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It should be noted that Maternally Derived Antibodies (MDA) have protection against CPV-2 in the first weeks of puppies\u2019 life. However, MDA declines with age. The most important influential factor is timely vaccination against CPV-2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 24 healthy 8-week-old terrier puppies were selected and divided into three identical groups based on a randomized, double-blind comparative trial. One of which was called the control group that was injected with the physiological serum. The second group was the group A that was vaccinated by the vaccine provided by Biocan DHPPi+L (Bioveta, Czech). The third group was group B that was vaccinated by the vaccine of Duramune Max 5\u2009+\u2009LCI \/ GP (Fort Dodge Animal Health, USA) from 8 to 16\u2009weeks of their life at every 4\u2009weeks. Then serum samples were analyzed with HI and ELISA tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MDA titer was protective in some puppies until 18\u2009weeks of age. Also, after the first vaccination, all puppies had a protective titer against CPV-2, and Duramune vaccine had seroconverted after the first injection and Biocan had seroconverted after the second injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is recommended that to reduce the risk of vaccine failure: such as the MDA titer should be measured in puppies before designing a vaccination schedule.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-022-03219-2","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T07:15:54Z","timestamp":1648538154000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The first evaluation of the effectiveness of canine vaccination schedule by two commercial vaccines in Iran"],"prefix":"10.1186","volume":"18","author":[{"given":"F.","family":"Shams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pourtaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Abdolmaleki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"issue":"1","key":"3219_CR1","doi-asserted-by":"publisher","first-page":"e22654","DOI":"10.1002\/jcla.22654","volume":"33","author":"M Hoang","year":"2019","unstructured":"Hoang M, Wu HY, Lien YX, Chiou MT, Lin CN. 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All experiments were performed in accordance with relevant guidelines and regulations. The study was carried out in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}