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Due to the ban of antibiotics in feed industry, alternatives like environment improvement and probiotics have been found to be effective as well. In our study, we aim to explore the protective effect of\n                      <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                      supplementation on\n                      <jats:italic>CP<\/jats:italic>\n                      infected chickens in two environments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that the\n                      <jats:italic>Clostridium perfringens<\/jats:italic>\n                      administration led to visible and histomorphological gut lesions. In the specific pathogen free or free-range system environment, dietary supplementation with\n                      <jats:italic>LP<\/jats:italic>\n                      obvious increased the ratio of intestinal villus height to crypt depth and the expression of\n                      <jats:italic>MUC2<\/jats:italic>\n                      mRNA in ileum mucosa, then reduced the mRNA expression level of\n                      <jats:italic>TNF-\u03b1<\/jats:italic>\n                      gene in the ileum mucosa.\n                      <jats:italic>LP<\/jats:italic>\n                      treatment significantly reduced the contents of total protein, total superoxide dismutase and glutamic oxaloacetic transaminase in serum of the chickens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The specific pathogen free environment contributed to the recovery of pre-inflammation of the chickens, and free-range system environment contributed to the repair of damage in the later stages of chicken inflammation. Supplementation of\n                      <jats:italic>LP<\/jats:italic>\n                      in FRS environment was more conducive to the recovery of\n                      <jats:italic>CP<\/jats:italic>\n                      infected in chickens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12917-020-2264-3","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T19:06:38Z","timestamp":1581015998000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effects of Lactobacillus plantarum on intestinal integrity and immune responses of egg-laying chickens infected with Clostridium perfringens under the free-range or the specific pathogen free environment"],"prefix":"10.1186","volume":"16","author":[{"given":"Tianyue","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"2264_CR1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2307\/1589343","volume":"21","author":"F Al-Sheikhly","year":"1977","unstructured":"Al-Sheikhly F, Truscott RB. 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