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Excessive production of ROS during anaesthesia affects the antioxidant capacity of plasma and may result in oxidative stress. The aim of this study was to evaluate the antioxidant capacity of lipid- (ACL) and water-soluble (ACW) antioxidants in client-owned dogs diagnosed with periodontal disease and early-stage myxomatous mitral valve degeneration (MMVD) and anaesthetised for a dental procedure with propofol and sevoflurane or with propofol only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dogs with MMVD were anaesthetised with propofol and sevoflurane (MMVD\/PS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) or with propofol only (MMVD\/P,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910). Dogs with no evidence of MMVD (PS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) were anaesthetised with propofol and sevoflurane. Blood samples for determination of ACL and ACW were collected before and 5\u2009min, 60\u2009min and 6\u2009h after induction to anaesthesia. In MMVD\/PS dogs, ACL was significantly higher at all sampling times when compared to PS dogs. Compared to basal values, only anaesthesia maintained with propofol significantly increased ACL at 60\u2009min in dogs with MMVD. In MMVD\/P dogs, ACW increased after induction to anaesthesia and remained elevated up to 6\u2009h after anaesthesia. Compared to basal values, anaesthesia maintained with sevoflurane significantly increased ACW only at 60\u2009min in both dogs with and without MMVD. The only difference between propofol and propofol\/sevoflurane anaesthesia in dogs with MMVD was significantly higher ACW at 60\u2009min after induction to anaesthesia in the propofol group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regarding antioxidant capacity, propofol could be a better choice than sevoflurane for anaesthesia of dogs with early-stage MMVD, although further studies are necessary to clarify the advantage of this antioxidant capacity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12917-020-02529-7","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T09:02:36Z","timestamp":1598259756000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antioxidant capacity of lipid- and water-soluble antioxidants in dogs with subclinical myxomatous mitral valve degeneration anaesthetised with propofol or sevoflurane"],"prefix":"10.1186","volume":"16","author":[{"given":"Katerina","family":"Tomsi\u010d","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alenka","family":"Nemec Svete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Nemec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Domanjko Petri\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Pirman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vida","family":"Rezar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toma\u017e","family":"Vovk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-9182","authenticated-orcid":false,"given":"Alenka","family":"Seli\u0161kar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"2529_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11357-016-9933-y","volume":"38","author":"B Mart\u00edn-Fern\u00e1ndez","year":"2016","unstructured":"Mart\u00edn-Fern\u00e1ndez B, Gredilla R. 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