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Eight sexually mature Peacock goats were randomly divided into two groups. The experimental group was administered altrenogest (0.088\u2009mg\/kg) orally once daily for 7\u2009weeks. The remaining four goats received an oral glucose solution and served as the control group. After completing the administration period, the reversibility of the medication was evaluated for another 7\u2009weeks (observation phase). The treatment effects were assessed by clinical examination; ultrasound examination of the testes, including one-dimensional grayscale analysis, blood testosterone levels, analysis of semen parameters and libido. At the end of the observation period, the animals were castrated and the testicles were examined histologically.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Altrenogest treatment had no significant effect on the physical development of the goats, the sonographic appearance of the testes, the gray values measured in the ultrasound images, or the blood testosterone levels. The effects of treatment on the testicular and semen parameters varied widely in the experimental animals; the testicle volume was significantly lower and the number of pathologically altered sperm in the ejaculate was significantly higher in treated animals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These findings indicate that daily altrenogest administration at a dose of 0.088\u2009mg\/kg does not reliably suppress gonadal function in the goat.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-021-02845-6","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T20:03:06Z","timestamp":1620158586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Downregulation of testicular function in the goat by altrenogest"],"prefix":"10.1186","volume":"17","author":[{"given":"Lisa","family":"Mihsler-Kirsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Failing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Wehrend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"2845_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.15653\/TPG-151145","volume":"44","author":"L Mihsler","year":"2016","unstructured":"Mihsler L, Wagner H, Wehrend A. 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All methods were carried out in accordance with relevant guidelines and regulations and in compliance with the ARRIVE guidelines. All bucks belonged and were maintained and managed at the Clinic of Obstetrics, Gynecology, and Andrology of Large and Small Animals with Ambulatory Service of the Justus Liebig University Giessen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"183"}}