, Pollari F, Fazil A, et al. 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