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With this study we compared the perioperative analgesic effects of thoracic epidural anaesthesia (TEA) and intrathecal morphine (ITM) in dogs scheduled for thoracic or cranial abdominal surgery. The dogs received methadone and dexmedetomidine, were anaesthetized with propofol maintained with sevoflurane, and randomly assigned to receive either TEA (ropivacaine 0.5% at 0.2 mg\/kg and morphine 0.1 mg\/kg administered at T<jats:sub>12<\/jats:sub>-T<jats:sub>13<\/jats:sub>) or ITM (morphine 30 \u03bcg\/kg administered at L<jats:sub>6<\/jats:sub>-L<jats:sub>7<\/jats:sub>). Intraoperative rescue analgesia (iRA) was fentanyl 1 \u03bcg\/kg administered if heart rate or mean arterial pressure increased by 30% above the pre-stimulation level. Glasgow Pain Composite Scale score (GPCS) dictated the use of postoperative rescue analgesia (pRA) with methadone 0.2 mg\/kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant difference in iRA, median time to first fentanyl bolus, median fentanyl dose after surgical opening, and median GPCS score at 30 minutes (min), 1 ,2, 4, 6, and 8 hours (h) between the two groups (<jats:italic>p&lt;<\/jats:italic>0.001;<jats:italic>p&lt;<\/jats:italic>0.001;<jats:italic>p<\/jats:italic>&lt;0.001;<jats:italic>p&lt;<\/jats:italic>0.01;<jats:italic>p&lt;<\/jats:italic>0.01;<jats:italic>p&lt;<\/jats:italic>0.001;<jats:italic>p&lt;<\/jats:italic>0.01;<jats:italic>p=<\/jats:italic>0.01;<jats:italic>p=<\/jats:italic>0.01, respectively). Fewer TEA than ITM group dogs required iRA during surgical opening and pRA: 5% (1\/18) and 2\/18 (11%), respectively, in the TEA and 83% (16\/18) and 10\/18 (55%), respectively, in the ITM group. Side effects were urinary retention in 3\/18 (16%) TEA group dogs and 2\/18 (11%) ITM group dogs and prolonged sedation in 2\/18 (11%) in ITM group dogs.<\/jats:p><jats:p>TEA and ITM were effective in managing perioperative pain in dogs undergoing thoracic or cranial abdominal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-022-03296-3","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T04:02:39Z","timestamp":1653624159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thoracic epidural anaesthesia vs intrathecal morphine in dogs undergoing major thoracic and abdominal surgery: clinical study"],"prefix":"10.1186","volume":"18","author":[{"given":"E.","family":"Lardone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Sarotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Giacobino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ferraris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Franci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"3296_CR1","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1001\/jama.290.18.2455","volume":"290","author":"BM Block","year":"2003","unstructured":"Block BM, Liu SS, Rowlingson AJ, Cowan AR, Cowan JA, Wu CL. 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No. n. 71 10\/01\/2020) and all procedures were performed with the dog owners\u2019 written informed consent. Authors ensured that our manuscript conforms to the \u2018ARRIVE Guidelines for Reporting Animal Research\u2019 summarized at. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"200"}}