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The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically na\u00efve and therefore more susceptible to reproductive disease if\n                      <jats:italic>T. gondii<\/jats:italic>\n                      infection occurs during pregnancy. The aim of this study was to assess the impact of infection with\n                      <jats:italic>T. gondii<\/jats:italic>\n                      on the reproductive performance of primiparous ewes in southern Australia using a prospective cohort study. This will inform the need for targeted control strategies for\n                      <jats:italic>T. gondii<\/jats:italic>\n                      in Australian sheep.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Toxoplasma gondii<\/jats:italic>\n                      seropositivity using indirect ELISA was detected at 16\/28 farms located across southern Australia. Apparent seropositivity to\n                      <jats:italic>T. gondii<\/jats:italic>\n                      was lower in primiparous ewes (1.1, 95% confidence interval (CI) 0.6, 1.8) compared to mature, multiparous ewes (8.1, 95% CI 6.0, 10.5;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                      <jats:italic>Toxoplasma gondii<\/jats:italic>\n                      seroconversion during the gestation and lambing period was confirmed for 11\/1097 (1.0, 95% CI 0.5, 1.7) of pregnant primiparous ewes that failed to raise a lamb, and 1\/161 (0.6, 95% CI 0.1, 2.9) primiparous ewes with confirmed mid-pregnancy\u00a0abortion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Low frequency of detection of\n                      <jats:italic>T. gondii<\/jats:italic>\n                      seroconversion during gestation and low frequency of seropositivity to\n                      <jats:italic>T. gondii<\/jats:italic>\n                      suggests that toxoplasmosis was not an important contributor to reproductive losses in primiparous ewes on farms located over a wide geographical area in southern Australia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12917-022-03211-w","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T02:03:04Z","timestamp":1647655384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study"],"prefix":"10.1186","volume":"18","author":[{"given":"Thomas","family":"Clune","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Lockwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serina","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew N.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieghan","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Beetson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus J.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Glanville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Trengove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"O\u2019Handley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,19]]},"reference":[{"issue":"8","key":"3211_CR1","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1016\/j.theriogenology.2004.06.017","volume":"63","author":"DO Kleemann","year":"2005","unstructured":"Kleemann DO, Walker SK. 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