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Vitiligo-like depigmentation occurs predominantly in horses displaying the grey coat colour and is observed at a prevalence level of 26.0\u201367.0% in grey horses compared with only 0.8\u20133.5% in non-grey horses. While the polygenetic background of this complex disease is well documented in humans, the underlying candidate genes for this skin disorder in horses remain unknown. In this study we aim to perform a genome-wide association study (GWAS) for identifying putative candidate loci for vitiligo-like depigmentation in horses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In the current study, we performed a GWAS analysis using high-density 670\u2009k single nucleotide polymorphism (SNP) data from 152 Lipizzan and 104 Noriker horses, which were phenotyped for vitiligo-like depigmentation by visual inspection. After quality control 376,219 SNPs remained for analyses, the genome-wide Bonferroni corrected significance level was <jats:italic>p<\/jats:italic>\u2009&lt;\u20091.33e-7.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identified seven candidate genes on four chromosomes (ECA1, ECA13, ECA17, ECA20) putatively involved in vitiligo pathogenesis in grey horses. The highlighted genes <jats:italic>PHF11<\/jats:italic>, <jats:italic>SETDB2<\/jats:italic>, <jats:italic>CARHSP1<\/jats:italic> and <jats:italic>LITAFD<\/jats:italic>, are associated with the innate immune system, while the genes <jats:italic>RCBTB1<\/jats:italic>, <jats:italic>LITAFD<\/jats:italic>, <jats:italic>NUBPL<\/jats:italic>, <jats:italic>PTP4A1<\/jats:italic>, play a role in tumor suppression and metastasis. The antagonistic pathogenesis of vitiligo in relation to cancer specific enhanced cell motility and\/or metastasis on typical melanoma predilection sites underlines a plausible involvement of <jats:italic>RCBTB1<\/jats:italic>, <jats:italic>LITAFD<\/jats:italic>, <jats:italic>NUBPL<\/jats:italic>, and <jats:italic>PTP4A1<\/jats:italic>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proposed candidate genes for equine vitiligo-like depigmentation, indicate an antagonistic relation between vitiligo and tumor metastasis in a horse population with higher incidence of melanoma. Further replication and expression studies should lead to a better understanding of this skin disorder in horses.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-021-03046-x","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T04:02:41Z","timestamp":1635134561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Equine vitiligo-like depigmentation in grey horses is related to genes involved in immune response and tumor metastasis"],"prefix":"10.1186","volume":"17","author":[{"given":"Thomas","family":"Druml","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Brem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Velie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Horna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ricard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrud","family":"Grilz-Seger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"3046_CR1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.dsi.2014.09.008","volume":"32","author":"IE Kingsley","year":"2014","unstructured":"Kingsley IE, Harris JE. 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