{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:08:41Z","timestamp":1774494521831,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>M\u00e9n\u00e9trier-like disease is a rare hypertrophic canine gastropathy, reported in only seven dogs. Clinical signs are vomiting, anorexia and weight loss. Macroscopically, giant cerebriform gastric mucosal folds are typically seen in the corpus and fundus of the stomach. Histopathologically, fundic mucous cell hyperplasia and loss of parietal and chief cells are typical.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A nine-year-old spayed female Pointer had a history of intermittent vomiting, marked weight loss and hypoalbuminaemia. A gastroduodenoscopy was performed three times within three months with macroscopic changes remaining the same. The gastric mucosa of the corpus, fundus and proximal antrum was markedly irregular, with cerebriform mucosal folds. In the first gastric biopsies, histopathology revealed a moderate granulomatous gastritis, with a severe manifestation of <jats:italic>Helicobacter<\/jats:italic>-like organisms. Treatment for <jats:italic>Helicobacter <\/jats:italic>spp. decreased the vomiting slightly. The dog was diagnosed with concurrent leishmaniosis; the conventional anti-<jats:italic>Leishmania<\/jats:italic> treatment decreased the vomiting moderately, the hypoalbuminaemia resolved and the dog gained weight back to a normal body condition. Granulomatous gastritis was not present in the gastric biopsies after these treatments. The dog increased vomiting when palliative treatment (maropitant citrate, ondansetron and esomeprazole) was discontinued, and thus, full-thickness biopsies of the stomach were taken and M\u00e9n\u00e9trier-like disease was diagnosed. The affected area was too large to be surgically removed; thus, palliative treatment was reinstated. The dog remained clinically well 39 months after the first clinical presentation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This is the first report of M\u00e9n\u00e9trier-like disease in a dog with a simultaneous manifestation of granulomatous gastritis, helicobacteriosis and leishmaniosis. The clinical signs decreased after treatment of helicobacteriosis and leishmaniosis, but vomiting remained probably as a sign of M\u00e9n\u00e9trier-like disease. Treatment options for dogs are surgical removal of the abnormal area or palliative treatment. In humans, promising results for a cure have been shown with cetuximab treatment, a human monoclonal antibody, but no canine antibody is commercially available yet. The dog here was doing well 39 months after first presentation, which is the longest reported survival time for M\u00e9n\u00e9trier-like disease with only palliative treatment in dogs. Full-thickness biopsies are preferred in macroscopic hypertrophic lesions of the stomach for better assessment of M\u00e9n\u00e9trier-like disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-021-02802-3","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:02:34Z","timestamp":1614668554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["M\u00e9n\u00e9trier-like disease in a Pointer with concurrent granulomatous gastritis, helicobacteriosis and leishmaniosis: a case report"],"prefix":"10.1186","volume":"17","author":[{"given":"E.","family":"Lagerstedt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Spillmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Airas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Solano-Gallego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kilpinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"issue":"8","key":"2802_CR1","doi-asserted-by":"publisher","first-page":"8ra18","DOI":"10.1126\/scitranslmed.3000320","volume":"1","author":"WH Fiske","year":"2009","unstructured":"Fiske WH, Tanksley J, Nam KT, Goldenring JR, Slebos RJ, Liebler DC et al (2009) Efficacy of cetuximab in the treatment of M\u00e9n\u00e9trier\u2019s disease. Sci Transl Med 1(8):8ra18","journal-title":"Sci Transl Med"},{"key":"2802_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4132\/jptm.2015.09.15","volume":"50","author":"WJ Huh","year":"2016","unstructured":"Huh WJ, Coffey RJ, Washington MK (2016) M\u00e9n\u00e9trier\u2019s disease: its mimickers and pathogenesis. J Pathol Transl Med. 50:10\u201316","journal-title":"J Pathol Transl Med."},{"key":"2802_CR3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1177\/030098587601300302","volume":"13","author":"I Van der Gaag","year":"1976","unstructured":"Van der Gaag I, Happ\u00e9 RP, Wolvekamp WT. A boxer dog with chronic hypertrophic gastritis resembling Menetrier\u2019s disease in man. Vet Pathol. 