{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:09:40Z","timestamp":1740143380615,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Toxoplasmosis is one of the most common parasitic infections in both humans and animals. It is a frequent cause of abortion and stillbirth in intermediate hosts, especially sheep and goats but rarely causes fatal clinical form in adult animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>In contrast, the study reports an unusual fatal case of toxoplasmosis in a young goat naturally infected with type II strain of<jats:italic>Toxoplasma gondii<\/jats:italic>. A three-month-old female goat was presented with dyspnea and died few days later. Grossly, lungs were firm, edematous and mottled with disseminated whitish areas. Generalized lymphadenopathy was found. The histopathological examination showed necrotic interstitial bronchopneumonia and necrotizing lymphadenitis with intralesional free and clustered within macrophages tachyzoites of<jats:italic>T. gondii<\/jats:italic>. DNA extracted from lungs and lymph nodes was positive for<jats:italic>T. gondii<\/jats:italic>by a fast qPCR. PCR-RFLP analysis and sequencing of GRA6 gene showed that the isolated strains belonged to type II genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is an unusual report of acute systemic toxoplasmosis caused by the type II strain of<jats:italic>T. gondii<\/jats:italic>with a fatal outcome in a young goat.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-020-02641-8","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T12:46:02Z","timestamp":1604493962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fatal systemic toxoplasmosis in a 3-month-old young tibetan goat (Capra hircus)"],"prefix":"10.1186","volume":"16","author":[{"given":"Silvia","family":"Pavone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Crotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2155-4742","authenticated-orcid":false,"given":"Deborah","family":"Cruciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"D\u2019Avino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Zema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gobbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Madeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"2641_CR1","doi-asserted-by":"crossref","unstructured":"Dubey JP, Odening K. Toxoplasmosis and related infections. In: Samuel WM, Pybus MJ, Kocan AA, editors. Parasitic diseases of wild mammals. 2nd ed. Iowa State University Press; 2001. p. 478\u2013519. .","DOI":"10.1002\/9780470377000.ch17d"},{"key":"2641_CR2","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","volume":"30","author":"AM Tenter","year":"2000","unstructured":"Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol. 2000;30:1217\u201358.","journal-title":"Int J Parasitol"},{"key":"2641_CR3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.rvsc.2020.07.005","volume":"132","author":"JP Dubey","year":"2020","unstructured":"Dubey JP, Murata FHA, Cerqueira-C\u00e9zar CK, Kwok OCH. Toxoplasma gondii infections in horses, donkeys, and other equids: the last decade. Res Vet Sci. 2020;132:492\u20139.","journal-title":"Res Vet Sci"},{"key":"2641_CR4","first-page":"e20170790","volume":"48","author":"JMF Neto","year":"2018","unstructured":"Neto JMF, Ferreira FP, Miura AC, de Almeida JC, Martins FDC, de Souza M, Bronkhorst DE, Romanelli PR, Pasquali AKS, dos Santos HLEPL, Benitez AN, Caldart ET, Zanella LF, Freire RL, Navarro IT. An outbreak of caprine toxoplasmosis - investigation and case report. Cienc Rural. 2018;48:e20170790.","journal-title":"Cienc Rural"},{"key":"2641_CR5","first-page":"57","volume":"40","author":"ML Dard\u00e9","year":"2004","unstructured":"Dard\u00e9 ML. Genetic analysis of the diversity in Toxoplasma gondii. 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