1976;13:172\u201385.","journal-title":"Vet Pathol"},{"key":"2802_CR4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.5326\/0430122","volume":"43","author":"TS Rallis","year":"2007","unstructured":"Rallis TS, Patsikas MN, Mylonakis ME, Day MJ, Petanides TA, Papazoglou LG, et al. Giant hypertrophic gastritis (M\u00e9n\u00e9trier\u2019s-like disease) in an Old English sheepdog. J Am Anim Hosp Assoc. 2007;43:122\u20137.","journal-title":"J Am Anim Hosp Assoc"},{"key":"2802_CR5","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1748-5827.2012.01291.x","volume":"53","author":"P Lecoindre","year":"2012","unstructured":"Lecoindre P, Bystricka M, Chevallier M, Peyron C. Gastric carcinoma associated with Menetrier\u2019s-like disease in a West Highland white terrier. J Small Anim Pract. 2012;53:714\u20138.","journal-title":"J Small Anim Pract"},{"key":"2802_CR6","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1177\/0300985812439076","volume":"49","author":"JS Munday","year":"2012","unstructured":"Munday JS, Aberdein D, Cullen GD, French AF. M\u00e9n\u00e9trier disease and gastric adenocarcinoma in 3 Cairn terrier littermates. Vet Pathol. 2012;49:1028\u201331.","journal-title":"Vet Pathol"},{"key":"2802_CR7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5326\/JAAHA-MS-5952","volume":"50","author":"DP Vaughn","year":"2014","unstructured":"Vaughn DP, Syrcle J, Cooley J. Canine giant hypertrophic gastritis treated successfully with partial gastrectomy. J Am Anim Hosp Assoc. 2014;50:62\u20136.","journal-title":"J Am Anim Hosp Assoc"},{"key":"2802_CR8","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1111\/j.1572-0241.1998.00347.x","volume":"93","author":"D Badov","year":"1998","unstructured":"Badov D, Lambert JR, Finlay M, Balazs ND. Helicobacter pylori as a pathogenic factor in M\u00e9n\u00e9trier\u2019s disease. Am J Gastroenterol. 1998;93:1976\u20139.","journal-title":"Am J Gastroenterol"},{"key":"2802_CR9","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1111\/jvim.14589","volume":"6","author":"AJ Gold","year":"2016","unstructured":"Gold AJ, Langlois DK, Refsal KR. Evaluation of basal serum or plasma cortisol concentrations for the diagnosis of hypoadrenocorticism in dogs. J Vet Intern Med. 2016;6:1798\u2013805.","journal-title":"J Vet Intern Med"},{"key":"2802_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.cmi.2017.08.017","volume":"24","author":"M Ala-Houhala","year":"2018","unstructured":"Ala-Houhala M, Koukila-K\u00e4hk\u00f6l\u00e4 P, Antikainen J, Valve J, Kirveskari J, Anttila VJ. Clinical use of fungal PCR from deep tissue samples in the diagnosis of invasive fungal diseases: a retrospective observational study. Clin Microbiol Infect. 2018;24:301\u20135.","journal-title":"Clin Microbiol Infect"},{"key":"2802_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jcpa.2018.11.005","volume":"167","author":"MI Casanova","year":"2019","unstructured":"Casanova MI, Mart\u00edn S, Marco A, Solano-Gallego L. Detection of Leishmania spp. infection by immunohistochemistry in archived biopsy samples from dogs with colitis in an area endemic for leishmaniosis. J Comp Pathol. 2019;167:12\u20137.","journal-title":"J Comp Pathol"},{"key":"2802_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1756-3305-4-86","volume":"4","author":"L Solano-Gallego","year":"2011","unstructured":"Solano-Gallego L, Mir\u00e1 G, Koutinas A, Cardoso L, Pennisi MG, Ferrer L, et al. LeishVet guidelines for the practical management of canine leishmaniosis. Parasit Vect. 2011;4:86.","journal-title":"Parasit Vect"},{"key":"2802_CR13","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1136\/gut.2010.220061","volume":"59","author":"A Rich","year":"2010","unstructured":"Rich A, Toro TZ, Tanksley J, Fiske WH, Lind CD, Ayers GD, et al. Distinguishing M\u00e9n\u00e9trier\u2019s disease from its mimics. Gut. 2010;59:1617\u201324.","journal-title":"Gut"},{"key":"2802_CR14","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1158\/1535-7163.MCT-13-0288","volume":"13","author":"J Singer","year":"2014","unstructured":"Singer J, Fazekas J, Wang W, Weichselbaumer M, Matz M, Mader A, et al. Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. Mol Cancer Ther. 2014;13:1777\u201390.","journal-title":"Mol Cancer Ther"},{"key":"2802_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/jvim.13797","volume":"30","author":"L Toresson","year":"2016","unstructured":"Toresson L, Steiner JM, Suchodolski JS, Spillmann T. Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia. J Vet Intern Med. 2016;30:101\u20137.","journal-title":"J Vet Intern Med"},{"key":"2802_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/jvim.15638","volume":"34","author":"S Kather","year":"2020","unstructured":"Kather S, Gr\u00fctzner N, Kook PH, Dengler F, Heilmann RM. Review of cobalamin status and disorders of cobalamin metabolism in dogs. J Vet Intern Med. 2020;34:13\u201328.","journal-title":"J Vet Intern Med"},{"key":"2802_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1017\/CBO9780511525391.006","volume-title":"Vitamin receptors: vitamins as ligands in cell communication","author":"B Seetharam","year":"1994","unstructured":"Seetharam B, Alpers DH. Cobalamin binding proteins and their receptors. In: Dakshinamurti K, editor. Vitamin receptors: vitamins as ligands in cell communication. Cambridge: Cambridge University Press; 1994. pp.\u00a078\u2013105."},{"key":"2802_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jcpa.2015.10.181","volume":"154","author":"I Amorim","year":"2016","unstructured":"Amorim I, Taulescu MA, Day MJ, Catoi C, Reis CA, Carneiro F, G\u00e4rtner F. Canine gastric pathology: a review. J Comp Pathol. 2016;154:9\u201337.","journal-title":"J Comp Pathol"},{"key":"2802_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1080\/01652176.2015.1050529","volume":"35","author":"G Ruiz","year":"2015","unstructured":"Ruiz G, Laloy E, Benchekroun G. Chronic gastritis and enterocolitis associated with Leishmania infection in an 18-month-old, intact female dog. Vet Q. 2015;35:236\u20139.","journal-title":"Vet Q"},{"key":"2802_CR20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1523-5378.2009.00674.x","volume":"14","author":"C Recordati","year":"2009","unstructured":"Recordati C, Gualdi V, Craven M, Sala L, Luini M, Lanzoni A, Rishniw M, Simpson KW, Scanziani E. Spatial distribution of Helicobacter spp. in the gastrointestinal tract of dogs. Helicobacter. 2009;14:180\u201391.","journal-title":"Helicobacter"},{"key":"2802_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tvjl.2016.03.014","volume":"213","author":"M Sharman","year":"2016","unstructured":"Sharman M, Bacci B, Simpson K, Mansfield C. Comparison of in vivo confocal endomicroscopy with other diagnostic modalities to detect intracellular helicobacters. Vet J. 2016;213:78\u201383.","journal-title":"Vet J"},{"key":"2802_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1939-1676.2000.tb02225.x","volume":"14","author":"R Neiger","year":"2000","unstructured":"Neiger R, Simpson KW. Helicobacter infection in dogs and cats: facts and fiction. J Vet Intern Med. 2000;14:125\u201333.","journal-title":"J Vet Intern Med"},{"key":"2802_CR23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1939-1676.2005.tb02651.x","volume":"19","author":"B Wiinberg","year":"2005","unstructured":"Wiinberg B, Spohr A, Dietz HH, Egelund T, Greiter-Wilke A, McDonough SP, et al. Quantitative analysis of inflammatory and immune responses in dogs with gastritis and their relationship to Helicobacter spp. infection. J Vet Intern Med. 2005;19:4\u201314.","journal-title":"J Vet Intern Med"},{"key":"2802_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.5009\/gnl.2009.3.2.137","volume":"3","author":"YS Kim","year":"2009","unstructured":"Kim YS, Lee HK, Kim JO, et al. A case of H. pylori-associated granulomatous gastritis with hypertrophic gastropathy. Gut Liver. 2009;3:137\u201340.","journal-title":"Gut Liver"},{"key":"2802_CR25","doi-asserted-by":"publisher","first-page":"691","DOI":"10.2169\/internalmedicine.42.691","volume":"42","author":"S Koyama","year":"2003","unstructured":"Koyama S, Nagashima F. Idiopathic granulomatous gastritis with multiple aphthoid ulcers. Intern Med. 2003;42:691\u20135.","journal-title":"Intern Med"},{"key":"2802_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1748-5827.2000.tb03127.x","volume":"41","author":"I Happonen","year":"2000","unstructured":"Happonen I, Linden J, Westermarck E. Effect of triple therapy on eradication of canine gastric helicobacters and gastric disease. J Small Anim Pract. 2000;41:1\u20136.","journal-title":"J Small Anim Pract"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-021-02802-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12917-021-02802-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-021-02802-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:03:18Z","timestamp":1614668598000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-021-02802-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,2]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2802"],"URL":"https:\/\/doi.org\/10.1186\/s12917-021-02802-3","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,2]]},"assertion":[{"value":"23 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication of the clinical details of the case was obtained from the dog\u2019s owner.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"98"}}